3SCY,6IGB


Conserved Protein Domain Family
Lactonase

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pfam10282: Lactonase (This model is not part of the current CDD release)
Lactonase, 7-bladed beta-propeller
This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.
Statistics
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PSSM-Id: 519296
Aligned: 53 rows
Threshold Bit Score: 251.386
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3SCY_A  16 XLVGTYTSgnsKGIYTFRF--NEETGE-SLPLS-DAEVANPSYLIPsaDGKFVYSVNEfSK----DQAAVSAFAFDKEk- 86  Bacteroides fragilis ...
O86271   5 ILLGGYTKrvsKGVYSVLL--DTKAAElSSLNE-VAAVQNPTYITLd-EKGHLYTCAA-DS----NGGGIAAFDFDGE-- 73  Lactococcus lactis su...
Q38YF6   5 VLIGGYTRrigKGIYRGTL--SPETATiTDIKP-YITLDNASYLAIs-KQQILYTVVK-EG----EQGGIAAYDISGTt- 74  Lactobacillus sakei s...
Q8DP45   5 VYFGTYTRrtsQGIYKADF--DTETGQlSNLEL-FAAEPSPTYLAFd-QHQHLYTVGS-QD----DKGGIAAYQTDGTv- 74  Streptococcus pneumon...
Q03PD4   5 FYIGTYTKrisRGIYRVSV--DTTTPKlMDCEW-LASAGSPTYIAKs-NAKRLYVINK-KEtdgqTHGGLIIYDMSEDkp 79  Lactobacillus brevis ...
Q04ER9   5 LLFGTYTKsesKGLYEAEL---SDSGElKNLKN-TAEIGSPTYFAVs-NAGLLYAVDK-QD----QRGGVSVWDTSTI-- 72  Oenococcus oeni PSU-1
Q5FL94   3 VLIGGYTKktsKGIYELPFigEDNEAHlEKAEN-IISVGGPTYFQK--DGDLVFTINN-AG----DEGGISAFKLSD--- 71  Lactobacillus acidoph...
Q1GB62   3 ILIGGYTKhesAGIYQFDFigSGDQAHlEQRRN-VVEVGGPTYFQK--DGQFIFTIKN-EN----GQGGIAAFA------ 68  Lactobacillus delbrue...
Q1WT01   5 IYFGTYTRnnsKGIYQAEL--DTEKKEiRDLELfIDDIVSPTYLTTt-NNGILLTITG-NDq---GQGGIASYNLTTPk- 76  Lactobacillus salivar...
Q21KS1  33 FAIGGYTDgpgQGVNGLSL--NHATGElTSLGL-LAETVNPSYVVFneDATVMYTVNE-K-----EHGGISAFTLNTTn- 102 Saccharophagus degrad...
3SCY_A  87 -GTLHLLNTQKTXGADPCYLTT--NGKNIVTANYSGGSITVFPIGQDGALLPASDVIEFKGS--GPDkERQTXPHLHCVR 161 Bacteroides fragilis ...
O86271  74 --TATHLGNVTTTGAPLCYVAVdeARQLVYGANYHLGEVRVYKIQANGSLRLTD-TVKHTGS--GPRp-EQASSHVHYSD 147 Lactococcus lactis su...
Q38YF6  75 -PVY--LNAILAAGAPPAYVAVdeTRQLIYAANYHKGEILVYAIQNDGHLVLANTVQHT-GH--GPRpEQA-SAHVHYTD 147 Lactobacillus sakei s...
Q8DP45  75 ------LNHVVEEGAPHCYVAVdeKRDLVYAANYHKGQVLVYKRQEDGSLLLSD-MDQHSGQ--GPHeNQA-SPHVHYTD 144 Streptococcus pneumon...
Q03PD4  80 rAIQQLLD----LGSSPAYVAVdeDRQLVYTANYHTAAVDVYAINPDGTLKRTDQVIDQDPV--GPApEQADGPHPHFAD 153 Lactobacillus brevis ...
Q04ER9  73 --PFKKTDEQISDGSSPAYIFVdeKRQLVFTGNYHKGLVSIYKIDGQKLIKSD--EFKNEGS--GPRp-EQESSHIHFTA 145 Oenococcus oeni PSU-1
Q5FL94  72 -HGSNEIDRHLTPGASPAYIGInkEKKLLYTANYHTAVLSVFQYSNSGKLALVAQ-TTHKAEslGPRpEQVDGPHPHFFD 149 Lactobacillus acidoph...
Q1GB62  69 --NGKLVSQLLHEGSSPAYIGInkEKKLLYTANYHTGVLAVISYDDQGQLTLLDQ-VKHENKalGPRpEQA-GAHPHYFD 144 Lactobacillus delbrue...
Q1WT01  77 -PVL--VDQKLADGASPCYVSYdgQRKLVYTANYHKGLVEVYRLENDNTLTLKDSVTYE-GK--GPRpEQD-KSHAHYAD 149 Lactobacillus salivar...
Q21KS1 103 -KTFTLTAATQGVAYAPCHISLspNGKFIAVANYMSGDVQLFSRAADANLALVSA-QQHTGK--GPNeSRQEAPHPHWIN 178 Saccharophagus degrad...
3SCY_A 162 ITPDGKYLLADDLGTDQIHKFNInpnanaDNKEkfLTKgtPEAFKVAPGSGPRHLIFNSDGKFAYLINEIGGTVIAFRYa 241 Bacteroides fragilis ...
O86271 148 LTPDGR-LVTCDLGTDEVTVYDV------IGEg-kLNI--ATIYRAEKGMGARHITFHPNGKIAYLVGELNSTIEVLSYn 217 Lactococcus lactis su...
Q38YF6 148 LTPD-NRLAVCDLGTDELTTYTI------ADNGd-LTK--TATYHSEPGFGARHLVFHPNHQVAYLLGELSSEVTVLNYd 217 Lactobacillus sakei s...
Q8DP45 145 LTPD-HYLVTCDLGTDQVITYDL------DQEGk-LSK--LYTYHSKPGAGSRHIIFHNHYKIAYLICELNSTIEVLIYd 214 Streptococcus pneumon...
Q03PD4 154 LTPD-NRLVVCDLGSDRVYVYDV------SATGk-LSA--VSHLDLPAGYGPRHIVFDAKKGVAYLVGELSSNVATLSYd 223 Lactobacillus brevis ...
Q04ER9 146 LTPDNR-LVAVDLGSDELLTFEL------SKDGk-LSQ--PTRFKTEKGFGPRHIRFSKDGNYAYLLGELSSKLSILKYk 215 Oenococcus oeni PSU-1
Q5FL94 150 ETPAGN-LVSCDLGNDTVDFYRL------ENNE--LKH--LAQYKNEAGFGDRHIVFSKDGNYFYVVGELSSQINVVKFn 218 Lactobacillus acidoph...
Q1GB62 145 ETPGGH-LVSCDLGQDRVDFYGF------DGQK--LTH--LASYQNEDGFGSRHLAFSPDGKYFYVAGELSSQVNVVKFd 213 Lactobacillus delbrue...
Q1WT01 150 LTPD-NKLVTINLGDDKVHTYDV------SEEGk-ISE--IAAFQTPEGFGPRHIVFSNNGKLAYLAGELSSEVAVLEYn 219 Lactobacillus salivar...
Q21KS1 179 WSPDGKFVYSVDLGIDQIIKYTV------TEQG--FSAg-EPAITLQGGDGPRHMVFHANKDIAYVVNELSNTVAVLSYn 249 Saccharophagus degrad...
3SCY_A 242 --DGXLDEIQTVAADTVNAQG---SGDIHLSpdGKYLYASNRLkADGVAIFKVdETNGTLTKVGYQLT-GIHPRNFIITP 315 Bacteroides fragilis ...
O86271 218 eeKGRFARLQTISTLPEDYHGangVAAIRISsdGKFLYTSNRG-HDSLTTYKVsPLGTKLETIGWTNTeGHIPRDFNFNK 296 Lactococcus lactis su...
Q38YF6 218 anTGEFTAVETYSMLPDDWHEangGAAIRISqdGQFLYASNRG-YNSIVVYRIsADGQQLTTIQQMSTdGEFPRDFNLSA 296 Lactobacillus sakei s...
Q8DP45 215 -gVGEFERMQVISTLPEAYEGfngTAAIHLSkdGKYLYASNRG-HDSIAVYTIlADG-SLELLEIVPThGQTPRDFDLTP 291 Streptococcus pneumon...
Q03PD4 224 taTGTFTVKTIVSTIPDDWTAhngAAAIRLSadGKFVYVSNRG-NNSLAVFASdEAG-QLTLVQRISTeGDFPRDFNWTA 301 Lactobacillus brevis ...
Q04ER9 216 --EGKFELVKTVSTIPADWTAhngAAAIRLSndYKFIYNSNRG-YNSIAVFKIsENQENVELIQQISTeGDFPRDFNVSP 292 Oenococcus oeni PSU-1
Q5FL94 219 enTWEFEDIATYKTIPEDFTEhngAAALYITndGKYIYNSNRG-HNSITVFKVnDDH-TLSLIQRISTfGDFPRDFNWDE 296 Lactobacillus acidoph...
Q1GB62 214 eeNWMFRSLATYSTIPESWDQhngAAAIRLSsdGKFLYVSNRG-HDSIAVFAVlPDQ-ALKLVQRVSTfGEFPRDFNWDA 291 Lactobacillus delbrue...
Q1WT01 220 --NGIFNLIQIVSTIPVDWTKhngVAAIRISsdDRFVYVSNRG-HNSIAVFEVeEDG-ILKLIQTISTnGDFPRDFALDN 295 Lactobacillus salivar...
Q21KS1 250 peTGALTEMQRIGTLDPAFSEhsqTAAIKVSsdQRFVYASNRG-ANTIAVFAV-AADGRLTYVHEHATeGKWPRDFTLTS 327 Saccharophagus degrad...
3SCY_A 316 NGKYLLVACRDTNVIQIFERDQATGLLTDIKKDIKVDKPV 355 Bacteroides fragilis NCTC 9343
O86271 297 TEDYIIVAHQESDNLSLFLRDKKTGTLTLEQKDFYAPEIT 336 Lactococcus lactis subsp. lactis Il1403
Q38YF6 297 NDQFLFAVNQNSDNGTLYHRDAQTGLLTPCQKGLETPEGV 336 Lactobacillus sakei subsp. sakei 23K
Q8DP45 292 DQKFLIVVHQDSDNATVFKRNCDNGRLAELSNDFHVPEAV 331 Streptococcus pneumoniae R6
Q03PD4 302 NQRLVLVVNQNSDNASLFERDAQSGKLTLVQKDFMVPEGV 341 Lactobacillus brevis ATCC 367
Q04ER9 293 DGKYLVAVNQNTNNATSYSINPENGKLTLIQKDFYLPEAV 332 Oenococcus oeni PSU-1
Q5FL94 297 TQKYVVAANQNTDNATLYLRNGGNGTLTPIQTEIPVPEGT 336 Lactobacillus acidophilus
Q1GB62 292 EEKYVVAANQNSNNATLYQRQ-SDGTLTPLEKDIAVPEGT 330 Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM ...
Q1WT01 296 SERFIVVAHQNSTIASLFARNATSGKLELLQTDIPVPEGV 335 Lactobacillus salivarius UCC118
Q21KS1 328 DGKYVLVANEHSSTITLLARDSETGKLSSTGKSIATHRPT 367 Saccharophagus degradans 2-40
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