Conserved Protein Domain Family
COA8

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pfam10231: COA8 (This model is not part of the current CDD release)
Cytochrome c oxidase assembly factor 8
Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.
Statistics
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PSSM-Id: 519256
Aligned: 31 rows
Threshold Bit Score: 152.032
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPS98567      20 RHLVGPSDPVSNLRPVIYDdaVPEHRTDLthpyslrefggdtrEYQWKMQRQQLDAYNHVFWTDCNLRFGAAKQAVLDSL 99 
XP_002411548  41 ATLVSPPDPVSNLRHVKLR--VPENESPA--------------EAQFRMQYAAVQDWNQEYWTKHNTDFHRKKDEFTRRK 104
EFX71456      44 TDVYGPPDPKSSLRLITFY--IPPDETEA--------------EKKYRLRRAQVQEWNHLFWTIHNVQFTQAKEEFVTSV 107
XP_004990081   4 STRVLAPHPVSNLRRIERV--PRADETRA--------------EKRLRLQLDADHEFHQRFWHKNNTDFKQAREAFLEEH 67 
XP_004346886  45 IVRMGPPDHVTNLRPFEII--PAANESVA--------------EREYREMRIAAAQGHDRFWRSNNTRFVQEKAAFEAEL 108
XP_007395938  26 RDLVGPPDPVSNLRPVIYDd-TPAQSAPAshpyslkeftgdtrEYQWKVQRQELDAYNHNFWADSNTRFNAALEARLSSL 104
XP_788825     60 RDWIGPADKKSNLRRVILA--QPQNETDV--------------ERDYRVSRTATNDWNHQFWSKQNEIFIKAKEEFVQAR 123
A8WJ42        17 FDWVGPPDSVSKIRKIMLR--RVDNESEL--------------ERQYRAAREELNQWNSDFWAEHNQLFDRQKSEFVEKK 80  Caenorhabditis ...
XP_002109076   1 DD-VGQPDPQSNIRPFILR--EKSLESPS--------------ERYLRQMRRDVQEWNHQFWREQNINFQQCKKEYIAKR 63 
XP_009019945   2 HDWIGPADKVSNLRPLKFY--KKKRESKR--------------EEELRIFREDTQAWNQEFWRKHNDNFTMMKKEYIKE- 64 
EPS98567     100 PESCPVEDr---------eS--------ALSAFYRRWADQEAERQRAYSAEWRRRNWASISLGARLAYEKVA 154
XP_002411548 105 LEEYSRQG-----------IkkenvpaeEMAEFYRTFLNDNHQKHMQYNWTWYKKNFGLLWPAIKSNWAYYS 165
EFX71456     108 LERRG--Kda--------sTtgqpltadDLSEFYRAFLDQNREKHLKYNVEWHMKNMGLLWPGIKANLSRFK 169
XP_004990081  68 REDMSagrl----------------pahLMAEFYCSFLEAHREDHITYNLEWWGRAARQIPLYVHAYVSRFF 123
XP_004346886 109 ARTQPgqpi----------------taeTLSVFYKRFLDHNLPLHKAYNAEWWRINISMLVPAARATIARVR 164
XP_007395938 105 PADSTSYDr---------eL--------AMSDFYGSWLAQEQDRLRAYNAEWRKRNWDNIVLEARVKYQKFM 159
XP_788825    124 LGEKQKETedssdndvigsGvkqvlsaeDMAEFYQQFLKDNQHSFHDYNKQWYRKNFSLLWPAVKANVSMFM 195
A8WJ42        81 QKELGrleh---------------vsanELSEFYRDFLNDRHVAMMVYNKEWYRRNLQLIWPALKVNVVRFF 137 Caenorhabditis briggsae
XP_002109076  64 DANCKMKEs---------nDeethlhadELAEFYGQFLNDNYKIHINYNKEWYKKNFYLLALTVYTKLNTVY 126
XP_009019945  65 -------N-----------GkdknlttaEMGIFYKKFLDDNYRIHLQYNKSWYLKNFKILWLTVLVQFEKIF 118
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