Conserved Protein Domain Family
Miga

?
pfam10265: Miga (This model is not part of the current CDD release)
Mitoguardin
Mitoguardin (Miga) was first identified in flies as a mitochondrial outer-membrane protein that promotes mitochondrial fusion. Later, the mammalian Miga homologues, Miga1 and Miga2, were identified. They are found to promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.
Statistics
?
PSSM-Id: 519283
Aligned: 21 rows
Threshold Bit Score: 503.831
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_012816054  22 LYNSFTQLKPTP-GLKKIIAVAAISG---VSLIFLARHLKRKRGKKKS---NMPQIEPGQFILQCSRHF----------- 83 
Q5BLE2        31 GQSIFSQLKLSP-SLKKVLFATALGS---VALALTAHQLKRRGRKRKQt-lGKEAQKPVGIPEQLLRSSrpasl-krgpv 104 zebrafish
XP_017952118  31 GQSTFSQLRLSP-GLRKVLFATALGT---VALALAAHQLKRRKHKKKQitaDKGGLKLGGVPSSVLPVRrsssa--kkgy 104
Q8BK03        31 GQSAFSQLRLTP-GLRKVLFATALGT---VALALAAHQLKRRRRKKKQvgpEMGGEQLGTVPMPILMARkvpsv--kkgc 104 house mouse
XP_002636748   6 MQGLPVGLKINDiVTKRTVLSVAAGIgigIVFANFVRYWKQRRESRIP-----LSAFIDEVPKEVDTNPsqpapslrrsh 80 
EDS26764       2 SVSRLLPFNLTT-SQKVIVVSVTAGM---AVLGVIASYLGRRRTPKPQqrrl-------------------------rkp 52 
8_pfamImport   1 SVSKYLPIHVST-SQKIIILSVSAGV---ALLGALAAYLGRRRTPLPQqrri-------------------------rkp 51 
Q9W3F7        12 G-GSLLPFRVST-TTKVVLFSLTAGV---ALMSVLSRFLRRRKPPRPPrra--------------------------rky 60  fruit fly
XP_425337     31 GQSVFSQLRLSA-GLRKVLFATALGT---VALALAAHQLKRRRRRKKQiapEKCGFKPGGVTVPILPTRrvssv--kkgy 104 chicken
XP_064420174  31 GQSIFSQLRLSP-SLKKVLFATALGS---VALALTAHHLKRRRRRRKQiaeEKDAQKPRDVAGHLLPAArptp---vkkg 103 coelacanth
XP_012816054  84 AEKGSSCSSSRQNLTLSLSSIKERGSLShlngelcsKYSGSVQSLASVQ-SINSCHSCACIH-SNSLNKTDE--DETRLV 159
Q5BLE2       105 PARQMMSPSTRSNDTLSGVSSIAQS-----------KHSSSSHSIASMR-VPSSPNQSVNA--GAAWEAEPVaeEPAVGE 170 zebrafish
XP_017952118 105 SRSRVQSPSSKSNDTLSGISSLEPS-----------KHSSSSHSLTSVV-AVNSSSVNVAS--AGPWESPEMd-ETLEEE 169
Q8BK03       105 SSRRVQSPSSKSNDTLSGISSIEPS-----------KHSGSSHSLASMV-VVNSSSPTAAC--SGSWEARGMe-ESVPTT 169 house mouse
XP_002636748  81 SGRGMRPSSSQGERSLRNSV-----------------RQNSQRSLS---------------------------------- 109
EDS26764      53 GGRKTRNSVRSPNDIISLAGSKASGRSY--------SPGGSIHGLSDRM-SLASGSLAAAGAg--------------PIG 109
8_pfamImport  52 GNRRTRNSVRSPNDIMSVAGSKVSARSY--------SPSGSVHAISDRM-SLASGSLVAAGGpVAAMGTVS------LLG 116
Q9W3F7        61 TGRRNRNSMRSPNDLISIAGSKASARSG--------SPVGSTLAYSDRL-SMASGSIGVGVLgVQNAGPGSSv------- 124 fruit fly
XP_425337    105 SSRRVQSPSSKSNDTLSGISSIEPS-----------KHSSSSHSLASMV-AVNSSSPTPAS--AGMWEAQAMg-DGGAIG 169 chicken
XP_064420174 104 SSKRVQSPSCRSNDTLSGISSIAPS-----------KHSSSSHSLASVHaGNFVSPVATPV--GV-WEASTLgeESGMTE 169 coelacanth
XP_012816054 160 NFPVTTPENLYLM-GMEL---FEEALRRWEQALTFRSRQA---EDEANCSSIKLGAGDAIAEENVEDIISADFIHKLEAL 232
Q5BLE2       171 D---ANAENLYLM-GMEL---FEEALRKWELALNIRHRSH---SRASASNS---QGSELVERHS-PEVRNHQFAERLETL 236 zebrafish
XP_017952118 170 D---SNAENLYIQ-GMEL---FEEALHKWEQALNLGQRSR----SNTPLSQVNEPLNKSYSEGLSEDSQSRQFAGRLEAL 238
Q8BK03       170 D---GSAESLYVQ-GMEL---FEEALQKWEQALSVGQRGDg-gSTPTPGDSLQNPDTASEALSE-PESQRREFAEKLESL 240 house mouse
XP_002636748 110 ----MNPIEADITnGQEMctdLRKTIERVHHNLEMVKNRS---------------------------SKDMERSIKIEGI 158
EDS26764     110 GTTPLTPQQLGVM-GMEA---LETVISYWEDALTGRNDID--------------------IPSRLS-ADQEEFCRELQNL 164
8_pfamImport 117 NTTPLTPQQLGVM-GMEA---LENVVSYWEDALTGRNDTD-------------------IIPGRAANVDQDEFCRELQNL 173
Q9W3F7       125 -VTQLTAQQLGMM-GMEA---LDTVINFWEDALAAHYSPG-------------------GLPALLTTAEDSEFCREIQNL 180 fruit fly
XP_425337    170 D---SSAESLYVQ-GMEL---FEEALQKWEQALTIRQRDSassSTPVPWDSKKHQENLSEH-AE-EESQKREFAEKLESL 240 chicken
XP_064420174 170 D---SNAENLYIL-GMEL---FEEALLKWEQALNIRQHRG---SDMGAKMKVIQPGASGDSVSE-QEFRNKDFAQKLEGL 238 coelacanth
XP_012816054 233 LQRAYRLQEEFEATLGASDPASLANDi--DKDTDITVMNNgGDFQ------QRDTLSIAST------------------- 285
Q5BLE2       237 LHRAYHLQEDFGSTI---PPDSLLADlesEGTLILPTLGSsHPIQ------DDDATTVTSD------------------- 288 zebrafish
XP_017952118 239 LHRAYNLQEEFGTSI---PPDSLLMDl--EGSLMFPLAESrRALL------TYEEGSTTSE------------------- 288
Q8BK03       241 LHRAYHLQEEFGSTF---PSDSMLLDl--ERTLMLPLTEGsLRLR------ADDEDSLTSE------------------- 290 house mouse
XP_002636748 159 LKGLKQVEDEITMLIPHMEDFR-------DDNTEFYSVSGgTGYAgsvrtgRSRTLSVLSD------------------- 212
EDS26764     165 LDAAYNLQENGELLFLD------------ERSVLYR---------------DDENKATQAAslsnghrss--sdpnmdsa 215
8_pfamImport 174 LDAAYNLQEQGELLFLD------------ERSVLYR---------------DDERKAITGAehgltnghrsgsdpnfdsa 226
Q9W3F7       181 LEMAYTLQEQSELLFLD------------QRSVLFREEHSiDEAEeeageaDDDRRSRKSGsvlsrags----dpnfdsa 244 fruit fly
XP_425337    241 LHRAYHLQEEFGSSL---PSDSMLLDl--EKTLMLPLTDGsLRLR------TDDEDSSISE------------------- 290 chicken
XP_064420174 239 LHRAYHLQEEFGVAL---PPESLMLDfenEGTLALPLSGSsERLY------LDDEASVTSE------------------- 290 coelacanth
XP_012816054 286 DSFLSAAE--LSD-NQELRPTRGLGSLYHNA-----LYEEAMQLVEE-------GKVHCRALRTEMLECLGDSDFLAKLH 350
Q5BLE2       289 DSFFSAAE--LFE-------TFSLEDS-FHLlkpaaLYEEALSLVKD-------GDVACRSLRTELLECYSDQDFLAKLH 351 zebrafish
XP_017952118 289 DSFFSAAE--LFD-------TLQLNEVPFRPpkpaaAYEEALMLVHT-------GEVACRTLRTELLGCYNDQDFLAKLH 352
Q8BK03       291 DSFFSATE--IFE-------SLQIGEYPLPLsrpaaAYEEALQLVKE-------GRVPCRTLRTELLGCYSDQDFLAKLH 354 house mouse
XP_002636748 213 DSFQSAVEefAVDiDDIDFVSEAAN-----------LEKEELKFLDEgmraamnGEVKYRKSRMDFCNCESETDFAAKLY 281
EDS26764     216 ESFASALDqvQSDlREFEDYGEVFSDVENYP-----LYQSALELLDD-------QPIPCRTIRTDMVGCNSDAEYYAKLH 283
8_pfamImport 227 ESFASALDq-VADlREFDD-TESFMDLERYP-----LYSSALETMDD-------QQIPYRTLRTDMVGCASDTEYLAKLH 292
Q9W3F7       245 ESFASALDq-VADlREFDGFIET--SYEEYP-----LFQSALKHHDE-------YTVPCRTIRAELMHCSTDTEYLAKLH 309 fruit fly
XP_425337    291 DSFFSAAE--LFD-------SLHFEEIPYHLsrpvaAYEEALQLVKE-------GKVACRTLRTELLGCYSDQDFLAKLH 354 chicken
XP_064420174 291 DSFFSAAE--LFE-------SLQFSGDSFQPakpaaLYEEALGLVRD-------RKVDCRTLRTEVLGCYNDQDFLAKLH 354 coelacanth
XP_012816054 351 CIRQAFQEIFLQRENRIFLMGTGRKLLSTLIVKARKNPKKFEDAYFEMMCFLEQSESWDTAEIELFSRGVKCINFYDIVL 430
Q5BLE2       352 CVRQAFQVLLLDETHRMFFMETGKQMISGLLVKANKSPKAFLESYEDMLQYTQREETWPVSKMELEGRGVVCMNFFDIVL 431 zebrafish
XP_017952118 353 CVRQAFEVLLLDERNRLFFGEVGKQMVSGLMQKAEKNPKGFLENYEEMLRYALKEDTWTTTQKELKGRGVVCMNFFDIAL 432
Q8BK03       355 CVRQAFEGLLEERSNQIFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVACMSFFDIVL 434 house mouse
XP_002636748 282 CVRHALTNALKDEHKRVWLAKCGRTLLADFIRHTKQDPVKFFNAYDEMLEYVSNDRNQEQLRQDVEGRGVCETGFYDVAV 361
EDS26764     284 CIRLAFQLLFKDPKISRWVADTGRQVLTDLLCLGDKDPKDFLVSYESMLEFLQNQDNWPDIEAELESRQVKAITFYDIVL 363
8_pfamImport 293 CIRLAFKLLFKDPKNGRWVADTGRQILTDLLCLGDKDPKDFLVAYESMLEFLQNPNNWVDIELELESRNVKAMTFYDVVL 372
Q9W3F7       310 CVRLAFQFLFKDPAVGQWICDAGRQILTDLLCLGDKDTKEFLVGYEDMVNYLHDSNNWPCIQMELEQRNVKAMTFYDICL 389 fruit fly
XP_425337    355 CVRQAFKELLEDESNQLFFGEVGKQMVIGLMTKAEKNPKAFLESYEEMLHYALKPETWPTTQQELEGRGVVCMSFFDIVL 434 chicken
XP_064420174 355 CVRQAFQVLLEDESQRLFFSEIGKEMITGLMTKAGKSPKGFLESYQEMLRYTVKEETWPTTQRELEGRGVVCMNFFDIIL 434 coelacanth
XP_012816054 431 DFIVMDSLEDLENPPLSIQNVVRNRWLNSSFKETAVTSSCWSVLKQKKQQIKVANGFFANFYTVCEQLCPVLAWGFLGPR 510
Q5BLE2       432 DFILMDAFEDLESPPSSVVAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFIAHFYVISEHVSPVLAFGFLGPH 511 zebrafish
XP_017952118 433 DFILMDAFEDLESPPSSVIAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPK 512
Q8BK03       435 DFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPK 514 house mouse
XP_002636748 362 DFIILDAFEDLKSPPSAVYSVTKNYFMSMSMKYSTLNTIIWSIIKSKRQRLKNPDGFIAKFYNISETVMPAITLGFLGTD 441
EDS26764     364 DFIILDAFRDLDTPPNSVLAVINNRFLSNSFKETALTTAVWSVLKAKKRLLKFPNGFMSHFYCVTEQLSPLMVWGFFGPD 443
8_pfamImport 373 DFIILDAFRDLDAPPNSVLAVINNRFLSNGFKESALATAVWSVLKAKKRMLKFPNGFMSHFYCITEQLSPLMVWGFFGPN 452
Q9W3F7       390 DFIILDSFKDLDAPPASVTAVVQNRWLSNGFKETALTTAVWSVLKAKKRMLKFPNGFMSHFYVISEQISPLMAWGFFGPN 469 fruit fly
XP_425337    435 DFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPK 514 chicken
XP_064420174 435 DFILMDAFDDLESPPSSVVAVLRNRWLSDSFKETALATACWSVLKAKRRLLLVPDGFISHFYSISEHVSPVLAFGFLGPK 514 coelacanth
XP_012816054 511 SSLHDLCCFYKDQVMFFLKDIFDFEKVRYSNVEHLAEDIMQCLQRRAELTVVYT 564
Q5BLE2       512 QHLSEVCTIFKQQIVQYLKDMFDHDKVRFTSVPSLAEDILRLSHRRADILMGYL 565 zebrafish
XP_017952118 513 EHLAEICNFFKHQIVQYLTDMFDLDKVSYTTIQSLADDILHLSRRRSDILLGYL 566
Q8BK03       515 PQLSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYL 568 house mouse
XP_002636748 442 ERLGELCQYFKEQVVQFVLDVFNTQRVCYRSLEEMTEDVWIVMRNRLEAVQTRM 495
EDS26764     444 EDLKEVCKYFKDQMVGFMIDMYNFQKMRYTTVEELAEDIHTNMRMRVNNIGVKF 497
8_pfamImport 453 ENLKDVCQYFKDETIGFLCDIYSFQKCRYTTVEELAEDILENMRKRVNNIGVKF 506
Q9W3F7       470 ENLRDICHYFREELLAFLGDIFSFQKSRFTTIEEFSQDVLQHMQTRVNNIGVKF 523 fruit fly
XP_425337    515 QQLAEVCSFFKHQIVQYLKDMFDLDNVRYTTVQLLAEDILQLSRRRSEILLGYL 568 chicken
XP_064420174 515 PQLCEICTFFKQQIVQYLKDVYDLDQVRYTTVQSLADDILQLSQRRSEILLGYL 568 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap