8G2Z


Conserved Protein Domain Family
ParcG

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pfam10274: ParcG (This model is not part of the current CDD release)
Parkin co-regulated protein
This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.
Statistics
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PSSM-Id: 519290
Aligned: 21 rows
Threshold Bit Score: 166.698
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8G2Z_4S       63 NLFKKYYDRGDLPIAVNFHGAH----RK--ISW--KLEPELLDYH---LYLPIFFEGLRETEEPYKFLADQGCEELL-Ar 130 Tetrahymena the...
XP_001421353   1 TRFRQKYDAGEIPARVAHGTGA----NA--IAW--RVDPSALDAS---AYLPLFIDGLKETKHPYRLLAVRGGIELTrAc 69 
Q19060       132 SQFRALFSRGDLHVRIIHSGGAgekpRE--LRW--AKDPSQMKNEticNLLAKFSTGMSLLDHPYRFVAETGITDLLiAl 207 Caenorhabditis ...
Q9D3X5        78 TAFAAIYSQGGIPCRLVHGSVK----HR--LQW--ECPPEILPFD---PLLITLAEGLRETKHPYTFVSKEGFRELLlVk 146 house mouse
EDO38477      21 SSFAAVYASGGVPCRLIHGSVK----HK--LQW--DTPPDNLPFD---PILITLAEGLRETKHPYTFVAREGFREMLdVe 89 
A0EGZ7        70 NSFAYVYNAGGIPCRVNHGCNT----MK--LQWnqGVEIGHLPYD---PLMVTCFEGLVEEAHPYCFIATNAIKDMLnEq 140 Paramecium tetr...
Q7QBN7        35 SRFRGFFLRGDIPISRECGTRC----VKhfIKW--HTPPEQLNYQ---RFLPLFFDGLCESTFPYREFARHGVSDLLiAg 105 Anopheles gambi...
XP_001707794  52 SDFRLFYDRGDLPISVEHTASG----NK--IIW--KAEIEQLDFH---HYLPIFFEGLREKDHPYAFLAREGVTNLLeH- 119
A0CJS0       128 SDFRRYYDRGDLPIKVDHQGSV----NR--IIW--KISPEQLDYH---HYLPIFFDGLREKMDPYRFLAILGTYGLLeN- 195 Paramecium tetr...
Q9VIX9        65 TVFKIYFNRGDIPCVMSGRSSKqdptKErpVKW--HCVPENLDYC---YYLPIFVDGLADMDYDTRLLAVNGAIDLImRs 139 fruit fly
8G2Z_4S      131 -----------GGaKIFAVLPQLIIPIKKALSTKSHPIMCTTLKKIQKLVTSSDMIGEALVPYYRQILPVMNMFKNKR-- 197 Tetrahymena the...
XP_001421353  70 -----------GErALLDALPRSVLPMKEALGTGDMAVTAVALELLREFVKVSPSIGEALVPYYRNLLPALNALKDVSdv 138
Q19060       208 ----------rNHqSIVTVLPQLVRGIRAGLYSFDIEKKKFCLKTLSRI-TAMQGIGAQLVPFYRQLLPPLRTVRQSR-- 274 Caenorhabditis ...
Q9D3X5       147 ----------gAPeKAIPLLPRLIPVLKAALVHSDDEVFERGLSALVQL---SVVVGPSLNGHLKLLLTSLS----KR-- 207 house mouse
EDO38477      90 ----------dSPeRTTPILPKLVFPLRAALSAPDLEVFQNSLDALVQL---SFVVREALNPHLKTLLPHVS----RR-- 150
A0EGZ7       141 vlnlnfiifqnAQeKVIPILAKLVWPLRTALSSQNDKVFMSSLEILKLL---SNTIGSHLNSHLKNLLVPLS----KR-- 211 Paramecium tetr...
Q7QBN7       106 -----------TErQIFQTIPMLILPMREALNTRNPDIIIATLNALQQLLRVGPSIGIALVPYYRQLLPMLNLYKQRR-- 172 Anopheles gambi...
XP_001707794 120 -----------GGsKVLPVIPQLILPLHAALETRDPEVICVVLNVLQLLVMCNEYAGPALVPYYRQLLPVINIFFNKN-- 186
A0CJS0       196 -----------GGnKILPVIPQLIIPIKTNLNTRDPSIMEVQLKVLQKLVLSGEMVGEALVPYYRQLLPIMNLYKNRN-- 262 Paramecium tetr...
Q9VIX9       140 -----------PK-KVLPVLPKLILPLKRAFQTRDKRIIISALQVIQLMVRLGPCVGQALVPFYRQLLAVCNLYKNIN-- 205 fruit fly
8G2Z_4S      198 ----LNIGDHIDYs---qRKNENLSDLIQETLEILEKYGGEDAYINIKYMIPTYES 246 Tetrahymena thermophila CU428
XP_001421353 139 yvslVNLTDCRSWrephrRSRRNIGSLVRATLRALERRGGADALVNIKYQIPTYQS 194
Q19060       275 -----SRSDRVHY-----DKGRQIEEIITSTLNDLERSGGPNALINIKYLLPHYES 320 Caenorhabditis elegans
Q9D3X5       208 ------------------LMDKKFKEPITSALQKLEQHGGNASLIIIKSKIPTYCS 245 house mouse
EDO38477     151 ------------------LMDKSLKEKIISSLQHIERNCGRESLPIIKLKVPTYQS 188
A0EGZ7       212 ------------------MDKKNQKEIIQDVLRQIQDNGGPDTLKVIKAAIPTYTN 249 Paramecium tetraurelia
Q7QBN7       173 ----VNIGDHIDF-----RGGRRIGDVVNATLELLEQCGGPDAYLNIKYMVPTYES 219 Anopheles gambiae str. PEST
XP_001707794 187 ----INLGDKIYYa---qRKRQNLGDLIQETLELMERKGGPDAFLNIKYMIPCYQS 235
A0CJS0       263 ----SNLGDFIEYn---qRKRVNVGDLIQETLELFEQTGGEDAYINIKYMIPTYES 311 Paramecium tetraurelia
Q9VIX9       206 ----VNLGEGIDP-----DRNCRIGDVIEDTLKLLEYCGGPNAFINIKYMVPTYES 252 fruit fly
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