Conserved Protein Domain Family
Ax_dynein_light

?
pfam10211: Ax_dynein_light 
Axonemal dynein light chain
Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.
Statistics
?
PSSM-Id: 402009
View PSSM: pfam10211
Aligned: 69 rows
Threshold Bit Score: 94.177
Threshold Setting Gi: 1016052431
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_006678959  64 EDILNSILP--PRE--WD----EN-GQLWV-QKVSSTPATRLDVINLQEQLDHMLQ---KRQARETGI-CPVRR------ 123 Batrachochytriu...
XP_001582280  42 RDVLNSLFP--PIE--FE----QD-EIKYT-RSISTAPISKTDVTKLRTELDTLLH---KNKTKPKGI-DIIRS------ 101 Trichomonas vag...
XP_003246751  44 NKVFEYIYP--PEE--WM----ED-GVKWR-RVASTEPADRNHVLALAEDLKSNLS---YWHARMHGV-CLVRR------ 103 pea aphid
XP_003247366  41 kSILEEIFP--PRV--WTrivnNNnKVITLrQTISREPSNRDGVQKMIVMLNHLEQ---FFRFKKKGI-CEIRN------ 106 pea aphid
CZT99740      80 ffnLSLLFP--IKV--FK----KT-DKTLI--QLISEDTNLSDL----ELIQAVLK--------------NIENnnmdkl 130 Plasmodium falc...
XP_001616752  68 NEPLYNMFP--LKC--VR----DK-KVDQI--SYVCRVTSEEDATACLKKIQDIVSkmyAQNM-------LIEK------ 123 malaria parasit...
CAM68828     268 SRVLSSATAaaARS--AA-------STPVMwRRADVAHLSRLDVVLLYKHLERRCA---CESARPRGVvCPNRE------ 329 Leishmania infa...
Q4DXE3       141 RNTFCS-----TRE--FG-------ESKWM-KVAAIDHTSRLDCVHLQDHLNRRCK---EENARPSGVlCTIRE------ 196 Trypanosoma cruzi
Q389G1       155 ETLLYTLLP--PQRivCE----ET-GETIV-KSVSLEQPSRVEVAKLHERTLQQLQ---QRRAREWGI-CPLRR------ 216 Trypanosoma brucei
Q4DPW6       146 ERVLYTLLP--PRRtvCK----ET-GNTIL-QCVSTEPSSRVEVADLHERLTERLR---QRRARDSGI-CPIRR------ 207 Trypanosoma cruzi
XP_006678959 124 ------ELYSQCFD---ELIRQVTISCQERGLLLLRVRDEIRMSIAAYQTLYESSVAFGMRKAL--QAE----QGKSDME 188 Batrachochytriu...
XP_001582280 102 ------ELYSQCFE---EVIRQVTIDSNARGRLLFRIRNHYKTLIQSYKDLNELALNFGANKNI--QVT----LGMDQLL 166 Trichomonas vag...
XP_003246751 104 ------ELYTQCFN---ELIRQVCVNSIDRGQLLIKIRNEYNASIKAHKLLFESGLIFRIKHTT--LDD----HKDDVTE 168 pea aphid
XP_003247366 107 ------SVHNLFFD---EVLRQVIIMDEDLGAILFRIHNEFKNMIFILKCMYDKAV-------LtnNSN----RDSSNID 166 pea aphid
CZT99740     131 nffyveNIIFELLD---EIIRQVICEYPKRGFAVLLITNELQKNINYYKNLID----------IieHNNemntQGFKEMN 197 Plasmodium falc...
XP_001616752 124 ------DFLEDLLSvfmELCRQVSVTCFQRGSLLRQLFNYNSMLLFHYHKLVRSSLTFNLKKEI--KRShtmsELRQEME 195 malaria parasit...
CAM68828     330 ------CIYNDGLR---ELIRQVTLLCPERGLLLDELARRMRQAIETYDVLLDSANQYAVRKST--ERD----LHQYLFA 394 Leishmania infa...
Q4DXE3       197 ------GIYTDGLR---ELIRQTTVLCPERGLLLAELATEMQQTTNKYDILFDSASQYAVRKAI--ERD----MRSYLFD 261 Trypanosoma cruzi
Q389G1       217 ------EIYTELFD---ELIREITLEEPARGVLLLRIRDEMNQTLAAHRALAERTLLFASKQRM--EPP----EDISALR 281 Trypanosoma brucei
Q4DPW6       208 ------EVYAEVFD---ELIRQITLEEPTRGILLLRIRDELYQTLAAHSSLAERAMYFASKQRE--EAG----EGMDELK 272 Trypanosoma cruzi
XP_006678959 189 VKik----eLEDDKRQLEQNVLELKAKCEAIEKRESERRAMEERKHAEEI------------AFLKKTNVQLK 245 Batrachochytrium dendr...
XP_001582280 167 DYnk----kLREKRRELELEANNLQIQLDGLEKRIQENKQIREKEFADEI------------AFLKKQGQSIK 223 Trichomonas vaginalis G3
XP_003246751 169 KDiq----dIEDAHVKLKKKLVDANNKYNKLKTDLKNELNNLKDANQHEL------------SFFNRNHEALK 225 pea aphid
XP_003247366 167 PE-------LFTEVEELTRINNELKIKCRHSKQRHKERLKKKESGEDYKFlvslkmkyemlnNYIKRSTKQLK 232 pea aphid
CZT99740     198 EKnnlilqdLLVEENKLKEKLIDVQTRLELLKEENKKKLQENKNKKEIQY------------DLLKHNESLLD 258 Plasmodium falciparum 3D7
XP_001616752 196 RK--------KEAINSLRSEILDTDRLIEEERANAEREMSEVNIIYQNKI------------DKLKKNNQRKR 248 malaria parasite P. vivax
CAM68828     395 EKt-----dLETEVRRREHRVNEWRAKYAGLQKRFQEQQEADRKLHAEEI------------AYAKRANQQLV 450 Leishmania infantum JPCM5
Q4DXE3       262 DKk-----sMESEVRRLENRVNELRAKRDGMIKRFEEQKQSEQNRHEEEV------------KYLKKANQQII 317 Trypanosoma cruzi
Q389G1       282 QRik----eLEEEREELLVKRRMATVREEQIQSALLDENTARVKLWQDET------------CYYRRANRQVS 338 Trypanosoma brucei
Q4DPW6       273 RRih----eLEEKRLELIVRKKAVQVREEQILRAIEQENNTRSKLRQDEL------------GYYRRANRQLT 329 Trypanosoma cruzi
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap