Conserved Protein Domain Family
O-FucT

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pfam10250: O-FucT 
GDP-fucose protein O-fucosyltransferase
This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.
Statistics
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PSSM-Id: 402041
View PSSM: pfam10250
Aligned: 160 rows
Threshold Bit Score: 85.839
Threshold Setting Gi: 299117371
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KRH01414     106 YLLV---SCNGgLNQMRSAICDMVAIARHLN-----------VTLIVPElDKA-SFWADLS-------DFKDIFDvdhfI 163 soybean
Q7YZS7        35 YLLYdcnPGEG-FNLRRDVYMRVANLVKSLResksck--gddwvLVLPPwGRIsYHWKEHgmeq-sliPWSMFFN----V 106 vase tunicate
EEN65550       9 YLLYdinPGEG-FNLRRDVYMRVANLVKKLQdhg-------swvLVLPPwGRL-YHWKSSTekqqtkiPWSAFFD----L 75  Florida lancelet
XP_003445344  60 YLLYdvnPPEG-FNLRRDVYIRMASLVKTLRkegd------dwvLVLPPwGRL-YHWQSPnlhq-iriPWGEFFS----L 126 Nile tilapia
XP_002116556  42 YLIYdvnDSEG-FNLRRDVYMRIANLIIQLNqrqh-----yhwtLVLPPwKRM-YHWRSTPspkqfplPWKTFFD----I 110 Trichoplax adha...
EGT34807      38 FLLYdvnFGEG-FNLRRDVYMRVANTVRLLResge------nwiLVLPPwGRL-HHWMRMev----alSWRLFFD----V 101 Caenorhabditis ...
Q5CSJ4        61 WIIYdvkDGEG-FNLQRNVFDRMALVVSSLNeimykknedkfAVLILPPfCNI-AHWTYNSkr---rlPWSTFFS----- 130 Cryptosporidium...
Q8I360        48 YIMYdvnIGEG-FNLQKEIFYRLSLVIYNLNkkdki----niyyLVLPPwCYV-THWNIRKgn---nlRWEFFFN----T 114 Plasmodium falc...
XP_001614629  51 YVLYdvhIGEG-FNLQKEVLYRVALAVYYLNqeert----hvhyLVLPPwCYV-THWGRERtna--riKWSIFFN----L 118 malaria parasit...
XP_021313443  82 alaerydNVTG---ELRKNIPTRLQSTTSSEygselqrspspS----PEpLQR-SWTREQS-------PRAAGFDf--fL 144 sorghum
KRH01414     164 TSLRDevriikqlppkvkrrvelglfysmppiswsnisy---------------yenqvlplllkhkvihlnrtdarlan 228 soybean
Q7YZS7       107 KSMSGfvpvieyedyieevgeavidelwylqnyaegwssgt----------weekmherdcienpvyetdsegkirgwfw 176 vase tunicate
EEN65550      76 ESLNRhipviefedyiketgsaemdemwylqsykdgffktgk---------weekvderdcndppvyhpdqsghyrgwfw 146 Florida lancelet
XP_003445344 127 TSLQAnvpvieyeefiaenggpfidhvlvlqnyaegwtdgk----------weekvderpcieklmyskdkhgyyrgwfw 196 Nile tilapia
XP_002116556 111 SSLNKfipvmeyqdyinqfgqtideiiylqpypdpfeggq------------fvdkveetncqsnqkyklmngnyygyff 178 Trichoplax adha...
EGT34807     102 ESLNRfipviefedfldetenhpidqviylqhyeegwgteyv---------rkfeerkclapadshykkvdgekwrgwfy 172 Caenorhabditis ...
Q5CSJ4       131 --IKQnglptleydiykrltgivnigaevvglnfdwnnksfqsstsieyynsfeisesrhlnskcffnnyvrngnvvygg 208 Cryptosporidium...
Q8I360       115 DIMKKvipiieyeeyeklygnysdiminskyildnyke-----------------ksflilpfeecninvnrfkqfckkc 177 Plasmodium falc...
XP_001614629 119 KALQNvipvmeyaeyegqfgphtdyilsyrhiigewpkrg------------dkksfqvlkldkcqvkgyklkknlrknc 186 malaria parasit...
XP_021313443 145 SNRNNdspvsrke------------------------------------------------------------------- 157 sorghum
KRH01414     229 nglpaeiQKLRCR-----------VNF--------------------------------------------NALRFTTQI 253 soybean
Q7YZS7       177 gyeetyaKTFKCVsvqgmsklfvkPLCggnttaksvmldrgen-------------mlhdmfggkrywdcrrSMVFADAL 243 vase tunicate
EEN65550     147 gydeayvLKFKCVsaqan-aglmvKPLtenttarsvminraev-------------llhdaygqtdywaarrSMRFSKEL 212 Florida lancelet
XP_003445344 197 gyeetraRNVTCLsaqgh-asviaPVLqknitatsvmldraet-------------llhdhyagkdywntrrSMVFAKHL 262 Nile tilapia
XP_002116556 179 glkgitaRKLRCMlaqgm-tsiiiPKLqqskarlilldraenl--------------lheaygqvgywnsrrSLVFAKHL 243 Trichoplax adha...
EGT34807     173 syedvraSNFKCVsiqgd-satlrDLLkhsnyssmtsimidrae-----------tilhehfgdadywkarrSMRYSKQL 240 Caenorhabditis ...
Q5CSJ4       209 rcelvkiRSLICLsff-----klmRFKevseeiykilesnrkegklhnylikhtegilvpwpwelskyrvlDVISYNNNI 283 Cryptosporidium...
Q8I360       178 ehkynvlYSGYCTtintkqsecysYNMisnyfitsilenlflynitsvl-ikqstnilvpfvnelyqsnleDILLFNNKL 256 Plasmodium falc...
XP_001614629 187 dhkysveYSGKCTnvkgkkmecleFFFitshfvsstlldifqydadsvl-ikhgsnilvafmnelvdanleDVLPYSEDL 265 malaria parasit...
XP_021313443 158 pedlasqSESDAKsedgd-ddgiaYTLhq------------------------------------------rvLELEDEL 194 sorghum
KRH01414     254 EELGRRIVKVLR--------------------EKG-----PFLALHLRYEmDMLAfsgcahgcdikeeeeltrmryaypg 308 soybean
Q7YZS7       244 IKTADQFRSKYLdsddvrdktv-mpenwkdhkCTEdaiggPYIAAHVRRK-DFLYa------------------------ 297 vase tunicate
EEN65550     213 RFVGNEFRRKHLnstdkddktimwedwrtfkpAVGtakggPYLAVHLRRG-DFARs------------------------ 267 Florida lancelet
XP_003445344 263 RLIGDDFRSSYLnstdetdhtpysedwtrmkaKPGsakggPYLGVHLRRK-DFIWg------------------------ 317 Nile tilapia
XP_002116556 244 RDEGNRYRQEILnstdeqdhivrhsdwrllnvKKSkkrggNYLAVHLRRR-DFLQg------------------------ 298 Trichoplax adha...
EGT34807     241 VEAADAFRDKYLdsddendkte-lvsdwrkerARRsalggPYLGIHWRRR-DFLYa------------------------ 294 Caenorhabditis ...
Q5CSJ4       284 RRYANLYMSAN----------------------TFfdekkPFISVHLRRN-DFVFl------------------------ 316 Cryptosporidium...
Q8I360       257 LSYGNNYISNIlk-------------------------tnHYISSHLRYT-DFKYi------------------------ 286 Plasmodium falc...
XP_001614629 266 INEGDQFVEKNfks------------------------skNYISCHLRYT-DFRKi------------------------ 296 malaria parasit...
XP_021313443 195 NMTNQKLQDANqk-------------------------leALEEKSLRCHcDYKAngngaeq------------------ 231 sorghum
KRH01414     309 wkekvinselkrkeglcpitpEE-----TALVLSALGIDRN---VQIYIASG------EIYGGEkrMASLLGEFPNLI-- 372 soybean
Q7YZS7       298 --------------------rKEfvpsiKQVAKVLSEKMKEykvDKVFIASD------GTKEe---MKELK-SLLP-Gm- 345 vase tunicate
EEN65550     268 --------------------hSKnvpslQGAAKQIRQIKKEqklKKVYLATD------ANDQe---VKELQ-KMVKg--- 314 Florida lancelet
XP_003445344 318 --------------------hREdvpslKGAVKKIRSLMKKhklDKVFVATD------ADDEe---IKELK-KLLPd--- 364 Nile tilapia
XP_002116556 299 --------------------rKNdipslEEAVLQIKSAMKKtnlSKVFLATD------AEESg---LNSIRDQM---Eim 346 Trichoplax adha...
EGT34807     295 --------------------rQEqlpsiKGTALILEKLCEQlklNRIYLATD------APEEe---VEELKSYLKE-Glk 344 Caenorhabditis ...
Q5CSJ4       317 --------------------rNDdiptfDQVIDRLLQLSNDlktKRVVISTD--------------SNEYEKNELLDIfl 362 Cryptosporidium...
Q8I360       287 --------------------sRYnvppiHIALLKLLYIMFInncRIIFIASDekveiqKVINKD--FHQYKKHFy----- 339 Plasmodium falc...
XP_001614629 297 --------------------sTYdvspvGISLLKLLYIMFLrksTLIFVSTDekkevkKVIDSQ--FPQFKHFF------ 348 malaria parasit...
XP_021313443 232 ---------------ttevsdKEqe--lEAEIVNLQEQMDSt--RRRFEEAL------SERDGE--ISKLKQELAD---- 280 sorghum
KRH01414     373 -RKEIllGPSELMYFQNHSSQmaAVDYLVSLESDIFIPTYDGNMAKVVEGH--------------RRFL 426 soybean
Q7YZS7       346 -FMYKp-TKTEKSEFKMGGVA--IIDQIICSHARFFMGTKESTFSFRIQEE--------------REIM 396 vase tunicate
EEN65550     315 iVRFKp-SKEELNKMKDGGIA--IIDQWICSHARYFVGTALSTFSFRIHEE--------------RTIL 366 Florida lancelet
XP_003445344 365 mVQFEp-STEDLELFKDGGVA--IIDQWICAHARFFIGTSVSTFSFRIHEE--------------REIL 416 Nile tilapia
XP_002116556 347 lCYVTt-TPDRIQQFGDGGIA--IIDQWICAHAKYFIGSKESTFSFRIYEE--------------RELM 398 Trichoplax adhaerens
EGT34807     345 vYRFTd-----TQKFNDGQIA--IIDQYLCAHARHFIGSHESTFTFRIQED--------------REIL 392 Caenorhabditis brenneri
Q5CSJ4       363 kHNLDlhIINIKDHLDDGIIS--AVSQVILLNGEYFIGTKESRFSFSVIWDcilsvmndfkddisRNFn 429 Cryptosporidium parvum
Q8I360       340 -------FYNNQNNLHEGEFS--IIEQWICTRSYIFIGNIFSRFTMNINWE--------------RHLI 385 Plasmodium falciparum 3D7
XP_001614629 349 -------FFYENEKLHTGQVA--IVDQWICARSGTFVGNIFSRFSMHIKWE--------------RSLI 394 malaria parasite P. vivax
XP_021313443 281 -ASENlqEEKYANGLQISELQq-SVEYIGSK------LEKVSEEKLLVENK--------------VKEL 327 sorghum
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