Conserved Protein Domain Family
Cluap1

?
pfam10234: Cluap1 (This model is not part of the current CDD release)
Clusterin-associated protein-1
This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell.
Statistics
?
PSSM-Id: 519259
Aligned: 37 rows
Threshold Bit Score: 223.615
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002904769  15 SLGYP-RPISMENFRTP-----NFELVSDLLYWMVKKYDPSSSIT-EEIDTEDDRVEFLTQVATEVLAKARIRLNPKKLY 87 
A8BGV3        15 qIGFP-RPISIDTFRKP-----DFFLVAEILHYITTVVAPSNAIA-MDIATQEDRVYFITTVVNVLQTTLHLKLDSKKIY 87  Giardia lamblia...
XP_049545805  15 LLGYP-NHIPLSVLTTPyggpeSFKAYSDILQWLINRLEPNLVLA-GGTRSEQERVLFVRSATEFLVTKSSIKMNPRRLY 92 
XP_002025318  15 LLGFP-RVFPLQSLANQhgslaSFHIVSELIQWLAGLMEPGTVLS-GGVETEEQRVLLVRSATEFFVTKSAIRLNPRKLY 92 
XP_001963907  15 LLGFP-RVFPLQALASPhgslaSFHIVAELLQWLAGLMEPGASLP-GGVESEEHRVLLVRSATEFFVTKAAIRLNPRKLY 92 
EFX89949       3 LLGYP-RLISRENFRST-----NFGLVAEILNWFCQQLDVNSGIN-FLIKTEQERVVFVTSVVKFLNTKLQIKLNPKRLY 75 
XP_003055032  15 SLGYP-RIVSVENFRTP-----NFELVADCLEWLAQRYDGGAVVE-DDISTETDRVRFLKSVAAVFLSKARIKLNLKRLY 87 
EFJ27015       7 SLGYPgDGLSMESFRTP-----HFDTVASCMRWLLPRYDPEVQLH-GDVSTEEGRIAFLKSAGRFMFLKTRMKLNLRSLY 80 
Q6I6D4        15 SLRYP-RLMSIENFRTP-----NFQLVAELLEWIVKKFEPESNLDaHEVQTEADRVAFIKNAVLLMLQNSRIKMNPKKLY 88  Caenorhabditis ...
XP_001579632  15 ILGYP-HPVGIDSFDTP-----NFGLMANLLHWLATLYDPEIVIL-AELSNEHGRVEFVRGIVQQMAIKSGIRLNPRKLY 87 
XP_002904769  88 AADGFAVKELIKLARVLYEASRIDlaaQQEPDDDDDEVSV-----KSMLGSRVKDPKAT-----------RQLASDITQS 151
A8BGV3        88 AAGPEAVRELRKIVQEVATYIGAA------ATSTDKGTSSa---aSVDLTLHSNALCVA--------------SSKIVEA 144 Giardia lamblia...
XP_049545805  93 ASSMAAAQELLKVTSLLIASPKIT-----RHEEESIKSHL-----EIDFSDKMNDLKMV-----------RGLSSELTNK 151
XP_002025318  93 AAAAVTASELQKITRLLIAPSQTE---AEREEEERDQYRSl---nQVDIGDKMEELRRA-----------RELSSDLTQR 155
XP_001963907  93 AAASVTAAELQKITRLLTAPGGQTe-tDHEDEEQRDQYRSl---nPVDIGDKMEDLRKA-----------RELATDLTQR 157
EFX89949      76 QADNIAVRELLNVANFFYEALQLA---RKGGENNEPS--------LYGFGGQAEDVREM-----------RQLASEITTK 133
XP_003055032  88 AADGLAVKELLKIANLLYQATAKA---DEDDADEEASGGT-----AFALDASAFDVKTT-----------RALASEITRL 148
EFJ27015      81 MADSNATAELLQVSTLLEQAIASA--------SSEKVCENfvflfLTTLFKRAFDVKAA-----------RSLVLEIIKA 141
Q6I6D4        89 QADGHAVQELLPAMKILYQAKAED----PNTDNSPKWTQV-----KNKLSSKMQEVRIT-----------RQLSSQLPET 148 Caenorhabditis ...
XP_001579632  88 ASDRFAVRELLKIAVPIYRGISSS--------------------------GRLADTKTTsfpknqntqkiSQLSATVPRH 141
XP_002904769 152 GAKLYDLLDTELD-VRDARQQAIRfldalstnheNSSEQKFLERSIQDILVNLQENVELTERQVVELDAEEKALAAKIKK 230
A8BGV3       145 STKLLTQLRLHVDdLYQRMQQAMS----------SQPDAASLSAAVQQRIKNLAAECNTLQEEVTTNKREKAKLEEQITQ 214 Giardia lamblia...
XP_049545805 152 GAVLYDLLKKELV-NREIRNAQST----------RPIELATAEKVIKGAISTVQSKLSGSTTALESLRNENTNLESKMRR 220
XP_002025318 156 GAALYDLLSKELQ-HKESRQTQAQ----------RPMELLSVERTLKNATQASQLKLQSSRAQLEAARVELNALNSKLQR 224
XP_001963907 158 GATLYDLLSKELL-NKEARTAQAQ----------RPLELLSVERTLKNAIQSNQLRLQSSKAQLEATRVELNALGSKLQR 226
EFX89949     134 GASIHDFLGQEMR-MKNQRDQVLQ----------RTYELGQIETALQSKMKKMEVEISQKQEAIDSISNNEASLDQKIDK 202
XP_003055032 149 GATLHDALGEEER-LRDARLSATR----------KNMDIEEIESQISEQIATVRENAANVERAMAELTEDESSLARQIER 217
EFJ27015     142 GATLYDDLATEMQ-LQGERNMAAS----------TNTDIEQIENLVREGTDSLLQTVSSVEQQQHSCEKDEKSLSITHEK 210
Q6I6D4       149 GALLSELLSRQEF-ISQQHERAAS----------RAVPLAEAEKVLQATVQNIAQETEQLSNKLNNVASDEAELDEKIER 217 Caenorhabditis ...
XP_001579632 142 SVELYDQLDKEVQ-IRETRTKILS----------TVPSLDEVEKSVLESVDGAAARLEQLTKELDRLNSDEDALNTKIKQ 210
XP_002904769 231 AQTDLERSEKRLKSLQ------------HVRPAFMDEYEKLEKELERQYAIYCERFRNLDYLQRELDLHN-SREMKK 294
A8BGV3       215 KKQSITHTMDRLDAIR------------STKPPFLAELEALEADLSKLHLEYARKFRSLLFLEGQLRAND-VREQQR 278 Giardia lamblia AT...
XP_049545805 221 KASELERSRQRLQALQ------------KVRPAYLEEFEKLEQELKGLYEQYIVRIKCVDTLRAQIISKN-RTPTPT 284
XP_002025318 225 KRAELERTKQRLEALQ------------KIRPAHMAEFEECEKELQMLFQRYFLRLHVRDALRSQLEART-KRTTPi 288
XP_001963907 227 RKAELERTRQRLEALH------------RIRPAHMAEFEDCEKELQQLFQRYFLRLHVRDALRFQLESRT-KRATPI 290
EFX89949     203 KSLELQRLRKRLETMK------------NIRPPFMDEFEKLEAELRQCYEDYVSKFRCLSYLDSQWQELE-KNEQQE 266
XP_003055032 218 KRAELERSEKRLATLEsgafytkvfhppSVRPAYMDEYERLEPEMDELHAAYIERHRNLTYLESELEKIE-RDEEd- 292
EFJ27015     211 RKVELERCKKRLSVLE------------NVRPAYLDEYEVLQSELQRLFGVYLEKFHNLRWLESQLETHN-QEEQEK 274
Q6I6D4       218 KKREYEQLQKRFAKLQ------------SFRPQYMDEYERFEERLKKLYEVYVLNFRNLSYLRKVHDDLA-RSERQR 281 Caenorhabditis ele...
XP_001579632 211 RKHEYERQSKRLMSVQ------------TIRPAYMEEYEMLEQELGELFKTYFQHYRNVDYFEKEISKQAeKVKKNN 275
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap