6LR4


Conserved Protein Domain Family
PEN-2
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pfam10251: PEN-2 (This model is not part of the current CDD release)
Presenilin enhancer-2 subunit of gamma secretase
This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex.
Links
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Statistics
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PSSM-Id: 519271
Aligned: 40 rows
Threshold Bit Score: 83.4248
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6LR4_D        49 SNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEqSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRP-RW 127 human
XP_006343444  48 SEQESVDHARRFFKFGFLLLPWLWAVNCLYFWPVIRRPSSYYH-PDLRRYVVRSAIGFAVFAVILSSWALTFSIGGErLF 126
XP_006578788  51 SEEESVGYARRFYTFGFALLPLLWAVNCFYFWPVLRHSHSF---PRIRPYVVGSAIGFAVCATLLSSWSLTFAIGGErLF 127
CAG1834542    44 SEEESAAYARSYFYWGFALLPLLWAVNCCYFWPVLRNSHPS---PHVRRYVMPSAIGFTIFTVLLGSWSLTFLIGGEqLF 120
XP_002306247  42 TEDESLTYARRFYKFGFALLPWLWAVNCFYFWPVLFNSRSF---PRIRPYVVRSAVGFTVFTTVLCSWALTFAIGGEqLF 118
EEF39540     387 SEEESIKYARRFYKFGYALLPWLWAVNCFYFWPALRNSRSF---PRIRPYVIRSAVGFTAFSILLCSWALTFAIGGErLF 463
XP_006843054  38 DEEDAVKYARNFFRAGFFLLPFLWFLNSFYFWPVLTRSSSF---PRLRPYVLGSAIGFAVFMVLLCLWALTFAIGGErLF 114
Q54BR1        10 DDEKMINIAKKLWFIGFFFLPWVWLINILYFIPYRNSLN-----DKVKWYLKFSLIGFLGYSTIFMGWMGIYLVNRN-KW 83  Dictyostelium d...
XP_020434406  10 NDEKMRGIARKLWIAGFFFLPWVWMINILFFLPHRKVLS-----PAIIWYLKYSLIGFFVYTGIFMTWMGIYLVNRN-KW 83 
XP_004366102  10 nDDKMRNIAKKLWIIGFFFLPWVWLINILFFFPHRKQLS-----TDVFWYLKYSLIGFFVYSTIFMTWMGIYLVNRN-NW 83 

6LR4_D       128 GALGDYLsFTIPLG 141 human
XP_006343444 127 GHVWDKL-VMYNVA 139
XP_006578788 128 GPVWDQL-VMYNLA 140
CAG1834542   121 GPAWNDL-VMYNLA 133
XP_002306247 119 GPVWDKL-VMYNVA 131
EEF39540     464 GPVWNEL-VMYNVA 476
XP_006843054 115 GPIWQHL-VMYNVA 127
Q54BR1        84 GAFGDDIsITIPFG 97  Dictyostelium discoideum
XP_020434406  84 GAFGDSIsITVPFG 97 
XP_004366102  84 GASGDNIsIVIPYG 97
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