3DEX,2LJK


Conserved Protein Domain Family
Rdx
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pfam10262: Rdx (This model is not part of the current CDD release)
Rdx family
This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown. Selenoprotein W contains selenium as selenocysteine in the primary protein structure and levels of this selenoprotein are affected by selenium.
Links
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Statistics
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PSSM-Id: 519280
Aligned: 210 rows
Threshold Bit Score: 46.39
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3DEX_A          14 RVQIEYCTQCRWLPRAAWLAQELLTTFETEL-T--ELALKPGTGGVFVVRVDDEVVWDRREQG-FPEPTAVKRLVRD 86  Streptomyces ave...
BAJ47203         4 NVRIVYCVPCGHLPTALELAKNLLSRYGQRLnKkfSVTLDTSDGGTFEVYIDGERIFSRHEARrFPTLDEIAEQVDK 80 
WP_052846377     3 SVKIVYCRPCGYLDRAINLARDILAYFEN---V--EVTLEQGKNGIFDVYLNGELIFSRYQEKrFPEHEEILKQIGK 74  Sulfurisphaera t...
3_pfamImport     1 SVKIVYCRPCGYLDRALEVSREVLSYFDD---V--KVELEQGKNGIFDVYVDGELKLSRYQLKrFPEVEEVLKEIAN 72 
Q4JBM6           4 NVKIVYCRPCGFLDRALNLARDLLSYYEG---V--NVELEQGKNGIFDVYVDGQLIFSRFKEKrFPDSQEILKELSK 75  Sulfolobus acido...
5_pfamImport     1 TVEIEYCVPCGFRERAIEMSEAILNGCEREL-D--ELSLVMGDHGVFRVNVDGETVYDKAEDS--AELDEVVRTVRS 72 
jgi:Halxa_2841  12 TVEIEYCVPCGFLSRAEDVQHALLSTFGEQL-D--AVTLATGANGVFVVRVDDTVIFDKSEDE--YDVDEIVRRVRD 83 
WP_049952224     3 TVEIEYCVPCGFLSRAIDIQRALLTTFGEQL-E--AVTLRTGSDGVFVVRCDGDVVFDKSADG--YDVDDIVRKVRT 74  Halostagnicola l...
jgi:Hbor_21890  23 EIEIEYCVPCGFLDRAETIQHAVLQQFGERV-N--RVSLVTGDHGVLTVAVDDEIVWDKADDE--YDVDEITRRVRS 94 
WP_020447418     3 DVEIHYCVPCGHLDRAQQLQYAILDQYGQDV-D--RVALRTGDGGVFTVSVDGEQVFDVDEDE--YDADAIVESIDE 74  Salinarchaeum sp...
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