Conserved Protein Domain Family
Menorin

?
pfam10223: Menorin (This model is not part of the current CDD release)
Menorin
This family includes proteins FAM151A and FAM151B, the mammalian homologues of C. elegans menorin which is involved in generation of neurons and regulation of dendrite extension. FAM151B has been shown to be essential for retinal function. Sequence analysis and the fact that these proteins have a TIM-barrel fold similar to that in phospholipase D and glycerophosphodiester phosphodiesterase (GDPD) families, indicate that they belong to PLC-like phosphodiesterase superfamily, although their substrates and function remain unknown.
Statistics
?
PSSM-Id: 519250
Aligned: 53 rows
Threshold Bit Score: 229.404
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q7Q3G4          7 NLTKVTWAHAVNDAEFLTRVL--ASD----IQFIEADISLGYLKDDvNKEreIPIMAHPPATESDISLETFLQRILqfnr 80  Anopheles gamb...
EDS41490       23 KLTDVTWAHAVNNKDYLVNVL--NGN----TNFIEADILIGHLENG-NPQekIPIMAHPPATQSNLSLKEFLDKCLqfn- 94 
13_pfamImport   1 NLTKIKWAHAVNSCTELQEALk-NNK----IQMLEADIILGQINNc-GSF--LPVMGHPPATSSDITLKDFLLTVLef-- 70 
EDV99354       15 NLTAISWAHAVNSQQLLGESL--SSD----IDMIEADIVLGKLNGe-GPD--LPVMAHPPAKVSDLTLEDFLQQIKvyn- 84 
XP_002064866   12 NLTDISWAHAVNSQQLLDAAL--SGD----IDFIEADIVLGKINGe-GED--LPVMAHPPATISDITLEDFLNQIKdyn- 81 
Q8MQP2          8 NLTAITWAHAVNSQQLLDEVLteTSG----IDFIEADIVLGKLNGd-GED--MPIMAHPPANVSDLTLSEFLNQIInfn- 79  fruit fly
KYB28162       11 NLTKITWAHAVNNKTYLAASLn-SSA----IMMLEADVIYGKINGSgEL---IPIMGHPPATQSDLSLEEFLTTIYnfnk 82 
Q642A7        342 DGLEVEWLALEVNDKGRKAAI--TVPd--rEGMILLDVGLQEPEVGnP----VPVLRTP--GGSVLTLESCLLHLA---- 407 Norway rat
O45879         41 DGLNVRVAHGVNSWPDLVDQL--HEPflnkSMMIEGDVFMQAHRRPrHRA--VPVMKADTKLADRITFKEWLREVA---- 112 Caenorhabditis...
2_pfamImport    1 NLTTVTWAHAVNNKTYLEAAL--ASE----VAMLEADIVLGHLTGHdGPP--IPIMAHPPATTSDLSLAEFLSTVAqy-- 70 
Q7Q3G4         81 eanDPSKVKGVKLDFKSIGAFERSIDII--RASYDM---TAFDTWINADILPGPVDNTaT-VPVDPTRFFTAARR-LGKA 153 Anopheles gamb...
EDS41490       95 qqaKKADVKGIKLDFKSIEALESSIDLI--KTLYDT---VEYPTWINADILAGPVNNTsT-IPVDHDRFFKCAKQ-LGPV 167
13_pfamImport  71 -nqNAVNSKGVKLDFKSIEVFEKSLGIL--EELWNK---ITFEIWLNADIVKGPVEQ--T-KP--------------SQA 127
EDV99354       85 -eeNEGAEKGVKLDFKSIEVFEGSLGILd-ETIPK----MTYPIWINADIISGPVKQIsS-VPVDPARFFAGCMR-YKQA 156
XP_002064866   82 -ddHEGAEKGVKLDFKSIEVFEGSLDILd-VTIPN----MTYPIWLNADILSGPVEQNkT-VPVDPDRFFAGCMR-YKQA 153
Q8MQP2         80 -rdHEDQKKGVKLDFKSIEVFEGSLDILd-VNIPNP---TTYPVWINADILSGPVEQNrT-VPVDADRFFAGCMR-YKQA 152 fruit fly
KYB28162       83 denNRKVRKGVKLDFKSTEVFTKSVDFI--KKQYNQ---IDYPLWINADIIRGPLNFE-T-VPVDPNIFLSTAKA-FDKS 154
Q642A7        408 ---VHATRWSIHVNITEPAALRPSLATLahLSTLGH---LPWPVWVGATVSYGSFVVP-GhI--AGRELLTAVAEvFPHV 478 Norway rat
O45879        113 -----TMNKAIKINFRSNEVVRPVLQDLyaSQADPTspvLQYPVILHANVFRSPRSVE-TeV--DPSTFVEKAKDlFPDA 184 Caenorhabditis...
2_pfamImport   71 -nnVNNKQKGVKLDFKSIEVFSKSQELIapYSKPQ----VTFPLWLNADILPGPVKAT-T-TPVDPIKFIELGAN-HPRA 142
Q7Q3G4        154 TLSIGWTTRWGpDF--------SEGl-YTESQVDAMIDAIRAngIDKVgn--aITFPVRGG-IVANSVTNMIRLFCALkd 221 Anopheles gamb...
EDS41490      168 VLSIGWTTKWDqHS--------TEGf-YSEMNIQCMIDTIKSnkIDMLga--pITFPIRAG-IAANSLAQLKKLYEALkt 235
13_pfamImport 128 VLSIGWTTLWGpEF--------REGv-YTKDELKDMIAAIKDnhITNKn----ITFPIRAG-IAANSLKEMKQFIQDLgk 193
EDV99354      157 VLSIGWTTKWGaNY--------REGe-YTEEQCDAMLQVINDnnVTSTgq--pITFPVRAG-IAANSATQLHDLVAAVng 224
XP_002064866  154 VLSIGWTTNWGaDF--------REGe-YTQEQCDAMLDTLKSnnVLSKelamgITFPVRAG-IAANSAERLHNLVAAVne 223
Q8MQP2        153 VLSIGWTTNWGaDF--------RDGe-YTQQQCDDMLETLSEnnVLSTgq--aITFPVRAG-IAANSEEQLHRLVAAVne 220 fruit fly
KYB28162      155 VLSLGWTTTRP-----------TMGlaYNNAEVNAMIEVIKEndVKQE-----ITFAVRAG-IAAQSLAEMKLLKDEVn- 216
Q642A7        479 TVAPAWPEEML-----------GSG--YQEQMVTEMLELCQG--LRQP-----VSFQLQAGpLGQSPANTVARLLAFS-- 536 Norway rat
O45879        185 TLSLGWTKQ---SNfshlhpkfKK---LSWRQLFHILEYISR--LDQP-----VMLSVRLS-VAAHSKEQLLWLLGMD-- 248 Caenorhabditis...
2_pfamImport  143 VLCMGWTTRYGgNI--------TEGe-YTPEQIGSMLRLVNEqkINQT-----ITFPVRAG-LACNSQPVLLDLLRETas 207
Q7Q3G4        222 TNnVTFTIW-SSADDA-VNVEKLREFIFTTGLDRTYVDVPDDLH 263 Anopheles gambiae str. PEST
EDS41490      236 TNyVTFTIW-SSADDA-VDVEKLRNFMYEIGTDHIYVDVPDELK 277
13_pfamImport 194 DNfYTFTIW-SSVQDF-VDVANLKTFILEFGFDRVYLDVPKDLE 235
EDV99354      225 TNeCTLTIW-SSANDY-VDVAQLRKLIFGFGLDRVYLDVPEELS 266
XP_002064866  224 TNeSTLTIW-SSDGDY-VDVALLRELIFSFGVERVYLDVPEELA 265
Q8MQP2        221 TNeSTLTIW-SSAGDY-VDVDKLRKLIFSFGLDRVYLDVPEELA 262 fruit fly
KYB28162      217 --nCTLTIW-SSEGDE-VDVPKLRDLIFEYGIKRVYVDVPKDLR 256
Q642A7        537 PR-ATVTVYhSSAGNSyADVWAGLWAARAVDRTRVYYRIPQEYR 579 Norway rat
O45879        249 QS-ISLLLW-SDAEDHvTNWTPIVELRRSTTKNRILYDLDPKHR 290 Caenorhabditis elegans
2_pfamImport  208 LN-SSMTVW-SSEGDS-VEVGRLKALILTVGLERTYLDVPHDLA 248
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap