5A63


Conserved Protein Domain Family
PEN-2

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pfam10251: PEN-2 
Presenilin enhancer-2 subunit of gamma secretase
This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex.
Statistics
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PSSM-Id: 402042
View PSSM: pfam10251
Aligned: 42 rows
Threshold Bit Score: 81.8728
Threshold Setting Gi: 586691157
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A63_D         7 SNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEqSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRP-RW 85 
XP_006578788  51 SEEESVGYARRFYTFGFALLPLLWAVNCFYFWPVLRHSHSF---PRIRPYVVGSAIGFAVCATLLSSWSLTFAIGGErLF 127 soybean
XP_009122505  45 TEEASVDYARRFYKFGFALLPWLWAVNCFYFWPVLRHSRAF---PQIRNYVVRSAIGFSVFTALLSAWALTFSIGGEeLF 121 field mustard
XP_006343444  48 SEQESVDHARRFFKFGFLLLPWLWAVNCLYFWPVIRRPSSYYH-PDLRRYVVRSAIGFAVFAVILSSWALTFSIGGErLF 126 potato
XP_002306247  42 TEDESLIYARRFYKFGFALLPWLWAVNCFYFWPVLFNSRSF---PRIRPYVVRSAVGFTVFTTVLCSWALTFAIGGEqLF 118 black cottonwood
EEF39540     387 SEEESIKYARRFYKFGYALLPWLWAVNCFYFWPALRNSRSF---PRIRPYVIRSAVGFTAFSILLCSWALTFAIGGErLF 463 castor bean
XP_006843054  38 DEEDAVKYARNFFRAGFFLLPFLWFLNSFYFWPVLTRSSSF---PRLRPYVLGSAIGFAVFMVLLCLWALTFAIGGErLF 114 Amborella trich...
Q54BR1        10 DDEKMINIAKKLWFIGFFFLPWVWLINILYFIPYRNSLN-----DKVKWYLKFSLIGFLGYSTIFMGWMGIYLVNRN-KW 83  Dictyostelium d...
EFA82289      10 NDEKMRGIARKLWIAGFFFLPWVWMINILFFLPHRKVLS-----PAIIWYLKYSLIGFFVYTGIFMTWMGIYLVNRN-KW 83  Heterostelium a...
EGG14582      10 nDDKMRNIAKKLWIIGFFFLPWVWLINILFFFPHRKQLS-----TDVFWYLKYSLIGFFVYSTIFMTWMGIYLVNRN-NW 83  Cavenderia fasc...
5A63_D        86 GALGDYLsFTIPLG 99 
XP_006578788 128 GPVWDQL-VMYNLA 140 soybean
XP_009122505 122 GPVWDKL-VMYNVA 134 field mustard
XP_006343444 127 GHVWDKL-VMYNVA 139 potato
XP_002306247 119 GPVWDKL-VMYNVA 131 black cottonwood
EEF39540     464 GPVWNEL-VMYNVA 476 castor bean
XP_006843054 115 GPIWQHL-VMYNVA 127 Amborella trichopoda
Q54BR1        84 GAFGDDIsITIPFG 97  Dictyostelium discoideum
EFA82289      84 GAFGDSIsITVPFG 97  Heterostelium album PN500
EGG14582      84 GASGDNIsIVIPYG 97  Cavenderia fasciculata
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