6SN1


Conserved Protein Domain Family
Mat89Bb

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pfam10221: Mat89Bb (This model is not part of the current CDD release)
Cell cycle and development regulator Mat89Bb
This is entry represents the cell cycle regulator Mat89b (also known as protein asunder), which plays an evolutionarily conserved role as a crucial regulator of both cell cycle and development. It is a component of INT (Integrator) complex, being involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5. Mat89Bb is also required for the correct dynein-dynactin perinuclear localization. Mat89Bb is a PNG kinase substrate, that is essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.
Statistics
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PSSM-Id: 519249
Aligned: 18 rows
Threshold Bit Score: 789.26
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SN1_A         61 FSESHKTVFVVDHCPYM-AESCRQHVEFDML--VKNRTqgi---iplAPISKSLWTCSVESSMEYCRIMYDIFPFK-KLV 133  human
XP_015795275    2 FPISHKTVIVLDNSYRFlSTSCGQPLDYDVC--HKMKGgtpsgiiplAPLAKSLWTSSVEAIQEYSRIVYDVFPGGeRLL 79  
EEC17319        3 fPASHKTVFVLDHSPYF-LMSCQQLIEFDIF--TKTRQpgi---iplAPISKSLWTCSVEAAIEYCRVVWDIFPTN-KLI 75  
4_pfamImport    1 FSLDHKTVFVLDHGPAL-AESSKQTVDFDIF--SKARPqgv---vplAPVSKSLWTCCTEALCEYSRVVWDIFPGE-KFL 73  
Q6DIK0          4 FSESHKTVFVVDHCPYM-SESCRQHVEFDML--TKNRTqgi---iplAPISKSLWTCAIEASMEYCRIMYDIFPFR-KLV 76   tropical claw...
5_pfamImport    1 NEINHKTVFVLDHTPYF-GISCESPIDCD-F--IKSKva-------vPPISKSLWTCAVEASVEYCRIAYDLFPVG-KLI 68  
EFO92991      944 EQLKMKTVIMLDRSAKF-IDDSNETFDIAIRegPKQKK---------VEFKKDIWTWCMEGLFEMQRVLADVYPLGnIPI 1013
O44500          2 EQRDMKTVFLLDRSAKF-VENCNETFDVTIRegPKQKK---------LQFEKTIWTWCLEGIFEMHRILSDVYPRGtLQL 71   Caenorhabditi...
XP_002634114    2 EQRDMKTVVVLDRNADF-AEETNETFDIAIRegVKQKK---------LEIKKDYWTWCVESVFEMHRILSDVYPHGsLQI 71  
XP_068075630    4 FSVSHKTAFVVDHCPYM-AESSRQLIECDML--TKSRSqgv---iplAPVAKSLWTCAVECSMEYCRILYDIYPTK-KLV 76   zebrafish
6SN1_A        134 NFIVSDSGAHVLN-SWTQEDQNLQELMAALAAVGPPNPRa----------dPECCSILHGLVAAVETLCKITEYQ--HEA 200  human
XP_015795275   80 SLVTCDEIGFKIAmGWNNEQQNLSNLNACFARSSYNTRSrassfpmgecfgTDDSTLVNGVKAALEALGTPTVTQtqMRK 159 
EEC17319       76 RFVVSGTSARHLN-TWLQEDQSMAHLMAVMAQVGAPSESt----------nPKKCNILTGLTAAIEALCQCSEVQ--HEY 142 
4_pfamImport   74 RYIVSDCSAVALN-SWKFDEQSMSHLMTSLASVGPPLRK-------------SECSVIPGLVSAVAALCEATETQ----- 134 
Q6DIK0         77 NFIVSDSGSRTLN-SWNQEDQNLQELMAALAVIGPPNPRa----------dPECCSILHGLVEAVESLCKITDYQ--HES 143  tropical claw...
5_pfamImport   69 RFVVSDTAAHIVN-TWNTNTQSLTHILNAMSMVGVPPRQt----------qASDYSVIHGLRAAIEALAEPTEFQ--KEQ 135 
EFO92991     1014 RFAVADYMGKMLEtEWKNKLLSREELGKIVVEIGRPSES------------NTDITPVGGLTMAIEALAVETSEQkeYNY 1081
O44500         72 RFALADFMGKMLDtQWTDGFLTREELGELIETVSRPSEA------------NTDITPIGGLTMAIEALAVQSPEQrnYNY 139  Caenorhabditi...
XP_002634114   72 RIALADYLARMLDaEWTTDLITRAELGELIEKTGKPCPE------------DIDIDSTCGWQMAIEALAVESPEQieHNF 139 
XP_068075630   77 NYIVSDSEVHILN-SWKQEDQNTHDLMSALAAVGPPNPRq----------dPECCSVLHGLVAAVESLCKITEYQ--HES 143  zebrafish
6SN1_A        201 Rtll---------------------menAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSD--HLMQIQ 257  human
XP_015795275  160 K---------------------------SSRVANSGRVMLIAYLKNENQLKMVTEFMGDCLSKYNIAMREKDdpNRLPIN 212 
EEC17319      143 Rtsl---------------------setAGKIVNRGRVVCVTSLRSDSEMRSIEERFYSQLTEHNKLAASSD--SLMPVH 199 
4_pfamImport  135 Qqfls--------------------rnpTSNVHN-GKIICITQLKNDSHRRALEGCVADAVTRHNKLAESSS--GVLPLS 191 
Q6DIK0        144 Rtel---------------------menADRVANRGRIICITNAKSDSHVQMLEDCVNETIHEHNKLAAGSD--HLMQIQ 200  tropical claw...
5_pfamImport  136 Lavha--------------------ksdCFKLVNRGRVICITSARDDASMKSLEDIFRTVLVQQNAISAGHK--EYINID 193 
EFO92991     1082 DirynlnkrtsqnsevvrvtnelkntppFSTVENKGNLILFTRLKTEDEMEALQKEVASLVVSRNSIANAPSnkTFCPIT 1161
O44500        140 DvrysankrtaqnsevirvtrelrglppLPTVQNAGNLIMYTRLNTQEEMEQLQTEIVELVVSRNKIADAPSnkTFCPIT 219  Caenorhabditi...
XP_002634114  140 NarfnikkrsdqnsevarvtkelndepaSPAIENNGNLIIYTRYKTDEEMMEAKEEIASLVSSVNAIASSESnrTFCPIT 219 
XP_068075630  144 Rttl---------------------mdmADRVANRGRIICLTNAKSDTHVRMLEDCVLETIQEQNKLAAGSD--RLMPIQ 200  zebrafish
6SN1_A        258 KCELVLIHTYPVGEDSLVSD-RSKKE--LSPVLTSEVHSVRAGRh---LATKLNILVQQHFDLASTTITNIPMK------ 325  human
XP_015795275  213 ECHLTIVNVYPVGDLSPSSQiREIANyyVSPTLSCEIHSSRGGTm---FALKLLSLVQSHYHLASTTVTGIPMK------ 283 
EEC17319      200 KCELVMIHTCPVNKESDVPT-VTKRD--LGPILSSEVHRVRSGRh---LAAKLGYLVQVHYNLASTTVTGIPMK------ 267 
4_pfamImport  192 TVELAIVHVKAFGSDCSVTEtRHALP--SSPGVLVEVHDVKATRhgisIGNRMLNLLQKHYNLSVTSITGIPMK------ 263 
Q6DIK0        201 KCHLVLIHTYPVGEDSLVSD-RPKKE--LSNVLISEVHSVKAGRh---LSTKLNQLVQLHFDLASTTITNIPMK------ 268  tropical claw...
5_pfamImport  194 QCHLVIINLYPANMESMVSN-RALIE--ISPILLSEIHSNKANT----ISNKLTHLILPHFDLASTTVTGIPMK------ 260 
EFO92991     1162 ALRVFIVNYYAVGEDCTVKT-HPLLEhpELPLLKFWVISRKVTD----MCVAIHSLLVASFDLGSTTVTKIPMK------ 1230
O44500        220 SLRLFIVNYYATGDECTVKT-HSLQAhpDLPLLKIWVISRKAAD----MCDAIHSLLVDAFDLGSTTVTKIPMK------ 288  Caenorhabditi...
XP_002634114  220 SLRVFIVNFYGADEECAVKT-HSLEEypDLPLLKFWVISRKASD----MCVAIHSVLVAAFDLSSTTVTKIPMK------ 288 
XP_068075630  201 QCELVLVHIYPQGDDTLVSD-RQKKE--LSSVLSSEVHSVRAGRy---LACKLNVLVQQHFDLASTTITNIPMKptlnvc 274  zebrafish
6SN1_A        326 --EEQHAntSANYDVELLHHKDAHVDFLKSGdSHLGg--gS--R---EGSFKETITLKWC-TPR-TNNIe---------- 384  human
XP_015795275  284 --EEQNAssSANYDVEIVHPADAHVNLPKIA-TGAGggdgScnRipkEDTNYETIPLKWC-TPR-TTSVe---------- 348 
EEC17319      268 --EEQNAnsSANYDVELLHPSAAHTELFKTGfSNTEgvhvStvK---EGQTYETVTLKWC-TPR-SNSVe---------- 330 
4_pfamImport  264 --EEQHAnsSANYDVLLMHERL-------GGsGNTAqikvT------DNELTSAMSLKWC-TPK-INVNe---------- 316 
Q6DIK0        269 --EEQHAntSANYDVELLHHKEAHVEFNKSAgEGYNg---SssR---ENCLKETVTLKWC-TPR-TNSVe---------- 328  tropical claw...
5_pfamImport  261 --EEQNAssSANYDVEIFHGRTAHSVFLG---TELVl--pHslK---DGSDYETVTLKWC-TPRsCGSSe---------- 319 
EFO92991     1231 --EDNRG--STNYDVELFHSGQVHTLLKEKElIAIE----SkkGradEGPTYDSIRLTWTtAPKsRWSLvrflsglkrfn 1302
O44500        289 --EDNRG--SSNYDVELFHSGKVHAMLKENNlIDTV----SkkGdsdKGVTYDTMRLTWTtAPKtKWSL----------- 349  Caenorhabditi...
XP_002634114  289 --EDNRG--STNYDVELFHSSKVHEQLKENNlIARV----SekGnanSGVTYDTMRLTWTtAPKiKWTL----------- 349 
XP_068075630  275 eqEEQHAntSANYDVELLHHRDAHMEFIKSGdLHMAg---StsR---DSGLKETVTLKWC-TPR-TNSVe---------- 336  zebrafish
6SN1_A        385 -----LHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKS------GSKVISHMLSSHGGEIFLHVLSSSRSIL 453  human
XP_015795275  349 -----LHHCSSAYRISPVDVNSRPSSCLTNFLLSGRTVMLEMTKLK------GSKVMSHMLSSHNGELYIHTLYTGRSLL 417 
EEC17319      331 -----LQYCTGAYRITPVDINSRPSSCLTNFLLGGRAVMLEMPRKV------GSKVMSHMLASHGGEIYIHTLGTGRSTL 399 
4_pfamImport  317 -----LHHCSGAARISPVDVNSRPSLCLTNFLLNGRSVLLEHWQKSes--sgNSSKNTHMISCCGSDIFLHALDVYQVPF 389 
Q6DIK0        329 -----LHYCTGAFRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKS------GSKVISHMLSSHGGEIFLHVLSSSRSIL 397  tropical claw...
5_pfamImport  320 -----MQPCLAQCRVTPVDVTSRPSSCLINFLLSGRSVLLEMPKKS------GGKITSHLLSAHGGEIFIHSLNTARSCL 388 
EFO92991     1303 lihfkFPYHGAAVPCTTAVAYSRPSACLTQFVRDGRCVMLDSEKTSefgmnmPEKLVSHILIANRGRIFIQEIDFMQKKF 1382
O44500        350 -----FPYHGAAVPCTTAQAYSRPSACLTQFVRDGRCVMLDSEKTTelgmnmHEKLVSHLLIANRGRIFIQEIDFMQKKA 424  Caenorhabditi...
XP_002634114  350 -----FPYHDDAVPCTTAVAYSRPSACLTQFVRDGRCVMLDSEKTSllgmnmPDKLVSHILIANRGRMYILDIDFMQKKM 424 
XP_068075630  337 -----LHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKS------GSKVISHMLSSHGGEIFLHVLNSTRSTL 405  zebrafish
6SN1_A        454 EDPPSISEGCGGRVTD--------------YRITDFgEFMRENRLTPFldpRYKI--DGSLEVPLERAKDQLEKHTRYWP 517  human
XP_015795275  418 EDPPSISEGIGGRITD--------------YRINDFgELMKRIKLSPI---KPSLisVEKTISPIDRAIGFLTRQTLYWP 480 
EEC17319      400 EDPPSISEGCGGRVTD--------------YRINDFgEFMKENKLVPY---RVGP--NDRHELPIDRAQKRLQRLTQYWP 460 
4_pfamImport  390 EDPPSISDGAGGRVTD--------------YRINDFtKVVKKAELLPF---GSKL--KSIEGDPIELSVKLLNRLSKQWP 450 
Q6DIK0        398 EDPPSISEGCGGRVTD--------------YRITDFgEFMRENRLMPFaepRYCM--DGGPEVPLERAKEQLERHTRYWP 461  tropical claw...
5_pfamImport  389 EDPPSISEGGGGRVTD--------------YRIKDFgALMQQHRLVPL---KPLP--ERQPDEHLQKMRGKLARNSRYWP 449 
EFO92991     1383 DKSRVVRQVKFPKATYgpkdpinlnqlkhtYKQMEL-KLVAKNRM-NEdmtEKRE--KKWKALKNSNIEKRFSRISKNIP 1458
O44500        425 D--RIAGKLKRPRVLHapedpinmnqlrhtYKQLEL-RFVAKNRM-DDnltEKET--EKWTGLKNSDLKKRFQRISKNIP 498  Caenorhabditi...
XP_002634114  425 RRLQRLRELKPPRRVRirdpinv-hqlkhtFKQIEF-KKVGKNFLEDDnvaEQKG--KQRKRLKTLDIQKRLRCITKNIP 500 
XP_068075630  406 EDPPSISEGCGGRVTD--------------YRITDFgEFMRENRLTPFp--DSMV--DAAGRAPIERAKSQLERHTRYWP 467  zebrafish
6SN1_A        518 MIISQTTIF---NMQAVV-PLASVIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTV--G----TRGKGPk-rDEQY 586  human
XP_015795275  481 IVLGHSIMF---NLQLHIaPLINLIPKDSLSVEDVNECKNAIYQIVKMESKGTSLVLPCV--A----NRGKGPk-kEELY 550 
EEC17319      461 MVISHTTIF---NMASQLdPLLTLITKEALTPDEIIECKKVIYLLVAMESKGTSLPVPTI--G----VRGKGPk-rEEQY 530 
4_pfamImport  451 LVFSKTIVY---NMKQ-VePLLDIITKENITQEELVDCQRVIYHLISMEKDGTALPVAGS--T----TRGTNKhkrEEQY 520 
Q6DIK0        462 MIISQTTIF---NMQAVV-PLASVIVKESLSEEDVLNCQKTIYNLVDMERKNDPLPISTA--G----TRGKGPk-rDEQY 530  tropical claw...
5_pfamImport  450 LTLGRTVLY---NVRHFVePLLLLTQKPELSEEEKMLCLKSIYNLSQLEERQEVLALPNM--G----HRLKGNk-kEEQY 519 
EFO92991     1459 AYADDTFIFq-pNVTNKLePLITVITKKKLTPADVEQCKAKIMKIHQMRALKEFIVPEEEdiElcpvEDLSDP---EEQI 1534
O44500        499 CFAADTFIFn-eKVTPKLePLISLITKTTLSENDVDKCKQCIVTLYQMKNERQYVISPESdiKissvRNLKDP---DEQL 574  Caenorhabditi...
XP_002634114  501 MYQEDTFIFysdEVTKKLePLVTKITKRRLTPADVQQCNSKIMKLHQMRALKEFIVPEDAdiDaclvEDLSDP---EEQM 577 
XP_068075630  468 MIISQTTIF---NMQAVV-PLANLIVKDTLTEEDVLTCQKTVYNLVDMERKSDPLPISTV--G----SRGKGPk-rDEQY 536  zebrafish
6SN1_A        587 RIMWNELETLVRAHINNsEKHQRVLECLMACRSKPPEEE---------ERKKRGRKREDKEDKSEKavK----------- 646  human
XP_015795275  551 KLLWKELDHYIEIHAST-PQHKEILSTLRDLHVTATSDTnqv---vknEPMSPDRANSPNGDKPAT--Ssviipplqvps 624 
EEC17319      531 RTMWNELENYIRMHCVT-AEHNVILDCLLECRKPADSDTgtsnhkgagAKKPAEKVVSVKDEKGEG--K----------- 596 
4_pfamImport  521 QSMWSELEGLLRMHSPIsTNHKQVLDCLLKCNGKGSEGN-------------------PPDDKPEA--Kfsvt------- 572 
Q6DIK0        531 RIMWNELETLVRAHVRGsDRHQRVMDCLMACRSKPPEEE---------ERKKRGRKREDKEEKAEK--Pp---------- 589  tropical claw...
5_pfamImport  520 RLLWSELETIVNCNGAS-PAHKAIVGCIRECRRMYPSAD-----------------GADPYDKTHG--Gt---------- 569 
EFO92991     1535 RVAIVELAKHLVKYVTYsDRHSQIYKTFMTTLGADKLLKvdaedyeavDNMFPKSPFFDGEE------------------ 1596
O44500        575 RVTFVELAKHIMKYVTFsEKHKEIYKTYMTTLNVDKLLEvdldddeavDKMFVKFSFFGKSD------------------ 636  Caenorhabditi...
XP_002634114  578 RVAIVELAKHLMKYSNFsVRHKAVYKTFMTTMGADKLLEvdleddeaiDKMFVKRPFFMKTRGDTD--V----------- 644 
XP_068075630  537 RIMWNELETLVKTHVGTsERHQRVLECISACRSKPPEEE---------ERKKRGRKREDKEDKTEK--Ng---------- 595  zebrafish
6SN1_A        647 ------------DYEQEKSW-QDSERLKGILERGKEElaeaeiikDSPDSPEPPNK------------------------ 689  human
XP_015795275  625 ssssmptftsniKDEALMAWkELDSYNNMTEREKREL--------DEKNKPPAKRLr----------------------- 673 
EEC17319      597 ------------WSEVDLGW-------------REGKfgdvekgeDGAGKAQ---------------------------- 623 
4_pfamImport  573 ---------giyKPQNGDQPiDRINEFHVNVLPSRVSskd--eifESPESPP---------------------------- 613 
Q6DIK0        590 -----------kENEHEKKW-QESERVKSVLDREKEDlaeaevikDSPDSPE---------------------------- 629  tropical claw...
5_pfamImport  570 ---------------aEGGVaAAAAAAAAAADAHRASvir--attDSPMSPPHSMGgstgaagasggatagggsnggtgg 632 
EFO92991     1597 ------------SEDSDSSDsSDFSENSDSEEAEESDgs------eDSENTLTTFLnnsldrhrlpsq---------krk 1649
O44500        637 ------------------------TASKTDEDEDSSDdedeeilkSPALKKLFGYVdarderkyeelyg--------qgf 684  Caenorhabditi...
XP_002634114  645 ------------SSESESSDtCSSCSDEEEEEMEEDDnkegegsgHRSRNMLKRFLkyadrdgspti-----------vd 701 
XP_068075630  596 -----------kDTE-EKSWtADTERLKGVMDREKDEqseceiikDSPDSPE---------------------------- 635  zebrafish
6SN1_A        690 ---------KPLvemdetp-------------------qvekskgPVSLLSLWSNRi---NTANSRKHQEFAGRln-sVN 737  human
XP_015795275  674 ---------IPDiqspsdsnssvsladgringtamdakmangstsNQNLLSLWVNQ----LNLKYRKRPDFEGR----AF 736 
EEC17319      624 ----------PAkkarvss-------------------ldegmlgCSSLLALWRNKv---TTENARRHVEFAGRln-gDG 670 
4_pfamImport  614 ----------PVkklkvene-----------------msirptkgAQSLLSMWQNHi---ENQNAQNHVEFYGRit-sDS 662 
Q6DIK0        630 ----------PPnkkphimved--------------tgpaekskgPMSLLSLWSSRi---NTANSRKHQEFVGRln-sVN 681  tropical claw...
5_pfamImport  633 gtgadatssSSGtsvtlavgsggvsvgllgargtmgsgkkgfgsgGRSLLDVLAST----ERAISQKRIDFSGRlctpSG 708 
EFO92991     1650 iskvevvkeKPIql------------------------------aKDIEINIFAKMcdmlEKKESQIRREFVGRe--aHG 1697
O44500        685 kkkkpeveeKPIvm------------------------------aKEIKVDIFSNMcdmlEVKESKIRREFVGRe--tHG 732  Caenorhabditi...
XP_002634114  702 ksknakldeLLFel------------------------------aKDIEFDLFTNVceriEKKEEGQRREFVGRe--aHG 749 
XP_068075630  636 ----------PLnkkprlatee--------------qqppekskgPVSLLALWTNRi---TQANSRKHQEFAGRls-sVN 687  zebrafish
6SN1_A        738 NRAELYQHLK 747  human
XP_015795275  737 KIAPLYINLN 746 
EEC17319      671 KVAILYPSLN 680 
4_pfamImport  663 NKARLYPDIE 672 
Q6DIK0        682 NKAELYQHLK 691  tropical clawed frog
5_pfamImport  709 QVAKLYSHVG 718 
EFO92991     1698 NKAPLYLQLM 1707
O44500        733 NIAPLYPQLA 742  Caenorhabditis elegans
XP_002634114  750 NKAPLYPQLA 759 
XP_068075630  688 NKAELYQHLK 697  zebrafish
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