Conserved Protein Domain Family
Rrn6_beta-prop

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pfam10214: Rrn6_beta-prop (This model is not part of the current CDD release)
Rrn6, beta-propeller
RNA polymerase I-specific transcription-initiation factor Rrn6 is a component of a multisubunit core transcription factor, essential for the initiation of rDNA transcription by Pol I. The DNA-bound core factor (CF) resembles a right hand holding the DNA molecule between the fingers and the palm, with the thumb pointing toward Pol I. The palm is composed of the N-terminal regions of Rrn11 and Rrn6, the thumb is composed of the C-terminal of Rrn11 while the fingers and knuckles are composed of Rrn7 and the C-terminal half of Rrn6, respectively. This entry represents the beta-propeller domain of Rrn6 which is part of the palm (or module I in) of the CF which interacts with Rrn11.
Statistics
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PSSM-Id: 519244
Aligned: 44 rows
Threshold Bit Score: 196.804
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE08759      147 LLAHGEISDIRVGERKS--CQVLAMATGESGHALRIVRV------T-PQDWAWAASGn--ISLELN------NIDVQDEG 209 
CCE84255      127 LTCTFRIRNHDDVV-----SKVFVYVTGETGCILNLCEM------RmSTHRLFSSKKgtyHGIA--------NIPDLGKP 187 
XP_004178204  170 LLVINKAQNVSEGRLDTatYQLLVYASGQSNSWLNIAVIk-------PKDSNYVIQTpklTPIKEIaideifGIK----- 237 
XP_003685981  187 LMVIGLLQTVADLRANKdpQQVIAYVSGNSDSVLNIAVL------TrSKKEFIKVDKhtkVPGKTW------EIKDQKSI 254 
XP_003671474  188 LIDVGIIQTLNDIRKGVdgTEIIVYVCGNTSSTLCISRY--------TDDSSYLLPT----------------------- 236 
XP_001646320  187 LLHVIKIQTVSDLRNGKdpHNFVVCVSGNSRSRLVLGVM------DdDYVPLSEPDTameTKARTW------FIKTSKNI 254 
XP_022463654  203 TMTMGIVQTAADVRNDVk-SQILAYL-GPQKHQLMLSLV--------SASSPENNLKcysRVGA---------------- 256 
XP_003959014  210 LFVIGNVQSSSDLRHDNeqRQIIAFSTGHSGSNLIISPLkl--epSdTEHDIYSIAGcssVF------------------ 269 
XP_003682278  185 LLITGAVQTIPDLRNNYnqHHIIAFSCGKTNSILKIGLLeytspsS--------------------------LTEQIRQA 238 
XP_056085986  178 RLEIEHIQTASDLRNYRdgTEVIAYASGKTNSLLNVGVL--------TRQDTLHLNRhnnVT------------------ 231 
EPE08759      210 YWCGNALAINQIKFVVDNPakpMS-WWLIVQTSAETLLFEPTlgrtlaledapcPDIDSQGPSFISMDLKIRIPMNETGG 288 
CCE84255      188 FKVTISEPIKQVGSKEASNalqPFp-IIIVRTDHKIFVLTSE------------PSEKGKKGVNFGLEMIGEIGYGSLKG 254 
XP_004178204  238 -KININATIKSIKIPTFSSlynKSsEILTLLTSDSLHILKI-------------LDILPEY-RVFNYKIYEPLRFNDFSD 302 
XP_003685981  255 ESIELNSPIKKILFPQLSAifrRMsDLIGILTENSLHIIKV-------------SNFNCQT-LKFKFQQYKYLSYSSLGD 320 
XP_003671474  237 -YINLQSPIKNIKIGRLSKnmlRAsDCIGILTENSFYVLKL-------------HQLHDPE-SNLSYILYGPLTFNEFND 301 
XP_001646320  255 VNIPYQTQIKKIVFPKLSDmfdRTpDMFAVITDTFIQIIKI-------------TNINSTS-GNITYSLSEKLKFNEFSD 320 
XP_022463654  257 -SISFSSKIISINFPKLAYsfsRAsDVIGIITKTSLHILKV-------------KGIDRKT-GEIDCVLFKPLHFSQLGD 321 
XP_003959014  270 -KIDLKSKIKTIKIPTVASslgRYsDCIIAITECSLHIIKI-------------KSIDNKY-TKIDCHVFDPLYFTELSD 334 
XP_003682278  239 ASIQLGSTIKGIKLPEYSSmldRRsDLIGVMTESALHVIKI-------------ECITSR--MEIKTSVCEPLPFQDFSD 303 
XP_056085986  232 -SIELHSPIRSIKIPRTSEsigRRsNLVGVITENSFQIFRI-------------ESIHSKS-CDVVITSSEPLYFVEVDD 296 
EPE08759      289 RMHCDMAFNPATSKrppQLAIVDDGGNWSVWNIIGDRHMRKt----------ILSTVLHAQGNLAEGLdpspyvatthGL 358 
CCE84255      255 HEFAHFSFDPYEDF---QFSVIDVKGNFGFWEIKYGPRNKSvkriqlkrnemEETLPNTSEYSIHDPL----------EL 321 
XP_004178204  303 FPIADVSFNPWDIH---QFAIVDIKGNWGIGVLP---KNKReg--------sSIKILREFQGTIFETD----------EL 358 
XP_003685981  321 FPFADFAFNPWDMN---ELAVIDIKGNWAVCSIS---SSLLkd--------dTIRVSQDARGTIYDPE----------EL 376 
XP_003671474  302 FTFADFAFNPWDIE---EFALVDIKGNWIIGSIPKLNKHAAt---------gKLFLKRHFSGTIFDIE----------EQ 359 
XP_001646320  321 FPFSDMAFNPWDMN---EIAVVDIMGNWSIGKIK---KSLNns--------wKISLVNDMSGSIFDEE----------EL 376 
XP_022463654  322 FPLADIAFNPWDMN---QFALIDIQGNWSIGQIPKSATKYGd----------VLSLSLESRGSVFQPD----------HT 378 
XP_003959014  335 FPFADVAFNPWDLT---QFAIIDTKGNWAIGSLPFQNKNFN-----------GLILNDSLRGSIFDPQ----------ET 390 
XP_003682278  304 FPFADFAFNPWDLQ---QFAVIDVKGNFGIGRLP---KSFKig--------hKARILREYGGSIFDPE----------EL 359 
XP_056085986  297 MQIVDFAFNPWDLQ---QFATIDVRGNWNIGMIP---KNFNnn-------krKLQLIDNLHGTIFDPE----------EL 353 
EPE08759      359 GHLNRIVWLplassgsgqaesskplhqnndasikaeasaaheeEQSMTLLLGNATAVNIVNIDHGK---KPVLTLNTVhs 435 
CCE84255      322 SNWKKIFWG----------------------------------NSNTNILAFSRSSITQFEVDKSAkgeRLVTFNTWS-- 365 
XP_004178204  359 SNWKKIAWS----------------------------------TKYTRILVLSRSKIVEVDFEENWq-nNLVEAKSWT-- 401 
XP_003685981  377 SNWKKIEWS----------------------------------SKFTKLIVMDRSKLFEIDFQKDLq-vEIIEAKTWS-- 419 
XP_003671474  360 SRWKKIEWS----------------------------------LSSSRILILNRSQMVEVDYRENWq-lQIIEAKTWS-- 402 
XP_001646320  377 SNWKKISWS----------------------------------SSYTRLVIMSRSQMIELDFMQNWq-iTIVEAKSWS-- 419 
XP_022463654  379 SLMKRIEWS----------------------------------NSFSRLLIVDPYGMTEIDFSENWq-vDLVEAITWS-- 421 
XP_003959014  391 SLRKKVIWS----------------------------------SHHTRILLMDQSKIVEVDFGLNWq-sEIVQAKTWS-- 433 
XP_003682278  360 SNWKKIEWS----------------------------------SSFSRLLVMDRSKMIELDFRQDWq-lEVIQSKTWS-- 402 
XP_056085986  354 SSWKKIEWF----------------------------------SQFQRILVFDRSKMIEIDFINGWq-aEVVQAKTWS-- 396 
EPE08759      436 gsldAIVDVQISpHNPAHIFVLTTVALFWFDlskVshhfnpkpvpgaPRAKQAQPLLLLSCPHLRNPTDRTIKLCLVSGA 515 
CCE84255      366 ----TLQDVQYS-NNHDFLFVLTSKEIIWFK---V----------------GPTLERLLSWKHFLDDNDPSLRISFMETT 421 
XP_004178204  402 ----SILDYKR--FNDSNGVLLTSKELIIIG----------------PKNGSSDLTRKISWKHDLKSTMGKLKISFTRIP 459 
XP_003685981  420 ----RLRDYKR--IDENISVLLTTKEIIAIR---Tnkn-------------tnCFDRILSWKHDLDPNDNTLKFSIQKII 477 
XP_003671474  403 ----RLRDYKR--VDDTISVLLTSREIIIIS---Tkdn-------------dgDLKRELSWKHDLDPSDCTIRMFIQRRR 460 
XP_001646320  420 ----TLRDYKR--VDDKMSVLLTSKEIIFLD---Tnsk-------------ndQITRKLSWKHDIS-LDNTIKFSFHLIK 476 
XP_022463654  422 ----EIRGFKN--IDESYSVLLTSREIIFLS-----------------TFMHRETKRELSWKHDLDTTDKSLTISVQKIN 478 
XP_003959014  434 ----ELLDLKE--MNEYFSILLTSQEIIFLR---Nksh-------------nnEITRDLSWKHNLDHNDKTYRMFIQKVD 491 
XP_003682278  403 ----RLLDYQR--LDDDYGILLTSREIIVIS---Tkqt-------------seHISREVSWKHDLDPNDSTLRFCIRKVN 460 
XP_056085986  397 ----NIRDYKR--VDDENGILLTSREIIIMGase-----------------anDAVRRISWKHDLDPDDTTLKVAIQKVK 453 
EPE08759      516 a----gAVTALIYSIKQPEAVVFRFPDAASGQEPTYEQQVIRFDYA 557 
CCE84255      422 cdkgetSFLCIIYSAVSPIMTIYNFGIRNEK--------PHSLKDP 459 
XP_004178204  460 igs-seLLLIFITSNTSNKIFCQGFLIEGENSIYCFTT-PFITKLE 503 
XP_003685981  478 kdk-vlTLIIYIFTSQSNNVYMHAFSIDTFNLQLTTSCQSNVMTIP 522 
XP_003671474  461 ept-vnLFSMFITSKRHNKVYVHVFSIDSDDKILQSYDESKLLNIP 505 
XP_001646320  477 gee-etEIIIFIYSKKHPLLYVHVFSINV-EGLLQASKNSRVITLP 520 
XP_022463654  479 cln-gtVVLSTIHSKKHNTIYLHPFSIN--NEVIQSLGQGILLKIP 521 
XP_003959014  492 dgy-kaIFFVYITSRRHKNVYMQAFTLTNNGELIRYVAEPIIFQIP 536 
XP_003682278  461 sgg-kkLLLVSIFSRNHSFLYIHPFLMNGDESLIQSAGSSTILQIP 505 
XP_056085986  454 mld-rlLLVAFVYSMRHNHIYVHAFSRKK-SNLFQSLGYSTVLEIS 497 
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