Conserved Protein Domain Family
DUF2464

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pfam10240: DUF2464 
Multivesicular body subunit 12
MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor.
Statistics
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PSSM-Id: 402032
View PSSM: pfam10240
Aligned: 38 rows
Threshold Bit Score: 237.976
Threshold Setting Gi: 525343209
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001266326  17 PVLSLQIVETVAKCPAGYWPVSRTYDEdSDAGL----QRQNg-LFGKKSSHYICLSKs-----eGVPGYVMDGMAVIGDG 86  domestic silkworm
XP_002121685   6 PITNVCIVAERNACPPRYNILDRTIEN-EDADF----WKDG--LFKSKIRRYLCFTRepsqnqlNE---VITDMALIGVK 75  vase tunicate
7_pfamImport   2 PITNVCIVAEKNNCPPRYEILDRTIEN-EDADF----WKDG--LFKSKVRRYICFTRtipsnqlNQ---VITDMALVGAK 71 
PDM64612      18 PITAICIVADRNKAPIGFTPILKTHDEsVDADL----WRESafSIWSRPVRYIAVSReik-taiPSSRSVITDLTVTKES 92  Pristionchus pa...
5_pfamImport   1 PITAICIVGDKNKSPRGFVPVVKCHDDqSDADL----WRDGffAI-NRQVRYICTSTeip-dtiKTAVQVVTNLIIVRES 74 
Q17687        16 PITAICIVADKNKAPRGFLPIIKCQDDqTEADL----WRDGffTI-NRQVRYICTSTeipdsniKTPVQVITNLIIVRES 90  Caenorhabditis ...
XP_001943561  14 PISGLCIIEDITKCPTGYNPISKTHDQdSDADLhmqsWKESv-FIGRKITRYLCLSKt-----eGISDYIVVNINIINEK 87  pea aphid
XP_002432728  13 PITSLCIVEDPDKCPSGYTVVSRTYDQdSDADL----WKESg-FFGRKFSRYLCLSKt-----vGTQDYVIQSLCIINEK 82  human body louse
XP_001966153  60 PITSLHIVEDFERCPKNFSAINRTYDQdSDADL----WRDYs-LFGRQNTRYLCLSKs-----eGLPEYVVETLQVIAEK 129 Drosophila anan...
ESN95197       6 PITNLGIVADLSKCPPSYIVLVKSTDKrEDCDL----WKDS--VFKSKCTRYLCFTRaiekhqdHL-QDVLVNIFLINDR 78  Helobdella robusta
NP_001266326  87 ELIPAGYSVAGRAG--------------KRRLCTRVSRhTASATSLVTDVIVCSKMRTAPQGFILAGAISGKMVCYKVSG 152 domestic silkworm
XP_002121685  76 DPVPVGYTALKETAdtre------qalkKHNLCIRYIP-KTSTSSAISDILLCRDNSYKERMYTLMGELNGINVAFKLST 148 vase tunicate
7_pfamImport  72 DPIPNGYTAIKETSdtre------qalkKHTLCVRYIV-KTATSSAISDIMLCRDNYYKEKMYTLIGELNGIYVAFKLSA 144
PDM64612      93 EPVPHGYIAIDYTAdske------kalrKRFLCVKTEP-LESCVDAVTDVIVLSKTKKPPRDHSLAGEVDGILICFKTGV 165 Pristionchus pa...
5_pfamImport  75 DPIPHGYVAIDYTAdsre------kslrKKWLCIRTEP-RDRVVDAIGEIIIMGKSKKVPRDYTSAGEIDSLLVCYKVVA 147
Q17687        91 DPIPHGYVAIDYTAdsre------kslrKKYVCIRTEP-RDRVVDAIGEIIILGKTKKVPRDYTSAGDIDSLLICYKVIS 163 Caenorhabditis ...
XP_001943561  88 ECPPDGYCLIPRTIdsdq------kawrKRQLCYKLSR-KSLATYAITDIILLSRSKKAPDGFNLVGDLNGLTLCYKTS- 159 pea aphid
XP_002432728  83 DMAPQNFKMIPKTSdtkq------kawrKKQLCYKFAQ-ISTSSTAITDIIVLGKMKKAPEGFVLSGEINGMTLCIRVGN 155 human body louse
XP_001966153 130 TQPPKEFSLLSRTAdsdq------kawrKRQIAYKLSK-RGTVTQAVTDIILCSKLKVAPDGFKLAGDINGVLICYKTGA 202 Drosophila anan...
ESN95197      79 DPVPEGCRIVHKTMdtcvfiiyfkkalqKKLLCIRMLP-RNSTCEAVSDMIILSRNKKPPNNYTAIGEINGLVLCYQMCN 157 Helobdella robusta
NP_001266326 153 GSAdtSPTHahneyenvvtnltpeanrrlravpeRPPKlptlitdlnnlnitqspasypkin----------------gl 216 domestic silkworm
XP_002121685 149 IHIptn-------------------------------------------------------------------------- 154 vase tunicate
7_pfamImport 145 ISQsht-------------------------------------------------------------------------- 150
PDM64612     166 I-----------------------------------PPhygmkqshsdtnigf--------------------------- 183 Pristionchus pa...
5_pfamImport 148 I-----------------------------------PQtygiptsnsssal----------------------------- 163
Q17687       164 I-----------------------------------PQtygiqtsnstsn------------------------------ 178 Caenorhabditis ...
XP_001943561 160 ------------------------------------PQspdvplptltygltptlstekipnsngsl-----sslpsles 198 pea aphid
XP_002432728 156 IENkkTGS--------------------------FYPNlpypfmpsnpgnpslnnshhnnh-----------------nl 192 human body louse
XP_001966153 203 I-----------------------------------PVrmppplpagngagatceveqalnrlnmqgqrnsrgplpqppt 247 Drosophila anan...
ESN95197     158 LANlqQGCVg------------------------GG-------------------------------------------- 169 Helobdella robusta
NP_001266326 217 vtdhdyealnpsynikpsrpaPRPPSSKSPVPeakspqpvaRKKGPAPLP---GPRNTIyqt-------lgGYNGMEGVP 286 domestic silkworm
XP_002121685 155 ------------------rpaPPPPVQRVNT-----------TAVNTPAPmndTIQRNHtqqq-----qhnVMSGIEGVE 200 vase tunicate
7_pfamImport 151 ------------------rpaPPPPVQMTHV-----------TPGNAPSPvynNTAKLNtsq------lhnPVSGIDGIE 195
PDM64612     184 -------nlggpsrlgpssayPQLDMPHPSSHs--------TSDLNHVRNdahNAFTIKgav-------psRINPIEGVN 241 Pristionchus pa...
5_pfamImport 164 ---------etkptsgglypgLPNPNIYNSTP----------SNLNVTGGsnsSAFTLKnvg-------ipRVKAIDGID 217
Q17687       179 ---------iesqaagglypgL--PNLSNSTP----------ANLDVTGSssnSAFTMKnag-------apRVKAIDGID 230 Caenorhabditis ...
XP_001943561 199 sahvlshdydrlmslkptrpaPKLPPTYSS---------------------------SNyst-------lnSYQGLEGIP 244 pea aphid
XP_002432728 193 psngnssnpdnvgpllpfrpaPKPPTSTYAti--------------------------------------sGYN--EGVP 232 human body louse
XP_001966153 248 ehhdyeeikanyqinspqrpaPPRPATAAASA-------------SGGKGt-yGGTgt-----------lgTYTELEGVP 302 Drosophila anan...
ESN95197     170 ---------------------DDDPMLHTINN---------VDNSNNNSCsdvNNTTTSnalvyyndigslVVNAMYDIP 219 Helobdella robusta
NP_001266326 287 FVLNSK----------------LRGLPSDSl--tQFPVIKKRT-RFELDRDYSYNFAIE 326 domestic silkworm
XP_002121685 201 WKLHDR----------------FTQTKAGMns-kTALNIEIRT-RSELIDLCAYDFTKE 241 vase tunicate
7_pfamImport 196 WKLHDR----------------LLKLKTTSpkveTLENIEIRT-RSEVVELCAYDFSQE 237
PDM64612     242 FIVNPR----------------IVNTQKKSs---SLPPIPSYD--TYFQDEFNYGFQLE 279 Pristionchus pacificus
5_pfamImport 218 FKLNPS----------------FV-SNDSDrd-sQLPDLSQFAhLEMNSDRYNYNFATE 258
Q17687       231 FKVNPM----------------FVNSSGSNns-sQLPDLSQFNdLDRLDDKYNYSYATE 272 Caenorhabditis elegans
XP_001943561 245 FILNQN----------------ISVEHKSIf--kDIPEIKIKT-SEDLDLEYNYSFEQE 284 pea aphid
XP_002432728 233 FILNSK----------------YSFSKNSIkd-iPIPKLKTK---SQIDEEYFYEFRTE 271 human body louse
XP_001966153 303 FVMDVR----------------LQRNQTGT----EIPTLPEI---STILKNLDYDFQLE 338 Drosophila ananassae
ESN95197     220 FCLNASigiddltrnellhlngYKNRYDED---------------MDIETEFSYDFTVE 263 Helobdella robusta
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