Conserved Protein Domain Family
PRCC

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pfam10253: PRCC 
Mitotic checkpoint regulator, MAD2B-interacting
This family constitutes the major, conserved, portion of PRCC proteins. In humans this family interacts with MAD2B, the mitotic checkpoint protein. In Schizosaccharomyces pombe this protein is part of the Cwf-complex that is known to be involved in pre-mRNA splicing.
Statistics
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PSSM-Id: 402044
View PSSM: pfam10253
Aligned: 69 rows
Threshold Bit Score: 62.757
Threshold Setting Gi: 388858065
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPS38158     223 SLFSL---------GSALNEKPLGAS-AVSTGEYKPMIIDDNpapavedipmegqtyeqvedtqty-------------- 278 Dactylellina ha...
EFH60257     140 SFFSAmpapkssqtLGALPSLGSGSGrRSNLETETPAIVIPQtdsgisdqqnqsyeslshsnseteqnvgvdnyyaagyg 219 Arabidopsis lyr...
PDM72735     251 DFFGL----------------SSTQSnIPTIITHVPGVPLLPsyglsdeagpvrpdpidtsygyeg-------------- 300 Pristionchus pa...
3_pfamImport   1 DFFGF----------------SSAPAvPKETSSDSPFMAINSsmdvvgpsrptedddmdvsqmypnve------------ 52 
Q18535       220 DFFGF---------------SSAPTRkESEIPSEIPYMTMNSsmdvvgpsrpdegmdprqmyempee------------- 271 Caenorhabditis ...
CAP22809     222 DFFGF---------------SSTPARkEMESAPEIPFMAMNSsmdvvgpsrpteedevdpsqmympe------------- 273 Caenorhabditis ...
XP_002069163 264 DFFSLnsehrlpevssneinalvakraarmaeasnkylenvte------------------------------------- 306 Drosophila will...
XP_001983549 283 DFFSLnseqqlpsvssneinalvakraakmveasqkfladq--------------------------------------- 323 Drosophila grim...
XP_001688851 236 DFFSFnkvdelptvstneisamvakkaakiaenvrkytepe--------------------------------------- 276 Anopheles gambi...
XP_001846330 227 DFFSLnkeealpeisaneinamvakraarmaetvkkfetp---------------------------------------- 266 southern house ...
EPS38158     279 ---------------------qqpiqgpqtyqsiseeigmdeasmRMFMGRRg-----------rNAeikLMDFNVDQEY 326 Dactylellina ha...
EFH60257     220 gyetnpsgsvgydgssyggntwngggfeattglpeavvamdsgarRGRRGRNqm--------------peIVEVKQDELM 285 Arabidopsis lyr...
PDM72735     301 ---------------------vedeevdegpsssaqmkkisdeaaQNMIFKYdyapfg--hdrrgFNeadIIDVSVDRAI 357 Pristionchus pa...
3_pfamImport  53 -------------------deeeeqttsssttdgwlhrkisdeqaHKLLMKFshdigpeerrsinEMassIVDVNVDAAL 113
Q18535       272 ---------------------eedvqegpsasnawlhrkindeqaHKLLMRFshdigqeerrsinEMansIVDVNVDDAL 330 Caenorhabditis ...
CAP22809     274 ---------------------eddsqegtsasnawlhrkisdeqaHKLLMRFshdigseerrsinEMansIVDVNVDDAL 332 Caenorhabditis ...
XP_002069163 307 -------rqvpeeesqehdrqaenehhlrqiqarnrdvqlnaeamDALVGKNakrr------rkeAKgmqVIEISGSEVH 373 Drosophila will...
XP_001983549 324 ----------ekeqeheeaaaqqkvaelqlaqkryheqhlnteamDALVGKNakrr------rkeAQemqLIDISGAQVM 387 Drosophila grim...
XP_001688851 277 ----------epsdggdtsgaassaydtaqphqpaeedlasetalAALIGGNrak-------rarLEevdLIEITSADIV 339 Anopheles gambi...
XP_001846330 267 ----------eeqepqpgssghysqmapipeaqaeaedlaneralASLIGGNkak-------rarLDevnIIDISSADIV 329 southern house ...
EPS38158     327 ---EKNEAARAAGELAPE-----------KNVVRSI-KPGKHQLTSLLNAAQSQRTALEESFAQGRRNKKEAGSKYGW 389 Dactylellina hapt...
EFH60257     286 knrPRVDQVKSTGIAFGPayqpa--tsssKGKVSKL-HKRKHQITALFMDMKHKESELTERRSRGLLTKAETQAKYGW 360 Arabidopsis lyrat...
PDM72735     358 g--PNVQENLLKNLNRNNmarasmpslptANAPNDKnAKRKHQITYLANIAVAREGELQQKWADGKAAKRMARQkygf 433 Pristionchus paci...
3_pfamImport 114 g--PDVKQNILKNLGHRAfvest-kapmpTVQTQGQmSRRKHQITYLASQAVAREEQLKDQWADQKQNKRMARQKYGF 188
Q18535       331 g--PDVKTNIIKNLGHRAfveat-saplpQVQTQGQmSRRKHQITYLASLAVSREEQLKDQWADQKQSKRMARQKYGF 405 Caenorhabditis el...
CAP22809     333 g--PDVKTNIIKNLGHRAfveat-sapipQVQTQGQtSRRKHQITYLASLAVAREEQLKDQWAEQKQSKRMARQKYGF 407 Caenorhabditis br...
XP_002069163 374 ---PNREEWMRTALASSTtfqpt--gvltDEEPVAG-TRRKHQITYLAHKAKANEAELQAMWSANRNTRRVTQSKYGF 445 Drosophila willis...
XP_001983549 388 ---PDREEWMRTALASTTafqat--gvltDEEPVAG-TRRKHQITYLAHKAKANEAELQAMWSANRQTRRATQNKYGF 459 Drosophila grimshawi
XP_001688851 340 ---PSKEDFLRRQLQDETgyvptghl----vgdwtctSKRKSHITQLASKAQANAQELEAMWAANRQSRRQTQSKYGF 410 Anopheles gambiae...
XP_001846330 330 ---PTKEDFLRRKLQEETgfvptghl----tgdwsctSKRKSHITYLASKAADNAQELEAMWSSNRQSRRQTQSntlv 400 southern house mo...
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