1RI6,6IGB,3FGB


Conserved Protein Domain Family
Lactonase

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pfam10282: Lactonase (This model is not part of the current CDD release)
Lactonase, 7-bladed beta-propeller
This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.
Statistics
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PSSM-Id: 491057
Aligned: 51 rows
Threshold Bit Score: 247.921
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RI6_A         7 VYIASPES----QQIHVWNL----NHEGALTLTQV--VDVPGQVQPMVVs--pDKRYLYVGVR---------PEFRVLAY 65  Escherichia coli
XP_659716     26 LYATHYST----SSIYTLTLkq-sNNTYSLAEASSl-KTCGRYPSWITLd--aSTKTLYCSDEygwrnaggtVNGSLTTV 97 
O59681         3 LVIGTCTD----GPVLVFDM-----ETKSITEKLE----GVSSPTWVEWe--kKSKRLYVANEi--------EEGYVAVF 59  Schizosaccharom...
Q2H0R7        33 LWVTTYPIgdgaGELLTLKL-----EGSKLSSVATs-DTCGPFPSWLTQ----VDDVLYCVNEaw-----ggQNGDLAAL 97  Chaetomium glob...
Q7S9K3        25 fatsmgTStd-pGFLSTIKY-----ADGKLEVINKqlGICGNNPSWLEF----VGDHIYCLDEaw-----ssITGSLYNF 89  Neurospora crassa
Q4WHI9        17 LYATHYS-----GAVYTLSLth-rNGKYNLSLASDm-TTCGGMPSWLTLdrdtTTSTLYCSDEtgd----atTNGTLTSY 85  Aspergillus fum...
XP_001272673  16 LYATHYS-----GSLSTLTLdraaNGSYALSIAASe-VTCGGMPSWLTLd--aTTRTLYCSDEtgd----asTTGSLSTY 83 
Q7S6A9        23 LLVSHFS-----GPVYTLSLtt-sGTTGKLSITSQa-GGCGTTPAWLEYy--nDTKTAYCFDEsw------tGSGVITQY 87  Neurospora crassa
Q0UJM1        19 LWATHYS-----GTLNYLTF-----SGKSLTLTSSs-KIGNNLPSWITYd--sAGKAIYVPDEvfq----gpSTGSLVSM 81  Parastagonospor...
Q8A8P5        37 LLVGCYMKpd-eEGVRMYRFd---GQTADVDYPCG--LRGISNPAFLTSd--sTGNRIYAIGDde------gKSSTANAL 102 Bacteroides the...
1RI6_A        66 RIAPDd--GALTFAAESA---LPGSLTHISTDHQGQFVFVGSYNAGNVSVTRL-ED-GLPVGVVD-VV------------ 125 Escherichia coli
XP_659716     98 NVGEDgslSEEAVTGTAPg--SGVHNIVYEGDGGEKYLAIAHYSGAAVSTYALpLE-NDADPLQVfEFeldtpg-evpdr 173
O59681        60 EWDN----GKFSLVDRFTi--DGHSPTSLCVLENGS-VLTANYNSASISR-------SKAKDEKPhVWhhegks-lhper 124 Schizosaccharom...
Q2H0R7        98 QIGAD---SSFTVLSSGKt--VGGPVSTIVYGNEGRGLAVADYAGGGIDTFDIsDP-AAIKTLVSkVFpgrdd--gaapp 169 Chaetomium glob...
Q7S9K3        90 QVPRDg--TNLTLINKLDt--LGGPVSSVRYGQNLKGLAIAAYAGGGFQSFDIsNP-AAPKALQNsTFtispkp-gsdpq 163 Neurospora crassa
Q4WHI9        86 AVGKD---GSLTQLAKVVdvgGGVHSVVYEGEGGAKYIAIAHYSGSAVSTFALpLEsGDEPLQ---ILryqtpp-gplpq 158 Aspergillus fum...
XP_001272673  84 TVGRD---GALTQTAKVVdvgGPVNSIVYEGVRGEKYLAIAHYTGSAVTTFSLpIQpSSKPHQ---VLrytlphpgprpe 157
Q7S6A9        88 NVGSD---GRLTQSGQTRtsgNTVHGKVYGGSDGKGFIATAQYSPSTITTYKLpLGqGQVQLEKF-TMsqrg----pnsr 159 Neurospora crassa
Q0UJM1        82 SIGNNg-tVKTTGTGITPq--GVVANTLYGGADGKGFIANAHYQTSQITTFKLpLT-GGQPIQ---SIkytgsg-pnqgr 153 Parastagonospor...
Q8A8P5       103 LFDKEs--GLLSLLNSQSt--DGELPIYITLSPKEYFVLTANYKGGSITVFSQdKK-GKLQRDTK-IIrfagng-pnkkr 175 Bacteroides the...
1RI6_A       126 EGLDGCHSANISPDNRTLWVPALKQDRICLFTV----SDDg---hLVAqdPAEV-TTVEGAGPRHMVFHP---N------ 188 Escherichia coli
XP_659716    174 QEAPHPHQTFLDPTGSFVLVPDLGADLIRVFAId---KSNg---eLNA--CPSL-NYTLGGGPRHGVFRT---Asdselr 241
O59681       125 QTSSHPHQV--TAHKHLVCSVDLGLDRFSIFDAe---DTSs--------dPVVVvNVPAGYGPRHIVFHK---T------ 182 Schizosaccharom...
Q2H0R7       170 QEQARPHEAILDPTGEFLVFPDLGADLIRVLKVd---KATl---eYTE--KPSY-EFARGTGPRHGAFYQsgdN------ 234 Chaetomium glob...
Q7S9K3       164 QKTSHPHEVVLDPTGNFIAAPDLGADLIRIFKVd---KNTl---sYVE--SKTV-PTPDLSGPRHGAFVKl-dS------ 227 Neurospora crassa
Q4WHI9       159 QDSSHPHQIILDPTGSFILVPDLGTDQVRVYAId---KQSg---qLNT--CPSL-NYTPGSGPRHGLFWS---Shhshrd 226 Aspergillus fum...
XP_001272673 158 QDSPHPHQVILDPTGAFILIPDLGADQVRVYAId---KHTg---qLDA--CPSL-EFTPGSGPRHGVFWSsadAvqrgsr 228
Q7S6A9       160 QDVPHPHETQLDPTGKFMLVPDLGADLIRIFKId---ASTg---rLTA--CPAG-QASPGDGPRHAQWWKsadG------ 224 Neurospora crassa
Q0UJM1       154 QEAPHPHHAFVDPTGDFLIVPDLGTDNIRINKId---KTTg---kLTE--CGAG-KPAPGSGPRHGAFWSpagAssrv-- 222 Parastagonospor...
Q8A8P5       176 QEQSHLHCVTFTPDGKFLLATDLGTDCIYLFPIgkrpEAGkahslLDEsrVVRI-QMDSGSGPRHICFHP---N------ 245 Bacteroides the...
1RI6_A       189 -------------EQYAYCVNELNSSVDVW--ELKd-pHG--NI-ECVQTLDMMPE--N-FSDT---R---WAADIHITp 240 Escherichia coli
XP_659716    242 i-----rgrapgpETVLYVTGELNGEVEAFavSYPk-sGCl-SF-EQIDTEIPYPS--D-LPDG---A---SLSEIRLV- 303
O59681       183 -------------LPVCYLICELANRILVY--DTN-------TF-ECLQDVSTLPPsmT-LEKDpkfPqppSAAEVAVVh 238 Schizosaccharom...
Q2H0R7       235 --------------TYFYVVCELSNLLQGFsvAYNe--DSslTF-TQLYNATTHGAtdAlPEET-------AAAEIFLAp 290 Chaetomium glob...
Q7S9K3       228 -------------GTYFYVVTELSNEIIGWkvTYNs-nGLdlDFgKELFIIPTHGP--G-STGIgntT---RASELVISp 287 Neurospora crassa
Q4WHI9       227 glriqktaaltapHTILYTVSELSRHFHAFavSYLp-sGCl-GF-RETQDFVPYPGg-E-ITEG---A---SLAELQQA- 294 Aspergillus fum...
XP_001272673 229 s-----rrpghaaETFLYTVSELSRHFDAFavSYPa--AGclAF-HRTQDFIPYPGgeT-PQGA-------SLAEIRLA- 291
Q7S6A9       225 -------------VLRLYTLNELGNSVSSWnvVYPtdsNGclAL-SRAQTLSTYAPgkKgGPTT-------KAAEIRVA- 282 Neurospora crassa
Q0UJM1       223 ---------rradNTFLFVANELANTLSSWavTYPa--GGclTL-KLKHTLTPYQGnsTaARGT-------KLGEVKVK- 282 Parastagonospor...
Q8A8P5       246 -------------GRFAYLISELSGKITVF--SYN---EG--KL-ERLQTIVCDP-----FVAE-------GNADIHVSs 292 Bacteroides the...
1RI6_A       241 dGRHLYACDRT-------------------ASLITVFSVsEDGSVLSKEGFQPTETQ---PRGFNVDHSGKYLIAAGQKS 298 Escherichia coli
XP_659716    304 -EDDLYVSVRLdsa-------------fggDDSLARLSL-RQDGKVEFEEISTSGGVl--PRTFAINKAGDLVAVGNQLS 366
O59681       239 dGPFLVASNRYlnh--------------gqCDSLWAARLdPVTGKVIEGTEMQIMLHgicPRHFMFNRGASLLAVAMQDD 304 Schizosaccharom...
Q2H0R7       291 nSNFLTVSSRFerelsytv----angtevaSDPLITFSI-DAEGQLTHVQTAPAGGIn--PRHFSFNSDGSRVASALQSD 363 Chaetomium glob...
Q7S9K3       288 dNKFLLVSSRFdektfdipdpednaagrikSDSIINYAI-EADGTLSLHQIFAAGGIn--PRQFSLSKDGSLVVSALQNS 364 Neurospora crassa
Q4WHI9       295 -GSNLYASIRSdha-------------fsgNDSLATLNR-SQNGTVTFQELTSSYGLv--PRTFVINRAGTLVAIGDQSS 357 Aspergillus fum...
XP_001272673 292 -GHNLYASVRSdha-------------fkpNDSLVTLTR-AHNGTVALRELTSAYGTv--PRTMVINKAGTLVAVGDQAS 354
Q7S6A9       283 -GNFLYASNRAdqtf------------gsnQDSVAIYTIdHQTGGIAWKEAANSYSYy--PRTFDINKDGTLVAFGGQTS 347 Neurospora crassa
Q0UJM1       283 -GNYVYTSNRNdkk-------------fspNDSMTQYTI-AADGTFTFTENTSSYGTy--PRTFDINKAGDFVAIGDQTS 345 Parastagonospor...
Q8A8P5       293 dGKFLYASKHLk------------------EDGIIVYSIdSQKGTLVQIGFQPT-GLy--PRSFAISPDGCYLAVVCRDA 351 Bacteroides the...
1RI6_A       299 HHISVYEIVGEQGLLHEKGRY-AVGQGPM 326 Escherichia coli
XP_659716    367 STVTIVERDPETGALGEVVAE-LLVGEPG 394
O59681       305 DLVHVYRREPKSMCLHLLFT--IPAPKPT 331 Schizosaccharomyces pombe 972h-
Q2H0R7       364 GRVVIFERDVTTGKIGKVVAEtDVAGMPN 392 Chaetomium globosum CBS 148.51
Q7S9K3       365 GHVALIKRNVQTGNLTEFIGAvHLGGQPT 393 Neurospora crassa
Q4WHI9       358 SNVAIVSRDSASGKLGDLVAN-LQVGEPG 385 Aspergillus fumigatus
XP_001272673 355 ANVAIIARNPKSGKLGDLVAS-VQVGEPG 382
Q7S6A9       348 SNVAIVSRDPATGKLGNLVAN-LQVGNKG 375 Neurospora crassa
Q0UJM1       346 SNVAIVARNPTTGKLGERVAD-LRIGATG 373 Parastagonospora nodorum SN15
Q8A8P5       352 NCIQIFERNRNTGLLKNTGKN-IRLERPA 379 Bacteroides thetaiotaomicron
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