Conserved Protein Domain Family
Ada3
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pfam10198: Ada3 (This model is not part of the current CDD release)
Histone acetyltransferases subunit 3
Ada3 is a family of proteins conserved from yeasts to humans. It is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. Ada3 plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumour suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage.
Links
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Statistics
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PSSM-Id: 519234
Aligned: 76 rows
Threshold Bit Score: 85.3281
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014174786 445 LDYTQVDERIKQELRHIGFLpfpdsahgssvvnstgngmgginnssgggnsngnggnsngngngsgngnsngsnganghg 524
XP_002115483 321 sqWKTLDKRIREELITLNIIsrsd-------------------------------------------------------- 344
EFN68943     320 qNSMNLELRMHKELVEQGIL------------------------------------------------------------ 339
XP_001605876 323 qNSMNLEMRMHKELVEQGIL------------------------------------------------------------ 342
Q1HQA8       326 KNSLTLEKCLRKELVEQGIL------------------------------------------------------------ 345 domestic silkworm
5_pfamImport   1 ---ILMEKRVKKELIEQGIL------------------------------------------------------------ 17 
Q17C72       363 kNGISIERRLRKELIEQGIL------------------------------------------------------------ 382 yellow fever mo...
XP_001991023 472 KHGVGIEQRLRKELIESGLI------------------------------------------------------------ 491
XP_002071550 414 KHGLGIEQRLKKELINTGLIe----------------------------------------------------------- 434
EDW29671     420 KHGVGIEQRLKKELLENGLM------------------------------------------------------------ 439

XP_014174786 525 sgggngngsanggggnaaIdPSLTADydGHYDDEVAARLRLLQSKLREQMLMNGARKARLAELVKERMAYQEYQTILEDL 604
XP_002115483 345 ---------------ivaD-SDGRN---NDDEDEVLSELHRRQQELKAVNQENVAFIQQLKEASIRETKRQKLLQSVRVC 405
EFN68943     340 ------------------E-PDAQKk--NQEDDEILAEIKRCQQELSALSSHNVVQLKRLFNLAQEESKRQALKRKISNA 398
XP_001605876 343 ------------------E-PDSQKk--NQDDDEIVAEIKRCQRELTALSSHNEMQLKRLLHLAQEESKRQALKRKIASV 401
Q1HQA8       346 ------------------D-PEDLPPltNPADDEILAEIKKCQTELTAVRKENCRNLKNLIGLCKQEMIRLNLKKQLDQV 406 domestic silkworm
5_pfamImport  18 ------------------E-DEPI----KHEDDEILSEIKRLTTELNAVAEFNHNELLRLHTSSKAELQRLEIKRKLDIV 74 
Q17C72       383 ------------------D-DDDMPk--SQQDDEILSEINRVRTEIAVIAEYNSNEIRKLQSMAQDEMKRIEVKRKLDRV 441 yellow fever mo...
XP_001991023 492 ------------------E-ANELAk--HEDVDEVLLEIKRVTAEISAVAQFNSDELKRLRSAASDEIKRIELKRKLDTI 550
XP_002071550 435 --------------------SAEPDD-----VDEVLLEIKRVTAEISTISHFNSEELKRLRQAASEEIKRIELKRKLDFV 489
EDW29671     440 ------------------D-ASDCAp--PEDTDDVLHEIKRVTAEISTVSTFNSEELKRLRLAASDEIKRIELKRKLDMI 498

XP_014174786 605 DGQVQAAYLK------RTRTMGKSKKGkrpgaggagaggaggaggaaggangagtARPGIGDMTRLLME 667
XP_002115483 406 DNEVIDYYKRfaptksKKKGLTKEETE----------------------------------RAWQLLKS 440
EFN68943     399 DNEVVEHYKKltkakqNKESLTRKEQE----------------------------------KAWACLRE 433
XP_001605876 402 DNQVVEHYEKlllakqRKVPLSRKEQE----------------------------------KAWTCLKE 436
Q1HQA8       407 DLECIDIYKKmvaakqKKRPVTKKEKE----------------------------------DAWKAINE 441 domestic silkworm
5_pfamImport  75 DQEIVESYKKvvaakiKKRPLSIDEQD----------------------------------DINRLIHE 109
Q17C72       442 DQEIIECYKKimaarlKRRPLTKQEKD----------------------------------EAYRLAEE 476 yellow fever mosquito
XP_001991023 551 DQEILECYKRmlqyraKRKGHTAEERQ----------------------------------EIMRLTSE 585
XP_002071550 490 DQEILECYKR------MLQYRSKRKGH----------------------------SLEEKQEILRLTNE 524
EDW29671     499 DTEILECYKRmlqyraKRKGHTVEEKQ----------------------------------EILRLTKE 533
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