Conserved Protein Domain Family
DUF2464

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pfam10240: DUF2464 
Multivesicular body subunit 12
MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor.
Statistics
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PSSM-Id: 491020
Aligned: 33 rows
Threshold Bit Score: 234.147
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001266326  16 RPVLSLQIVETVAKCPAGYWPVSRTYDEdSDAGLQRQNg-LFGKKSSHYICLSKSEGVPGYVMDGMAVIGDGELIPAGYS 94 
XP_008207118  22 RPITAINIIEDLDKCPPNFTVVSRTYDLdSDADLWRESg-LFIKKKSRYICFSKTEGLPHSVIEKILIIDEREPPPKGFS 100
XP_011135038  22 RPITAISVVEDVDKCPPNFTVVSRTYDQdTDADLWRESg-LFIKKKGRYICFSKTEGQPDCVVEDIVVINERDTPPEGYC 100
XP_011258265  21 RPITAISVVEDVDKCPPNFTVVSRTYDQdTDADLWRESg-LFIKKKGRYICFSKTEGPPGCVVEDIVVINERDTPPEGYN 99 
XP_008199111  18 KPITAIQVIENLDKCPKGFHPISRTYDQdQDADLRESS--IFKSSAARYLCVSKSEGLPNFVIQELFVLTEKFNPPRGFS 95 
Q178L3        24 RPITSLQLVEDFEKCPKNFQPINKTYDQdQDADLFRENi-LFGKRSCRYLCQSKTEGLPDYILETLKVIGEKEALPEGFS 102 yellow fever mo...
XP_023037115  65 RPITSLHIVEDSDRCPKNFSAISRTYDQdADADLWRDYniLFGRQTTRYLCLSKSEGLPEYVVETLKVIAEKVPPPKEFS 144
XP_001966153  59 RPITSLHIVEDFERCPKNFSAINRTYDQdSDADLWRDYs-LFGRQNTRYLCLSKSEGLPEYVVETLQVIAEKTQPPKEFS 137
XP_002057389  60 RPITSLHIVEDFDRCPKNFNAIHRTYDQdADADLWRENniLFGRQTTRYLCLSKSEGLPEYVVETLKVIAEKVPPPKEFS 139
XP_001995775  68 RPITSLHIVEDFERCPKNFSAIHRTYDQdADADLWRENnlLFGRQTTRYLCLSKSEGLPEYVVETLKVIAEKVPPPKEFS 147
NP_001266326  95 VAGRAG--------KRRLCTRVSRhTASATSLVTDVIVCSKM-----RTAPQGFILAGAISGKMVCYKVSGGSAdtSPTH 161
XP_008207118 101 MISHTVdsmqkawrKRQLCYKIRN-KDLCSCAVSDIILCSRVgk-gsKLAPDEFTYAGVINGVYVCYKTVPLQTgsLTAQ 178
XP_011135038 101 MISYTVdsrqrawrKKQVCYKLRN-KDLCEKAVTDIIICSRIihkdyKLAPIGFSAAGIINGVRVCYKTVDITNanSNSQ 179
XP_011258265 100 MISYTVdsrqkawrKKQVCYKIRN-KNLCAKAVTDIIICSRIihkdsKLAPIGFSAAGVINGVRVCYKTVDIINanSDSQ 178
XP_008199111  96 LLNRTAdseqkawkKKQLCYKLVN-LRDTKVAVTDIIVCSRL-----KKAPEGFKLAGELNGVTVCFKMGNVQD--TQNS 167
Q178L3       103 QLTRTAdseqkawrKKQLVYRLAK-KGVAKQAITDIILCSRL-----RQAPEGFTLAGEINGILICYKTTLV-------- 168 yellow fever mo...
XP_023037115 145 LLSRTAdsdqkawrKRQIAYKLSK-RGSVTQAVTDIILCSKL-----KIAPDGFKLAGDINGILICYKTGAI-------- 210
XP_001966153 138 LLSRTAdsdqkawrKRQIAYKLSK-RGTVTQAVTDIILCSKL-----KVAPDGFKLAGDINGVLICYKTGAI-------- 203
XP_002057389 140 LLSRTAdtdqkawrKRQIAYKLSK-RGTVVQAVTDIILCSKL-----KIAPDGFKLAGDINGVLICYKTGAI-------- 205
XP_001995775 148 LLSRTAdsdqkawrKRQIAYKLSK-RGTVTQAVTDVILCSKL-----KIAPDGFKLAGDINGVLICYKTSAI-------- 213
NP_001266326 162 ahneyenvvtnlt-peanrrlravpeRPPK-----LPtLITdlnnlnitqspasypki---------------------- 213
XP_008207118 179 pyanielfqtssptlsngtphrvapeRPPKpkfvaKP-TNGlypqispvsagktt------------------------- 232
XP_011135038 180 syvnidllqsaspnpsngtphraapeRPPKpkfspKP-ANGiypligaakdgde-------------------------- 232
XP_011258265 179 syvnidllqspspnpsngsphrpapeRPPKpkfspKPpVNGiypqiggatnkdnd------------------------- 233
XP_008199111 168 p------------------------dSNGRnitppVRpAPPypgngpiypsigad------------------------- 198
Q178L3       169 ----------------------------AHrappsVPsRQSitdlertiedlkiqaahdk-------------------- 200 yellow fever mo...
XP_023037115 211 ----------------------------PMrlpppVPaSAAlasgticeaeqalnrlnlqgqrns-------------rg 249
XP_001966153 204 ----------------------------PVrmpppLPaGNGagatceveqalnrlnmqgqrns----------------- 238
XP_002057389 206 ----------------------------PVrlpppVPgNGCevelalnrlnlhgqrnsrgpl------------------ 239
XP_001995775 214 ----------------------------ATrlpppIPgIPSsnsnananansnssceveqalnrlnlhgqqqqraggarg 265
NP_001266326 214 ------nglvtdhdyealnpsyNIKPSRPAPRPPSSKSPvpeakspqpvarKKGPAPlpg---prnTIYQTLGGYNGMEG 284
XP_008207118 233 --------enndqdyevlspsaRIRPTRPAPRPPPNKSP------------LVNSVP---------ATYGTLPGSSDLDG 283
XP_011135038 233 ---------sgdrdyeiltpsaRIRPTRPAPQPPTSS--------------AIGSTP----------IYGTLPGSSDLDG 279
XP_011258265 234 --------esgdrdyevlslnaRIRPTRPAPQPPTSALP------------VVGSTP----------VYGTLPGSSDLDG 283
XP_008199111 199 --------ggdhdyeilkppgyPSGPSRPAPRPPAPNPRqn-----------------------stTGTLGASGGNNLDG 247
Q178L3       201 ----plpaepvdhdyeqllptyQLSPNRPAPRPPAYST-------------------------------GTMNVHTEMEG 245 yellow fever mo...
XP_023037115 250 plpqlptenqdhdyeeiqahyqINSPQRPAPPRPATSVG---------------AAGravgngsivIYSGTLGTYTELEG 314
XP_001966153 239 rgplpqpptehhdyeeikanyqINSPQRPAPPRPATAAAs-------------aSGGkgty-----ggtGTLGTYTELEG 300
XP_002057389 240 --pqvpattehhdyeeiqahyqINSPQRPAPPRPASTTGaa---------tGTETAGragh-----fgiGTLGTYTELEG 303
XP_001995775 266 plpqlpaggehhdyeeiqahyqINSPQRPAPPRPA-------------------TSGrsgy-----ggtGTLGTYTELEG 321
NP_001266326 285 VPFVLNSKLRGLPSDSlT--QFPVIKKRTRFELDRDYSYNFAIE 326
XP_008207118 284 VPFVLNPLLSTSATNS-FskQFPVIKIRTQKELDKEYFYDFRTE 326
XP_011135038 280 VPFVLNPRLTA-HLDS-AsnKLPVIKVWTQKDLDREFFYDFRAE 321
XP_011258265 284 VPFALNPRLIVNQSDS-AnnKLPVIKVWTQRDLDREFFYDFRAE 326
XP_008199111 248 VPFIVNPKFLNASTADr--fQFPTIRAKTMQQILKEYDYAFTVE 289
Q178L3       246 VPFILNPSLCKYt------fEIPPLYTVD-SAAVKEYDFHLERQ 282 yellow fever mosquito
XP_023037115 315 VPFVVDVRLQSSNQWTa--dDLPSFPDT--SKLLKSLDYDFQLE 354
XP_001966153 301 VPFVMDVRLQRNQTGT----EIPTLPEI--STILKNLDYDFQLE 338
XP_002057389 304 VPFAMHAMLQRSQLMT----ELPTLPEI--SSLLKTLDYDFQLE 341
XP_001995775 322 VPFILNPLLQRSQPIT----ELPTLPDI--STLLKTLDYDFQLE 359
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