Conserved Protein Domain Family
Scs3p

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pfam10261: Scs3p 
Inositol phospholipid synthesis and fat-storage-inducing TM
This is a family of transmembrane proteins which are variously annotated as possibly being inositol phospholipid synthesis protein and fat-storage-inducing. The members are conserved from yeasts to humans and are localized to the endoplasmic reticulum where they are involved in triglyceride lipid droplet formation.
Statistics
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PSSM-Id: 402051
View PSSM: pfam10261
Aligned: 74 rows
Threshold Bit Score: 180.995
Threshold Setting Gi: 74609687
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCE65002      33 KTWDINRDSIINSVFVKRGWFWNSLVLWYVILFtnitivdEPkrnnSIEGRktkt------------------------- 87  Tetrapisispora ...
XP_004194678  63 YNYYNDKRNILNQFFVKKGWAWTTVVIVVFYILilrs----------khpKvqsq------------------------- 107 Pichia farinosa...
EMG45163      57 YNYYNNKGNIFNQYFVKKGWGWTTLVILLFYSNll--------------yKtpa-------------------------- 96  Candida maltosa...
EER30745      56 YNYYSNKKNIFNKLFVKQGWGWTTLVILIFYSNli--------------yKtsny------------------------- 96  Candida tropica...
CCE44412      70 YNYYNNKHNFFNTVFVKRGWGWTTLIIIVFYAVivmpklyS---------Nkndtts----------------------i 118 Candida parapsi...
XP_001524468  63 YNYYNDKRNVLNQWFVKRGWGWTTLVVVLFYSLfavpqilNStlttATAARttttarrvdeneddsvlvsgkkekklytt 142 Lodderomyces el...
XP_001386227  60 YNYYTNKKNVLNQVFVKNGWFWTTANIVLFYGIvl--------------yKekss------------------------- 100 Scheffersomyces...
Q6BUP0       109 YNYYNNKRNVFNQVFVKRGWGWTTLIIVVFYSFlm--------------yGnshari----------------------r 152 Debaryomyces ha...
EGV62536      93 YNYYNDKNNVFNQLFVKRGWFWTTVVMAAFYGSvfygkhpQLgtnrF--------------------------------- 139 Yamadazyma tenu...
EGW35656      56 YNYYTDKRNILNQLFVKNGWAWTTIVIVVFYVSiltqsrpRKs------------------------------------- 98  Spathaspora pas...
CCE65002      88 --rihTLNIKKFIkRYVIVTMWWILFTQGipFFKiPPIMDLCFVFTGGSCN--------------------FEIfde--- 142 Tetrapisispora ...
XP_004194678 108 --qekIRLLRNGLiKYSIMTFWWVLFTQW--CFG-LPIMDKVFVWTGGKCQkvaekell----rhfpgalkDKFfspssd 178 Pichia farinosa...
EMG45163      97 --adrIRVLRRAVtNYIIATVWWILFTQW--CFG-LPIMDKIFVWTGGKCKiditnh--------dvnhvhSSFihsl-- 161 Candida maltosa...
EER30745      97 --sirQKLIYKGIlNYLLSTLWWILFTQW--CFG-LPIMDKIFIWTGGKCKiegieik-------ninhlhNSFiqtl-- 162 Candida tropica...
CCE44412     119 qqqqkIEFLIKAVvRYAIATFWWILFTQW--CFG-LPIMDKIFVLTGGVCVlephpttqttppstianhalGQSflqdle 195 Candida parapsi...
XP_001524468 143 kserlSKYFLGAIvRYLLLTIWWVLFTQW--CFG-LPIMDKIFVVSGGACVieppqfaasqqkisnsqhlfGKfiqdl-e 218 Lodderomyces el...
XP_001386227 101 --airINIAKGAViRYVLATVWWIFFTQW--FFG-LPIMDKVFVYTGGSCViekethpgqsrflhlfeaagEEVgnk--- 172 Scheffersomyces...
Q6BUP0       153 tkqqrISVLKKAIfNYVVATLWWVLFTQW--CFG-LPLMDKVFVWTGGKCTgiaqekla----lhipsygtSSIfteies 225 Debaryomyces ha...
EGV62536     140 ------PVAKNAIiSYTIATAWWILFTQW--CFG-VPIMDKIFLWTGGRCVsvaed----------rlahhSEFfnkv-- 198 Yamadazyma tenu...
EGW35656      99 ------KVIREAViRYAVITMWWILFTQW--CFG-LPIMDRIFVLTGGKCVvedpgrhvkl--------------fanlg 155 Spathaspora pas...
CCE65002     143 -snaINIKFQdseyrklkslkriykilkdykesyiessylhhlrcaidenaegcmdfvpskdtnelikkiqdldpmvqfi 221 Tetrapisispora ...
XP_004194678 179 gesfEASSIT---------------------------------------------------------------------- 188 Pichia farinosa...
EMG45163     162 eniwESTGIT---------------------------------------------------------------------- 171 Candida maltosa...
EER30745     163 eniwESTGIT---------------------------------------------------------------------- 172 Candida tropica...
CCE44412     196 tlvwKSKDVS---------------------------------------------------------------------- 205 Candida parapsi...
XP_001524468 219 tlvwRSSSVS---------------------------------------------------------------------- 228 Lodderomyces el...
XP_001386227 173 ---lsSTSIT---------------------------------------------------------------------- 179 Scheffersomyces...
Q6BUP0       226 dlsyESKAIT---------------------------------------------------------------------- 235 Debaryomyces ha...
EGV62536     199 edlyESTVVG---------------------------------------------------------------------- 208 Yamadazyma tenu...
EGW35656     156 ngksVSSTIS---------------------------------------------------------------------- 165 Spathaspora pas...
CCE65002     222 SSKCKRNGG-HWVGGHDPSGHIFLLTLMMMMIIAELP--------KINRirKQnmiyqkdskiRRVNivEKISKIIGEii 292 Tetrapisispora ...
XP_004194678 189 SYTCRKLKG-AWTGGHDPSGHVFLLVHSSLYLFLETSqfwgswpsFFGSarNLcgklrrvpadQSAEpkSKLAQVVDF-- 265 Pichia farinosa...
EMG45163     172 SYYCRKMKG-NWIGGHDPSGHVFLMIHSSLYLFFETSssfpsltvLKQNfnHFk---------RTTTlkEKLNVVWNTp- 240 Candida maltosa...
EER30745     173 SYTCRKFKG-NWIGGHDPSGHVFLMIHSSLYLYLETIdyfpgfsnIKNNlkRLv---------RVNSfkEKLIILWNTp- 241 Candida tropica...
CCE44412     206 SYHCRKFKG-SWLGGYDPSGHVFLMIHSSIYLYFETAawfn-wtdVRGAlySIkqslrdrrylESHIwqLVYGIVq---- 279 Candida parapsi...
XP_001524468 229 SYHCRKLRG-NWEGGHDPLGHVFLMIHSSLYLYLECAawfd-wksLVRCvvYVyrklqnyggkSLVRgfEHNEKLFVG-- 304 Lodderomyces el...
XP_001386227 180 SYHCRRIKG-SWEGGHDPSGHVFLLIHSSLYLFLEVSpywvsyshFKASlsKLrke-----vvKPVSlgEKFSSFIKY-- 251 Scheffersomyces...
Q6BUP0       236 SYMCRKLKG-SWEGGHDPSGHVFLLIHSSLYLFLEALpfwiswatLKHHlcQFvks-------wrLTsgSKPKLLFGL-- 305 Debaryomyces ha...
EGV62536     209 SKVCRQLRG-NWEGGHDPSGHVFLLIHSSLYMFFETVpfwrnwthVRTTlgKLk---------QDLSvsDNRTITVGR-- 276 Yamadazyma tenu...
EGW35656     166 SYNCKRIKGsSWEGGHDPSGHVFLLIHSSLYLFLETAeywpgwgaLINSisSVvhn-----heKTIIekLKQLAILGV-- 238 Spathaspora pas...
CCE65002     293 gtipsrsilsngllstyeklyqflilpimqnvkliiqlisytihfALFQEpaVLLISLLGMWCYSFLITIIVFHTFYEQV 372 Tetrapisispora ...
XP_004194678 266 ----------------------------------------------FHGTphFIVFLLLSLWWFMLLMTNIYFHSLAEKL 299 Pichia farinosa...
EMG45163     241 ---------------------------------------------------qVLVGLLLALWWFMLLMTNIYFHSILEKF 269 Candida maltosa...
EER30745     242 ---------------------------------------------------sIFISLLIGLWWFMLLITNMYFHSILEKL 270 Candida tropica...
CCE44412     280 ----------------------------------------------------LSLVGLVALWWFMLLMTNVYFHSIVEKL 307 Candida parapsi...
XP_001524468 305 ------------------------------------------------ELaqLSVVLLISLWWFMLLMTNMYFHSIAEKL 336 Lodderomyces el...
XP_001386227 252 ----------------------------------------------SVANppIVVAKLITLWWFMLLMTNIYFHSLGEKL 285 Scheffersomyces...
Q6BUP0       306 ----------------------------------------------FAQDphTIIIPLISLWWFMLFMTNIYFHSIGEKL 339 Debaryomyces ha...
EGV62536     277 ---------------------------------------------FFLHNpwIPVGMLILLWWFMLLMTNVYFHSILEKL 311 Yamadazyma tenu...
EGW35656     239 -----------------------------------------------KIHpqLLVIGMISFWWFMLLTTNIYFHSIAEKL 271 Spathaspora pas...
CCE65002     373 TGFLSAYIVAVIIY 386 Tetrapisispora phaffii CBS 4417
XP_004194678 300 VGLLFAYAGALLVY 313 Pichia farinosa CBS 7064
EMG45163     270 AGLLFGYIGVLIMY 283 Candida maltosa Xu316
EER30745     271 VGLIFGYLGIAVIY 284 Candida tropicalis MYA-3404
CCE44412     308 SGLVFGYFGVIVVY 321 Candida parapsilosis
XP_001524468 337 VGLVFRYVGVFAIY 350 Lodderomyces elongisporus NRRL YB-4239
XP_001386227 286 VGLVFGYIGVVGIY 299 Scheffersomyces stipitis CBS 6054
Q6BUP0       340 VGLVFGYVGLAVVY 353 Debaryomyces hansenii
EGV62536     312 VGLLFGY--AISLV 323 Yamadazyma tenuis ATCC 10573
EGW35656     272 VGMVYGYLGIVVVY 285 Spathaspora passalidarum NRRL Y-27907
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