Conserved Protein Domain Family
DUF2181

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pfam10223: DUF2181 
Uncharacterized conserved protein (DUF2181)
This is region of approximately 250 residues conserved from worms to humans. Its function is unknown.
Statistics
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PSSM-Id: 402018
View PSSM: pfam10223
Aligned: 61 rows
Threshold Bit Score: 222.073
Threshold Setting Gi: 81884090
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7Q3G4         7 NLTKVTWAHAVNDAEFLTRVL-ASD----IQFIEADISLGYLKDdVNKEreIPIMAHPPATESDISLETFLQRILqfnre 81  Anopheles gambi...
2_pfamImport   1 DLTLVTWEHAVNSKEKLEKAL-AGD----SLMIEADISLGYVIGdVTKEl-RPIMAHPPANTSDLSLEDFLYIFS----- 69 
EFX69415      28 DFTQVTWAHAVDNRKKLRRAL-RGS----AMMLEADVSLGKLKSdPHSEd-RPIMAHPPISASDLSLEDFLDAVL----- 96  common water flea
EFX75485     148 DLSRIKWGHGINSKVQLNTSL-YGK----DMMIEADVSMGTIVGg-DGSi-LPIMAHPPLVSSDLSLEEFMDTIL----- 215 common water flea
EFX69416      65 DLSRVKWGHGVNSKAQLSQSL-QGT----DMMIEADVSMGIVTGr-EGKf-LPIMAHPPFKSSDLSLEEFLDITL----- 132 common water flea
EEC05789      24 dMSSVVWSHATNSRWKLDKALnDKQ----NPYLEADVSYADG---------IAVMAHPPVKSWDLSLKEFLRLVC----- 85  black-legged tick
XP_002411529  24 dVSSVRWNRATHSRALLQDALqRDS----APFVEADVVLVDG---------SAVLPRPVNENWTVSLSELLYRVS----- 85  black-legged tick
XP_002401368  27 DATYARWFHGTNSRRLLDEALkGDE----PVFLEADVVVEGS---------MAVLEHPLDQPWDLSLRDLLNLVT----- 88  black-legged tick
O45879        41 DGLNVRVAHGVNSWPDLVDQL-HEPflnkSMMIEGDVFMQAHRRpRHRA--VPVMKADTKLADRITFKEWLREVA----- 112 Caenorhabditis ...
Q642A7       342 DGLEVEWLALEVNDKGRKAAI-TVPd--rEGMILLDVGLQEPEVgNP----VPVLRTP--GGSVLTLESCLLHLA----- 407 Norway rat
Q7Q3G4        82 anDPSKVKGVKLDFKSIGAFERSIDII--RASYDM---TAFDTWINADILPGPVDNtaT-VPvdptrff-taarrlGKAT 154 Anopheles gambi...
2_pfamImport  70 --KSSARKGIKLDFKSKEAFSHSEFILeaSLYNRD---VDYPVWLNADIIKGPVNSe-V-QPvdadyflsrsvtkfPVAT 142
EFX69415      97 --DEAYYKGIKLDFKSVEVLERALRIVktR--EHK---IRVPLWLNADIIKGPVDSt-S-QPidaqlflsltkhyfPTAV 167 common water flea
EFX75485     216 --NSGTFKGIKLDFKDIEALEPSLMAIksR--ASK---ITAPLWLNADILAGPVNAt-T-KPvdigrffdltknyfPDSV 286 common water flea
EFX69416     133 --SSRTPKGIKLDFKDMEAVELSLRTIktR--ANK---IYAPLWLNADIIQGPVNAt-T-KPmdarrflnltksyfPDAV 203 common water flea
EEC05789      86 --STPKNTTLKLDFKSNDVLHAAFHDLdnAPVKNL-----QDLWLNADVVQGAGGAp----LvdgrrfvhmcstrfPWAV 154 black-legged tick
XP_002411529  86 --ATPMNVTLKLNLKSTEVLEVAKRNLleAHLQNL-----KGLWFHADILPATGGEa----PvnasyylhqfassfPQAV 154 black-legged tick
XP_002401368  89 --AKPKRVTLKLDFKSTEVLPSAINVLmgALTENL-----KDLWLHADAVPGPGGKp----PvdastflryttpfhPFAV 157 black-legged tick
O45879       113 ----TMNKAIKINFRSNEVVRPVLQDLyaSQADPTspvLQYPVILHANVFRSPRSVe-TeVdpstfve--kakdlfPDAT 185 Caenorhabditis ...
Q642A7       408 --VHATRWSIHVNITEPAALRPSLATLahLSTLGH---LPWPVWVGATVSYGSFVVp-GhIagrellt--avaevfPHVT 479 Norway rat
Q7Q3G4       155 LSIGWTTRWGpDF--------SEGlYTESQVDAMIDAIRAngIDKVgn--aITFPVRGG-IVANSVTNMIRLFCALkdTN 223 Anopheles gambi...
2_pfamImport 143 LSVGWTTRFGnGI--------DKGeYTVGIIEEMTDALNRnlVTSP-----VTFAVRAA-IAAQSYEQLSNL-IGSsvPG 207
EFX69415     168 ISAGWTTKl-----------aKEGyYTLDQCRNMKDALIAaqVTAP-----VTFPVRAG-LVANLESRQNILWLLSeiPG 230 common water flea
EFX75485     287 LSVGWTTRFGpQMtwpl-qiiNEGsYTMDHMIQMRDALHAaqIRQP-----VTFPIRAG-LSTSPESQRNILWLLEqiEN 359 common water flea
EFX69416     204 LSVGWTTRYGpDVsswplqiiNEGsYTMNHMIQLRDALRAaqIRQP-----VTFPIRAG-LCTTPESQRSIIWLLEqvED 277 common water flea
EEC05789     155 ISPGWTTL-------------PQStYTWGQVEAMARLL----LCEAplpprTTFPVRAS-LVATSIPQLSWLLDVT--RN 214 black-legged tick
XP_002411529 155 VSVGWTTY-------------PETfYTWEVVDRMTRLL----LCGPhlparVSIAARAS-MLPNSVAQVSWMLDVI--PQ 214 black-legged tick
XP_002401368 158 VSLGWTTK-------------NKGaYSWRNVETMARLT----RCGQpylrrVAFSVRAS-MVENSLPQLAWLVDVV--PN 217 black-legged tick
O45879       186 LSLGWTKQ---SNfshlhpkfKK--LSWRQLFHILEYISR--LDQP-----VMLSVRLS-VAAHSKEQLLWLLGMD--QS 250 Caenorhabditis ...
Q642A7       480 VAPAWPEEML-----------GSG-YQEQMVTEMLELCQG--LRQP-----VSFQLQAGpLGQSPANTVARLLAFS--PR 538 Norway rat
Q7Q3G4       224 nVTFTIW-SSADDA-VNVEKLREFIFTTGLDRTYVDVPDDLH 263 Anopheles gambiae str. PEST
2_pfamImport 208 -TTLTIW-CGSNDK-TDLNLLRRLIHGIGRDKIYLDLPPE-- 244
EFX69415     231 -STVTIW-SSYGDE-VDVFGLLDFIDAIGKEFIYIDVHSglr 269 common water flea
EFX75485     360 -SSLTVW-SSQYDI-VDVPALMKLVNHIGKENIFVDVPSgls 398 common water flea
EFX69416     278 -STLTIW-SGPFDT-VDVPGLMKLIKHVGTKRIYIDVSsgll 316 common water flea
EEC05789     215 -STLTVW-ASDNDP-WATEGLVRLRQELPWSSVYYDLPGQQd 253 black-legged tick
XP_002411529 215 -ASLSIW-AQDNDP-RVTDTLIQLRKALPWSVVYYDLSEEQR 253 black-legged tick
XP_002401368 218 -STLSVW-YPSSEA-PPTEALLKLRQTIPESSVVYDLPRDyp 256 black-legged tick
O45879       251 -ISLLLW-SDAEDHvTNWTPIVELRRSTTKNRILYDLDPKHR 290 Caenorhabditis elegans
Q642A7       539 -ATVTVYhSSAGNSyADVWAGLWAARAVDRTRVYYRIPQEYR 579 Norway rat
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