Conserved Protein Domain Family
MMADHC

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pfam10229: MMADHC (This model is not part of the current CDD release)
Methylmalonic aciduria and homocystinuria type D protein
This entry represents methylmalonic aciduria and homocystinuria type D protein and homologues. These proteins are involved in cobalamin (vitamin B12) metabolism.
Statistics
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PSSM-Id: 519255
Aligned: 17 rows
Threshold Bit Score: 276.996
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006003858  24 RIAGTKMFSTAGSSGSDEPH-VVFTPPDIGPRTVWPDEKMGPF--------------------------GPQDQRFQLPG 76 
2_pfamImport   1 RVGNAKAFSTAGSSGSDEPH-VAAAPPDLCPRTVWPDELMGPF--------------------------GPQDQRFQLPG 53 
NP_991157     24 RVVGARSFS--GASGSDEPH-LNTSTPDIAPRTVWPDESMGPF--------------------------GPQDKRFQLPG 74 
3_pfamImport   1 NMSAARSLCFAGDSGSNQPH-ETIVPLNLGLWAGGPDDRKGSF--------------------------GAQDR--QLPT 51 
Q9W375        22 TVHRGSNRLNDLLSTKVTNT-AIIPVARYSKRNGPPSDAGGYFktvksrdlddddelnslesepnweltAERGNRFYLPN 100 fruit fly
Q9XWC9         5 KGPQMRAFTQRVAAFSTQLQ-IDPIPIVFVGKGTTP-RQNSLL--------------------------GPNDSQYPFQG 56  Caenorhabditis ...
XP_003456271  26 RVAGGRAFTAADSSGLKEPA-LASAPSAKGLQTLRPDEMMGPF--------------------------GPQDQRFLLPG 78 
XP_040057199  24 RVTGTRNFSATGSSSSHELC-VAITPSEMA----WPDEIMGPF--------------------------GPQDHRFQLPG 72 
XP_015213734  24 RIAGARCFSAAGSSGSDEPY-VAITPLDIGLRTVWPDEKMGPF--------------------------GPQDQRFQLPG 76 
XP_046464561  26 HQPHGKHFSSQGSGDKRHPHaIVLLDENADGTTVWPDPSLGLL--------------------------GPKDLRMPLPG 79  common water flea
XP_006003858  77 NVGFGCHLNGTAAQQKNQVHKTVPDVLTEPAASERHEFIFAQFVNEYQGNEATPPTQQVNNADNYFENAN---------- 146
2_pfamImport  54 HMGFGCHLQGTAPPRSPP---SLPDLLAEPSAADRHQFVMAQCISELQGSDA-PQKQQINNAETYFENAK---------- 119
NP_991157     75 NVGFDCHLESPVEQRTTSVHSVMPDVLTAQSNNQRHDFILAQFINELHEDDKTSTAQNMDKAEQFFDHSS---------- 144
3_pfamImport  52 NL-LSCDLRGAAGQQRCLDSTVLP------IQARRSDLTMTEVLEEPLVTEELPR----SPPEAYFDGST---------- 110
Q9W375       101 GIG-------------------------PAWQGDSTTVGLLEPLGHLVNFHKGPNTDKSR-------------------- 135 fruit fly
Q9XWC9        57 DVSFAHKPLSIRQQVENSKIERVMDD-------TEHNLINLLSNTNIEVDRTHLAQLKEEAMEEIQANAAdv-------- 121 Caenorhabditis ...
XP_003456271  79 NVGFDCQLEGETEQQKSLTDKMLPDVLSAPSCYEKHEWLLAPSVGELSNKGDPASSDKVSTAEHYFDNSR---------- 148
XP_040057199  73 NLGFDCDLQGIAEQMKSLAHSKVPDVLSSPPSSEQHELILAQVNRDSFEEDEPASSQDVHTADRYFDSSS---------- 142
XP_015213734  77 NVGFGCHLEGTADQKQTPVHRPVPDVLSAPSSSERHEFILAQFVSEHQEKEVAPTSEQVNKAEKYFEMSN---------- 146
XP_046464561  80 NVGFS--------------HRISPSVSPATVQSTKKTWQDTELFSTLTNYERQYQVVKQSAQEDLDELNSteieellldl 145 common water flea
XP_006003858 147 ------VECAIQTCPELLRKDFESLFP-EAPTN---SLTVLTVTQKTKndmtvwseEVEQERELLLEKFINGAKEICYAL 216
2_pfamImport 120 ------VECAVQACPELLRKELQPLFP-ELGAR---SLTVLTVTQRSAqdmsawspEVQQEREQLLDNFINGAKEICYAI 189
NP_991157    145 ------VECAIQSCPELLKRDFESMFP-EAPST---GMMVVTVTQRTQndmtawteQVDQEREELLAKFIEGAKEICHAL 214
3_pfamImport 111 ------VECAVQFCPDQLRDDFRCIFP-EAPSS---GMTVVTVTQKTQndmtswscAVEQEREQMLAKFIDGAKEICSVL 180
Q9W375       136 ------LEFTCCKCPLLIRVPLLEIFPvPVVAQqciNITMLVLSHEGDiem-------------gaAKFVLAAREMCDRL 196 fruit fly
Q9XWC9       122 -----eIELSAIEAPKLLKKEMKYLFP-QMETQkmnNVTVFNLTQKSEfdmkawseAMEEEREKLTASFIMSANAICSTL 195 Caenorhabditis ...
XP_003456271 149 ------VECATQACPELLKKDFQSMFP-EAPSC---GMMVVTVTQKTQndmaswsaEVEDEREQMLDKFVAGARDICCAL 218
XP_040057199 143 ------LECAVQCCPELLKKDFQSMFP-EAPST---GMMVVTVTQKTRndmtswcaEVEQERDQMLDKFCDGAQEICHAL 212
XP_015213734 147 ------VECAIQTCPVLLKKDVEAMFP-EAPAG---TQTVVTVTQKTQqdmtawseAVQVERETLLEKFVSGAKEICYAL 216
XP_046464561 146 pqpsdvLECVAQDCPKLVRKDFADLFP-SRDVTf-gPLTVVTLAQKTKsdmsswseVVEYEREELVACFVDAAKEICEQL 223 common water flea
XP_006003858 217 RSEGYWADFIDPSSGLAFFGSYTNNTLFETDERYrHLGFRIEDLGCCKVIRHNLWGAhvFVGSLFTNAPSDSLVMKKLQ 295
2_pfamImport 190 AAEGYWADFIDPTSGLAFFGPYTNDSLLETDERYrHLGFAVDDLGCCKVIRHNLWGThvVVGSIFTNAE-----SNKKK 263
NP_991157    215 RNEGFWADFIDPSSGLAYFGSYTNNTLFETDDRYrHLGFQIEDLGCCKVIRHVMWGThaFVGTLFTSAPPNSQIMKKLQ 293
3_pfamImport 181 QTEGFWADFIDPSSGLAFFGPYTNNTLFETDDRYrHLGFHIEDLGCCRVIQHSLWGThvFVGTIFTSAAPDSHIMERLL 259
Q9W375       197 LSYGYWADFMNPFSGRPFFLPREGANLYRLDSRFrGLNMRLSEQNRCTVISAEKNDStrFSGTIYSTAPNHYGQLMKLL 275 fruit fly
Q9XWC9       196 HRFGYWADFIDPSSGRPYMGDYTNHTLFETNDAYkQMGFKIEDLGCCKVLQHACWGSnaFVGTIFTDAPVDGDAVRDIL 274 Caenorhabditis e...
XP_003456271 219 QREGFWADFIDPSSGLAYFGPYTNNTLYETDDRYrHLGFQIEDLGCCKVIRHSLWGThaFVGTIFTSAPPDTPAMKTLQ 297
XP_040057199 213 QKEGFWADFVDPSSGLAFFGSYTNNTLFETDDRYrHLGFQIEDLGCCRVIRHSLWGThvFVGTIFTSAPPSSLVMKNLQ 291
XP_015213734 217 QTAGYWADFIDPSSGLAYFGSYTNNVLFETDERYrHLGFQIEDLGCCKVIRHTLWGThaFVGSLFTNAPPESLIMKKLQ 295
XP_046464561 224 QNDGYWSDFIDPSSGRPYLGSYTNATLFETDERYrHLGFSIEDLGCCKIIRHGTWGThaFVGCIFTNAPFDGDALQDVL 302 common water flea
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