Conserved Protein Domain Family
Eapp_C

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pfam10238: Eapp_C (This model is not part of the current CDD release)
E2F-associated phosphoprotein
This entry represents the conserved C-terminal portion of an E2F binding protein. E2F transcription factors play an essential role in cell proliferation and apoptosis and their activity is frequently deregulated in human cancers. E2F activity is regulated by a variety of mechanisms, frequently mediated by proteins binding to individual members or a subgroup of the family. EAPP interacts with a subset of E2F factors and influences E2F-dependent promoter activity. EAPP is present throughout the cell cycle but disappears during mitosis.
Statistics
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PSSM-Id: 519263
Aligned: 45 rows
Threshold Bit Score: 125.848
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002291237 102 YCSNMDDEDEAWVYKHMRSgqeelvyvrqrqqqkevaegktgqpnvkgesgsgqqdgktgndgqsntkqetpvsqnqqiq 181
XP_001024504 159 FNPIQDEEDDVWVKQNLKSd------------------------------------------------------------ 178
XP_020430513  57 YNEDEDDENEAWVEKNLKK------------------------------------------------------------- 75 
XP_004366975  70 YDDKEDDLNQQWVDKNLKS------------------------------------------------------------- 88 
XP_067742421 209 YDEQLDNADEQWVETNLRG------------------------------------------------------------- 227
XP_002998034 219 YDEQLDDADEQWVQTNLCGtr----------------------------------------------------------- 239
ESS32388     280 YDSSADEEDEKWVAKHLRV------------------------------------------------------------- 298
Q4N739        36 YGSDLDDLDDDFVNDNYRQ------------------------------------------------------------- 54  Theileria parva
Q8I657       104 YDEKIDNYDEEYVNKKYRF------------------------------------------------------------- 122 Plasmodium falc...
XP_001612870 110 YDERIDIFEEEYVNKKYRF------------------------------------------------------------- 128 malaria parasit...
XP_002291237 182 qalllKPRSSDAILSCPRCFTTVCMDCQEHERYAGQYRAMFVMNIGVDWNKRMVYDeamgGLKLASAGAGGRITAASGSA 261
XP_001024504 179 -----LSEKTGIILSCPCCFVQLSYDSQRHEFYDNQYRSICVKNVKINTSKIIQPTeednEATTRSQMKSKFRKNKRKQQ 253
XP_020430513  76 -----SGSKSDAYLSCPCCFTLVCVDCQRHDTFKNQYRAMFVKNCKIDFSNRLLYQnddgDDTLDEKQQEDDEEEVDDEQ 150
XP_004366975  89 ------TNKTDAYLSCPACFTLLCVDCQRHDLYKNQYRAMFVKNCTIDYQSKLVYK----EEKKKHPKKSKGKGNGNGKE 158
XP_067742421 228 -----AKPETDATLCCPCCFVTVCMVCERHATYTNQYRATAAINCRVKKDEILTYTse-gSHVPASLPFHKRQNLAACGN 301
XP_002998034 240 ----aTKPETDATLCCPCCFVTVCMVCERHATYTNQYRATAAINCRVKRDEILAYTsgegSQVPASLPFHKRQTLVAS-- 313
ESS32388     299 -----GDRTTDAILCCPGCFTPVCYQCQRHEKFLFQYRAVSACNVVVDSAFVSPSNrvpaERPDARASSSPRPASRDGAC 373
Q4N739        55 -----GDKSTDAVLCCAMCFTPVCYQCKT---VGNTFSSKLALNAYVEDNYSDSANrsdsRDVLGKGDSTKRKLRGST-- 124 Theileria parva
Q8I657       123 -----GTKSCDSSLCCCGCFIPVCYQSQRHEYYVNQYRALYAINIRIDEDTIIDEHeinsKRYEENDKDHGNNENKQNNE 197 Plasmodium falc...
XP_001612870 129 -----CTKNCDSSLCCCGCFIPVCYQSQRHEIYVNQYRSFYAVNVRIDDKRVIHEHeinaAENGGNHKEGDPKGGNSKRG 203 malaria parasit...
XP_002291237 262 MQADGedgamdedda---------------------------------------------------------pdtiphdh 284
XP_001024504 254 KNKKEqaqntlvihedddlan---------------------------------------------qnleeleqqinkqk 288
XP_020430513 151 EEDDDnynedvntpkednt-------------------------------------------------ankkqvdtgttk 181
XP_004366975 159 PTSIAttddhd-----------------------------------------------------------------nddq 173
XP_067742421 302 RASITtgqqi-------------------------------------------------------------------arl 314
XP_002998034 314 NKATSsgqql-------------------------------------------------------------------arl 326
ESS32388     374 EAGGDggetaeegkgdkadkadrerreiegerekgqelsfvnhlremvqdrswerggnkrgstqktdrkrgeeeeifceg 453
Q4N739           --------------------------------------------------------------------------------     Theileria parva
Q8I657       198 SDK----------------------------------------------------------------------------- 200 Plasmodium falc...
XP_001612870 204 SGKRNhqhgdpkspppvdkaenqte-------------------------------------lphpecvetpegkknged 246 malaria parasit...
XP_002291237 285 ekDELYYSVHCGYCQHELAVLDMGdEIYYFFGCIA 319
XP_001024504 289 dlFLIYFSAECLNCSTEVAAYELNeKVYHFFNVIP 323
XP_020430513 182 rnKEYYHAVHCQICSTQLAVYDQD-EIYHFFNVFP 215
XP_004366975 174 qiEEDYYSVECSNCTTKVAVYDKD-EIYHFFNVFP 207
XP_067742421 315 lqEDEFYPVACSDCGTMVGVYDQN-QQYHFFNALP 348
XP_002998034 327 lqEDEFYPVACSDCGTMVGVFDRD-QHYHFFNALP 360
ESS32388     454 leGQSAHAVKCATCSATVALLDEA-ETFHFFHVLP 487
Q4N739       125 --SDSERIVKCIECNNVIAVLDFS-NNYNFKNVIA 156 Theileria parva
Q8I657       201 --SLKYHAVFCINCNNHIAYFEIQeRIFHFFDVLP 233 Plasmodium falciparum 3D7
XP_001612870 247 ekSQIYHAVFCENCNNHIAYLEIKkNIFHFFDVLP 281 malaria parasite P. vivax
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