Conserved Protein Domain Family
CCDC85

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pfam10226: CCDC85 (This model is not part of the current CDD release)
CCDC85 family
This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.
Statistics
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PSSM-Id: 519253
Aligned: 12 rows
Threshold Bit Score: 180.736
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023183633  28 AEDVAKIPDEELLKWSKQELVRRLRQTETEKRAVIVEHGNLMREVNRRLQQHLTEIRSLKDVNQKLQ-------EDNQEL 100
1_pfamImport   1 AEDSSNMSDEELLTRGKEELVRWLRRAEAGKRSAIMDHGDRMREVNRRLQQHLNEIRSLKDVNQKLQ-------EDNQEL 73 
XP_011601483  15 TEELSKISDEELLKWSKEELVRRLRRAEMEKRGVIVEHGNLMREVNRRLQQHLNEIRSLKDVNQKLQ-------EDNQEL 87 
XP_011477970  23 AEDISGITDEDLLKWTKEDLVRRLRRSEADKMSVILDHGNLIREVNRSLQLHLNEIRGLKDINQKLQ-------EDNREL 95 
Q15834         5 AGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQ-------AENREL 77  human
XP_015194332  10 QRELGRLSDEDLLRSSKEELVARLRREEADKIAALLQRGRLIAEVNRQLQGHLLEVRELKAVNQRLQ-------QDNREL 82 
A2CEM9         9 NRELSKLSDEDLLACTKEELVNRLRKEESDKMSALIQRGRLIKEVNKQLQGHLLEIRELKVINQRLQ-------EENQEL 81  zebrafish
XP_022528990  10 RDDLSKISDEELFRLSKDELVRRLRKVDSEKMSLMVEHGNMIKDVNRRLQVHLHEIRGLKEVNQKLQ-------DDNQEL 82 
XP_001374725  11 KEDLSKVPDEELLRWSKEELARRLRRAEGEKMGLMVEHGNLMKDVNRRLQLHLHEIRGLKEVNQKLQ-------DDNHEL 83 
XP_012663047   9 SKDLSQVPDEELLRWSKVELARRLRYAQGEKVGLMLEHRGLLRHVNRRLHQHLLEIRSLKDVNQRLQ-------DDNQEL 81 
XP_026696207  26 GCLRS-PTDIELRHEGLDHVIQRLRFAENENKKLLVERSRAMKDVNRKLQVHLLEVRGVREVNQKLMlekdallKEKEEL 104 vase tunicate
XP_047287284  12 SEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRLQQHLLEIRGLKDVNQRLQ-------DDNQEL 84  human
XP_023183633 101 RDLCCFLDDDRQKGKRVSREWQRLGRFSAGLMRKEVAVYLQKLKELEQRQMEVVQENLELKEVCFMLEEERAAataggga 180
1_pfamImport  74 RDLCCFLDDDRQKGKRVSREWQRLGRYSAGLMRKEVSIYLQKLKELEQRQVEVVRENLELKEVCLMLDEERAAvggha-- 151
XP_011601483  88 RDLCCFLDDDRQKGKRVSREWQRLGRYSASLMRKEVAIYLQKLKELEQQQVEVIRENLELKEVCLMLEEERVMtaagg-- 165
XP_011477970  96 RDLCCFLDDDRQKGKRVSREWQRLGRYSASIMRKEVTLYLQKLKELELRQEEVIRENLELKELCLLLDEEKGGsfvggnl 175
Q15834        78 RDLCCFLDSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEWGP------- 150 human
XP_015194332  83 RDLCCFLDDDRLKAKRLAREWQLFGQHAARVLRDDLGGYLQKLAELERLQGALLRENLDLKELCLVLEEECVG------- 155
A2CEM9        82 RDLCCFLDDDRLKVKKLAREWQLFGHHAAKVMREDLGGYLKKLADLERMQDGLVKENLDLKELCLVLEEECVS------- 154 zebrafish
XP_022528990  83 RELCCFLDDDRQKGKKLSREWQRFGRYTASVMWKEVGVYQQKLKELEANQDTIMRENMELKEIILMLEEERSGa------ 156
XP_001374725  84 RELCCFLDDDRQKGKKLSREWQRFGRHTAGVLWKEVALSQQKLRELEARQEALLRENLELKEIVLMLDEERSga------ 157
XP_012663047  82 RELCCFLEDDRQKGRKLAREWQNFGRHAADAVWHEVARSQQKLRELEARQEALLCENLELKELVLLLDEERTSlaaagga 161
XP_026696207 105 AGICCFLDDDREKAKKVAREWQMFGRYATGVLQKELATCHQKIKDLELKQTTLVQENKTLKEICLMLDQENAG------- 177 vase tunicate
XP_047287284  85 RELCCFLDDDRQKGRKLAREWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRenlelkelvllldeeraalaatgaa 164 human
XP_023183633 181 --htqgdpgCRSSIDSQNSLSQ-LGGGGPTPGl-LRDVGDGSSTSSAGSTDSPDK 231
1_pfamImport 152 ----vggpgRRSSIDSQSSLSQ-LGGTLPAPGl-LRDVGDGSSTSSGGSTDSPDN 200
XP_011601483 166 ----ggglgRRSSVDSQSS-SQ-LCGSGPAPGl-LRDVGDGSSTSSAGSTDSPDN 213
XP_011477970 176 sggntgmggCRNSIDSQNSLLL-VPGQGLL----MRDVGDGSSTSSAGSADSSDH 225
Q15834       151 ----------RGGPSGAGGSGAgPAPELALPPcgPRDLGDGSS--STGSVGSPDQ 193 human
XP_015194332 156 ----------RAEGSPAGS------SELSLPCl-ARDLGDGSS--STGSVGSPDQ 191
A2CEM9       155 ----------RSDSSPGGS------TDLNIPCmvARDVGDGSS--STGSVGSPDQ 191 zebrafish
XP_022528990 157 --------gSRSSIDSQSSLTN-LNGGSSN----MRDVGDGSSTSSTGSAGSPDH 198
XP_001374725 158 --------gSRSSIDSQASLTN-LAGGSGGAG--PRDVGDGSSTSSTGSGGSPDH 201
XP_012663047 162 g-sggggagALISIHSQASLSGpLVGGAAGAR--ARDVGDGSSTLSTGSGGSPDH 213
XP_026696207 178 ---------NRSSVDSQSSFPPpPN-LLHTPE--TRDSGDGSSNGSTASNYSPDH 220 vase tunicate
XP_047287284 165 sggggggggagsrssidsqaslsgplsggapgagardvgdgsstssagsggspdh 219 human
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