Conserved Protein Domain Family
Mlf1IP

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pfam10248: Mlf1IP (This model is not part of the current CDD release)
Myelodysplasia-myeloid leukemia factor 1-interacting protein
This entry is the conserved central region of a group of proteins that are putative transcriptional repressors. The structure contains a putative 14-3-3 binding motif involved in the subcellular localisation of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions.
Statistics
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PSSM-Id: 519269
Aligned: 24 rows
Threshold Bit Score: 129.814
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_031813434   26 MRQMM-KSLAqpf-------------------gqlLSIAgGGRAR-HDDDDDDDKvsccarnhalvpfssfgdpsslmpf 84 
XP_030842741   31 MGSMFpQQFM-------------------------PSIEaRGVRRpPQPFRPNPA------------------------- 60 
3_pfamImport    1 MDQMM-NQMMdpfgvfgma--------prhpfmasNALE-DGMQR-SRGSAVAFPr------------------------ 45 
Q566M7         28 MRHMFsGDYGvs---------------------pfLSLT-DGSVRgLPRPAPSRT------------------------- 60  tropical clawe...
2_pfamImport    1 MRSLF-GSFGfdpf------------------plsPQIQ-PSRT---PQIQA---------------------------- 29 
Q4V8X5         25 MRSMF-GSFGmdpf------------------altPQIQ-HPRTRiQPQ------------------------------- 53  zebrafish
NP_001163164   36 MNRLM-NSFMpd-------------------------------------------------------------------- 46 
10_pfamImport   1 MNNLM-SSFFrdpfsdmmfggnggrsggmlgiggpL-------------------------------------------- 35 
XP_046447762    4 MDSMM-NSMMdpf-------------------asmMSMHhQMMGIqPPPQQRHP-------------------------- 37  common water flea
XP_003966341   25 MRAMF-GPFGmdpf------------------aitPHIQ-PHRA---PRRQ----------------------------- 52  torafugu
XP_031813434   85 gsfgAMNTDVNPFQ-----AMDRM-----MSNMRQN-MQD-----LQRRFSDM-S----VDPE-GHS--YCS----SSIM 136
XP_030842741   61 ----NNPMAMAPFG-----MMGGMgs--mFANMNSM-MGN-----MQSHMERV-A----SDPN-SHC--YSS----SSVM 111
3_pfamImport   46 ----QEMMMRDPFGfggfgAFGGMpd--iFAQRRPRrVFGip--rIFREMNGM-AqaamNDPN-GTV--YSS----STMI 109
Q566M7         61 ----IQQGAVTPYG------MMGMgg--gFMDMFGM-MND-----LVGNMEQM-T----SGSN-CQT--FSS----STVI 110 tropical clawe...
2_pfamImport   30 ------AGALSPFG------MMGAgg--gFMDMFGM-MSG-----MMENMERM-S----GS----QM--YSS----STVI 74 
Q4V8X5         54 ------AGALTPFG------MMGMgg--gFMDMFSM-MSG-----MMENMERM-S----GSPN-CQT--FSS----STVI 101 zebrafish
NP_001163164   47 -----pfMQVSPFDq---gFQQNAlm--eRPQMPAMpAMGlfgmpMMPNFNRLlNa--dIGGNsGAS--FCQ----STVM 108
10_pfamImport  36 ------GGDLLPFT-------------------GGRhLQSpvammLSGGFPSI------LDPM-GSTgtGSHvsamSTVM 83 
XP_046447762   38 ------AGAMVPFGgm-pgFPMGMgmsmdPFGMPS--VGQ-----MFQSF---------GQPGfGASpmYSS----SSVM 90  common water flea
XP_003966341   53 ------AGPLAPFG------MMGMgg--gFMDMFGM-MEE-----MMGNVERM-T----SAPN-CQT--FSS----STVI 100 torafugu
XP_031813434  137 TFSKV-GNEPPKVFQASSQTRRAPGGIKETRKSLKDSDTGIEKMAVGHHIYDRAHVINRLKNSKTGDQELNQEFINMREA 215
XP_030842741  112 SYSNT-GNGAPQYYQASSSTRQAPGGIRETRKTVRDSAQGIEKMAIGHHINDRGHVIEKSKNTRTGDQEEKQDFLNIDES 190
3_pfamImport  110 SMDGS-G-RAPRIVETSTRR---SGDVKETRRRVQNGDE--EEMVIGHTIGDREHILEKKRD-KDGNVRNQQRFRNLDQA 181
Q566M7        111 SYSNMpGGNTPKVYQETTQTRMAPGGIRETRRAVRDSNSGMEQMSIGHHIRDRSHIVQRSHNRRTGDQEERQEFINMDEN 190 tropical clawe...
2_pfamImport   75 SYSSS-GSGAPKVYQQTSEMRAAPGGIRETLQTIRDSESGLERMSIGHHIRDRGHVMERSRNRKTGDREERQDFINLEES 153
Q4V8X5        102 SYSST-DPGTPKVYQQTSEYRTAPGGIRETRQTMRDSQSGLERMSIGHHIGERGHVMERSRNRLTGDREERQDFFNLEES 180 zebrafish
NP_001163164  109 TMSSG-PDGRPQIYQASTSTKTGPGGVRETRRTVQDSRTGVKKMAIGHHIGERAHIIEKEQDMRSGQLEERQEFINLEEG 187
10_pfamImport  84 TMTQG-PDGRPQVYQASQSVRQGPGGIRETKKTVADSRTGVKKMSIGRHVYDRGHIIEREQNVYSGEREENEEFINMDEE 162
XP_046447762   91 TMTTG-PDGQPQVYQASTTTRTAPGGVREVQRSVSDSRSGVRKMAVGRHLGERGHVVEKEQNCYTGDSEQREDFINIEEE 169 common water flea
XP_003966341  101 SYSSS-GPGAPKVYQQTSQTTTGPGGIRETRQSLRDSESGLERLAIGHHIGARAHIMERSQNRRTGDREERQDFINLDES 179 torafugu
XP_031813434  216 DARDFNNEWQSQ 227
XP_030842741  191 DAPTFDNEWKQK 202
3_pfamImport  182 EAEAFDREFKTR 193
Q566M7        191 DAASFDEEWSRQ 202 tropical clawed frog
2_pfamImport  154 EAAAFDEEWRRE 165
Q4V8X5        181 EAAAFDEEWRRE 192 zebrafish
NP_001163164  188 EAEQFDREFTSR 199
10_pfamImport 163 EADDFNKEWESR 174
XP_046447762  170 EAHQFDEEWQRR 181 common water flea
XP_003966341  180 DAAAFDEEWRRG 191 torafugu
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