Conserved Protein Domain Family
Med8

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pfam10232: Med8 
Mediator of RNA polymerase II transcription complex subunit 8
Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.
Statistics
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PSSM-Id: 402025
View PSSM: pfam10232
Aligned: 37 rows
Threshold Bit Score: 123.614
Threshold Setting Gi: 400601966
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEC15453       1 ME-ReekaldiaLDAMISRTQDLKNSIASFIVKLETEYETLQWPSVLDSFALLSGQLNTLLKVLrNDKTPPLRNRILLPL 79  black-legged tick
XP_002794656   1 MAsIspdq-lkvLEQTRQRLVQLTQSLASFINNINQSDPLPSWSSLQSQATIISNNLLNVSQQL-TDHHDLFASLVAYPT 78  Paracoccidioide...
XP_002150647   1 MTaInesq-vkiLEQTRQRLLQLTHSLDSLTGSLHHSDPLPSWSSLQSQASIISNNLVNICSQL-AEHQELLSSLVAYPA 78  Talaromyces mar...
EED16260       1 MTaInesq-vkvLEQTRQRLLHLTHSLDSLTGSLHQSDPLPSWSSLQSQASIISNNLINICSQL-AEHQELLSSLVAYPA 78  Talaromyces sti...
XP_002559238   1 MSnLtqeq-ikvLEQSRQRLVQLTRSLGSLIASLNQSDPLPPWTSLQSQASIISNNLISVSDQL-SDQRDLLSNLVAYPG 78  Penicillium rub...
A1CHE9         1 MAsPsqdq-ikvLEQSRQRLVQLTRSLGSLIGSLNQSDPLPSWSSLQSQASIISNNLLSVSEHL-SDNCDLLSALVAYPG 78  Aspergillus cla...
Q4WP83         1 MAsLnqdq-ikiLEQSRQRLVQLTRSLASLIGSLNQSDPLPSWSSLQSQAGIISNNLVSISEHL-ADNKDLLSALVAYPG 78  Aspergillus fum...
XP_002376999   1 MAtPtqeq-lktLEQSRQRLVQLTRSLASLITSLNQSDPLPSWSSLQSQASIISNNLLSVSDHL-SDNRDLLTSLVAYPG 78  Aspergillus fla...
A2QID5         1 MSsLnqdq-iktLEQSRQRLIQLTHSLASLITSLNQSDPLPSWTSLQSQATIISNNLLTISDHL-SDNRDLLSNIVAYPD 78  Aspergillus nig...
XP_008080896   2 ayasltpeelkaLDATRQKFFQLTSSIQSLKNDLARTHPLPQWSSLQVTTAMLSNYMDSITRHL-AEHSELMNKVVVYPS 80  Glarea lozoyens...
EEC15453      80 LLNPERDEElakltenriqffnhE--VVPDYLRTKPDPEIE--------------------------------------- 118 black-legged tick
XP_002794656  79 PQFPGRTEA--------------S--MLSQLLRTKLEPRVEdwvfqglsmgnadatrl--------------rtgltehq 128 Paracoccidioide...
XP_002150647  79 PSFPGNTQQ--------------G--VLEQLLRTKLDPRVEdwvtrgriagteassg---------------daglsesd 127 Talaromyces mar...
EED16260      79 PSFPTNTQQ--------------G--VLEQLLRTKLDPRVEdwvtrgriagteaslke--------------ngglsdad 128 Talaromyces sti...
XP_002559238  79 PEYPGRTQA--------------N--TLEQLLRTKLDPRVEdwvargraagtestgpsnfsd------pdaaykplsdaq 136 Penicillium rub...
A1CHE9        79 PEYPGRTQA--------------S--TLEQLLRTKLDPRIEdwvargrragasaled---------------kdalsete 127 Aspergillus cla...
Q4WP83        79 PSYPGRTQA--------------P--TLEQLLRTKLDPRVEdwvsrgrragasaled---------------rgalsesa 127 Aspergillus fum...
XP_002376999  79 PDYPGRTQA--------------N--TLEQLLRTKLDPRVEdwvargrkagasaled---------------ksglaeae 127 Aspergillus fla...
A2QID5        79 ASYPSRVPA--------------NnvALEQVLRTKLDPRVEdwvargrragapttssdagagalgqyqtssgqrllsdda 144 Aspergillus nig...
XP_008080896  81 TNYPGREQE--------------G--LLGMLLRKKLEPPVEalveeareieiknpka---------------vsqeneef 129 Glarea lozoyens...
EEC15453     119 --------AAELQVTSKASLLSLDTA-QKQIAALNKAANTILDGV------------KNLQENWESNsgqrgtiaqtssl 177 black-legged tick
XP_002794656 129 laelwqwaPIEANMEARRRNWGGNYTlEEKEMGVKNVVTGLRRNLsee-------esGSESGS-EEGeglega------- 193 Paracoccidioide...
XP_002150647 128 laelwswaPIEANAEARRRNWGGNYThEEKEMGIQNVVTGLKRTLpdd-------ddDEDEDE-DEDedeefedvd---e 196 Talaromyces mar...
EED16260     129 laelwswaPVEANQEARRRNWGGNYTlEEKELGIQNVVTGLKRALpdd-------ddEE-----DEDedeefedvne--d 194 Talaromyces sti...
XP_002559238 137 laelwewaPLEANQEARRRNWGGNFTlEEREAGIENVVTGLRRQLedd-------dgEEESEG-EEEdgee--------- 199 Penicillium rub...
A1CHE9       128 laelwdwaPVEANQEARRRNWGGDYTlEEREMGIQNVVTGLRRQLedde-----rdeDEDEDDEEEEegeged------- 195 Aspergillus cla...
Q4WP83       128 laelwdwaPVEANQEARRRNWGGNFTlEEREMGIQNVVTGLRRQLede-------deEASE---SEEeveee-------- 189 Aspergillus fum...
XP_002376999 128 laelwdwaPVEANQEARRRNWGGNFTlEEREMGVQNVVTGLARVLede-------gsESE----DEEegeed-------- 188 Aspergillus fla...
A2QID5       145 iaelwdwaPVAANEEARKRNWGGNYTlEEREMGIENVVTGLSRVLedd-------deEDESDS-EEGegead-------- 208 Aspergillus nig...
XP_008080896 130 adwaagwiHQRVATAAQSE-MVENFTqDERIAGVENVRTGLRRKIdlkppkiaseeeESSEEEGSEDeemedagldtapt 208 Glarea lozoyens...
EEC15453     178 qdtnaliaALSVGKGLRPSLGSPKsqsplpqvsgqqrggkafampslgyikrfftpvkvnadlsgrgqasavhpggkMPS 257 black-legged tick
XP_002794656 194 ---gmevvSMQRRPGG-SGVQFEIssaghgpp-------------------------------------aqlstalsLED 232 Paracoccidioide...
XP_002150647 197 ggekmdivGVHTRPGA-SGVEFDIarsrdhvls------------------------------------aaaspaipLDE 239 Talaromyces mar...
EED16260     195 ggenmeivGVHTRPGA-GGVEFDIaggrdhvps------------------------------------asaspalpLDE 237 Talaromyces sti...
XP_002559238 200 ----mdvvGVHRKPGA-AEFEYNIaphhphp----------------------------------------vqpfvpLDL 234 Penicillium rub...
A1CHE9       196 --eemevvGVRRRSDAGAGLGFDTavptpassqq---------------------------------vqkgagpvvpLDD 240 Aspergillus cla...
Q4WP83       190 ---emevvGVRRRSGAGAGLEFDIaapapgsrqqq-------------------------------qqqkaagpavpLED 235 Aspergillus fum...
XP_002376999 189 ---emeivGVRRQS-AGAGFEFDIapasaaqhqq----------------------------------qkfvepavpLED 230 Aspergillus fla...
A2QID5       209 ---emevvGARRRSGAGAGLEFDIaaantgsganag------------------------------agakvvapvvpLDE 255 Aspergillus nig...
XP_008080896 209 rpvefgmgTVRKNPNALVRTE---------------------------------------------------------DD 231 Glarea lozoyens...
EEC15453     258 TIKTNIKSA 266 black-legged tick
XP_002794656 233 VFRFMMTGA 241 Paracoccidioides lutzii Pb01
XP_002150647 240 VFRYMMTGA 248 Talaromyces marneffei ATCC 18224
EED16260     238 VFRYMMTGM 246 Talaromyces stipitatus ATCC 10500
XP_002559238 235 ILRYMTTGR 243 Penicillium rubens Wisconsin 54-1255
A1CHE9       241 VLRFMTTGT 249 Aspergillus clavatus NRRL 1
Q4WP83       236 ILRYMTTGI 244 Aspergillus fumigatus Af293
XP_002376999 231 ILRFMTTGA 239 Aspergillus flavus NRRL3357
A2QID5       256 ILRFMTTGA 264 Aspergillus niger CBS 513.88
XP_008080896 232 ILRFATNGA 240 Glarea lozoyensis ATCC 20868
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