6SYT


Conserved Protein Domain Family
Smg8_Smg9

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pfam10220: Smg8_Smg9 
Smg8_Smg9
Smg8 and Smg9 are two subunits of the Smg-1 complex. They suppress Smg-1 kinase activity in the isolated Smg-1 complex, and are involved in nonsense-mediated mRNA decay (NMD) in both mammals and nematodes.
Statistics
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PSSM-Id: 402016
View PSSM: pfam10220
Aligned: 24 rows
Threshold Bit Score: 914.803
Threshold Setting Gi: 239977625
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SYT_B    42 WREDEICVVGIFGKTALRlNSEKFSLVNTvcdRQVFPlFRHQDpgdpgpgirteagavgeaggaedpgaaaggsvrgsga 121 
B4JE52    24 ELKNSLVVVGVVGRSKCS-LANKMSVFGM---QPEET-HEPAN------------------------------------- 61   Drosophila grimshawi
B4LS82    24 ELQNSLVIVGIIGRSKCA-QANKMSAFGM---QPDKT-HEPAD------------------------------------- 61   Drosophila virilis
O62301    17 QLDTKIKVIGVIGKDy-P-DHGKGDNINCylrENVFPvAATEDe------------------------------------ 58   Caenorhabditis ele...
EFO94737  17 QLDTKIKVIGIIGKDy-P-DHGKGDNINCylrENVFPvTTGENe------------------------------------ 58   Caenorhabditis rem...
B4MV81    23 KLGDSLVVVGVLGRSRNR-HANKMQAFDM---KPNSSnYQPIE------------------------------------- 61   Drosophila willistoni
B4GH42    24 QLGRSLVVVGVIGRSRCV-LANKMRAFGM---EPPVD-HEPTD------------------------------------- 61   Drosophila persimilis
Q9VKQ6    23 QLNGSLVVVGIVGRSDCD-QANKMVAFGM---EPPSE-HTPKD------------------------------------- 60   fruit fly
B3MJV4    22 QLENSMVVVGIVGRSKCE-RANKMQAFGM---SPPME-HTPAD------------------------------------- 59   Drosophila ananassae
B4KKN5    24 ELNNSLVVVGVIGRSRGP-QANKMSAFDM---RPNKL-HEPAD------------------------------------- 61   Drosophila mojavensis
6SYT_B   122 vaegnrteagsqdySLLQAYYSQESKVLYLLLTSICDNSQLLRACralqsgeagggLS-----LPHAEAHEFWKHQEKLQ 196 
B4JE52    62 --------------GQIMCYYKPGTSTLLLHFESTHDEVVLGQKL-----------LE-----QTSIDFDHFYGNMRSQF 111  Drosophila grimshawi
B4LS82    62 --------------GQILCYYKPGTNMLLLHFETTHDEAVLGQQL-----------LK-----QTSVDFDSFYEQMRSRF 111  Drosophila virilis
O62301    59 -------------tCTIRGHFSEDDQILFLVMNGVDDVANIRKCL-----------KSnp-----kSNYFDAMAESECQQ 109  Caenorhabditis ele...
EFO94737  59 -------------tCSISAHFSDDEQILFLVMNGADDVANIRKCL-----------NSen---rkTTNYFDAMAESESQE 111  Caenorhabditis rem...
B4MV81    62 --------------GQILCYFTPGTSTLFLHFETPWDEVILSKLL-----------LEek--dPEKFDFDQFYETTRNRF 114  Drosophila willistoni
B4GH42    62 --------------GQLQCYYKPGSSTLLLHFETTFDDAILGQQI-----------DEtmeqdGAPFDFDGFYERMKCRF 116  Drosophila persimilis
Q9VKQ6    61 --------------GQMQCYYKPGTSILLLHFESTYDAEIAGQMI-----------DVciedvDTPFDIDSFFEGIRCRF 115  fruit fly
B3MJV4    60 --------------GQVQCYYKRGTSCIFLHFETTYDEPILHRMI-----------EDsmadhQNAFDFDHFYEQMRSRF 114  Drosophila ananassae
B4KKN5    62 --------------GQILCYYKPGTNTLMLHFETTYDEAVLSQQL-----------LS-----QTSIDFDNFYYRMRSRF 111  Drosophila mojavensis
6SYT_B   197 CLSLLYLFSVCHILLLVHPTCSFDITYDRVFRALDGLRQK-VLPLLKTA-----IKDCP----VGKDWKLNCRPCPPRLL 266 
B4JE52   112 VRMMLLALHTCHIVVYVETGQTFDPALVTICQLLKYVREQhLLEFLPQL-----LRETS----AGNLLGDRARLCTPRIL 182  Drosophila grimshawi
B4LS82   112 LRMLLLALHVCHILVYVETAQTFDTTLVTICQLLKYVREKhVLDFLPQM-----LRETA----AGSLLSDRARLCTPRVL 182  Drosophila virilis
O62301   110 IRMLHFLFISCHFIIIFEQTSRIDLELMRFLKKVNSARIQ-LRKKINQRlvasdLRDVSfnnrILSSAESEGRMVVPRLL 188  Caenorhabditis ele...
EFO94737 112 MRMLHFLFISCHFIIIFEQTSRIDLEFMRFLKKVNSLRLQ-LRKKVNKLlvssgLRDVSfnnrTMTNSESEGRMVIPRLL 190  Caenorhabditis rem...
B4MV81   115 IRHMTLALHVCHILVYVETAQIFDMKLVTIFQLLKQVREQqIMQFAPQL-----LAELPl---VGR--GVKCRLCTPRIL 184  Drosophila willistoni
B4GH42   117 VRMMLLALHVCHILVYVETGQTFDLSLVTIFQLMKFAREQhLMQFLPSL-----LKETP----AGRLLGEKCRLCTPRIL 187  Drosophila persimilis
Q9VKQ6   116 VRMMLLALHVCHIVVYVETGQTFDPTLITVFQLAKFAREQhLMQFLPQM-----LRETP----AAR-MSERTRLCTPRIL 185  fruit fly
B3MJV4   115 VRMMLLALHTCHIIVYVETGPTFDPTLVTVFQLLKFSREQhLKQFLPQM-----LRDTP----AAK-LGEKSRLCAPRIL 184  Drosophila ananassae
B4KKN5   112 VRNMLLALHVCHIVVYVDTAEIFDTTLVTICQLLKYVREQhVLEFLPQM-----LHETS----VGLMLGDRARPCTPRML 182  Drosophila mojavensis
6SYT_B   267 FLFQ---------------LNGAlkvepprnqdpahpDKPKKHSPKRRLQHALEDQIYRIFRKSRVLTNQSINCLFTVPA 331 
B4JE52   183 FIFE---------------NYPA--------------DVEKTREFISTHEFQTEDKIYELFRQYNIVMQSASNSLLALPN 233  Drosophila grimshawi
B4LS82   183 FLFE---------------NYPQ--------------DEEKSRERISAYEFQTEDKIYELLRQYNIVTNNANNSLFALPN 233  Drosophila virilis
O62301   189 IAFQrnnirpd-----------------------vnpgkkLQRELYEKLEKNLDNQFSDILKLYD-LIDCGASSLCQLNE 244  Caenorhabditis ele...
EFO94737 191 VAFQrnnirpdvnvnkkrsARNF--------------AKLFKQELYEKLEKNLDNQLTDILKLYD-LIDCGANSLCQLNE 255  Caenorhabditis rem...
B4MV81   185 FLFE---------------NYPH--------------DEEKTKETISAYEFQTEDSIYQLLRHHNIVTNSSSSSLLALPN 235  Drosophila willistoni
B4GH42   188 FLFE---------------NFTH--------------EEGKTRECVSACEFQTEDSIYELLRHHQIITNSSSSSLLALPN 238  Drosophila persimilis
Q9VKQ6   186 FLFE---------------NFPS--------------DEPKTRECVSTYEFQMEDCIYELLRHHNIVTNSSSNSLVALPN 236  fruit fly
B3MJV4   185 FLFE---------------NFPS--------------DELKTRENVSAYEFQTEDNIYEMLRHHHIFTNSSPSSLVALPN 235  Drosophila ananassae
B4KKN5   183 FLFE---------------NYPR--------------DEEKTRDHISSYEFKTEDQIYHLLRQYNILTNNVNTSLVALPN 233  Drosophila mojavensis
6SYT_B   332 NQAFVYIVPGSQE-EDPVGMLLDQLRSHC-------TVKDPESllvPAPLSGPRRYQVMRqHSRQQlsfhiDSSss---- 399 
B4JE52   234 NKQFVFYNANEILrPDRLLLAIDALNATMyk----qDVKEEEE---DLEIIALAPFEGFVkPFGDAy----TVRks---- 298  Drosophila grimshawi
B4LS82   234 NKQFVFYNAHEKLrPDQLLLAIEALNATMyk----sDSKEEEE---DTEILELAPFEGFVkPYGAGy----EARes---- 298  Drosophila virilis
O62301   245 TIPVVHLLNPKIVkRDIIGEMFEILMADAentkisgN------------------------------------------- 281  Caenorhabditis ele...
EFO94737 256 TIPIVHLLNPNIVkRDIVSEMFEIFMAEAentkltgN------------------------------------------- 292  Caenorhabditis rem...
B4MV81   236 NKQFVFYNAYEDLhPDRLLQAIDSLNRAIqk----tDLKEDEE---DLEILELSPFEGFVkPFGEFp----VSRaillnp 304  Drosophila willistoni
B4GH42   239 NKQFVFYNAHDQLhADRLLQSIEFLNLDMrk----lDVKEEED---DLEVLELAPFDGFVkSFGESf----ESTny---- 303  Drosophila persimilis
Q9VKQ6   237 NKQFVFFNAHEELrEDTLMKAVECLNETMyk----pDLKEEEE---DLEILALAPFDGFVkPFALPv----DEKew---- 301  fruit fly
B3MJV4   236 NKQFVYFNAHEELhPDYLLKAIDCLNKTMfk----pDMREEEE---DLEILELAPFEGFCkPFG-Pp----GERdv---- 299  Drosophila ananassae
B4KKN5   234 NKQFVFYNAHEELhPDQLSHAIEALNTTMnk----pDAKEEDE---DLDIISLAPFEGFVkPFGADy----KTRds---- 298  Drosophila mojavensis
6SYT_B   400 --sSSGQLVDFTLREFLWQHVELVLSKkGFDDSVGRN-P-QPSHFELPTYQKWISAASKLYEVAIDG--KEEDLGSptgE 473 
B4JE52   299 --dEQLYRESHTVWHFLQRHVQDALEG-CFDEGSFKQ-LsQSPPFQLLNFKTWHMCMVSIHKLLVGN--VEDVNYV---S 369  Drosophila grimshawi
B4LS82   299 --dEQLYRKKHTVWHFLQRHVQDALQG-CFDEGSFKQ-LpQSAQFQLLGVNDWHICMDTIHRLLIGN--IQEVSYV---T 369  Drosophila virilis
O62301   282 ---AGTLPSNNSFVKFLEDNFR-----------------------------------------------SEKNEISl--E 309  Caenorhabditis ele...
EFO94737 293 ---NHKLASNNSFVKFLEDNFR-----------------------------------------------SERNEITl--E 320  Caenorhabditis rem...
B4MV81   305 kdeEEQYKKDHTAWHFLQRHVQDALQN-CFDEGSFKQgSpQGQQFQRLNINDWHKWMDNLYKILIAN--VANSNYE---T 378  Drosophila willistoni
B4GH42   304 --eEQQYKTEHTAWHFLQRHVQDALLG-CFDEGSFKQ-VpQRGQLQLLNAQEWHDCIAELHKLLVSSagTQESLNE---I 376  Drosophila persimilis
Q9VKQ6   302 --dNQQYKKDHTVWNFLERHVQDALMG-CFEAGSFKQ-HaQQGTFQLLNSKEWHDCMATMHTLLVEN--TKDPNLE---T 372  fruit fly
B3MJV4   300 --eAQQYKRQHTAWHFLQRHIQDALHG-CFDEGSFKQ-LpHLGQFQLLSFPEWQGCMDTLTQLLVEN--AKDTNFE---T 370  Drosophila ananassae
B4KKN5   299 --kELDYKKNHTAWHFLQRHVQDALQG-YFDEGSFKL-LtQTPQYQLLSARDWHSCMAEIYRLLIQN--VHDANYV---T 369  Drosophila mojavensis
6SYT_B   474 LTSKILSSIK-VLEGFLDIDTKFSENRCQKALPMAHSAYQSNLPHNYT-----------------------MTVHKNQ-- 527 
B4JE52   370 TNAHYQAYLR-DFTESLNYEKRFWYHLSELGLKKGISAYKHSAAVTYG-----------------------SAAHKQM-- 423  Drosophila grimshawi
B4LS82   370 NNQNYKAYLR-DFNESLNYEKKFWGHLCDLGLKKGISAYKSSAPAIYG-----------------------SVTHRQL-- 423  Drosophila virilis
O62301   310 NVIELMNCLQcVLDGDLEEKHEKTA--IQTFIKRIQNDHMEEARRLYTnaqrpgerrg---adrfkdsekpVKIRSKEeh 384  Caenorhabditis ele...
EFO94737 321 NVIKVMTTLQcVLDGSLEENPDSTVTQMQSFIKRIQTDHLEEARRLYTnekrpisgerrgfrmtdmevtepVRIRSKEeh 400  Caenorhabditis rem...
B4MV81   379 NNEDYRVYLR-NFDQSLNYERKFWLHLCELGLKKGISCYKHSVPAFYG-----------------------QETHDKL-- 432  Drosophila willistoni
B4GH42   377 RNEDYQVFLQ-SFDESLNYEKKFWAHLCEIGLKMGIEAYKKAAPAIYG-----------------------SSMHQQL-- 430  Drosophila persimilis
Q9VKQ6   373 SNEEYKNFLK-NFDESLNYEKKFWAHLCELGLKKGIAAYKNAAPENYG-----------------------SATHRQL-- 426  fruit fly
B3MJV4   371 NNEEYKNFLL-NFEDSLNYEKKFWAHLCELGLKKGISSYKSSAPANYG-----------------------SATHRKL-- 424  Drosophila ananassae
B4KKN5   370 DNTNYQAYLR-ELNESLNYEKKFWCHLCELGLKKGVSAYRNAAPAIYG-----------------------SATHNQL-- 423  Drosophila mojavensis
6SYT_B   528 ---LAQALRVYSQHARGPAFHKYAMQLHEDCYKFWSNGHQLCEERSLTDQHCVHKFHslpksgekpeAdrnpPVLYHNSR 604 
B4JE52   424 ---LANATLVFEEEGRGPYAELALAKLNDVCLRYWHDGRQQCEFPSLRGNPCILPRD----------V----SHDKHSSG 486  Drosophila grimshawi
B4LS82   424 ---LADAILAFEEEGRGPYAELALAKLSEICLRHWHDGRQQCEQLSLRGNPCTQPKD----------A----PHDKHSSG 486  Drosophila virilis
O62301   385 lmrFNEAT-HYIDSVVGVNSREALSQLQAQCNEMWQSDMRACESVSMMGRSCVRKIHptfgdqtapeH----RWTAHDAS 459  Caenorhabditis ele...
EFO94737 401 qmrFNEAT-LYIESVVGVNSPQILSEMQAQCNEMWQSDLRACESISMMGHPCIKKVHptygdqtapeS----RWTSHDAS 475  Caenorhabditis rem...
B4MV81   433 ---LAEAILAFEEEGRGPPSEATRAKLSAICLKYWQDGRQQCEQLSLRRHPCTQAKE----------A----PHEKHASG 495  Drosophila willistoni
B4GH42   431 ---LAEATLAFEEEGRGPPAEASIAKMTATCLRHWQDGRQQCEQLSLRSQPCTQPKE----------M----PHDKHNSG 493  Drosophila persimilis
Q9VKQ6   427 ---LAEATLAFEEEGRGPQAQAALAKLASICHKHWQDGRQQCEQLSLRSHPCTLPKK----------V----PHEKHNSG 489  fruit fly
B3MJV4   425 ---LAEATIAFEEEGRGPPAQAALARMAAICLKHWQDGRQQCEKLSLRSQPCTLPKD----------V----PHDKHNSG 487  Drosophila ananassae
B4KKN5   424 ---LADATLAFEEEGRGPYVEMALAKLSDVCLKYWHDGRQQCEQLSLRGHPCTLPKD----------L----AHDKHSSG 486  Drosophila mojavensis
6SYT_B   605 ARSTGACNCGRKQAPRDDPFDIKAANYDFYQLLEEKC--CGKLDHINFPVFE---PSTPDPAPAKNESS----------- 668 
B4JE52   487 VVHISSCNCGRTLGRREDPYTLRQANYDYYEHMAVMCnlCVKVKRFQFPVFT---PSISDYRAAAFEAAfplllqahknr 563  Drosophila grimshawi
B4LS82   487 IVHISSCNCGRTQGRREDPFTLRQANYDYYEHMAAMCnlCVKVKKFQLPVFT---PSISDYRAAAFEAAfplllqaaknr 563  Drosophila virilis
O62301   460 NTMISTCVCGRKQLIRPEPFSVKEANSDFYDHPDFKC--CRRLWRYQFQLYQedsEEKDDIMWADRESN----------- 526  Caenorhabditis ele...
EFO94737 476 NTSVGTCICGKKQMVRQEPFSVKEANCDFYENPEFKC--CKRLWRYQFQLYQedtEEKDDIMWADRESN----------- 542  Caenorhabditis rem...
B4MV81   496 IIHVSSCNCGRTQGRREDPFTLRQANYEFYEYMAQICnlCVKVKQYQFPIFE---PSVSDYRAAAFEAAfpllhggkpn- 571  Drosophila willistoni
B4GH42   494 VIHVSSCNCGRTQGRREDPFSLRQANYEFYEHMVKMCnlCVKVKQFKFPIFE---PTNNEYRAAAFEVAfpllhagknrl 570  Drosophila persimilis
Q9VKQ6   490 VIHISSCNCGRTQGRREDPFNLRQANYEFYEHIAQMCnlCVKVKQYQFPIFE---PSVSDYRAAAFEAAfpllnngksga 566  fruit fly
B3MJV4   488 VIHISSCNCGRTQGRREDPFNLRQANYDFYELIAQICnlCVKVKQYQFPIFE---PSVSDYRAAAFDAAfpmlntgkict 564  Drosophila ananassae
B4KKN5   487 IVHISSCNCGRTQGRREDPFTLRQANYDYYEQLAVMCnlCVKVKKFQFPLFT---PSISDYRAAAFEAAfplllasknrl 563  Drosophila mojavensis
6SYT_B   669 ----------------------------PAPPDSDADKLKEKEPQ--TQGESTSLSLA-----LSLGQST---------- 703 
B4JE52   564 aepqveedsdqeanaaeepysqpateaePEPEKEPQASANEWSQPm-SATYGSDLNMSiagfgVSLKEGGaeaevee--- 639  Drosophila grimshawi
B4LS82   564 teiatggd--sdleaagelysqpinateQAPQKPQITLSNGCSQPalSATYGSDLNMSiagfgASLNEGEevrspeiss- 640  Drosophila virilis
O62301   527 --------------------------------SLRAAKKMAQREDelAEE-DTDLDIP-----ESLLDPDstsp------ 562  Caenorhabditis ele...
EFO94737 543 --------------------------------SLRAAKKMAQREDelAEETIDDLDIP-----ESLRESEssseft---- 581  Caenorhabditis rem...
B4MV81   572 -------------------aeggeqaagACEEDEQLT--NGCSQPl-SATFGSDLNMSig-dfDSLLEGSqveepeis-- 626  Drosophila willistoni
B4GH42   571 aqd-----------aeldpdeedeelptGEREEQHITQSNGCSQPl-SPTFGSDLNMSiagfgVSLNESEpcfd------ 632  Drosophila persimilis
Q9VKQ6   567 pqded-------aeedeaeeeegqeqeqPTEEQLQNTASNCCSQPl-SPTFGSDLNMSiagfgASLKESQasse------ 632  fruit fly
B3MJV4   565 pqg------------edenedgeteeadeDTEEKEQAEGDNCSQQl-SPTFGSDLNMSiagfgASLNESQesse------ 625  Drosophila ananassae
B4KKN5   564 epavqgds-dldaeaadelysqpikaaePAPQKQLQTLGDCCSQPl-SATYGSDLNMSiagfgDSLNEGEdadadadspe 641  Drosophila mojavensis
6SYT_B   704 -------------DSLGTYPADPQaggDNPEVHGQV-EVKTEkr----------------pnFVDRQASTVEYLPGMLHS 753 
B4JE52   640 ------aevcdkgSQDNSTSSDTS---TESEIELQPkERSAQk-------------------ANQILISTTEYLPGLVHM 691  Drosophila grimshawi
B4LS82   641 -----qiassglsSRSNSTSSGTSsanTANELVLQLkERTDQnaanaavse--icpealpivASTEQVSTTEYLPGLVHM 713  Drosophila virilis
O62301   563 ---------sdedDVRVRTMSSSEsssQESDAYLRPtSRRDEsmaskterel-tidhvkrmqKLELAGKSEDFLITVPNS 632  Caenorhabditis ele...
EFO94737 582 -------dsdedeDIRVQSASDSLs---DTDSFIRPnSRREEltssakterdlavehakrmqKLEKSGKMDEFLMGVPNS 651  Caenorhabditis rem...
B4MV81   627 -----ygsadeddEESLSNTNESLsenTENELVLQFkGPQKAannddeld----etetivqsSGGYSNSTTEYLPGLVHT 697  Drosophila willistoni
B4GH42   633 ---------qsssSEAESTCSGTSseeSNNELVLQLkEPAKKheescdp-------dsiaplPSMCLTSTTEYLPGLVHT 696  Drosophila persimilis
Q9VKQ6   633 ---------qllnSEQNTTSSGTSsadTDNELVVELqEPAKKeare------------dagpAHAVSTSTTEYLPGLVHT 691  fruit fly
B3MJV4   626 ---------qlsgSEHESPNSGTSsadTENELVLQIkEPARKestp----------------tggFSTSTTEYLPGLVHT 680  Drosophila ananassae
B4KKN5   642 irsqicssgqssrSRSNSSSSDTSsanTENELVLQLkERSDQknatealse--scpesqsvaSMPELVSTTEYLPGLVHM 719  Drosophila mojavensis
6SYT_B   754 NCPKGLLPKFSSWSLVKLGPAKSYNFHTGL-D--QQGFIPGTNYLMP----WDIVIRTRAEDEgdldtnswpaPNKAi-- 824 
B4JE52   692 CSGLELLPLFPSWSLACVGPSSIYSHNTGLqEhfQSGFLSGANYLLP----WDVQVRLVQPHY----------KHQQ--- 754  Drosophila grimshawi
B4LS82   714 SSGCELLPLFPSWSLACVGPSSIYSHNTGLqEhfQSGFLSGANFLLP----WDVHVRLVQPHK-----------HPQq-- 776  Drosophila virilis
O62301   633 MT-TGKLPIFPSWHLTSLGDSSIYSHGAGLkN--QPNFKIGGDYLSPvvvlLDVNFDVWNRDL----------------- 692  Caenorhabditis ele...
EFO94737 652 LT-AGKLPIFPSFFLTCLGDSSIYKHAGGLkD--QPNFKMGGEYLSPavvfLDVNPDVWARDV----------------- 711  Caenorhabditis rem...
B4MV81   698 FSNPSLLPMFPSWSLACVGPSSIYSHNTGLqEhfQSGFLSGANFLLP----WDVHVRLVQAQK------------NQh-- 759  Drosophila willistoni
B4GH42   697 LSKVGLLPLFPSWSLACVGPSSIYSHNTGLqEhfQSGFLSGANFLLP----WDVQLRLVHASK----------HYHNs-- 760  Drosophila persimilis
Q9VKQ6   692 VSNFGLLPLFPSWSLACVGPSSIYSHNTGLqEhfQSGFLSGANFLLP----WDVQLRLVHAPK------------QQy-- 753  fruit fly
B3MJV4   681 VSDFGLLPLFPSWSLACVGPSSIYSHNTGLqEhfQSGFLSGANFLLP----WDVLLRLVHANK----------HHQQhhh 746  Drosophila ananassae
B4KKN5   720 CSACELLPLFPSWSLACVGPSSIYSHNTGLqEhfQSGFLSGANFLLP----WDVHVRLLQPHH----------KHPP--- 782  Drosophila mojavensis
6SYT_B   825 ---pGKR-SAVvMGRGRR------RDDIARAFVGFEYEDSRGRRFMCS-GPDKVMKVMGSg-PKESALK-----ALNSDM 887 
B4JE52   755 ----QQLmGKK-NQRYRKq----gDRLALKIFIGFEYECSRGHRFMMR-SPERVLRGGADi-ERDTSTK-----VINNNM 818  Drosophila grimshawi
B4LS82   777 ---qQQSmGKK-SQRYRKh----gDRLALKIFVGFEYECSRGHRFMMC-SPDRVLRGGADi-ERDTSSK-----VVNNNM 841  Drosophila virilis
O62301   693 ----NKIrSEDfSRKCGKdn--kdDSARVKLFVGFEYECSRGHRFFVDyNGEPLIYSKGSnvIRESAHRsslgnVLQADL 766  Caenorhabditis ele...
EFO94737 712 ----NKMrSEDsSRKCGKeq--kdDVPRVKLFVGFEYECSRGHRFFVDhRGEPIIYSKGSsiIRESTHRaslgdVLDSDL 785  Caenorhabditis rem...
B4MV81   760 ---hLQQmGKKhLQRYRKshlsggDRLTLKIFVGFEYECSRGHRFMMC-SPERVLRGGADi-ERDTSHK-----VVHQNM 829  Drosophila willistoni
B4GH42   761 ---hQPHmSKK-QQRYRKh----gDRMVLKIFVGFEYECSRGHRFMMC-RPDRVLRGGADi-ERDTCSK-----MVHTNM 825  Drosophila persimilis
Q9VKQ6   754 ---qQQHhGKK-QQRWKKq----gDRLSLKIFVGMEYECSRGHRFMMC-APDRVLRGGADi-ERETCSM-----VVHNNM 818  fruit fly
B3MJV4   747 nmhlQQHpGKK-QQRWKKq----gDRLSIKIFVGMEYECSRGHRFMMC-APDRVLRGGADi-ERDTCNK-----VVHSNM 814  Drosophila ananassae
B4KKN5   783 ----LQQmGKK-NQRYRKq----gDRLALKIFVGFEYECSRGHRFMMC-SPDRVLRGGADi-ERDTCSK-----LVNNNM 846  Drosophila mojavensis
6SYT_B   888 PLYILSSSqgRGLKPHYAQLMRLFVVVPDAPLQIILMPQV-----QpgpppcPVFYPEKQE-ITLPPDGLWVLRFPYAYV 961 
B4JE52   819 PLYFPCPC--RAQNTFLAQLMRIHVVTPKAPVNIILDPKVlv--gK------YTFTLGCSIlPMLSQSAYWILRLPYVYQ 888  Drosophila grimshawi
B4LS82   842 PLYFPCPC--RAQPTYLAQLMRIHVVTPKAPVNIILDPKMcv--gK------YTFTLGCPTlPRLSQSAYWILRLPYVYQ 911  Drosophila virilis
O62301   767 PIRRPCTC--RKLPLQSAQLQKVHVVTPKAPVHITIDPKVlipthE------GVYGTG-QEpLELHHSKYYILHLPTVYS 837  Caenorhabditis ele...
EFO94737 786 PLRRPCTC--RKLPLKSAQLQKIHVVTPKAPVHISINPKMlvpghE------GVYGTG-QEpLELHHSKYYILHLPVVYS 856  Caenorhabditis rem...
B4MV81   830 PLYYPCPC--RSQSNYLAQLMRIHVVTPKAPVNIILDPRVcv--gQ------YTFTLGTVSpPRLSQSAYWMLRLPYVYQ 899  Drosophila willistoni
B4GH42   826 PLYYPCPC--RSQNNYLAQLMRIHVVTPKAPVNIIVDPKVcmgkdK------YTFTLGSMVpPRLSQSAYWILRLPYVYQ 897  Drosophila persimilis
Q9VKQ6   819 PLYYPCPC--RSQNNFLAQLMRIHVVTPKAPVNIIVDPKVcv--gR------YTFTMGSIVpPRLSQSAYWIIRLPYVYQ 888  fruit fly
B3MJV4   815 PLYYPCPC--RSQSNYLAQLMRIHVVTPKAPVNIIVDPKVcv--gK------YTFTLGTIIpPRLSQSAYWILRLPFVYQ 884  Drosophila ananassae
B4KKN5   847 PLYFPCPC--RGQVSFLAQLMRIHVVTPKAPVNIIVDPKVrv--gK------YTFTLGCTVlPRLSQSAYWILRFPYVYQ 916  Drosophila mojavensis
6SYT_B   962 TERGPCFPPKE---NVQLMSYKVLRGV 985 
B4JE52   889 GDNEIIAPPEKiepTNRLAGGCILAGL 915  Drosophila grimshawi
B4LS82   912 GDNVLITPPERlepDDNMASGCLLAGM 938  Drosophila virilis
O62301   838 GPSGAWMPGE----FNPEKQGVWMGGA 860  Caenorhabditis elegans
EFO94737 857 GPSGTWMPEE----YSSDKQGTLRKGA 879  Caenorhabditis remanei
B4MV81   900 GDDNLLTPPQKleaDDILSGGYLLAGM 926  Drosophila willistoni
B4GH42   898 GDDALIAPPEKlepDDIMAGGYLLAGM 924  Drosophila persimilis
Q9VKQ6   889 GDDVLIAPPEQldpGYPLTGGYLLPGM 915  fruit fly
B3MJV4   885 GDNVMIAPPEKldpDNPMAGGYLLPGM 911  Drosophila ananassae
B4KKN5   917 GDNVLIAPPAKfepDDPFASGCLLAGM 943  Drosophila mojavensis
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