2ZFY,4DHJ,8CMS


Conserved Protein Domain Family
Peptidase_C65

?
pfam10275: Peptidase_C65 (This model is not part of the current CDD release)
Peptidase C65 Otubain
This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumour domain) in which there is an active cysteine protease triad (ii) a nuclear localisation signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.
Statistics
?
PSSM-Id: 519291
Aligned: 22 rows
Threshold Bit Score: 199.422
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2ZFY_A         3 EIAVQNPL-VSER----LELSVLYKEYAEdDNIYQQKI---------KDLHKK--YSYIRKTRPDGNCFYRAFGFSHLEA 66  human
Q2H586       170 APHTQGPL-VGKK----TPSSAIMEQYADaDAIYVQKT---------MALPQT--YSDYRPIQGDGNCGWRAIGFGYFET 233 Chaetomium glob...
Q7SI56       234 yqpelnglpVGDK----LPSTAITEEYAKaDPVYVQKT---------RSLPAV--YSHYRPMLGDGNCGWRAIGFGYFET 298 Neurospora crassa
XP_001464809  19 REVAHYPL-LSLSlp-lNKESMIVKEMEH-DDAYLAQTlslfgaspvSTKQYD--FDSIRYSRRDGNCFYRCAGFRLCEL 93 
Q57ZU6        21 SEIDAAPL-LSPTveklGDGCNLMTEFSD-NPPMLVKVvs-----lwRNEETK--YKGIRYARRDGNCFYRSVVFGMHES 91  Trypanosoma brucei
Q4DPS6        17 SEIESVPL-LSDPvealSETCSLVKEFAN-SASILPKVlsl----faSDNDDR--YSGIRYARRDGNCFFRCVVFSLLES 88  Trypanosoma cruzi
Q7XPN5       230 DSCKTRDK---------KPIVDLADEFE--NNTIKKKI---------TLLSEK--YDFFRPVDRDGSCFYRAFIFSYMER 287 Japanese rice
Q5KB39        20 ENTSDKPL-VSTP----VPLSVIREEYLKgSQQIVKKL---------DYLQENg-WDQVWRARGDGDCFYRSFTLAYLLR 84  Cryptococcus ne...
A0E9B0        29 EIEAQDPFiITQP----IELQILESEYLQ-NQGFLQKI---------QKIRQS--YPQFRRVRRDGSCFYRAVLFRIFEY 92  Paramecium tetr...
XP_011388746  28 ESTSHQAL-ISAV----EPIEVLEKEYAA-NRAFLGKI---------KWLKEEagFIGLRRAKGDGDCFYRAFAFAFIYK 92 
2ZFY_A        67 LLDDSK------ELQRFKAVSAKSKEDLV---SQGFTEFTIEDFHNTFMDLIEQVEKQTSV----A---DLLASFNDQST 130 human
Q2H586       234 LVKSGSk----aRIEAERQRLEGLNSLIEn--VGEFSPYVSQDFVDETLALLSKMAALVGHreqaMt--ELREAFNTPSI 305 Chaetomium glob...
Q7SI56       299 LIKLGNk----aQVDGERERLESLNEYIQh--HGGFDPMVFVDFVEETDELLKRISDKLNVpeeaMs--EVMHAFTDAEK 370 Neurospora crassa
XP_001464809  94 IVEHPD------RAAEYVALLKSREESLS-----RLFGLFVFDFTDALAEILKGVADKTITsv-----aQVYNRFISDDG 157
Q57ZU6        92 LLNNKE------RAGAHLERITDLSRQVV-----ADYGNFAEDFCHPAVEMAKKIESGECSt------vEQLYELSTNGE 154 Trypanosoma brucei
Q4DPS6        89 MLGDNE------LTARYLEQATELRTKLI-----EDYGDFVEDFCDAAIAVIRQIESGGCTt------sEELYALATSHD 151 Trypanosoma cruzi
Q7XPN5       288 IVAMQDdleriiEVSRIGERIGKYKQAYArfgSFGIPQEEFLKALSAFEQLINLIEk--------GvavEQLYQIDETDI 359 Japanese rice
Q5KB39        85 ILHSPEpd---vEANLAYDAIQRALPAME---QCGFQKDIYEEFLDPLLALIRSFAESDETtaneY---SIVQALQDPER 155 Cryptococcus ne...
A0E9B0        93 IIESKDq----qILDKFSTIIANSKADLT---AVGYEQIVIDDFYDEIMKQIKLCPNNITIq-------GIVDAFCNKVT 158 Paramecium tetr...
XP_011388746  93 IMMMKDr----pMHHFTVKHVESTLQLLK---HAGFDEEVVTDFYEPLKNLLNRMYSTDPEsqelNe-hALLQAMNEPEQ 164
2ZFY_A       131 SDYLVVYLRLLTSGYLQRESKFFEHFIEGg--------RTVKEFCQQEVEPMCKESDHIHIIALAQAL----SVSIQVEY 198 human
Q2H586       306 SDSVMYHFRMLASSYLKGHRETYSAFVTGg--------TGVDGYCLEVLERHNVEIDHLGLILLANVLlkdaGFVLEVAY 377 Chaetomium glob...
Q7SI56       371 SNAIIYHLRLLASSWLKENRGSHEAFITTd--------ESVEKFCQRVIEVPNIEIDQLGLQALVSILlkpvGFVLRVAY 442 Neurospora crassa
XP_001464809 158 AY-VLAALRYLISAYLQEHEEEYEPFVSGlg------yGTVRDYCNAEVELVDHESDNVQLAAFAKAF----NVCIKVYA 226
Q57ZU6       155 AEYALYFYRYAVSHHIRTHEDDFLPFVVGmg------hETVSEFCSVEVDAVASEADNVQVVAFAQCF----DVRVIVEY 224 Trypanosoma brucei
Q4DPS6       152 SEYVIYFYRYAVSNYIRGHKDDFLPFVMGln------yENVEDFCRAEVDAVSSESDNVQVVAFARCF----QLKIVVEY 221 Trypanosoma cruzi
Q7XPN5       360 TKNSLRFLRFLTEIEICTHEDHYKGFLLTad------ySSVFEFCQVEVRPENAEASNEQMKALVEAL----GIPVLVEN 429 Japanese rice
Q5KB39       156 SNYIVVSLRLITSSYIRTHADLFSPFLFSptt---flpLSTEEFCRQEVEPCGKEADNAQIMALAEAM----NAGVRVAY 228 Cryptococcus ne...
A0E9B0       159 SDYLIMYMRMMTSGYIKANSFLFEGYIET---------GTVELFCQQEVDPIDREADQMQIIALQNYL----QIPIRIFY 225 Paramecium tetr...
XP_011388746 165 SNSIVVYLRLLTSAFLKLNADEYTPFLFSldtssdagpPDMASFCANQVEAIGKEADHVQITALSRAL----KVSLDVAY 240
2ZFY_A       199 MD------------------------------RG----EGGTTNPHIFP-----------------EG------------ 215 human
Q2H586       378 LD------------------------------RS----PGPEVNTYRIPeean---------grhpSE------------ 402 Chaetomium glob...
Q7SI56       443 LD------------------------------RS----PGSEVNTYSFPeeai---------sqptSP------------ 467 Neurospora crassa
XP_001464809 227 LD------------------------------RN----AGNNITEYSFNged------------ndAE------------ 248
Q57ZU6       225 VD------------------------------GR----EGDCTTRHTFQqkds---------hdanEY------------ 249 Trypanosoma brucei
Q4DPS6       222 LD------------------------------GS----VGTRTTRHSFSgdss----------dtgDN------------ 245 Trypanosoma cruzi
Q7XPN5       430 LDttsetdtpilnqhfiyprpeseegtmlgplNSheivSPESSGYHAARgelqnqpstsgsstnssTEalglqsigtsst 509 Japanese rice
Q5KB39       229 LD------------------------------RSe--vGGKTINWVEFGkd--------------tSE------------ 250 Cryptococcus ne...
A0E9B0       226 LD----------------------------------------GNVSTFDatifq-------ipedaDS------------ 246 Paramecium tetr...
XP_011388746 241 LSpqqappqtpl----------deefpaeqlhQStensSDPTCRASASIpvpgndaq--rtrsaaeHPdrcdvvr----- 303
2ZFY_A       216 -------SEPKV------------YLLYRPGHYDILYK 234 human
Q2H586       403 -------LGPII------------HLLYRPDHYDILYV 421 Chaetomium globosum CBS 148.51
Q7SI56       468 -------LDPVI------------CLLYRPDHYDILYp 486 Neurospora crassa
XP_001464809 249 -------DRLVV------------GLLYMPGHYNLLGR 267
Q57ZU6       250 -------TTIEV------------TLLYRPGHYDLLYK 268 Trypanosoma brucei
Q4DPS6       246 -------THLVV------------TLLYRPGHYDLLYK 264 Trypanosoma cruzi
Q7XPN5       510 pnerdgkGDRTIndlspaerrrlaILLYRPGHYDILCP 547 Japanese rice
Q5KB39       251 -------NARPL------------TLLYRPGHYDVVTK 269 Cryptococcus neoformans
A0E9B0       247 -------KSIFI------------NLLYRPGHYDILYP 265 Paramecium tetraurelia
XP_011388746 304 -feveggQITEIg-----------TMLLRPGHYDLLVE 329
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap