Conserved Protein Domain Family
Pacs-1

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pfam10254: Pacs-1 (This model is not part of the current CDD release)
PACS-1 cytosolic sorting protein
PACS-1 is a cytosolic sorting protein that directs the localisation of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef.
Statistics
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PSSM-Id: 519273
Aligned: 23 rows
Threshold Bit Score: 473.411
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009014889  456 FMEQMSSILSCDHN-SPEVIVMl-----------LAQ--ALQSTKH-RtICTCSPSEVRTIVSTIASKIQKCTNKSLTQE 520 
14_pfamImport   1 VYDQLNQILVSDTA-LPENLILvnitd--wqgqfVAD--LLHAQKL-PvVCTCSGAEIQAVLSAVLTRIQKFCNCNSSMP 74  
XP_005453237  482 VYDQLNQILLSDSA-LPESLILvnstd--wqgqyVAE--QLQVQRH-PvVCTCSAAEIQAVLSAVLTRIQKFCNCNSSMP 555 
ELV09543      372 VYDQLNQILVSDAA-LPENVILvnttd--wqgqyVAE--LLQDQRK-PvVCTCSTVEVQAVLSALLTRIQRYCNCNSSMP 445 
EEC00724      471 VLDQLGQLFAGDEA-VPDRLLLvea-------pwLAT--ALQRAALpGvLSLAHGADLKAALAALVSRIQKFCNCNSRAP 540 
2_pfamImport    1 LMEQLSKVLPPEDK-MPEVLCLihyad--plgcqLAS--KLQNYQF-KvITPAGLADVRATFVCIINKIQKYCNSNPKPP 74  
XP_002426114  466 VVEQITKILGSDDS-LPDHLLIissnd--pqgslLAS--RLQERQL-KvLPVVSTSEIRLTLTYLVNKIQKFCHSSAKPP 539 
EGI64595      491 LVEQLSRVLP-DDS-LPEAVSLisiad--pggavLAA--KLQERNH-KvLTPASPADIRATFTCLVTRIQKFCNSSAKPP 563 
Q95R71        343 LLDQLSRVFAGEDSaIPEVVTIisppealggsalLAKlvTLFANSFkPaFVPQNTAEVKAVLQALMAKIQKYCNSNAKPP 422  fruit fly
XP_064407914  514 MYDQLNQILVSDAA-LPESVILvnatd--wqgqyVAD--LLQSQKR-PvVCTCSPAEVQAVLNALLTRIQRYCNCNSSMP 587  coelacanth
XP_009014889  521 LPIKVAIVGGDKYISSVLRPYVELFSNkSSDWINYIRFLVVPLGPSI--I-----------GKNLSSIDNRYAG--LFND 585 
14_pfamImport  75 RPVKVAAVGGQSYLGSILRFFVTQLANkTSDWLNHMRFLVVPLGKVP--AgrgraggagvpGRNLGEVTRRVQP--RDLK 150 
XP_005453237  556 RPVKVVAVGSQSYLGAILQFFVTQLANkTSDWLNHMRFLVVPLGSHP--V-----------AKHLGALDNRYSS--SFLD 620 
ELV09543      446 RPVKVAAVGGQSYLSSILRFFVKSLASkTSDWLSYMRFLIIPLGSHP--V-----------AKYLGSVDSRYSS--TFLD 510 
EEC00724      541 LTVRVGLLGSDPFLHSVVRLYVEHFSTkPPEWQAYLRFFFVPTGGSP--V-----------ARYLSSVDNCYAS--LFGD 605 
2_pfamImport   75 SQMKILLAGSDSFVNYVLRQYVEQLSFkPPDWMNYIKFYIIPLGINT--L-----------SRYLGTVDSYYGTtfLFKE 141 
XP_002426114  540 NTIKLMVVGSDAFINNILRQYVDQLSQkPPEWQGFIKFLIVPLGSSS--I-----------SRYLASVDSTYGA--YFAG 604 
EGI64595      564 APIKVIIAGGDSFINAVLRHYVDLLSFrPPDWQNYMKFLVVPLGSNT--L-----------TRYLSSIDTKYSK--LFGD 628 
Q95R71        423 HTVKVLLIGGDWLQGATLRHYVELMGVrPPDWLNHLRFYLVPVGGSCgsV-----------ARHLSQMDQAYAV--MFGS 489  fruit fly
XP_064407914  588 RPVKVAAVGGQSYLSAILRFFVEQLANkTSDWLNFMRFLIIPLGSHP--V-----------AKYIGLLDGRYNS--VFLD 652  coelacanth
XP_009014889  586 SAWKDnVFERFDFSNRfnq---------------------smDIGEVATRIVKYLNNARHMIQLPLSEAILTNKDK-GID 643 
14_pfamImport 151 GAVKR---------------------------------------VDATPRISCW---TSALELVPLATGCDSCPH---DE 185 
XP_005453237  621 GVWRD-VFSRSEPPQT--------------------------DQLDVAGRISQYISGATVTHQLPIAEAMLTCKHRtRDE 673 
ELV09543      511 SGWRD-LFSRSEPPVS--------------------------EQLDVVGRVMQYVNGASATHQLPVAEAMLTCRHKfPDE 563 
EEC00724      606 SSWRE-LVERGSP-----------------------------EAPELADRVADYLSGAHSCLQLPVAEAMVTYKGHsSDD 655 
2_pfamImport  142 DYWKE-QLECG-------------------------------DGTDIIGKIQNYIMEASNTIQLQIAEAMLSYKEKsSDD 189 
XP_002426114  605 EKWRD-LSER--------------------------------EINEVVNKIGLYMNNGTSTIFLPVAEAMLTYKEKsSDD 651 
EGI64595      629 E-WKE-LLEREGG-----------------------------GSSECAARASEYLVTANTILLLPIAEAMVTYRET---D 674 
Q95R71        490 DNWTQ-LCERAAATAAavsavttvnatalttnladaagvaksDIAELVQRIQRYLLAAGPCTQIPIAEAMVNYK----DE 564  fruit fly
XP_064407914  653 SAWRD-LFSKSEAPIS--------------------------DTLDVGGRIMQYITGASVSHQLPIAEAMLTCKHKsRDE 705  coelacanth
XP_009014889  644 DSShLIVPFLGEVRL-----GVMDVGNtsnifSSLIDydetsN----ANASLSNSPPQSSHmishmtNmdkvkeniSHTP 714 
14_pfamImport 186 DSYqKFIPFIGVVKV-----GLIEPSPa----SAGADad-egGa--tSLAVPSTSPPSHGSgvg-lvKe------aAATP 246 
XP_005453237  674 DSYqKFIPFIGVVKV-----GLIESGQ-----SPTGDae-egVa--vSLAVPSTSPPSHGSptg-miKe-------TATP 732 
ELV09543      564 DSYqKFIPFIGVVKV-----GLVEDSP-----STAGDgd-dsPv--vSLTVPSTSPPSssg----lsRd------aTATP 620 
EEC00724      656 ESTqVFIPFISVKKRkkfaeGEMTKPG-----CYAVDle---------eaLPGSSPPGGPMer------------eSTTP 709 
2_pfamImport  190 EALqTFIPFVNDVRI-----CSGDTAS------GSNDtddqcSiiidRKSILD-----------------------KTTP 235 
XP_002426114  652 ESSqIFVPFVNDVRL-----GSMDSAS-----GASVDlddmqAt--cGSSPP------------------------KITP 695 
EGI64595      675 DSSqIFIPFINDVRV-----GCPDSSS-----STSVDleesnVs--mSGSPPSLPPPSLPVpt-----------pgKLTP 731 
Q95R71        565 DSCqIFVPFVSDVRI-----GYLDA-Q------ASLDleenaAgsnaVGSGLGSGSASSSAipigsqSspnvhgvvSGSP 632  fruit fly
XP_064407914  706 DSYqKFIPFIGVVKV-----GLIEQCS-----VSSAGdgediTt--vSLSVPSMSPPPHTSasgl-------ikeaSATP 766  coelacanth
XP_009014889  715 PESNNFLSTPtttTTASSTTTaa------------------------qnIDAFNLQVDYWLMSGTSSQSSNATSNlptnl 770 
14_pfamImport 247 PPSPSMSSGLavlGSPSMPHG----------------------------VDAIGLQVDYWVA-LGGERKKEGERR----- 292 
XP_005453237  733 PSSPSMGSVLtvqGSPSMSHG----------------------------VDAIGLQVDYWLA-SLAEKRREGERR----- 778 
ELV09543      621 PSSPSMSSALaivGSPNSPYG-----------------------------DVIGLQVDYWLG-HPAERRREGDKR----- 665 
EEC00724      710 PSSPSMSSAGlapAGCVST-------------------------------SAMDLQLDYWTLGPSARKGAEPS------- 751 
2_pfamImport  236 PNSPNIGMQYlppPTKQVNWEl---------------------------CEPLELQLDYWLVPNTNKEVTTRGNEpssk- 287 
XP_002426114  696 PSSPNVNSMHitnHSRESNLV-----------------------------EPLELQIDYWTSNKSSEAKEVGKGKdp--- 743 
EGI64595      732 PSSPNVGQPAregW------------------------------------EPVELQLDYWS------------------- 756 
Q95R71        633 PQQQSLGRISpplQTPPSSASshrerntseslstpssvqqqsfsgalaaAEAVELQVDYWPLVRPGEGHAKESKGgl--- 709  fruit fly
XP_064407914  767 PSSPSLNSGLvvlGNPSGPHG----------------------------GDAIGLQVDYWLA-QPVEKKKEGEKR----- 812  coelacanth
XP_009014889  771 fnsdlksdllTNITSsasgkflskkdlKCSLKMMFRSVKI-----FRNSglqlsgdgsllAGGsNAG-------LSMVVV 838 
14_pfamImport 293 ----------D--TGs-----------KNTLKSTFRSVQV-----SRLP-----------GAA-GEGppg-lntMSMTVV 331 
XP_005453237  779 ----------D--TSc-----------KNTLKSAFRSLQV-----SRLP-----------GGG-SSDpqaqvntMAMTVV 818 
ELV09543      666 ----------D--ASs-----------KNTLKSVFRSVQV-----SRLP-----------HGG-EAQls---gtMAMTVV 702 
EEC00724      752 ---------------------------KLTLKAWFRSVQArlhscSRRK-----------MVGkGVEalg--psLTLNYV 791 
2_pfamImport  288 -----------------------rvdtKFTLKTGFKSLHI-----SRLF-----------LTNeEPLa-----fFTVSYI 323 
XP_002426114  744 --------------------------nKSTLKTNFKAVQI-----QRIP-----------SPGeQPGs-----yLLMNYI 776 
EGI64595      757 ---------------------------KQYVTSSFQSVAC-----AKTS-----------LIRrSSRt-----sLVYEFH 788 
Q95R71        710 --------skGSDAGg-----------KNSIKSTFRNLQV-----WRLP-----------QHAqQLGdmf--ngLTVSFA 752  fruit fly
XP_064407914  813 ----------D--LNt-----------KNTLKSVFRCVQV-----SRLP-----------SSG-EQQlv---gtMSMTVV 849  coelacanth
XP_009014889  839 TREKKQK-----------------IMRIG-KRSKESELN-KSQQIDGISRLICTSRSQNHP-LNVTIDGVDWSGIKFFQV 898 
14_pfamImport 332 TKEKNKKv---------------pTIFLG-KKPKEKEVDsKSQVIEGISRLICSAKQQQTI-LRVSIDGVEWNDVKFFQL 394 
XP_005453237  819 TKEKNKKv---------------pTIFLG-KKPKEKDVDsKSQVIEGISRLICSAKQQQTI-LKVSIDGVEWNDVKFFQL 881 
ELV09543      703 TKEKNKKv---------------pTIFLS-KKPREKEVDsKSQVIEGISRLICSAKQQQTM-LRVSIDGVEWSDIKFFQL 765 
EEC00724      792 TKEKKQK-----------------IMRLGkKKERESDRDaRCQLVEGVHRLICSCRNLQAP-LKVTIDSVEWTGVKFFQL 853 
2_pfamImport  324 -KEKKQK-----------------IMRLGkKKEKEKDLDpKNQVIDSVLRLICSPKTQHFP-LTITIDGYEWSGVKFFQL 384 
XP_002426114  777 TKEKKQK-----------------IMRLGkKKEKERETEnKNQQIEGVTRLICSPKTQALP-LKVSIDGVEWTGVKFFQL 838 
EGI64595      789 DKREKTKnnvqyikstlkencplsVMRLGkKKEKEKENEpKSQSVDGVTRLICSAKTHNIP-LRVSIDGTEWYGVKFFQL 867 
Q95R71        753 TKEKKQKq----------------IMRLGkKKDKERDLE-KEQCVEGVARLICSPKQSHPVpLRVYIDGTEWTGVKFFQV 815  fruit fly
XP_064407914  850 TKEKNKKv---------------pTIFLS-KKPKEKEVDsRSQVIEGISRLICSAKQQQIM-LKVSIDGVEWNDVKFFQL 912  coelacanth
XP_009014889  899 SSQWQTHIKYFPVLIFGDL 917 
14_pfamImport 395 AAQWPTHVKYFPVGLFSYS 413 
XP_005453237  882 AAQWPTHVKYLPVGLFGYS 900 
ELV09543      766 AAQWPTHVKHFPVGLFSGS 784 
EEC00724      854 SSQWQTHIKYFPVGLYMAP 872 
2_pfamImport  385 SSQWQTHIKHFPVAVYSLD 403 
XP_002426114  839 SAQWQTHIKTFPVALFAQD 857 
EGI64595      868 SAQWQTHIKTFPIALLEYN 886 
Q95R71        816 SSQWQTHVKNFPIALIGCT 834  fruit fly
XP_064407914  913 AAQWPTHVKHFPIGLFCYS 931  coelacanth
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