8T1L


Conserved Protein Domain Family
Med8

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pfam10232: Med8 (This model is not part of the current CDD release)
Mediator of RNA polymerase II transcription complex subunit 8
Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.
Statistics
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PSSM-Id: 519257
Aligned: 35 rows
Threshold Bit Score: 132.479
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8T1L_E         1 MQ-REEKQLEAsLDALLNQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLkHEKTPLFRNQVIIPL 79  house mouse
XP_001821236   1 MAtPTQEQLKT-LEQSRQRLVQLTRSLASLITSLNQSDPLPSWSSLQSQASIISNNLLSVSDHL-SDNRDLLTSLVAYPG 78 
A1CHE9         1 MAsPSQDQIKV-LEQSRQRLVQLTRSLGSLIGSLNQSDPLPSWSSLQSQASIISNNLLSVSEHL-SDNCDLLSALVAYPG 78  Aspergillus cla...
Q4WP83         1 MAsLNQDQIKI-LEQSRQRLVQLTRSLASLIGSLNQSDPLPSWSSLQSQAGIISNNLVSISEHL-ADNKDLLSALVAYPG 78  Aspergillus fum...
A2QID5         1 MSsLNQDQIKT-LEQSRQRLIQLTHSLASLITSLNQSDPLPSWTSLQSQATIISNNLLTISDHL-SDNRDLLSNIVAYPD 78  Aspergillus nig...
XP_002559238   1 MSnLTQEQIKV-LEQSRQRLVQLTRSLGSLIASLNQSDPLPPWTSLQSQASIISNNLISVSDQL-SDQRDLLSNLVAYPG 78 
Q1DLG1         1 MAsLNQEQLKI-LEQTRQRLLHLTQSLGSLSNSINQSDPLPPWSSLQSQATIISNNLLSISHLL-TEHQELLSSIVAYPT 78  Coccidioides im...
XP_045287573   1 MAsISPEQLKV-LEQTRQRLVQLTQSLASLINNINQSDPLPSWSSLQSQATIISNNLVNVSQQL-TDHHDLLSSLVAYPT 78 
XP_002794656   1 MAsISPDQLKV-LEQTRQRLVQLTQSLASFINNINQSDPLPSWSSLQSQATIISNNLLNVSQQL-TDHHDLFASLVAYPT 78 
6_pfamImport   1 ------EELKA-LDATRQKFFQLTSSIQSLKNDLARTHPLPQWSSLQVTTAMLSNYMDSITRHL-AEHSELMNKVVVYPS 72 
8T1L_E        80 VLSPDRDEDlmrqtegrvpvfshE--VVPDHLRTKPDPEVE--------------------------------------- 118 house mouse
XP_001821236  79 PDYPGRTQA--------------N--TLEQLLRTKLDPRVEdwvargrkagasaled---------------ksglaeae 127
A1CHE9        79 PEYPGRTQA--------------S--TLEQLLRTKLDPRIEdwvargrragasaled---------------kdalsete 127 Aspergillus cla...
Q4WP83        79 PSYPGRTQA--------------P--TLEQLLRTKLDPRVEdwvsrgrragasaled---------------rgalsesa 127 Aspergillus fum...
A2QID5        79 ASYPSRVPA--------------NnvALEQVLRTKLDPRVEdwvargrragapttssdagagalgqyqtssgqrllsdda 144 Aspergillus nig...
XP_002559238  79 PEYPGRTQA--------------N--TLEQLLRTKLDPRVEdwvargraagtestgpsnfsd------pdaaykplsdaq 136
Q1DLG1        79 PNFPGRTES--------------T--ILHQLMRTKLEPRVEewvargrnvarhntassqiraqq-gaaaegetvrlsvde 141 Coccidioides im...
XP_045287573  79 PQFPGRTEA--------------A--MLSQLLRTKLEPRVEdwvsqglsmgnpdatrl--------------rtglteqq 128
XP_002794656  79 PQFPGRTEA--------------S--MLSQLLRTKLEPRVEdwvfqglsmgnadatrl--------------rtgltehq 128
6_pfamImport  73 TNYPGREQE--------------G--LLGMLLRKKLEPPVEalveeareieiknpka---------------vsqeneef 121
8T1L_E       119 --------EQEKQLTTDAARIGADAA-QKQIQSLNKMCSNLLEKI------------SK--EERESESGGLRPNKQTFNP 175 house mouse
XP_001821236 128 laelwdwaPVEANQEARRRNWGGNFTlEEREMGVQNVVTGLARVLede-------gsESe----DEEEGEE--------- 187
A1CHE9       128 laelwdwaPVEANQEARRRNWGGDYTlEEREMGIQNVVTGLRRQLedde-----rdeDEdeDDEEEEEGEG-------ED 195 Aspergillus cla...
Q4WP83       128 laelwdwaPVEANQEARRRNWGGNFTlEEREMGIQNVVTGLRRQLede-------deEAs---eSEEEVEE--------- 188 Aspergillus fum...
A2QID5       145 iaelwdwaPVAANEEARKRNWGGNYTlEEREMGIENVVTGLSRVLedd-------deEDesDS-EEGEGEA--------- 207 Aspergillus nig...
XP_002559238 137 laelwewaPLEANQEARRRNWGGNFTlEEREAGIENVVTGLRRQLedd-------dgEEesEG-EEEDGE---------- 198
Q1DLG1       142 lldlwhwaPIAANMEARRRDWGGDYTlEEKEMGVKNVITGLKRQLd----------eGDeeDEEEEEEEED------MQG 205 Coccidioides im...
XP_045287573 129 llelwrwgPIEANMEARGRNWGGDYTlEEKEMGVKNVVTGLKRKLnee-------dsGSesGSGDEEEGSEGEEGGDGGG 201
XP_002794656 129 laelwqwaPIEANMEARRRNWGGNYTlEEKEMGVKNVVTGLRRNLsee-------esGSesGS-EEGEGLE--------G 192
6_pfamImport 122 adwaagwiHQRVATAAQSE-MVENFTqDERIAGVENVRTGLRRKIdlkppkiaseeeESseEEGSEDEEMEDAGLDTAPT 200
8T1L_E       176 GDTNALVAAVAFGKGLSnwrpSGSSGPGqpgqpgagtilagasglpqvqmpgapnqqqpmlsgvqmaqaGQPgkMPSGIK 255 house mouse
XP_001821236 188 DEMEI--VGVRRQS-AGagfeFDIAPAsaaqhqq-----------------------------qkfvepAVP--LEDILR 233
A1CHE9       196 EEMEV--VGVRRRSDAGaglgFDTAVPTpassqqv----------------------------qkgagpVVP--LDDVLR 243 Aspergillus cla...
Q4WP83       189 EEMEV--VGVRRRSGAGagleFDIAAPApgsrqqqq--------------------------qqkaagpAVP--LEDILR 238 Aspergillus fum...
A2QID5       208 DEMEV--VGARRRSGAGagleFDIAAANtgsganag-------------------------agakvvapVVP--LDEILR 258 Aspergillus nig...
XP_002559238 199 -EMDV--VGVHRKPGAae-feYNIAPHHphp-----------------------------------vqpFVP--LDLILR 237
Q1DLG1       206 EEMEV-VVGAHTKAGGGsgveFDIArgsship-------------------------------skpvapGMP--LDDIFR 251 Coccidioides im...
XP_045287573 202 NGMGV--VGVHGSPGAgg-vqFDISkeggyvq-------------------------------stsmspALP--SEDVFR 245
XP_002794656 193 AGMEV--VSMQRRPGGsg-vqFEISsaghgp--------------------------------paqlstALS--LEDVFR 235
6_pfamImport 201 RPVEFGMGTVRKNPNALvr------------------------------------------------------teDDILR 226
8T1L_E       256 TNIKSAsmhP 265 house mouse
XP_001821236 234 FMTTGAe--P 241
A1CHE9       244 FMTTGTl--P 251 Aspergillus clavatus NRRL 1
Q4WP83       239 YMTTGIp--P 246 Aspergillus fumigatus Af293
A2QID5       259 FMTTGAv--P 266 Aspergillus niger CBS 513.88
XP_002559238 238 YMTTGRmp-- 245
Q1DLG1       252 FMMTGAp--P 259 Coccidioides immitis RS
XP_045287573 246 FMMTGAvpkg 255
XP_002794656 236 FMMTGAaprg 245
6_pfamImport 227 FATNGAts-- 234
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