8PNT


Conserved Protein Domain Family
PHAX_RNA-bd
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pfam10258: PHAX_RNA-bd (This model is not part of the current CDD release)
Phosphorylated adapter RNA export protein, RNA-binding domain
The phosphorylated adaptor for RNA export (PHAX) protein transports U3 snoRNA from the nucleus after transcription. This entry represents the highly conserved U3 snoRNA-binding domain of PHAX, which is characterised by having two pairs of adjacent glycines with the sequence motif GGx12GG. This domain adopts a novel helical fold and binds non-specific single-stranded RNA and comprises five alpha-helices linked by short loops containing 1 to 4 residues, apart from helices alpha3 and 4 that are linked by 13 residues. The fold is unique to this kind of RNA binding domains which show no structural homology with other RNA-binding domains.
Links
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Statistics
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PSSM-Id: 519277
Aligned: 46 rows
Threshold Bit Score: 75.2262
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8PNT_C       230 VADEISFRLQEPKKDLIARVVRIIGNKKAIELLMETAEVEQNGG-LFIMNGS---RRRTPGGVFLNLLKNtpSISEEQIK 305 human
XP_003059403 144 AARDLCGDLGEPKESLMRRAIECIGIPMANDLAIEVGAIEGGGG-QMTADGS---RRRTPGGVFWALLKT--KVAKEDWD 217
XP_002500818 133 AARDLCGDLGEPKESLMRRALEVIGVVEANDIAIQVYRIEGEGG-QMTSDGA---RRRTPGGVFWALLRE--RVTKEEWA 206
XP_002502266 202 LAERICRRLREHKKHLVRLLIAQFGAALCEGALEETIRVEKNGGsFVTLDGAggvRRRLPGGVFIATVKS--RAPPVEFK 279
XP_024387609 120 FVVQTCRRIEETKYPLFREAVDRIGIEAMKGLLNQVDAIQKCGG-QMTADGL---RRRSAGGVLWNLLRD--HVGPVLYK 193
Q9LTP9        94 FVRDTCRRLKEKKSYMIYTAVGCLGIAALSDLVNEVVAIETCGG-QVTADGT---RKRTSGGVLWNIIKA--R-QPEAYR 166 thale cress
XP_002278710  94 FVLDTCKRLKEKKSYLVWTAVGCLGVSALSDLVKEVDAIQACGG-QMTADGK---RSRTGGGILWSIIKV--R-DPNAYK 166
XP_006644266 110 FVNETCKRLKEKKSYLVWNAVGCLGVSVVSDLVREVEAIQKCGG-QTIADGS---RFRTGGGILWNILKS--R-EPKAYK 182
XP_006853912  88 FVTNTCRHLGEKKSYLFWEAISCLGLSVLTDLIKEVDVIQDCGG-QLTADGG---RPRTGGGILWNIIKA--R-HPTAYK 160
XP_002516471  92 FVLDVCRRLKEKKSYMVYTAVACLGVSRLGDLVKEVDAVLSCGG-QMTADGG---RFRTGGGILWNIVKT--K-EPKAYQ 164

8PNT_C       306 DIFYIENQ 313 human
XP_003059403 218 FIFEEERE 225
XP_002500818 207 DIFAEEKE 214
XP_002502266 280 AVMKRAAE 287
XP_024387609 194 EIMKEGNR 201
Q9LTP9       167 EIMKKTKE 174 thale cress
XP_002278710 167 EIMKRGKE 174
XP_006644266 183 EIMAKGRE 190
XP_006853912 161 EIVARGKE 168
XP_002516471 165 EIMKKTKE 172
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