Conserved Protein Domain Family
Ax_dynein_light
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pfam10211: Ax_dynein_light (This model is not part of the current CDD release)
Axonemal dynein light chain
Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.
Links
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Statistics
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PSSM-Id: 519241
Aligned: 64 rows
Threshold Bit Score: 100.725
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_009028373  71 QDILNAMLPPRE--WI-AN-EQQWIQHVSSTPATRSDVVNIQELLDKKLQ---QRQARETGI-CPVRRELYSQCFD---E 139
Q4DXE3       141 RNTFCS---TRE--FG----ESKWMKVAAIDHTSRLDCVHLQDHLNRRCK---EENARPSGVlCTIREGIYTDGLR---E 205 Trypanosoma cruzi
Q389G1       155 ETLLYTLLPPQRivCE-ET-GETIVKSVSLEQPSRVEVAKLHERTLQQLQ---QRRAREWGI-CPLRREIYTELFD---E 225 Trypanosoma brucei
Q4DPW6       146 ERVLYTLLPPRRtvCK-ET-GNTILQCVSTEPSSRVEVADLHERLTERLR---QRRARDSGI-CPIRREVYAEVFD---E 216 Trypanosoma cruzi
XP_001582280  42 RDVLNSLFPPIE--FE-QD-EIKYTRSISTAPISKTDVTKLRTELDTLLH---KNKTKPKGI-DIIRSELYSQCFE---E 110
4_pfamImport   1 NKVFEYIYPPEE--WM-ED-GVKWRRVASTEPADRNHVLALAEDLKSNLS---YWHARMHGV-CLVRRELYTQCFN---E 69 
Q8ILP2        68 NDPIYYIFPSKC--IK-VK-KAEHI-SYVSRVTNDEDIVLCLKRIYEVLSnmySKNM-------IIKEEYLNELLNiltE 135 Plasmodium falc...
Q4DLN1        85 RIVIDSFITPRA--WHdEA-GVLWVQHGSPHPVSRTETVETHEKLRRRMQ---ELGVQRTGI-CPLRSLLLAECFL---E 154 Trypanosoma cruzi
Q4QC94        97 RVVIDSFITPRR--WVdAStGVVWVQHASPFPSSRIDAAETQERLHAQLE---AHQARRTGT-SPIRSLLVAECML---E 167 Leishmania major
XP_001616752  68 NEPLYNMFPLKC--VR-DK-KVDQI-SYVCRVTSEEDATACLKKIQDIVSkmyAQNM-------LIEKDFLEDLLSvfmE 135 malaria parasit...

XP_009028373 140 LIRQVTINCAERGLLLLRVRDEIRLTLDAYQVLYESSVAFGMRKCLQSE----QGKVDMIKQIEDLTREKAELERQVAEE 215
Q4DXE3       206 LIRQTTVLCPERGLLLAELATEMQQTTNKYDILFDSASQYAVRKAIERD----MRSYLFDDK-KSMESEVRRLENRVNEL 280 Trypanosoma cruzi
Q389G1       226 LIREITLEEPARGVLLLRIRDEMNQTLAAHRALAERTLLFASKQRMEPP----EDISALRQRIKELEEEREELLVKRRMA 301 Trypanosoma brucei
Q4DPW6       217 LIRQITLEEPTRGILLLRIRDELYQTLAAHSSLAERAMYFASKQREEAG----EGMDELKRRIHELEEKRLELIVRKKAV 292 Trypanosoma cruzi
XP_001582280 111 VIRQVTIDSNARGRLLFRIRNHYKTLIQSYKDLNELALNFGANKNIQVT----LGMDQLLDYNKKLREKRRELELEANNL 186
4_pfamImport  70 LIRQVCVNSIDRGQLLIKIRNEYNASIKAHKLLFESGLIFRIKHTTLDD----HKDDVTEKDIQDIEDAHVKLKKKLVDA 145
Q8ILP2       136 LCRQISVTCFQRGLLLKQLFNYNIMLLFEYHKLVKSSLAFNLKKQMKQNdilnNFHKEIEKKnn----siNSLTKEIINT 211 Plasmodium falc...
Q4DLN1       155 VIRQVTAECWERGLLLLKIHTERTAAQTAHRELFESRVGHAFRLALKGE----KDTSRVQQDIEALKRRTEELAEEEKVL 230 Trypanosoma cruzi
Q4QC94       168 VLRQVTAECWERGLLLLHVHSERVAAQAAHRRLFESRVGHAFRLALKGE----KDVAKVEEDMAALKQRVELLGQEEADL 243 Leishmania major
XP_001616752 136 LCRQVSVTCFQRGSLLRQLFNYNSMLLFHYHKLVRSSLTFNLKKEIKRShtmsELRQEMERK----KEAINSLRSEILDT 211 malaria parasit...

XP_009028373 216 KARCEQTERRYQEQKHLEEKKHSDEVQFLKKINQQLKVQLEG 257
Q4DXE3       281 RAKRDGMIKRFEEQKQSEQNRHEEEVKYLKKANQQIISEIKR 322 Trypanosoma cruzi
Q389G1       302 TVREEQIQSALLDENTARVKLWQDETCYYRRANRQVSQRIKT 343 Trypanosoma brucei
Q4DPW6       293 QVREEQILRAIEQENNTRSKLRQDELGYYRRANRQLTQRIKS 334 Trypanosoma cruzi
XP_001582280 187 QIQLDGLEKRIQENKQIREKEFADEIAFLKKQGQSIKMIYDQ 228
4_pfamImport 146 NNKYNKLKTDLKNELNNLKDANQHELSFFNRNHEALKDQLKL 187
Q8ILP2       212 EEMMEQEKINSEKEIAEVNIIYQNKIDKLKKNNQRKKDEFTR 253 Plasmodium falciparum 3D7
Q4DLN1       231 RKECDELASNGEEQMLILEKLHADEITAIKKEGVQKRNQLEQ 272 Trypanosoma cruzi
Q4QC94       244 RRLCSEFEQRAEEQVLIANKEHSDALTKLKREGVQKRAQLEQ 285 Leishmania major
XP_001616752 212 DRLIEEERANAEREMSEVNIIYQNKIDKLKKNNQRKRDEFTR 253 malaria parasite P. vivax
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