Conserved Protein Domain Family
zf-CCHH

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pfam10283: zf-CCHH 
Zinc-finger (CX5CX6HX5H) motif
This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- and PNK-like forkead association domain-containing protein. The ZnF is highly conserved both in primary sequence and in the spacing between the putative zinc coordinating residues and is configured CX5CX6HX5H. Many of the proteins containing the APLF-like ZnF are involved in DNA strand break repair and/or contain domains implicated in DNA metabolism.
Statistics
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PSSM-Id: 402071
View PSSM: pfam10283
Aligned: 72 rows
Threshold Bit Score: 42.0556
Threshold Setting Gi: 347972057
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001463473  491 RPNCWYGKECRAQfhNEQHAQNYNHvcyQE 520  Leishmania infantum JPCM5
XP_011433142  103 RPDCTYWEKCYRK--DPNHLKQFRH---PA 127  Pacific oyster
XP_004346784  376 RPVCTYHPHCYRK--NVEHLKQFAH---PP 400  Capsaspora owczarzaki ATCC 30864
EEB09885      345 KPPCIYGSNCYRR--NSTHRKQFYH---PP 369  human body louse
Q22W29        542 KPDCWYGVNCYTR--NPQHNKIYNH---AC 566  Tetrahymena thermophila SB210
XP_005473094  590 RPDCYWGRNCRTQv-KAHHAAKFNHiceQT 618  Nile tilapia
XP_002121818  392 KPECEYGLDCYRR--NPLHRKQFKH---TK 416  vase tunicate
EEC00376      403 RESCKYGKKCFRK--NALHLKNFKH---PT 427  black-legged tick
ESN98431      863 RPACRYGSNCYQK--SFLHRIHFKH---PK 887  Helobdella robusta
XP_008192479   12 RTPCRYGEKCYQK--SVEHRNKFKH---PP 36   red flour beetle
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