6XP5


Conserved Protein Domain Family
Med11
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pfam10280: Med11 (This model is not part of the current CDD release)
Mediator complex protein
Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organisation is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans. Med11 appears to be necessary for the full and successful assembly of the core head sub-region.
Links
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Statistics
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PSSM-Id: 519294
Aligned: 83 rows
Threshold Bit Score: 67.2551
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6XP5_K        28 AERIQQLGEIDNDIASLLQHLSAALKALatppgkrifqeqdseSNsPSASDTSNPNdtppsscgidpVTAFKTAQNDFFR 107 Thermochaetoide...
XP_020431202   1 mnSLTVLNNIEDRVVESINTAGKALNIL---------------SK-SLDIKQTTPS-----------IQEFKQLSDRYFN 53 
EDO47970       5 RDRLKQLEEIEKDIVKVMQSAGETIAEL---------------SN-------ENPS-----------EDMVNMKATEFVK 51 
XP_032529842   5 iERIQVLDEIEKDIITCLQCAAQALLEL---------------GK-------EKSS-----------QKQAESNTSQFLR 51 
XP_008215119   5 mERIQILEAIEKDIITCLQSAGQAFMEL---------------SK-------DKPN-----------SKQAEGQTHQFIK 51 
NP_001156198   5 mERIQALELIEKDIITCLQSAGQALLEL---------------SK-------EKSS-----------LKQVENQSHQFLK 51 
XP_974541      5 mERIQVLDSIEKDIITCLHSAGQVFVEL---------------SK-------EKSS-----------LKQAENHTQTFLK 51 
XP_007236272   3 NDRLRALEDVEKEIAVVLQCAGTIILEL---------------SK-------EKHN-----------ASLLDRQLNQFQT 49 
Q6P255         8 NERLRALEEIEREIAAILLNAGNVILEL---------------SK-------EKPN-----------ERVLDKQATQFTA 54  tropical clawed...
XP_003497246   8 NERLRALEDIEREIGAILQNAGTAILEL---------------SK-------EKTN-----------ERLLDRQASAFTT 54 

6XP5_K       108 TIDR-IDKHLTRQIYALEEAGIitlksgtgsgagtvgagateeqaqqlpqpqmipgqpqaagitadasvapvpKARLEPD 186 Thermochaetoide...
XP_020431202  54 IVEKdVYKGLMEFVDSMTD------------------------------------------------------VAPFDHS 79 
EDO47970      52 SLEG-VEKGLTEQINYLTQVAT---------------------------------------------------GQPHEGS 79 
XP_032529842  52 TLSQ-VESKLSDQINYLTQVST---------------------------------------------------GQPHEGS 79 
XP_008215119  52 TLGL-VESKLSDQINYLTQVST---------------------------------------------------GQPHEGS 79 
NP_001156198  52 SLGN-VESKLTEQINYLTQVST---------------------------------------------------GQPYENS 79 
XP_974541     52 TLGA-VESKLTEQINYLTQVST---------------------------------------------------GQPHEGS 79 
XP_007236272  50 SLNR-VESELSSQIRYLTQVAT---------------------------------------------------GQPHEGS 77 
Q6P255        55 SVQR-VESELSGQIRYLTQVAT---------------------------------------------------GQPHEGS 82  tropical clawed...
XP_003497246  55 SVQH-VEAELSAQIRYLTQVAT---------------------------------------------------GQPHEGS 82 

6XP5_K       187 GMGRYGKLDVGR-----LNMASSIVEREMEGELwrK-AREHL 222 Thermochaetoides thermophila DSM 1495
XP_020431202  80 SYSNKCELDVSHnfteiILLHL-------------EeMEEIL 108
EDO47970      80 TYGVDKDFELATsrtaiVKGQLQEVQKILKNptvakt----- 116
XP_032529842  80 GYASQKVLQMAWhrlehVRSWVNELERLKASHMaassrsnsn 121
XP_008215119  80 GYESQKVLQMAWhrlqhVRSRVDELERLKNKhmhsrslaalg 121
NP_001156198  80 GYASQKVLQMAWhrlehARSRVKELERSKNKYLqdqeqlkgn 121
XP_974541     80 GYASQKVLQMAWhrlehARSRVNELDRLKLKHmqgrrvqppn 121
XP_007236272  78 TYSARKDCQMALnraeyARVKLGELGRT---------CELML 110
Q6P255        83 SYSARKDGTMALnridyARVKLAELSRT---------CDQML 115 tropical clawed frog
XP_003497246  83 SYSSRKDCQMALkrvdyARLKISDVVRT---------CEQML 115
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