6C14


Conserved Protein Domain Family
L_HMGIC_fpl
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pfam10242: L_HMGIC_fpl (This model is not part of the current CDD release)
Lipoma HMGIC fusion partner-like protein
This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumour cell lines.
Links
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Statistics
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PSSM-Id: 519265
Aligned: 17 rows
Threshold Bit Score: 168.664
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6C14_B        32 VGVMWGTLTICFSVLVMALFIQPYWIGds---------------vsTPQAGYFGLFSYCVgnvl----sselICKGGPLD 92  house mouse
Q568B9         9 RSMLWTLMSIVVAFAELVAFMSAEWLVgysegsel---nftvtashRSDQRTLGIYNRCLkvaq----qkvvQCGPYATD 81  zebrafish
Q4S279         9 RSMLWTLLSIVAAFGELIAFMSTDWLVgyprtpdavfgrhgataagEAYRPTLGIYGRCIklphl---qrgiLCGPYAIH 85  spotted green p...
Q178A0        25 IAVLWAIFSICYAIISVVAFVTPEWVGds----------------dSDAGGRLGLWQICQkdd------lndSCSGKLED 82  yellow fever mo...
Q2M056        25 IGVLWAIFTICYAIIGIVAFVTPEWIGdp----------------dNDGAGRLGLWQQCQrde------ifdNCRRRWEN 82  Drosophila pseu...
Q7TSY2        22 IGVLWAIFTICFAIINVVVFIQPYWVGds---------------vsTPKPGYFGLFHYCVgsgla---grelTCRGSFTD 83  Norway rat
Q5PPI7        25 VGVMWGTLTICFSVLVMALFIQPYWIGds---------------vsTPQAGYFGLFSYCVgnvl----sselICKGGPLD 85  Norway rat
Q7ZZL8        25 MGVLWALFTLCFSILMVVTFIQPYWIGds---------------idTPQAGYFGLFSYCIgnal----tgelICKGSPLD 85  chicken
Q6ZUX7         9 RSMLWTLLSIVVAFAELIAFMSADWLIgkarsrggvepagpgggspEPYHPTLGIYARCIrnpgvqhfqrdtLCGPYAES 88  human
XP_029682125  22 VGVLWTVFTITFAVITVVVFIQPYWIGds---------------vsTPQAGYFGLFHYCIgnal----tselTCKGSALD 82  torafugu

6C14_B        93 FSSIPSRAFKTAMFFVALAMFL-IiGSIICFSLFFVCN----TATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRM 167 house mouse
Q568B9        82 FMEIASGFWQATVIFLVIGIFL-L-SVVGILSVFSMCFqsilKKSIFNVCGLLQGIAGLFLILGLMLYPAGWGSKKVVDY 159 zebrafish
Q4S279        86 FGEIASGFWQATSIFLAAGILL-L-CAVAFISVFTMCFqsimKKSIFNVCGLLQGIAGLFLILGLMLYPAGWGSEKVQLY 163 spotted green p...
Q178A0        83 LLAMQSIAFQVATVFCGLAVATsV-LAICCLLLMVFMK----STTVFHICGWMQMLSALCMVIACVSFPFGWNSDEFRKV 157 yellow fever mo...
Q2M056        83 VLAVPTFSFQLATFFMMGAIGLaL-LTIFFLVCLLFMK----STRVFHICGWMQIISALCMIVACAAFPFGWNSDDFRKI 157 Drosophila pseu...
Q7TSY2        84 FSTIPSSAFKAAAFFVLLSMVLiL-GCITCFALFFFCN----TATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDM 158 Norway rat
Q5PPI7        86 FSSIPSRAFKTAMFFVALAMFLiI-GSIICFSLFFVCN----TATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRM 160 Norway rat
Q7ZZL8        86 FGTIPSSAFKTAMFFVGISTFLiI-GSILCFSLFFFCN----AATVYKVCAWMQLAAATGLMIGCLIYPDGWDSSEVKRM 160 chicken
Q6ZUX7        89 FGEIASGFWQATAIFLAVGIFI-L-CMVALVSVFTMCVqsimKKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDY 166 human
XP_029682125  83 FGSIPSGAFKTAMFFVGISMLLvV-GSIVCFSLFFFCN----AGSVYKICAWMQLASSTCMVIGCMIYPDGWDSDEVKRM 157 torafugu

6C14_B       168 CgeQTGKYTLGHCTIRWAFMLAIlsigDALILSFLAFVLGYR 209 house mouse
Q568B9       160 CgpDASAYKVGLCSLGWAFYTAI----GGTVLTFICAMFSAQ 197 zebrafish
Q4S279       164 CgqDAAPYRTGLCSMGWAFYTAM----GGTVLTFICAVFSAQ 201 spotted green pufferfish
Q178A0       158 CgpESNRFEVGLCGLRWAYPLAIiaciDGFILATLSFILATR 199 yellow fever mosquito
Q2M056       158 CgpEANRFELGLCGIRWAYPLAIigcvDGVVLATLAFILATR 199 Drosophila pseudoobscura
Q7TSY2       159 CgaKTGKYSLGDCSVRWAYILAIigilNALILSFLAFVLGNR 200 Norway rat
Q5PPI7       161 CgeQTGKYTLGHCTIRWAFMLAIlsigDALILSFLAFVLGYR 202 Norway rat
Q7ZZL8       161 CgdKTDKYTLGACTVRWAYILCIigilDALILSFLAFVLGNR 202 chicken
Q6ZUX7       167 CghYASAYKPGDCSLGWAFYTAI----GGTVLTFICAVFSAQ 204 human
XP_029682125 158 CgqRTDKYTLGNCTVRWAYILAIisimDSLVLSLVAFSLGSR 199 torafugu
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