Conserved Protein Domain Family
DUF2151

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pfam10221: DUF2151 
Cell cycle and development regulator
This is a set of proteins conserved from worms to humans. The proteins are a PAN GU kinase substrate, Mat89Bb, essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.
Statistics
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PSSM-Id: 402017
View PSSM: pfam10221
Aligned: 18 rows
Threshold Bit Score: 778.084
Threshold Setting Gi: 308492001
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAP22953        2 EQRDMKTVVVLDRNADF-AEETNETFDIAIRegVKQKK---------LEIKKDYWTWCVESVFEMHRILSDVYPHGsLQI 71   Caenorhabditi...
XP_015795275    2 FPISHKTVIVLDNSYRFlSTSCGQPLDYDVC--HKMKGgtpsgiiplAPLAKSLWTSSVEAIQEYSRIVYDVFPGGeRLL 79   two-spotted s...
XP_002414011    3 fPASHKTVFVLDHSPYF-LMSCQQLIEFDIF--TKTRQpgi---iplAPISKSLWTCSVEAAIEYCRVVWDIFPTN-KLI 75   black-legged ...
4_pfamImport    1 FSLDHKTVFVLDHGPAL-AESSKQTVDFDIF--SKARPqgv---vplAPVSKSLWTCCTEALCEYSRVVWDIFPGE-KFL 73  
Q6DIK0          4 FSESHKTVFVVDHCPYM-SESCRQHVEFDML--TKNRTqgi---iplAPISKSLWTCAIEASMEYCRIMYDIFPFR-KLV 76   tropical claw...
Q5TZE9          4 FSVSHKTAFVVDHCPYM-AESSRQLIECDML--TKSRSqgv---iplAPVAKSLWTCAVECSMEYCRILYDIYPTK-KLV 76   zebrafish
XP_003108191  944 EQLKMKTVIMLDRSAKF-IDDSNETFDIAIRegPKQKK---------VEFKKDIWTWCMEGLFEMQRVLADVYPLGnIPI 1013 Caenorhabditi...
O44500          2 EQRDMKTVFLLDRSAKF-VENCNETFDVTIRegPKQKK---------LQFEKTIWTWCLEGIFEMHRILSDVYPRGtLQL 71   Caenorhabditi...
XP_307882       2 NEINHKTVFVLDHTPYF-GISCESPIDCD-F--IKSKva-------vPPISKSLWTCAVEASVEYCRIAYDLFPVG-KLI 69   Anopheles gam...
XP_022527430    4 FSVSHKTVFVVDHCPYM-AESSRQQIECDVL--TKSRSqgv---iplAPVSKSLWTCAVECSMEYCRILYDIYPSK-KLV 76   Mexican tetra
CAP22953       72 RIALADYLARMLDaEWTTDLITRAELGELIEKTGKPCPE------------DIDIDSTCGWQMAIEALAVESPEQieHNF 139  Caenorhabditi...
XP_015795275   80 SLVTCDEIGFKIAmGWNNEQQNLSNLNACFARSSYNTRSrassfpmgecfgTDDSTLVNGVKAALEALGTPTVTQtqMRK 159  two-spotted s...
XP_002414011   76 RFVVSGTSARHLN-TWLQEDQSMAHLMAVMAQVGAPSESt----------nPKKCNILTGLTAAIEALCQCSEVQ--HEY 142  black-legged ...
4_pfamImport   74 RYIVSDCSAVALN-SWKFDEQSMSHLMTSLASVGPPLRK-------------SECSVIPGLVSAVAALCEATETQ----- 134 
Q6DIK0         77 NFIVSDSGSRTLN-SWNQEDQNLQELMAALAVIGPPNPRa----------dPECCSILHGLVEAVESLCKITDYQ--HES 143  tropical claw...
Q5TZE9         77 NYIVSDSEVHILN-SWKQEDQNTHDLMSALAAVGPPNPRq----------dPECCSVLHGLVAAVESLCKITEYQ--HES 143  zebrafish
XP_003108191 1014 RFAVADYMGKMLEtEWKNKLLSREELGKIVVEIGRPSES------------NTDITPVGGLTMAIEALAVETSEQkeYNY 1081 Caenorhabditi...
O44500         72 RFALADFMGKMLDtQWTDGFLTREELGELIETVSRPSEA------------NTDITPIGGLTMAIEALAVQSPEQrnYNY 139  Caenorhabditi...
XP_307882      70 RFVVSDTAAHIVN-TWNTNTQSLTHILNAMSMVGVPPRQt----------qASDYSVIHGLRAAIEALAEPTEFQ--KEQ 136  Anopheles gam...
XP_022527430   77 NYIVSDSEFHILN-SWRQEDQSVQELMAALAAVGPPNPRe----------dPECCSILHGLVAAVESLCKITEYQ--HES 143  Mexican tetra
CAP22953      140 NarfnikkrsdqnsevarvtkelndepaSPAIENNGNLIIYTRYKTDEEMMEAKEEIASLVSSVNAIASSESnrTFCPIT 219  Caenorhabditi...
XP_015795275  160 K---------------------------SSRVANSGRVMLIAYLKNENQLKMVTEFMGDCLSKYNIAMREKDdpNRLPIN 212  two-spotted s...
XP_002414011  143 Rtsl---------------------setAGKIVNRGRVVCVTSLRSDSEMRSIEERFYSQLTEHNKLAASSD--SLMPVH 199  black-legged ...
4_pfamImport  135 Qqfls--------------------rnpTSNVHN-GKIICITQLKNDSHRRALEGCVADAVTRHNKLAESSS--GVLPLS 191 
Q6DIK0        144 Rtel---------------------menADRVANRGRIICITNAKSDSHVQMLEDCVNETIHEHNKLAAGSD--HLMQIQ 200  tropical claw...
Q5TZE9        144 Rttl---------------------mdmADRVANRGRIICLTNAKSDTHVRMLEDCVLETIQEQNKLAAGSD--RLMPIQ 200  zebrafish
XP_003108191 1082 DirynlnkrtsqnsevvrvtnelkntppFSTVENKGNLILFTRLKTEDEMEALQKEVASLVVSRNSIANAPSnkTFCPIT 1161 Caenorhabditi...
O44500        140 DvrysankrtaqnsevirvtrelrglppLPTVQNAGNLIMYTRLNTQEEMEQLQTEIVELVVSRNKIADAPSnkTFCPIT 219  Caenorhabditi...
XP_307882     137 Lavha--------------------ksdCFKLVNRGRVICITSARDDASMKSLEDIFRTVLVQQNAISAGHK--EYINID 194  Anopheles gam...
XP_022527430  144 Rtsl---------------------mdmAERVANRGRIICLTNAKSDTHVRMLEDCVLETIQEQNKLAAGSD--RLMPIQ 200  Mexican tetra
CAP22953      220 SLRVFIVNFYGADEECAVKT-HSLEEy---pDLPLLKFWVISRKASD----MCVAIHSVLVAAFDLSSTTVTKIPMKEDN 291  Caenorhabditi...
XP_015795275  213 ECHLTIVNVYPVGDLSPSSQiREIANy---yVSPTLSCEIHSSRGGTm---FALKLLSLVQSHYHLASTTVTGIPMKEEQ 286  two-spotted s...
XP_002414011  200 KCELVMIHTCPVNKESDVPT-VTKRD-----LGPILSSEVHRVRSGRh---LAAKLGYLVQVHYNLASTTVTGIPMKEEQ 270  black-legged ...
4_pfamImport  192 TVELAIVHVKAFGSDCSVTEtRHALP-----SSPGVLVEVHDVKATRhgisIGNRMLNLLQKHYNLSVTSITGIPMKEEQ 266 
Q6DIK0        201 KCHLVLIHTYPVGEDSLVSD-RPKKE-----LSNVLISEVHSVKAGRh---LSTKLNQLVQLHFDLASTTITNIPMKEEQ 271  tropical claw...
Q5TZE9        201 QCELVLVHIYPQGDDTLVSD-RQKKE-----LSSVLSSEVHSVRAGRy---LACKLNVLVQQHFDLASTTITNIPMKEEQ 271  zebrafish
XP_003108191 1162 ALRVFIVNYYAVGEDCTVKT-HPLLEh---pELPLLKFWVISRKVTD----MCVAIHSLLVASFDLGSTTVTKIPMKEDN 1233 Caenorhabditi...
O44500        220 SLRLFIVNYYATGDECTVKT-HSLQAh---pDLPLLKIWVISRKAAD----MCDAIHSLLVDAFDLGSTTVTKIPMKEDN 291  Caenorhabditi...
XP_307882     195 QCHLVIINLYPANMESMVSN-RALIE-----ISPILLSEIHSNKANT----ISNKLTHLILPHFDLASTTVTGIPMKEEQ 264  Anopheles gam...
XP_022527430  201 QCELVLVHIFPQGDDTLVSD-RPKKEvrlrdISSVLSSEVHSVRAGRh---LASKLNVLVQQHFDLASTTITNIPMKEEQ 276  Mexican tetra
CAP22953      292 RG--STNYDVELFHSSKVHEQLKENNlIARV----SEKGnanSGVTYDTMRLTWTtAPKiKWTL---------------- 349  Caenorhabditi...
XP_015795275  287 NAssSANYDVEIVHPADAHVNLPKIA-TGAGggdgSCNRipkEDTNYETIPLKWC-TPR-TTSVe--------------- 348  two-spotted s...
XP_002414011  271 NAnsSANYDVELLHPSAAHTELFKTGfSNTEgvhvSTVK---EGQTYETVTLKWC-TPR-SNSVe--------------- 330  black-legged ...
4_pfamImport  267 HAnsSANYDVLLMHERL-------GGsGNTAqikvT------DNELTSAMSLKWC-TPK-INVNe--------------- 316 
Q6DIK0        272 HAntSANYDVELLHHKEAHVEFNKSAgEGYNg---SSSR---ENCLKETVTLKWC-TPR-TNSVe--------------- 328  tropical claw...
Q5TZE9        272 HAntSANYDVELLHHRDAHMEFIKSGdLHMAg---STSR---DSGLKETVTLKWC-TPR-TNSVe--------------- 328  zebrafish
XP_003108191 1234 RG--STNYDVELFHSGQVHTLLKEKElIAIE----SKKGradEGPTYDSIRLTWTtAPKsRWSLvrflsglkrfnlihfk 1307 Caenorhabditi...
O44500        292 RG--SSNYDVELFHSGKVHAMLKENNlIDTV----SKKGdsdKGVTYDTMRLTWTtAPKtKWSL---------------- 349  Caenorhabditi...
XP_307882     265 NAssSANYDVEIFHGRTAHSVFLG---TELVl--pHSLK---DGSDYETVTLKWC-TPRsCGSSe--------------- 320  Anopheles gam...
XP_022527430  277 HAntSANYDVELLHHRDAHMEFIKSGdLHMVg---TTSR---DSGLKETVTLKWC-TPR-TNSVe--------------- 333  Mexican tetra
CAP22953      350 FPYHDDAVPCTTAVAYSRPSACLTQFVRDGRCVMLDSEKTSllgmnmPDKLVSHILIANRGRMYILDIDFMQKKMRRLQR 429  Caenorhabditi...
XP_015795275  349 LHHCSSAYRISPVDVNSRPSSCLTNFLLSGRTVMLEMTKLK------GSKVMSHMLSSHNGELYIHTLYTGRSLLEDPPS 422  two-spotted s...
XP_002414011  331 LQYCTGAYRITPVDINSRPSSCLTNFLLGGRAVMLEMPRKV------GSKVMSHMLASHGGEIYIHTLGTGRSTLEDPPS 404  black-legged ...
4_pfamImport  317 LHHCSGAARISPVDVNSRPSLCLTNFLLNGRSVLLEHWQKSes--sgNSSKNTHMISCCGSDIFLHALDVYQVPFEDPPS 394 
Q6DIK0        329 LHYCTGAFRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKS------GSKVISHMLSSHGGEIFLHVLSSSRSILEDPPS 402  tropical claw...
Q5TZE9        329 LHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKS------GSKVISHMLSSHGGEIFLHVLNSTRSTLEDPPS 402  zebrafish
XP_003108191 1308 FPYHGAAVPCTTAVAYSRPSACLTQFVRDGRCVMLDSEKTSefgmnmPEKLVSHILIANRGRIFIQEIDFMQKKFDKSRV 1387 Caenorhabditi...
O44500        350 FPYHGAAVPCTTAQAYSRPSACLTQFVRDGRCVMLDSEKTTelgmnmHEKLVSHLLIANRGRIFIQEIDFMQKKAD--RI 427  Caenorhabditi...
XP_307882     321 MQPCLAQCRVTPVDVTSRPSSCLINFLLSGRSVLLEMPKKS------GGKITSHLLSAHGGEIFIHSLNTARSCLEDPPS 394  Anopheles gam...
XP_022527430  334 LHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKS------GSKVISHMLSCHGGEIFLHVLNSTRSTLEDPPS 407  Mexican tetra
CAP22953      430 LRELKPPRRVRirdpinv-hqlkhtFKQIEF-KKVGKNFLEDDnvaEQKG--KQRKRLKTLDIQKRLRCITKNIPMYQED 505  Caenorhabditi...
XP_015795275  423 ISEGIGGRITD--------------YRINDFgELMKRIKLSPI---KPSLisVEKTISPIDRAIGFLTRQTLYWPIVLGH 485  two-spotted s...
XP_002414011  405 ISEGCGGRVTD--------------YRINDFgEFMKENKLVPY---RVGP--NDRHELPIDRAQKRLQRLTQYWPMVISH 465  black-legged ...
4_pfamImport  395 ISDGAGGRVTD--------------YRINDFtKVVKKAELLPF---GSKL--KSIEGDPIELSVKLLNRLSKQWPLVFSK 455 
Q6DIK0        403 ISEGCGGRVTD--------------YRITDFgEFMRENRLMPFaepRYCM--DGGPEVPLERAKEQLERHTRYWPMIISQ 466  tropical claw...
Q5TZE9        403 ISEGCGGRVTD--------------YRITDFgEFMRENRLTPFp--DSMV--DAAGRAPIERAKSQLERHTRYWPMIISQ 464  zebrafish
XP_003108191 1388 VRQVKFPKATYgpkdpinlnqlkhtYKQMEL-KLVAKNRM-NEdmtEKRE--KKWKALKNSNIEKRFSRISKNIPAYADD 1463 Caenorhabditi...
O44500        428 AGKLKRPRVLHapedpinmnqlrhtYKQLEL-RFVAKNRM-DDnltEKET--EKWTGLKNSDLKKRFQRISKNIPCFAAD 503  Caenorhabditi...
XP_307882     395 ISEGGGGRVTD--------------YRIKDFgALMQQHRLVPL---KPLP--ERQPDEHLQKMRGKLARNSRYWPLTLGR 455  Anopheles gam...
XP_022527430  408 ISEGCGGRVTD--------------YRITDFgEFMRENRLTPFp--DMPV--DAAGRLPFERAKAQLERHTRYWPMIISQ 469  Mexican tetra
CAP22953      506 TFIFysdEVTKKLEPLVTKITKRRLTPADVQQCNSKIMKLHQMRALKEFIVPEDAdiDaclvEDLSDP---EEQMRVAIV 582  Caenorhabditi...
XP_015795275  486 SIMF---NLQLHIAPLINLIPKDSLSVEDVNECKNAIYQIVKMESKGTSLVLPCV--A----NRGKGPk-kEELYKLLWK 555  two-spotted s...
XP_002414011  466 TTIF---NMASQLDPLLTLITKEALTPDEIIECKKVIYLLVAMESKGTSLPVPTI--G----VRGKGPk-rEEQYRTMWN 535  black-legged ...
4_pfamImport  456 TIVY---NMKQ-VEPLLDIITKENITQEELVDCQRVIYHLISMEKDGTALPVAGS--T----TRGTNKhkrEEQYQSMWS 525 
Q6DIK0        467 TTIF---NMQAVV-PLASVIVKESLSEEDVLNCQKTIYNLVDMERKNDPLPISTA--G----TRGKGPk-rDEQYRIMWN 535  tropical claw...
Q5TZE9        465 TTIF---NMQAVV-PLANLIVKDTLTEEDVLTCQKTVYNLVDMERKSDPLPISTV--G----SRGKGPk-rDEQYRIMWN 533  zebrafish
XP_003108191 1464 TFIFq-pNVTNKLEPLITVITKKKLTPADVEQCKAKIMKIHQMRALKEFIVPEEEdiElcpvEDLSDP---EEQIRVAIV 1539 Caenorhabditi...
O44500        504 TFIFn-eKVTPKLEPLISLITKTTLSENDVDKCKQCIVTLYQMKNERQYVISPESdiKissvRNLKDP---DEQLRVTFV 579  Caenorhabditi...
XP_307882     456 TVLY---NVRHFVEPLLLLTQKPELSEEEKMLCLKSIYNLSQLEERQEVLALPNM--G----HRLKGNk-kEEQYRLLWS 525  Anopheles gam...
XP_022527430  470 TTIF---NMQAVV-PLANLIVKDSLTEDDVLTCQKTVYNLVDMERKNDPLPISTV--G----SRGKGPk-rDEQYRIMWN 538  Mexican tetra
CAP22953      583 ELAKHLMKYSNFsVRHKAVYKTFMTTMGADKLLEvdleddeaiDKMFVKRPFFMKTRGDTDV------------------ 644  Caenorhabditi...
XP_015795275  556 ELDHYIEIHAST-PQHKEILSTLRDLHVTATSDTnqv---vknEPMSPDRANSPNGDKPATSsviipplqvpsssssmpt 631  two-spotted s...
XP_002414011  536 ELENYIRMHCVT-AEHNVILDCLLECRKPADSDTgtsnhkgagAKKPAEKVVSVKDEKGEGK------------------ 596  black-legged ...
4_pfamImport  526 ELEGLLRMHSPIsTNHKQVLDCLLKCNGKGSEGN-------------------PPDDKPEAKfsvt-------------- 572 
Q6DIK0        536 ELETLVRAHVRGsDRHQRVMDCLMACRSKPPEEE---------ERKKRGRKREDKEEKAEKPp----------------- 589  tropical claw...
Q5TZE9        534 ELETLVKTHVGTsERHQRVLECISACRSKPPEEE---------ERKKRGRKREDKEDKTEKNg----------------- 587  zebrafish
XP_003108191 1540 ELAKHLVKYVTYsDRHSQIYKTFMTTLGADKLLKvdaedyeavDNMFPKSPFFDGEE----------------------- 1596 Caenorhabditi...
O44500        580 ELAKHIMKYVTFsEKHKEIYKTYMTTLNVDKLLEvdldddeavDKMFVKFSFFGKSD----------------------- 636  Caenorhabditi...
XP_307882     526 ELETIVNCNGAS-PAHKAIVGCIRECRRMYPSAD-----------------GADPYDKTHGGt----------------- 570  Anopheles gam...
XP_022527430  539 ELETLVKTHVGTsERHQQVLECISACRSKPPEEE---------ERKKRGRKREDKEDKTEKNg----------------- 592  Mexican tetra
CAP22953      645 -----SSESESSDtcssCSDEEEEEMEEDDnkegegsgHRSRNMLkrflkyadrdgspt-----------ivdksknakl 708  Caenorhabditi...
XP_015795275  632 ftsniKDEALMAWkeldSYNNMTEREKREL--------DEKNKPPakr-------------------------------- 671  two-spotted s...
XP_002414011  597 -----WSEVDLGW-------------REGKfgdvekgeDGAGKAQ----------------------------------- 623  black-legged ...
4_pfamImport  573 --giyKPQNGDQPidriNEFHVNVLPSRVSskd--eifESPESPP----------------------------------- 613 
Q6DIK0        590 ----kENEHEKKWqe-sERVKSVLDREKEDlaeaevikDSPDSPE----------------------------------- 629  tropical claw...
Q5TZE9        588 ----kDTE-EKSWtadtERLKGVMDREKDEqseceiikDSPDSPE----------------------------------- 627  zebrafish
XP_003108191 1597 -----SEDSDSSDssdfSENSDSEEAEESDgs------eDSENTLttflnnsldrhrlps---------qkrkiskvevv 1656 Caenorhabditi...
O44500        637 -----------------TASKTDEDEDSSDdedeeilkSPALKKLfgyvdarderkyeel--------ygqgfkkkkpev 691  Caenorhabditi...
XP_307882     571 --------aEGGVaaaaAAAAAAADAHRASvir--attDSPMSPPhsmggstgaagasggatagggsnggtgggtgadat 640  Anopheles gam...
XP_022527430  593 ----kESE-EKTWtqdsERPKGLTEREKDDqsesevikDSPDSPE----------------------------------- 632  Mexican tetra
CAP22953      709 delLFELA------------------------------KDIEFDLFTNVceriEKKEEGQRREFVGRe--aHGNKAPLYP 756  Caenorhabditi...
XP_015795275  672 lriPDIQSpsdsnssvsladgringtamdakmangstsNQNLLSLWVNQ----LNLKYRKRPDFEGR----AFKIAPLYI 743  two-spotted s...
XP_002414011  624 ---PAKKArvssld-------------------egmlgCSSLLALWRNKv---TTENARRHVEFAGRln-gDGKVAILYP 677  black-legged ...
4_pfamImport  614 ---PVKKLkvenems-----------------irptkgAQSLLSMWQNHi---ENQNAQNHVEFYGRit-sDSNKARLYP 669 
Q6DIK0        630 ---PPNKKphimvedt--------------gpaekskgPMSLLSLWSSRi---NTANSRKHQEFVGRln-sVNNKAELYQ 688  tropical claw...
Q5TZE9        628 ---PLNKKprlateeq--------------qppekskgPVSLLALWTNRi---TQANSRKHQEFAGRls-sVNNKAELYQ 686  zebrafish
XP_003108191 1657 kekPIQLA------------------------------KDIEINIFAKMcdmlEKKESQIRREFVGRe--aHGNKAPLYL 1704 Caenorhabditi...
O44500        692 eekPIVMA------------------------------KEIKVDIFSNMcdmlEVKESKIRREFVGRe--tHGNIAPLYP 739  Caenorhabditi...
XP_307882     641 sssSGTSVtlavgsggvsvgllgargtmgsgkkgfgsgGRSLLDVLAST----ERAISQKRIDFSGRlctpSGQVAKLYS 716  Anopheles gam...
XP_022527430  633 ---PFNKKprlaseei--------------vsiekskgPVSLLSLWTSRi---TQANSRKHQEFAGRis-sVNNKAELYQ 691  Mexican tetra
CAP22953      757 QLA 759  Caenorhabditis briggsae
XP_015795275  744 NLN 746  two-spotted spider mite
XP_002414011  678 SLN 680  black-legged tick
4_pfamImport  670 DIE 672 
Q6DIK0        689 HLK 691  tropical clawed frog
Q5TZE9        687 HLK 689  zebrafish
XP_003108191 1705 QLM 1707 Caenorhabditis remanei
O44500        740 QLA 742  Caenorhabditis elegans
XP_307882     717 HVG 719  Anopheles gambiae str. PEST
XP_022527430  692 HLK 694  Mexican tetra
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