3JD5


Conserved Protein Domain Family
DAP3
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pfam10236: DAP3 
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Mitochondrial ribosomal death-associated protein 3
This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).
Links
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Statistics
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PSSM-Id: 370907
View PSSM: pfam10236
Aligned: 26 rows
Threshold Bit Score: 279.561
Threshold Setting Gi: 757943685
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3JD5_GG       98 LMVRKPALELLHYLKNT-NFAHPAVRYVLYGEKGTGKTLSLCHIIHFCAKQ-DWLILHIPDAHLWVKNCRDLLQSTy-NK 174
O59677       170 LLHRKITTELVNVLQRSkDQGTKDGRFLLDGAPGSGRSIALIQAELFALSQpNFIVLPVHNCEGWVNSTSSYGYDE--QL 247 Schizosaccharom...
P82922        98 LMVRKPALELLHYLKNT-NFAHPAVRYVLYGEKGTGKTLSLCHIIHFCAKQ-DWLILHIPDAHLWVKNCRDLLQSTy-NK 174 cattle
NP_001092207  98 VMVRPAALELISYLKKA-DYNKPPLRYVLYGQTGSGKSISLCHTLHYCYTQ-GWLILHVPDAHLWVKNCKEMLPSTy-NP 174 zebrafish
CAG11844      37 iMVRSPALEVISYLKKT-DNTRPAVRYLFYGLKGSGKTMSLCHVVHFCYTQ-GWLVLHIPDAHIWVKNCKELLPSSy-NR 113 spotted green p...
Q9W253        93 LMVRNPALELLQYIKDG-DLTKPVVRYVLYGENGTGKTLTMAHVLHYGALN-DFLLVHVPWAPNWMKRPKEASNAAg-QE 169 fruit fly
Q171E7        86 LMVREPAVELINYMNAA-DYSKPANRFVLYGKDGVGKSIVLAHLLHYGYNQ-EFVLVHVPWVPNWMKRAKETANSIt-HE 162 yellow fever mo...
EDO14441     116 SLVREGT---TKKFLDL-LKKSANKKFIVTGEPGVGKTVLLSQVHAFATEA-KSITVNISYPELFLNGRNDFFYDE--NS 188 Vanderwaltozyma...
Q755C9       113 CYTREATGQLLERLSGT-----EHQRVILTGQPGVGKSTLLAQAQVAAFEK-GSVIINISHPELFLNGRNDFRHDTtgEQ 186 Eremothecium go...
Q6CWQ9       111 SLVRDST---TRKLYEA-LRKSENKKLVLTGEPGVGKSTLLAQLHAHALEN-KGLVLTVSNSELLTNGRNDFFLDE---- 181 Kluyveromyces l...

3JD5_GG      175 QRFDQPLEASIWLKNFKTANE-RFLSQIK--VQDKYVWNk-----------RESTEKGsPLAEVVEQGIMRVRNATDAVG 240
O59677       248 KLWVQPDLIKGFLTSVMKTNS-DKLKKLK--TFESHELLq-----------NECIPAGtDLLSFLHKLIASSNAPK-SLE 312 Schizosaccharom...
P82922       175 QRFDQPLEASIWLKNFKTANE-RFLSQIK--VQDKYVWNk-----------RESTEKGsPLAEVVEQGIMRVRNATDAVG 240 cattle
NP_001092207 175 LRFDQPVQATQWLKDFKITNE-HFLSKIK--TTRRYVWTk-----------RESTEEGrTLGELIDQGVNRMKSSSDVVG 240 zebrafish
CAG11844     114 ARFDQPLQANEWLRNFKTTNE-KFLSTIK--TKHRYVWTk-----------RESTNEGsTLGELVDQGINRMKSSSDVVA 179 spotted green p...
Q9W253       170 GMIDLPFDAAAWLVHFKTQNG-PLLQRLQlkTSKEYVWSk-----------RESTPAGsSLIELVEHGIARIKYASETTA 237 fruit fly
Q171E7       163 GCLDLPLDGAAWLIHFKNQNS-KLLAKLDlkVSRDYVWTk-----------RETTPAGaPMLELIDHGINRAKFSCDAIA 230 yellow fever mo...
EDO14441     189 KLYVQPMYLKSFIRKILKGNDkSVLKSIT--LANDYKFPnndskd-vnrkhLTLFGGKnTLYDLLSVKTVSRSRGE-LFQ 264 Vanderwaltozyma...
Q755C9       187 EQYTQPMYLKKLLTKILKSNKkSVLSSVA--LTQEYKFPvadtresaskrvTRLVPGKtPLYGLLSMKTTPAARGM-LFQ 263 Eremothecium go...
Q6CWQ9       182 DRYIQPMYIKNLLTKFVKSNKkELLQSIK--LSKDYKLVhsggkdlsvkrnVNLSAGKsTLYDLLSVKAPSRHRGA-VFD 258 Kluyveromyces l...

3JD5_GG      241 IVLKELKRQSSl-----gVFRLLVAVDGVNALWGR--TTLKREDKSPITPEELALIYNLRKMV--KNDWQGGAIvltVSQ 311
O59677       313 IFLQELNNNTKsn----sNMKVLLVIDNISILSVV--TKYKDKKNNFLPPKDFYFINLLFKYIsgSLTFNRGTV---LAA 383 Schizosaccharom...
P82922       241 IVLKELKRQSSl-----gVFRLLVAVDGVNALWGR--TTLKREDKSPITPEELALIYNLRKMv--KNDWQGGAIvltVSQ 311 cattle
NP_001092207 241 AVLRELRLQAGattegeeVFKLAVAVDGVNALWGN--TTLKKEDRTMCEPEELTLIHNLRKMm--KTDWRGGAIltaLSQ 316 zebrafish
CAG11844     180 AVMKELRLQSGqp---esNFRLAVAVDGVNALWGR--STIKKEDKSFVDPEELTLVYNLRKLm--RNDWAGGAIittLSQ 252 spotted green p...
Q9W253       238 ALIAELKQLSTa-----gQCKVMVAIDGFNAFFHPv-TRIFSDNKQLVTPDRVTLTQPFLDIt--NYDWTNGVCilsVDK 309 fruit fly
Q171E7       231 ALLGELKQQSTq-----gKLKTMVIIDGFNAFFHPq-TRITTENKVRVTPDKVTLTKPFLDIt--RPDWCNGVCilaVDR 302 yellow fever mo...
EDO14441     265 SIMQELKSQSK--------VPVYFTIDNFSRILVTsdCAYKNVNNKNIRSLDLQIVKTIMDFVsgDSKFKNKNSaivMAT 336 Vanderwaltozyma...
Q755C9       264 AVIDELVAQSA--------VPVYLTVDNFSRILSEplSAYKDTSCRSIHVLKLQLGRIIMNFVsgATKLNHKDSrvvLAT 335 Eremothecium go...
Q6CWQ9       259 AFIKELTNQTD--------HPVYFTVDNFSHLLTTpfTAYKDTSNKNIHILKFQVGQSIFDLVsgDLQFAAKDScvvLAT 330 Kluyveromyces l...

3JD5_GG      312 TGSLFKPRKAYLPQELLGKEGFdtlDPFI-------------------PILVSNYNPKEFEGCIQYYLENNWLQHeK--- 369
O59677       384 TSSQPRVSTPSLDIALGVAHR----NPYKssdetil-----dslqsvhILNMEPYTLDESRRMMEYLVSSNVCLE-K--- 450 Schizosaccharom...
P82922       312 TGSLFKPRKAYLPQELLGKEGFdtlDPFI-------------------PILVSNYNPKEFEGCIQYYLENNWLQH-Ek-- 369 cattle
NP_001092207 317 TGSLFKPRSAYLPSELLGEEGFdemEPFV-------------------PVCVSGYNEKEFGSCYLYYLDRNWLQH-Pr-- 374 zebrafish
CAG11844     253 TGSLYTSRAEYLPQELLGEMGFdnmDPFV-------------------PVSVPNYSEKEFESCYLYYTDRHWLQH-Pq-- 310 spotted green p...
Q9W253       310 IAMTEGHMDSYMPRYLLGKEGFehlDPFV-------------------PIHVENYTDKEFHSYISYYLDRHWIN------ 364 fruit fly
Q171E7       303 MALTEDRMESELPMYQLRREGFehlDPFV-------------------PIRVDNYSEEEYYSCVQYYLNRKWIQ------ 357 yellow fever mo...
EDO14441     337 SGDDRTNR--TLPIALGKAQH----DEYIprkqydpefaeilkkgkveEFQVPKLTKEEVKELMSFYLESDIVLK-Kdkd 409 Vanderwaltozyma...
Q755C9       336 SGVDRETK--TLPTGLGQTPH----DPYAakynydavlaemmlkggvkEFRVEPLSKPEVAELVDFYAKAGILSE-Kdqe 408 Eremothecium go...
Q6CWQ9       331 SGLDRTNR--TLSIGLQKLPH----DPYLtryhyeqilaekllkgkvqEFEVTKLNKDEVAKLMEFYQKAGIVLD-Kdlq 403 Kluyveromyces l...

3JD5_GG      370 --AHTEEGKKELLFLsNrnpglleRL 393
O59677       451 --VDNYLQNHVLS---GgnprkffDA 471 Schizosaccharomyces pombe 972h-
P82922       370 --AHTEEGKKELLFLsNrnpglleRL 393 cattle
NP_001092207 375 --SRSEEGKKELIFLsNrnpsileRL 398 zebrafish
CAG11844     311 --SLTEDGKKELIFLsNrnpsvfeRL 334 spotted green pufferfish
Q9W253       365 --KTPQGFEEQLKFMsNknpyslmQL 388 fruit fly
Q171E7       358 --TTEQGFDKELEFLsGrnpfelmEL 381 yellow fever mosquito
EDO14441     410 skSLDQLVDEKYFLSgNgnpreliKS 435 Vanderwaltozyma polyspora DSM 70294
Q755C9       409 nrREGRLVDEKYLLSgNgnlrellKS 434 Eremothecium gossypii
Q6CWQ9       404 nkTFEQLTEEKYFLSgNgnprellKS 429 Kluyveromyces lactis
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