6TX2,6TX3,6X0L,6TX1


Conserved Protein Domain Family
HPF1
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pfam10228: HPF1 (This model is not part of the current CDD release)
Histone PARylation factor 1
Histone PARylation factor 1 (HPF1, previously known as C4orf27) is a key regulator of ADP-ribosylation (ADPr) signaling in response to DNA damage. It forms a complex with PARP-1 (poly(ADP-ribose) polymerase 1), creating a composite active site. HPF1 is essential for Ser-ADPr (ADPr on serine residues), which represents the major fraction of ADPr synthesised after DNA damage. This protein is organised into two tightly-associated domains connected via an elaborate linker, showing an alpha-beta structure.
Links
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Statistics
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PSSM-Id: 519254
Aligned: 35 rows
Threshold Bit Score: 267.564
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6TX2_A         49 GLQLVGPYDILAGKHKtK--KKSTGLNFNLHWRFYY--DPPEFQTIIIGDNK-TQYHMGYFRDSPDEFPVYVGINEAKKN 123  human
XP_004996565   48 GIDLVGPCQVLHSVDK------PQTKDLHCWHRHVYnfDPPECMTVAVRHA--TKEHWCYFRDDPSETPVMVVHNKASDG 119 
XP_015782073   53 DLLLVGPFDVIDGKLKdEvlDSADPASILCYYRFFY--DVPEFQTVLRDTK--SNFHIGYFRDSPSEMPSMVVSNDPDKS 128 
EGT37142       64 NMKLVGPFRKLMENSD------VTGTDLIMLDREKT--DLPEMQTFM----LtTFGRYAFWRDTPSEKNPVIVFVDLKTI 131 
XP_003108394   63 DIVFFGPFRKLKENSD------VNGVELIMLDREPS--DLPEMQTFM----KcGTGRYSFWRDEPSERNPVVMFLDQHTC 130 
XP_002634233   64 NMSFIGPFRVLREGVE------VNGVELIMTDRDET--DLPEMQTFL----KcSHGKFSFWRDTPSEKNPVIVFSDIQGI 131 
O62291         66 SVTLVGPFRKLRGESD------ADGTDLIMLDREMT--DLPEMQTFM----KcSHGRYAFWRDKPNDKKPVIVFMDLKTI 133  Caenorhabditi...
XP_008192479  229 NLELVGPFDVLAGKFK-R--VKRPPEDYLRHWRFYY--DTPELLTVLKGDDS-TGYHIGYFYDSPNEPPQVLVSNHGTKD 302 
XP_011062524  191 RLKLVGPYDILDGKIK-IssSENDKEKYLIHWRYYY--DPPEFQTIVKCDDK-EGLHFGYWRDDAVEKPVFIAKNQANVN 266 
9_pfamImport    1 NLELVGPFDVLNGAIM-----KCTKETALRHYRYFY--DPPEFQTLLKGDEK-EQLHYGYFRDDPKEFPCCVARNKAAVS 72  

6TX2_A        124 cIIVPNGDNVFAAVKLFLTKKLKEITDk-----KKINLLKNIDEKLTEAARELGYSLEqRTVKMKQRDKKVVTKTFHGAG 198  human
XP_004996565  120 gVYGDAGDSILALLVAECKAA------------DRKRDASELRQKLQDLAKKYNIPLT-LGKAKRKRKAKVNAPTFSGIG 186 
XP_015782073  129 cIINPLGDNIFSGLLAFCEDLKRRRSEk----dDKKANAEKLSLKIKAYAEKNDIPL--VNNNMKERKKKVVAKTFHGAG 202 
EGT37142      132 pELSMVGNTVEHAIHHFCGLFAKCQDNgkeakaAASNILEILGDA--KMKKE-------TTRAIKKRQSISVGG-LLGPG 201 
XP_003108394  131 pEVTVVGNKVEHAIHHLCMRVSKYQDNtkeikeAISTILDILGDN--AMKDE-------IARVIRNRKRETIVG-IVGPG 200 
XP_002634233  132 pVVTVVGNTVEHAIYGFCNKISKLQDNskevksAIAEILGLLGAQ--KMEKE-------ANQVMKKRKKETITG-VLGPG 201 
O62291        134 pDLSVVGNEIRHAILDFCTRCSKCIDCsakskaANSKIQSFFTPS--KISSE-------VKEVLKHREKTTVRG-ISGPG 203  Caenorhabditi...
XP_008192479  303 gVFTKMGDNIFAAVCSYLGELQQSGDP------FKKMHVGKFLTQLKTKAQKLHLSTSaHSEKIKKRGNKIVAKTFNKIG 376 
XP_011062524  267 gIFEPVAENIFGAVDAYLQNKVKTANP------FEKTSIIRLHSQLKNFAKQHNITLDkNTADMRAREKRVVARTFHKAG 340 
9_pfamImport   73 pAISCVAGNLFGTVNVHAEEVKGTADI------FRKMQIQKIQSALVKWAKQKKFTLDtVTASIKARRSKVVAKTFNGIG 146 

6TX2_A        199 LVVPVDkn-----------dVGYRELPETDA--DLKRICKTIVEAA-SDEERLKAFAPI-QEMMTFVQFANDECDYGMGL 263  human
XP_004996565  187 ICVPFDed----------teIGYRPLSVSDK--KLRSILDAIVKAK--RKNQTPDYSQL-DLLVQYANISNDEFDFGQAL 251 
XP_015782073  203 IVVPFEn------------dVGYRPLPENEQ--NLKKLLKKIADMPeEDRQRSKAYESL-REIVNLTNLANDECDFGMAL 267 
EGT37142      202 IYLEQHsng----------sprYRRLLHSRHdpHIENLLRCLTNAK-VKSDEQAVIKLInEEIVGHVIICNDEGDFGNGL 270 
XP_003108394  201 LLVGELprg----------gsrYRVMDDAQNp-NIESLLRCLKHVP-FPKQQDTVVDII-DSLMGDFTVYNDEGFYGNGL 267 
XP_002634233  202 LLVGDFpntn---------ksrYRVVSKES---NIENLLRCLSNTG--KQHQDAVIGEI-DELMNNVMMYNDEGFYGNGL 266 
O62291        204 MLIDVVptgnsgkknkknerTGYRDLSKNAYciNIEHLVRSLRLCQ-TKEQEEKVLDFV-YGLMNEINICNDEGDFGNGL 281  Caenorhabditi...
XP_008192479  377 LVVPYArk----------tqLGYRELAMGDK--DLMVLLNKLNKAS--PEQKNKYLADL-QPVLTFANIALDECDFGTGV 441 
XP_011062524  341 IVVPYDkk----------tqLGYRDLAATDN--DLQKILKQIEEAD-TPEDRKMPIAKL-DEIVRLATIAADECDFGTCL 406 
9_pfamImport  147 VVVPYDkk----------tdVGYRPLAVSDD--ELKQILKKIASAN-TNSEQDVAWSKL-QPVITAANIANDECDFGTSL 212 

6TX2_A        264 ELGMDLFCYGSHYFHKVAGQLLPLAYNLLKRNLFAEI 300  human
XP_004996565  252 QLGLDLYAHSL-IFKTDALHLLAPTYALLQRDVFADI 287 
XP_015782073  268 ELGIDLFCFGEECYHRLVSFTLGTAYELLDRHQFGTI 304 
EGT37142      271 ELGHVMFLANHKAIEDDLKMILIPAYKFLKRSDFIEI 307 
XP_003108394  268 ELGHLLFLANHKSVSNQALILLQTAYQLLKRNDFITI 304 
XP_002634233  267 ELGHVLFLSNQSSISNQVLLVLTTAYNLYGRTDFVNI 303 
O62291        282 ELGHILFLANMKAVADPMMITLHIAYKNLHRPDFAKI 318  Caenorhabditis elegans
XP_008192479  442 KLGWELLFHGIDSLNATIAQFLGNSNRLLGREAFAKI 478 
XP_011062524  407 ELGHDLFSNGGIHVQTRALQMLSIAYTHLKRPQLLKI 443 
9_pfamImport  213 ELGLDMFAFGEESLHATIEQVLCTTYNLLQRNNFADI 249
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