7D3E


Conserved Protein Domain Family
DuoxA

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pfam10204: DuoxA (This model is not part of the current CDD release)
Dual oxidase maturation factor
DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.
Statistics
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PSSM-Id: 519237
Aligned: 31 rows
Threshold Bit Score: 307.986
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7D3E_B        10 FYAGPKPTFPMDTTLASIIMIFLTALATFIVILPGIRgKTRLFWLLRVVTSLFIGAAILAVNFSSEWSVGQVS-TnTSYK 88  human
XP_029834116  21 YMSDNRTSVSADPAEVLVYLAFVTLLVAFLAVVPGIR-KERCTTVFCVSSSLLVGAAILIGVHGTSWHVGRGQtV-TYYR 98 
Q171Q5        17 YSFSNRTPVTGDVSIVAVCVLFATIYLAFLVIFPGVR-KQKFTTFTTVTLSLFVGLVILVTRLGSGWHVAQST-IvAPYK 94  yellow fever mo...
Q9VJQ7        17 YSFSNRTPVTGDVSIVAVSVLFATFYVAFLVIFPGVR-KQKFTTFSTVTLSLFVGLVILITRLGSAWHVAHAT-IiAPYK 94  fruit fly
XP_032517617  17 YAYHNRTAVAADVPAVALLVAALTLYLAFLTIFPGIR-KERFSTFTIVTLSLFVGTVILVCKHGSSWHVAGARvArAAYR 95 
6_pfamImport   1 YNVPNRTAVTGDVPCIAACLAFITLYIAFLIIFPGVR-KERFSTFSTVTLSLFAGNVIMVCRMGSSWHIANTK-IlSPYS 78 
1_pfamImport   1 YGYSNRTPVTGDVQMITTCLVFGTIFTAFLIIFPGVR-KERFTTFTTVTLSLFVGNVILLSILGSSWHVAETV-ItSAYR 78 
XP_008191434  17 YSFNNRTAVTGDVTLITFLTIFSTLYVAFLIIFPGIR-KERFTTFFAVTLSLFVGATILVTLFGSAWHVATAS-IvSTYR 94 
XP_011259239  17 YSYSNRTPVTGDVPLVIIFVIFGTLFTAFLVIFPGIR-KERLTTFLTVTMSLFVGATIQVAQYGSSWHTSTAT-IvSSYS 94 
EFX87619      17 YDRANRTAVTGDVSTITFCVIAITLFVAFLIVLPGMR-KERFTTFTSVTISLFVGAVILVTGNGCGWHTGEGQ-ItSSYR 94 
7D3E_B        89 AFSSEWISADIGLQVGLGGVNITLTGTPVQ---QLNETINYNEEFTWRLGENYAEEYAKALEKGLPDPVLYLAEKFTPRS 165 human
XP_029834116  99 AFSRERIPARLGVYVGLSSVNVTYAAVVENarsNETLDINFNEEFWWPKPTSLRKEYYDALVKGLPFPILTVLDYLSQDS 178
Q171Q5        95 AFSREKLPARLGAHIGLMHINITLAALPVGnwsTP--DIDFNERFSWNQANDMGNSYKNALQRGLPYPILTVAEYFSLGQ 172 yellow fever mo...
Q9VJQ7        95 AFSREKLPARIGTHIGLMHVNVTLTAIPIGnwtPP--DIDYNERFTWEGANDMSANYRHALQRGLPFPILTVAEYFSLGR 172 fruit fly
XP_032517617  96 AFSAERLDCWLAVHVGLGHVNVTLNALSWGnvsTGDPGIDYNEQFRWEEAGAIQEWYRAGLLRGLPYPVLSVAEHFAAEH 175
6_pfamImport  79 AFSKELLSAELGAYIGLTHVNITL--LGEQhwkQ---QIDFNERFTWRGSGEMGESYKAGLERGLPFPILTVAEYFTLGQ 153
1_pfamImport  79 ALSKELITAELGAYVGLGHINITLCAMPSDnssVPLEDISFNERFSWLGAHEMGESYQAALYRGMPFPILTVAEYFSLGQ 158
XP_008191434  95 AFSTDKLSSNIGVYVGLRHVNITLQASGGH---NWTSDIDFNEQFLWINSDQMGDSFREAMVRGLPFPILTVAEYFTMGQ 171
XP_011259239  95 AFSRHKAMADIGGYIGLMHINITYKLLPENeqtNS--DVEYNERFWWRSSGEMTSAFKQALYQGAPFPIVSLAEYFSLHQ 172
EFX87619      95 AFSNEKIIAKLGIHIGFNHVNVTLRSAGVFnlsD---RIDYNERFGWRGPDDMVNEYHKALHKGLPYPILTVAEYLSLNE 171
7D3E_B       166 P-CGLYRQYRLAGHYTSAMLWVAFLCWLLANVMLsMPVLVYGGYMLLATGIFQLLALLFFSMAtSLTSPCPLHLGASV-L 243 human
XP_029834116 179 GgFLWGRMYRAAGGWAQLFLWASFAAWLLANVLL-CAVPRYGTYTLQLTGALMVVSTIIYSSL-LPDLPLVIPLEGDF-L 255
Q171Q5       173 EgFAWGGQYRAAGYYASILLWASFASWLLMNLLL-VAVPRYGAYTMTLTGALLIGASIGYSQM-LPKRPLTIFIEGGR-I 249 yellow fever mo...
Q9VJQ7       173 EgFSWGGQYRAAGYFASIMLWASLASWLLMNLLL-IAVPRYGAYMKALTGALLVCTTVGYHCL-LPKRPLSIHLEGGR-L 249 fruit fly
XP_032517617 176 EgFEWGAKYRAAGYTTATLLWTALALWLLMNLLL-VVVPRYGAYAMASLGVTLCAAAGGYWAS-LPHAPLVVRLDGAM-L 252
6_pfamImport 154 EgFTWGGNYRHAGYYASILLWTAFASWLVMNLLL-VVVPRYGACAMVLTGCLMLASTLVYHCL-LPVRPLHVKFEDTT-L 230
1_pfamImport 159 EgFAWGGQYRAAGYYGSIFLWTAFVLWFLMNILL-IVVPRYGAYTMIGMGSFMVGATVAYHSM-LPSSPLVIRFQDDKfL 236
XP_008191434 172 EgLSWGGQYRAAGYYAIIMLWTSFSVWILMNLML-IVVPRYGAVLMTTCGFLLLATACGYFGL-LPETPLVVHIEGST-L 248
XP_011259239 173 EgFSWGSQYREAGYYASIMLWTSFASWLMMNLLL-MVVPRYGAYSMILTGLCMLLTNLIYTSL-LPCEPLIAHIDGSI-L 249
EFX87619     172 EgFGWGRTYRQAGYYSCIALWASFAAWLLMNILL-VTVPVYGGYMMLLTGGLMLLSNLIYFIN-VPSRPLLIRFEDTI-I 248
7D3E_B       244 HTHHGPAFWITLTTGLLCVLLGLAMAVAHRMQPHRLKAFFNQSV 287 human
XP_029834116 256 QLSMGWNFWLVLIIGILAIILGGVMALVDILYPSKFPTVLEVDY 299
Q171Q5       250 SFRLGWCFWLVLIAGILCLSVGLIISIIDLVWPHRFSTILEVYY 293 yellow fever mosquito
Q9VJQ7       250 EFHFGWCYWLVLVAGILCFIAGVLISIIDLVWPHTFSTVLEVYY 293 fruit fly
XP_032517617 253 FFSMGWCFWLVLIAGAICLVVGLLIAALDLVWPHRFSTVLEVDY 296
6_pfamImport 231 SFRFGWCFWLVVVAGALCILVGLIILTIDLIYPNRFSTILELDY 274
1_pfamImport 237 LFRLGWCFWLTLFTGLLCISVGLIIVAIDCVYPHKFSTILEVDF 280
XP_008191434 249 HFSFGWCYWLVLIAGSICLLSGVIITVLEIIFPHSFSTILEVDY 292
XP_011259239 250 SFNFGWNYWLVLSAGAACLLAGIVITAIDMIFPHQFSTILEVDY 293
EFX87619     249 SFTYGWCFWLVLAAGLLVSLLGLIITLVEIAYPHKFSTVIELDY 292
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