Conserved Protein Domain Family
Med11

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pfam10280: Med11 
Mediator complex protein
Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organisation is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans. Med11 appears to be necessary for the full and successful assembly of the core head sub-region.
Statistics
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PSSM-Id: 402068
View PSSM: pfam10280
Aligned: 84 rows
Threshold Bit Score: 59.5685
Threshold Setting Gi: 505755385
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:MYCTH_2301973  25 GERIQQLSETDQDIASLLVHLSAAMRALATppgttvsetgnnnnssnnnsstiatgdpdlessEPAPATGNDPVSAFNAA 104 Thermothel...
EFA79080            1 mnSLTVLNNIEDRVVESINTAGKALNILSK---------------------------------SLDIKQTTPSIQEFKQL 47  Heterostel...
XP_001640033        5 RDRLKQLEEIEKDIVKVMQSAGETIAELSN---------------------------------------ENPSEDMVNMK 45  starlet se...
OWR51048            5 iERIQVLDEIEKDIITCLQCAAQALLELGK---------------------------------------EKSSQKQAESN 45  Danaus ple...
XP_016845859        5 mERIQILEAIEKDIITCLQSAGQAFMELSK---------------------------------------DKPNSKQAEGQ 45  jewel wasp
BAH71487            5 mERIQALELIEKDIITCLQSAGQALLELSK---------------------------------------EKSSLKQVENQ 45  pea aphid
XP_974541           5 mERIQVLDSIEKDIITCLHSAGQVFVELSK---------------------------------------EKSSLKQAENH 45  red flour ...
XP_007236272        3 NDRLRALEDVEKEIAVVLQCAGTIILELSK---------------------------------------EKHNASLLDRQ 43  Mexican tetra
Q6P255              8 NERLRALEEIEREIAAILLNAGNVILELSK---------------------------------------EKPNERVLDKQ 48  tropical c...
XP_007625140        8 NERLRALEDIEREIGAILQNAGTAILELSK---------------------------------------EKTNERLLDRQ 48  Chinese ha...
jgi:MYCTH_2301973 105 QTAFFNTLDR-VDKHLTRQILALEEAGIitlkntaagsgtaagtaaaegtpqggegaaggpsgtqqqqpqqqspeggagd 183 Thermothel...
EFA79080           48 SDRYFNIVEKdVYKGLMEFVDSMTD------------------------------------------------------- 72  Heterostel...
XP_001640033       46 ATEFVKSLEG-VEKGLTEQINYLTQVAT---------------------------------------------------- 72  starlet se...
OWR51048           46 TSQFLRTLSQ-VESKLSDQINYLTQVST---------------------------------------------------- 72  Danaus ple...
XP_016845859       46 THQFIKTLGL-VESKLSDQINYLTQVST---------------------------------------------------- 72  jewel wasp
BAH71487           46 SHQFLKSLGN-VESKLTEQINYLTQVST---------------------------------------------------- 72  pea aphid
XP_974541          46 TQTFLKTLGA-VESKLTEQINYLTQVST---------------------------------------------------- 72  red flour ...
XP_007236272       44 LNQFQTSLNR-VESELSSQIRYLTQVAT---------------------------------------------------- 70  Mexican tetra
Q6P255             49 ATQFTASVQR-VESELSGQIRYLTQVAT---------------------------------------------------- 75  tropical c...
XP_007625140       49 ASAFTTSVQH-VEAELSAQIRYLTQVAT---------------------------------------------------- 75  Chinese ha...
jgi:MYCTH_2301973 184 aakarvagPRRLEPDGMGRYGNLDVGK-----LNMASSTVERDMERELwrR-AREEL 234 Thermothelomyces thermophilus ATC...
EFA79080           73 --------VAPFDHSSYSNKCELDVSHnfteiILLHL-------------EeMEEIL 108 Heterostelium album PN500
XP_001640033       73 --------GQPHEGSTYGVDKDFELATsrtaiVKGQLQEVQKILKNptvakt----- 116 starlet sea anemone
OWR51048           73 --------GQPHEGSGYASQKVLQMAWhrlehVRSWVNELERLKASHMaassrsnsn 121 Danaus plexippus plexippus
XP_016845859       73 --------GQPHEGSGYESQKVLQMAWhrlqhVRSRVDELERLKNKhmhsrslaalg 121 jewel wasp
BAH71487           73 --------GQPYENSGYASQKVLQMAWhrlehARSRVKELERSKNKYLqdqeqlkgn 121 pea aphid
XP_974541          73 --------GQPHEGSGYASQKVLQMAWhrlehARSRVNELDRLKLKHmqgrrvqppn 121 red flour beetle
XP_007236272       71 --------GQPHEGSTYSARKDCQMALnraeyARVKLGELGRT---------CELML 110 Mexican tetra
Q6P255             76 --------GQPHEGSSYSARKDGTMALnridyARVKLAELSRT---------CDQML 115 tropical clawed frog
XP_007625140       76 --------GQPHEGSSYSSRKDCQMALkrvdyARLKISDVVRT---------CEQML 115 Chinese hamster
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