Conserved Protein Domain Family
ParcG

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pfam10274: ParcG (491052 is an unknown moldel)
Parkin co-regulated protein
This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.
Statistics
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PSSM-Id: 491052
Aligned: 20 rows
Threshold Bit Score: 168.633
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9VIX9        65 TVFKIYFNRGDIPCVMSGRSSKqdptKErpVKW--HCVPENLDYC---YYLPIFVDGLADMDYDTRLLAVNGAIDLIMRs 139 fruit fly
XP_001421353   1 TRFRQKYDAGEIPARVAHGTGA----NA--IAW--RVDPSALDAS---AYLPLFIDGLKETKHPYRLLAVRGGIELTRAc 69 
Q19060       132 SQFRALFSRGDLHVRIIHSGGAgekpRE--LRW--AKDPSQMKNEticNLLAKFSTGMSLLDHPYRFVAETGITDLLIAl 207 Caenorhabditis ...
Q9D3X5        78 TAFAAIYSQGGIPCRLVHGSVK----HR--LQW--ECPPEILPFD---PLLITLAEGLRETKHPYTFVSKEGFRELLLVk 146 house mouse
XP_001630540  21 SSFAAVYASGGVPCRLIHGSVK----HK--LQW--DTPPDNLPFD---PILITLAEGLRETKHPYTFVAREGFREMLDVe 89 
A0EGZ7        70 NSFAYVYNAGGIPCRVNHGCNT----MK--LQWnqGVEIGHLPYD---PLMVTCFEGLVEEAHPYCFIATNAIKDMLNEq 140 Paramecium tetr...
1_pfamImport   1 NSFAYVYNAGGIPCRVNHGSVH----MY--IQWnkDVDLKSMPYD---PLLATCFEGLIEEKHPYNFIAYNCIKDMLEQe 71 
Q7QBN7        35 SRFRGFFLRGDIPISRECGTRC----VKhfIKW--HTPPEQLNYQ---RFLPLFFDGLCESTFPYREFARHGVSDLLIAg 105 Anopheles gambi...
XP_001707794  52 SDFRLFYDRGDLPISVEHTASG----NK--IIW--KAEIEQLDFH---HYLPIFFEGLREKDHPYAFLAREGVTNLLEH- 119
A0CJS0       128 SDFRRYYDRGDLPIKVDHQGSV----NR--IIW--KISPEQLDYH---HYLPIFFDGLREKMDPYRFLAILGTYGLLEN- 195 Paramecium tetr...
Q9VIX9       140 -----------PK-KVLPVLPKLILPLKRAFQTRDKRIIISALQVIQLMVRLGPCVGQALVPFYRQLLAVCNLYKNIN-- 205 fruit fly
XP_001421353  70 -----------GErALLDALPRSVLPMKEALGTGDMAVTAVALELLREFVKVSPSIGEALVPYYRNLLPALNALKDVSdv 138
Q19060       208 ----------rNHqSIVTVLPQLVRGIRAGLYSFDIEKKKFCLKTLSRI-TAMQGIGAQLVPFYRQLLPPLRTVRQSR-- 274 Caenorhabditis ...
Q9D3X5       147 ----------gAPeKAIPLLPRLIPVLKAALVHSDDEVFERGLSALVQL---SVVVGPSLNGHLKLLLTSLS----KR-- 207 house mouse
XP_001630540  90 ----------dSPeRTTPILPKLVFPLRAALSAPDLEVFQNSLDALVQL---SFVVREALNPHLKTLLPHVS----RR-- 150
A0EGZ7       141 vlnlnfiifqnAQeKVIPILAKLVWPLRTALSSQNDKVFMSSLEILKLL---SNTIGSHLNSHLKNLLVPLS----KR-- 211 Paramecium tetr...
1_pfamImport  72 ----------nVEdKIVPMINKLAWPLRNALQHNNEKNFENALTVLKLL---SDKIGPNLNPHLKNLLQPIV----KK-- 132
Q7QBN7       106 -----------TErQIFQTIPMLILPMREALNTRNPDIIIATLNALQQLLRVGPSIGIALVPYYRQLLPMLNLYKQRR-- 172 Anopheles gambi...
XP_001707794 120 -----------GGsKVLPVIPQLILPLHAALETRDPEVICVVLNVLQLLVMCNEYAGPALVPYYRQLLPVINIFFNKN-- 186
A0CJS0       196 -----------GGnKILPVIPQLIIPIKTNLNTRDPSIMEVQLKVLQKLVLSGEMVGEALVPYYRQLLPIMNLYKNRN-- 262 Paramecium tetr...
Q9VIX9       206 ----VNLGEGIDP-----DRNCRIGDVIEDTLKLLEYCGGPNAFINIKYMVPTYES 252 fruit fly
XP_001421353 139 yvslVNLTDCRSWrephrRSRRNIGSLVRATLRALERRGGADALVNIKYQIPTYQS 194
Q19060       275 -----SRSDRVHY-----DKGRQIEEIITSTLNDLERSGGPNALINIKYLLPHYES 320 Caenorhabditis elegans
Q9D3X5       208 ------------------LMDKKFKEPITSALQKLEQHGGNASLIIIKSKIPTYCS 245 house mouse
XP_001630540 151 ------------------LMDKSLKEKIISSLQHIERNCGRESLPIIKLKVPTYQS 188
A0EGZ7       212 ------------------MDKKNQKEIIQDVLRQIQDNGGPDTLKVIKAAIPTYTN 249 Paramecium tetraurelia
1_pfamImport 133 ------------------MNKPQLREKIFVTLRTLEENGGSDVLKTIKSCIPTY-S 169
Q7QBN7       173 ----VNIGDHIDF-----RGGRRIGDVVNATLELLEQCGGPDAYLNIKYMVPTYES 219 Anopheles gambiae str. PEST
XP_001707794 187 ----INLGDKIYYa---qRKRQNLGDLIQETLELMERKGGPDAFLNIKYMIPCYQS 235
A0CJS0       263 ----SNLGDFIEYn---qRKRVNVGDLIQETLELFEQTGGEDAYINIKYMIPTYES 311 Paramecium tetraurelia
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