Conserved Protein Domain Family
Tmemb_cc2

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pfam10267: Tmemb_cc2 (This model is not part of the current CDD release)
Predicted transmembrane and coiled-coil 2 protein
This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.
Statistics
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PSSM-Id: 519285
Aligned: 25 rows
Threshold Bit Score: 368.605
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015782805  49 IKAAIEHYQAKIMRTKEAIKAEQTSRDENVNEYLKLAANA--------DKVQTQRIKSMFEKKNQKSAHTIAQLQKKLDS 120
XP_009019798  87 ARSAIEQLQVKIGKTQQRIKLEQNAKEDNVNEYLKLSTDA--------DKQQLQRIKAVFEKKNIKSAQAIAHLQKKLEE 158
2_pfamImport   1 TRAAMDHVRSKIVRTKDLIRSEQTARDDNVNEYLKLASNA--------DKQQLARIKSIFEKKNQKSAVGISQLQKKLEG 72 
XP_002424303 148 RSAAIEHIQSKISKTMDQIRAEQTTRDDNVNEFIKLATNA--------DKQQIQRIKSVFEKKNQKSAQIISQLQKKLET 219
XP_001954619 253 SVQAIDRLNTKIQCTKESIRQEQTARDDNVNEYLKLAASA--------DKQQLQRIKAVFEKKNQKSAHNISQLQKKLDN 324
EDS32659     117 SSLAHNRIITKIACTKESIKKEQTTRDANVNEYLKLAASA--------DKQQLQRIKAVFEKKNQKSAHNISQLQKKLES 188
XP_042930780  40 GLDDRTRIERKIEQIKERLSRISLAREADVDDFLSMTSSMeg----grENPQLARVRQHFEKKNKKSSQEIEHLKKKLEQ 115
Q18025        20 DEREKAKIVQKLIEIKDKLRALNEKREADVEKFLSITRQSeisrgvgaDNPQRARIRNNFERQNRKHAHETEMLQKKLID 99  Caenorhabditis ...
7_pfamImport   1 TKQMVEHIQQKILKISEAIKLEQSTRDENVSEYLKLASNA--------DKQQAARIKSVFEKKNQKSNATITQLKKKFDS 72 
XP_014347179 238 SRAAQRHLQQKILRLVEQIRVEETERDQNLSEYLQMANNV--------EKRQAFRIKQTFEHRNQKSAAAIAQLQHRLEH 309 coelacanth
XP_015782805 121 YLKR---IRDIENy-----gIQALHQH-------SRSKAMLTNVGHGLKGVGtnIKEG----ISGLSE------------ 169
XP_009019798 159 YDRK---LREISL-------QGTTAIH-------KGSKGVLKDVGQGLRVLF--VRDPtrsrDASPSTs----------- 208
2_pfamImport  73 YNKR---LKDLET-------HGLTTSHh-----lKQPKEMLRDVGHGLRHVGgnIRDG----ISGLSG------------ 121
XP_002424303 220 YNKR---IRDIES-------QKLHTSH-------RQPREVLRDMGQGLKNVGgnIRDG----ISGLSG------------ 266
XP_001954619 325 YTKR---AKDLQNh-----qYQTKSQH-------RQPREVLRDVGQGLRNVGgnIRDG----ITGFSG------------ 373
EDS32659     189 YSKR---YKDLQYhq----sQKQQQSH-------RQPREMLRDVGQGLRNVGgnIRDG----VSGLSA------------ 238
XP_042930780 116 LQSK---LVDLNMgivsevsPKSSVLNn-----iRKTGPLLR-------------------------------------- 149
Q18025       100 YEER---LKLVDSge----yEPSPTKSrvfptgiRKAKGMTE-------------------------------------- 134 Caenorhabditis ...
7_pfamImport  73 YQRR---LREVE--------SSGVGG--------RQSKSALRDVGANLRDFSggLVDGvkggLSAG-------------- 119
XP_014347179 310 YHHKvmeLKELELklranpeQESKG---------RSPR--LSNVTR----------------ESSLSMiqsmqsvaprkp 362 coelacanth
XP_015782805 170 -----------------GVIGSIKSFSspnthhssgdnfnskpkdSF--KNKIGSADNINSADnsindsst--------- 221
XP_009019798 209 -----------------TMQLKSRNAAtlpgvwk-----tkdshhAF--KNRYGSADNITSSLi---------------- 248
2_pfamImport 122 -----------------SVMSKPREFAh-----------------LI--RNKFGSADNINSISrss-------------- 151
XP_002424303 267 -----------------TVMSKPREFAh-----------------LL--KNKFGSADNINSLSr---------------- 294
XP_001954619 374 -----------------SVMSKPREFAh-----------------LI--KNKFGSADNINQMT----------------- 400
EDS32659     239 -----------------TVMSKPREFAh-----------------LI--KNKFGSADNINQLAanhnviemnrdltasni 282
XP_042930780 150 -----------------EVIAAPRGIAh-----------------II--KSTFGSADNIPDSI----------------- 176
Q18025       135 -----------------TMVNAPIEFAq-----------------RV--KSAF-SADNVNSTQ----------------- 160 Caenorhabditis ...
7_pfamImport 120 -----------------AIAFKPKDFAs-----------------RL--KSKFGSADNLSSLK----------------- 146
XP_014347179 363 atwprngrvsssepvedTMSLRPPDFA------------------MGtlKTTVPAADSRDMAG----------------- 407 coelacanth
XP_015782805 222 ---mnesesneGKEAQSkssgvHNQGGSVFYTHSHTHSHSTK--------------------------HTSDESSSISSV 272
XP_009019798 249 -----------PTQSSVnpsnpNNLQSSSSANNSPIVNLTSQqqrlqlqq----------rlqqqqhqQLQDDSLNDEQQ 307
2_pfamImport 152 --------eadLTEDNSdkqsgRNHHGSATLPGGVGLHASTAgaa---------------------asRSEDGASECSSV 202
XP_002424303 295 -----------NGENGStgeedKTHHGSATLPGNCTLTTTTTttattvttq--------gstpgntkkFASDEGSPCSSV 355
XP_001954619 401 -----------DAELQG-----MQSSNADVLAANERLQQTPGvgtstgsggggqnnntgggagsgtgkFNSDNGSECSSV 464
EDS32659     283 ddsvsfhydnlSSSNVGihgvcLDPADTRVISNTRIVEDASG--------------------------KYSEHESECSSV 336
XP_042930780 177 ------------------------ASGASNVGHSTFYSDTQT-----------------------------NDRIHKLDF 203
Q18025       161 ----------------------NGTTGAPKTGQSTFFTTRKSadtdev---------------esnavHKNRGAKRNSST 203 Caenorhabditis ...
7_pfamImport 147 ----------------------FDEQEGDFLSTCNYSFIIad------------------------irYGSADDVSSTSg 180
XP_014347179 408 ---------------------------------------------------------------------TSPDEAASSRV 418 coelacanth
XP_015782805 273 Sdnigaiaglvtsgassa----------------------spakqlyrtfdsqlvsQSGSSHNIHDLETILSQLRDREGD 330
XP_009019798 308 Q-------------------------------------------------------QQLAIMQAKDLATIITNLTEFQEM 332
2_pfamImport 203 Tsesipprtgpg-------------------------------------------appppasattsLEPVWAEL------ 233
XP_002424303 356 Tseslhlgqvthh-----------------------------------------htsprhnrtsynLDPLFRELQERREE 394
XP_001954619 465 Tsesipags--------------------------------------------gksqsgaSQYHIVLKTLLTELAERKAE 500
EDS32659     337 Tsdsiplssgkh------------------------------------------------rrlrsqhctnYKAMGDIRDG 368
XP_042930780 204 Enrdvapspakrghkrnetlps-------------mafdldnlvisslpemlphdePEVKFTAANTVIELHNDIQELKAQ 270
Q18025       204 LppnlsltspdplsaykeedssdpesrpgsaadetsnvpyhtadnslylppnhpyhSAHAAPSEEGFNAIHEHLNSILQH 283 Caenorhabditis ...
7_pfamImport 181 sidigmaisnedqaa--------------------------hnsilsgpdspisggLNRRSDSQYVQSLFLNEWEEWKSM 234
XP_014347179 419 E-------------------------------------------------------LIAEHLNPNTYTSILQQLADLKEE 443 coelacanth
XP_015782805 331 CQRLAEEIEAVKTSLHAEYSLINQSLQEERYKSERLEEQMNDLIELHQNEIENLKQNIGDMEEKVQYQSEERLRDIYEML 410
XP_009019798 333 QYKLHCSVSTLKTQLDEEGIFCRQALEEEHDRCERLEEQINDLTELHQNEMYNIKQEMVGMQEKMEYQLEERTRDIQELL 412
2_pfamImport 234 -DHLRSKMEHIKQLVSKDIASLNHSLQEERFRTERLEEQINDLTELHQNEVENLKQTITDMEEKVQYQSEERLRDIHEML 312
XP_002424303 395 IEILKEKLENLKG-VHQEIQYLTMAIQEEKFRSERLEEQINDLTELHQNEVENLKQALTDMEEKVQYQSEERIRDLHEML 473
XP_001954619 501 NEKLKERIERLET-GQKEFNNLTATLESERYRAEGLEEQINDLTELHQNEIENLKQTIADMEEKVQYQSDERLRDVNEVL 579
EDS32659     369 YDRMKTKLERLEL-MHKDVTDLAIALETERYRTERLEEQVNDLTELHQNEIENLKQAIADLEEKVQYQSDERLRDVYEIM 447
XP_042930780 271 NQALFEQLNKLQTQNKSEFNYFNSALHEERIKTQRLEEMLNETIELHQAEMIALKSDLNTIATRMDYQYSDRFRSIEENI 350
Q18025       284 LMLIDRKYDRLEDDIKKEIKFYAEALEEERFKTTKLEEILNEAVELQQAEIATLKEQ-NLMATRVDYQHNDRFRNVEENM 362 Caenorhabditis ...
7_pfamImport 235 HQQCAGKWDEWKTSEQN----ITSYLQDERFRYERLEGQVNDLTELHQREISNLKQELFSMEEKMEYQARERARDMQEAI 310
XP_014347179 444 QVNLEASFEKLRENYQHENKFLMNSIQEEKHKYRDLEAQVNDLMDIQQTELMNIKQDLSSMEEKLVYQSYDRARDLWEVI 523 coelacanth
XP_015782805 411 ESCQTRISRMEHQQHQhlQqLVNLDSLENSNARALVLKLINVLLTILQVVLLLVATVANIVTPFLKTRIRFLTTIFILVI 490
XP_009019798 413 LTCQTRINKMELQQQQ--QqLISMEGIENTSFRGLATKLINIVLAVLAVVLVLVSEVANLIGPFLQTRLRIVGTALLASL 490
2_pfamImport 313 EACQTKMSKMEHQQAQh-QqYVTLEGLDNSNARALVVKLINVLLTVLQVVLLLVATFAGILMPFLRTRLRIITTTAVVAG 391
XP_002424303 474 ENCQTKISKMEHQQAQh-QqYVTLEGIDNSNARAVVVKLINVLLTVLQVVLLLVATAAGILMPFLKTRLRILSTLVLIAA 552
XP_001954619 580 ENCQTRISKMEHMSQQq---YVTVEGIDNSNARALVVKLINVVLTILQVVLLLVATAAGIIMPFLKTRVRVLTTFLSICF 656
EDS32659     448 ENCQTRVSKMEHLSQQq---YVTIEGIDNSNARAVVVKLINVVLTVLQVILLLVATAAGITMPFLRTRIRVLTTVVCIVM 524
XP_042930780 351 ESTQNKMIRMEVNVKEw------TESRPQTTFNSVMLSGTNILVEFIKLVLLIVSFALDFVKPFTGTRTRAGFVIFFWLA 424
Q18025       363 ESLQNHLVRIENALMDvrQvKLTSNVW-----QRVALNAGNIVVELLKIALFVVASILDLVRPLTGSRNRSAMAFGLVFL 437 Caenorhabditis ...
7_pfamImport 311 ESCQTRLSKMELQQQQq---LVSVDGLENATARALLGKLINLLLSVMAVLLVLVSTVSGLLKPLTRSPIRIASTIVAVGA 387
XP_014347179 524 ESFQTRIGKLELQQQ-----AAQLEVLENPSTRAFFAKFMSLVLASITVILVFVSAMTSITIPLVKTRLRTLTTIFLLLL 598 coelacanth
XP_015782805 491 VMMFVRQK 498
XP_009019798 491 LAILWNRR 498
2_pfamImport 392 LFIAVKQW 399
XP_002424303 553 TVFVLKQW 560
XP_001954619 657 VIFVIRQW 664
EDS32659     525 LAFMVRQW 532
XP_042930780 425 LMILTHFI 432
Q18025       438 AIFFGHHL 445 Caenorhabditis elegans
7_pfamImport 388 IIITYKNW 395
XP_014347179 599 GTSYWWHQ 606 coelacanth
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