5KXH


Conserved Protein Domain Family
O-FucT

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pfam10250: O-FucT (This model is not part of the current CDD release)
GDP-fucose protein O-fucosyltransferase
This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.
Statistics
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PSSM-Id: 519270
Aligned: 137 rows
Threshold Bit Score: 58.5365
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5KXH_A         10 YLLYc--PCMGRFGNQADHFLGSLAFAKLLN-----------RTLAVPPwIEY-QHHKPPFtnl--hvSYQKYFK----L 69   house mouse
XP_002289731  184 YLTFe--PDGGGFNNIRMSLETIILMAHAMG-----------RTLVMPP-SQGmYLLRKDRdkqkvhfSFDDFYHmeqvG 249 
XP_002290318  791 YLAFm--PDKGGFNNVRMSFEIILIMAVALE-----------RTLVLPP-EMPmYLLRNDStkr--rrGLDGFFDmq--- 851 
CBN75327      141 YVTFe--PDHGGFNNIRMAMEVMLVFARETG-----------RTLVMPA-AQKfYLLNRPAv------EFADMFP----I 196 
XP_002116556   42 YLIYdvnDSEG-FNLRRDVYMRIANLIIQLNqrqh-----yhwtLVLPPwKRM-YHWRSTPspkqfplPWKTFFD----I 110 
EDO42964        3 FLIYdvnPGEG-FNLRRDVYMRVANLVKLLNkkq-------swvLVTPPwRRL-YHWRSRieq--tglPWRTFFD----M 67  
XP_009015731    4 FLLYdvnPGEG-FNLRRDVYLRMANLVKMLNkvq-------lwtLVLPAwNHL-YHWRSdvnq--tniPWYTFFD----I 68  
Q5CSJ4         61 WIIYdvkDGEG-FNLQRNVFDRMALVVSSLNeimykknedkfAVLILPPfCNI-AHWTYNSkr---rlPWSTFFS----- 130  Cryptosporidi...
Q8I360         48 YIMYdvnIGEG-FNLQKEIFYRLSLVIYNLNkkdki----niyyLVLPPwCYV-THWNIRKgn---nlRWEFFFN----T 114  Plasmodium fa...
A5K6G1         51 YVLYdvhIGEG-FNLQKEVLYRVALAVYYLNqeert----hvhyLVLPPwCYV-THWGRERtna--riKWSIFFN----L 118  Plasmodium vi...
5KXH_A         70 ---EPLQAYH-RVVsledfmEnlapshwppekrvay-------------------------------------------- 101  house mouse
XP_002289731  250 fehAGL-----DIIsmeeflLkeamtgnlknkttgvasyppnnrtnwdgmdpkelkeylrdvtltpldwspgsclaafps 324 
XP_002290318  852 --sSSFKKRV-KYItmeefiLkeghpggqfvthpkefeellkasrgchqgevkqagfdppcglvhdylsqhgti------ 922 
CBN75327      197 ---EYLSDYM-DVItmeeflKkegltgrlgkvppgnkssghskeavqdylrevadvvphwhhmdeali------------ 260 
XP_002116556  111 ---SSLNKFI-PVMeyqdyiNqfgqtideiiylqpypdpfeggqfvdkveet---------------------------- 158 
EDO42964       68 ---KNLARYV-PVIdfdqflKvnggtgideiiylqryaegwkdgvweekiddr--------------------------- 116 
XP_009015731   69 ---GSLNKHV-PVIefhdfvKvmdgrpiddviyfqhykegwggkwvekmdd----------------------------- 115 
Q5CSJ4        131 -----IKQNGlPTLeydiykRltgivnigaevvglnfdwnnksfqsstsieyynsfei---------------------- 183  Cryptosporidi...
Q8I360        115 ---DIMKKVI-PIIeyeeyeKlygnysdiminskyildnykeksflilpf------------------------------ 160  Plasmodium fa...
A5K6G1        119 ---KALQNVI-PVMeyaeyeGqfgphtdyilsyrhiigewpkrgdkksfqvl---------------------------- 166  Plasmodium vi...
5KXH_A        102 -------------------------------------------------------cfevaaqrspdkktCPmkegnpfgp 126  house mouse
XP_002289731  325 ddgkqhfdelndmmhevqqnmpkvndfvdkpvavdappvdrmreavagqikrlciydeemqkapvvhfmCYhkmr----- 399 
XP_002290318  923 -----------------pnitathhqclvfdegmfnngtpendksakdfcssgdrkmvyvtqemqspqlLFvradkp--- 982 
CBN75327      261 -----------------------fgpspevpkvpddeesqawlqefltdkrrqldygedmqrarhihfrTSpgqgre--- 314 
XP_002116556  159 --------------------------------------ncqsnqkyklmngnyygyffglkgitarklrCMlaqgm---- 196 
EDO42964      117 --------------------------------------dcidnpvyykdggkyrgyfwgmadvyarkfkCVsvqgt---- 154 
XP_009015731  116 ---------------------------------------recndnhpfyqledglwhwympnitsvrfkCVsiqae---- 152 
Q5CSJ4        184 ---------------------------------sesrhlnskcffnnyvrngnvvyggrcelvkirsliCLsff------ 224  Cryptosporidi...
Q8I360        161 -----------------------------------------eecninvnrfkqfckkcehkynvlysgyCTtintkq--- 196  Plasmodium fa...
A5K6G1        167 --------------------------------------kldkcqvkgyklkknlrkncdhkysveysgkCTnvkgkk--- 205  Plasmodium vi...
5KXH_A        127 fwdqfhVSFnkselftgisfsasykeqwtqrfpakehpvlalpgapaqfpvleehrelqKYMVWSDEMVRTGEALISAHl 206  house mouse
XP_002289731  400 --vrllTHFyaflffedwr------------------------------hdlwskrfvrDHLRYSDDIQCAAARIVASVr 447 
XP_002290318  983 -asrmlAHYygyihftdvs------------------------------lgnyfkrlirDLLHFRSEIFCAAGKIVNELq 1031
CBN75327      315 -eyrlfTHFytfvgfsdpv------------------------------aarhhrrlvrDLVHFRESLFCAAATIVGRLr 363 
XP_002116556  197 -tsiiiPKLqqskarlilldraenl--------------------lheaygqvgywnsrrSLVFAKHLRDEGNRYRQEIl 255 
EDO42964      155 -aaimePYLldkiksrsvfidrfee-------------------vlhihygqkdywearrSLVFAKHLRDEGDKFRRKVl 214 
XP_009015731  153 -ysflkDYLihnlsnswavmfprg---------------------eqvmhgeysewtarrSVRFSKDLVSIGDKFRSTMl 210 
Q5CSJ4        225 ---klmRFKevseeiykilesnrkegklhny------likhtegilvpwpwelskyrvlDVISYNNNIRRYANLYMSANt 295  Cryptosporidi...
Q8I360        197 -secysYNMisnyfitsilenlflynitsvl-------ikqstnilvpfvnelyqsnleDILLFNNKLLSYGNNYISNIl 268  Plasmodium fa...
A5K6G1        206 -mecleFFFitshfvsstlldifqydadsvl-------ikhgsnilvafmnelvdanleDVLPYSEDLINEGDQFVEKNf 277  Plasmodium vi...
5KXH_A        207 ---------------------------VR-----------------------PYVGIHLRIGsDWKNacamlkdgtagsh 236  house mouse
XP_002289731  448 erarkr---------------dptgnpNG-----------------------EYDSFHIRRG-DFQY------------- 475 
XP_002290318 1032 endgas---------------svdsdgGG-----------------------GFTALHIRRG-DFQY------------- 1059
CBN75327      364 aagggdpgnwsgyygewgglgeregwvGGgevagvgggsyadeggggvrkraGFSTFHIRRG-DFQY------------- 429 
XP_002116556  256 nstdeqdhivrhs-dwrllnvkkskkrGG-----------------------NYLAVHLRRR-DFLQg------------ 298 
EDO42964      215 qstdeedntlmde-dwrknkkqegvakGG-----------------------PYIGVHLRRA-DFLYa------------ 257 
XP_009015731  211 dsddfrdqtvmed-nwkkmkrkhgdalGG-----------------------PYLAAHLRRR-DFLYg------------ 253 
Q5CSJ4        296 ff-----------------------deKK-----------------------PFISVHLRRN-DFVFl------------ 316  Cryptosporidi...
Q8I360        269 --------------------------kTN-----------------------HYISSHLRYT-DFKYi------------ 286  Plasmodium fa...
A5K6G1        278 k-------------------------sSK-----------------------NYISCHLRYT-DFRKi------------ 296  Plasmodium vi...
5KXH_A        237 fmaspqcvgysrstatpltmTMclpdlKEIQRAVTLWVRalNa--RSVYIATD------SES--Y--VSEIQQLFKDKV- 303  house mouse
XP_002289731  476 --------------------KNtrleaDEIYENSKDEMK--Pg--GTVFVATD------HNGkpF--FKPLADKY--DLv 521 
XP_002290318 1060 --------------------KKmklsaEEIYDNVKEGLQ--Pk--EILYIATD------EKDktF--FAPFRDA-GHSLf 1106
CBN75327      430 --------------------VRmkppaETIAGATKDLIQ--Pg--EVLFIATD------ERKkeF--FDVFTHEH--RVf 475 
XP_002116556  299 -------------------rKNdipslEEAVLQIKSAMK--KtnlSKVFLATD------AEEs---gLNSIRDQM---Ei 345 
EDO42964      258 -------------------hPDkvpslDNVAKQLKKFLK--KeklEKVFLSTD------ADQsgKcnVDYLK-SKLPi-- 307 
XP_009015731  254 -------------------hQDklpsmKAAAQRINEILD--DlhlKKVFVATD------ASGe---eLEGLKINIKP-Sv 302 
Q5CSJ4        317 -------------------rNDdiptfDQVIDRLLQLSN--DlktKRVVISTD--------------SNEYEKNELLDIf 361  Cryptosporidi...
Q8I360        287 -------------------sRYnvppiHIALLKLLYIMF--InncRIIFIASDekveiqKVInkD--FHQYKKHFyfynn 343  Plasmodium fa...
A5K6G1        297 -------------------sTYdvspvGISLLKLLYIMF--LrksTLIFVSTDekkevkKVIdsQ--FPQFKHFFffyen 353  Plasmodium vi...
5KXH_A        304 --RVVSl----------KPEVAQIDLYILGQADHFIGNCVSSFTAFVKRE--------------RDLH 345  house mouse
XP_002289731  522 flSDFKkele----gvnTNYYGMIDQLVASRGRVFFGCYHSTFTGFIFRI--------------RGYH 571 
XP_002290318 1107 flDDFReladl--dvmdPNHMGMVETVVASRGRAFVGTFRSTFSGYINRL--------------RGYY 1158
CBN75327      476 ylDDFQdvle----gidPSYYLMIDTIVASQGRTFIGTWRSTFTGYITRL--------------RGYY 525 
XP_002116556  346 mlCYVTttpdr-iqqfgDGGIAIIDQWICAHAKYFIGSKESTFSFRIYEE--------------RELM 398 
EDO42964      308 --VKYDppqri-lekfgDGGVAIIDQWICAHARFFIGTCESTFSFRIYEE--------------RDIL 358 
XP_009015731  303 evYRYQgdknv-lrkygDGGVAIIDQWICAHARYFIGTTSSTFSFRIHEE--------------REIL 355 
Q5CSJ4        362 lkHNLDlhiinikdhldDGIISAVSQVILLNGEYFIGTKESRFSFSVIWDcilsvmndfkddisRNFN 429  Cryptosporidium parvum
Q8I360        344 ------------qnnlhEGEFSIIEQWICTRSYIFIGNIFSRFTMNINWE--------------RHLI 385  Plasmodium falciparum 3D7
A5K6G1        354 -------------eklhTGQVAIVDQWICARSGTFVGNIFSRFSMHIKWE--------------RSLI 394  Plasmodium vivax Sal-1
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