Conserved Protein Domain Family
Ints3_N
?
pfam10189: Ints3_N 
Integrator complex subunit 3 N-terminal
The Integrator complex is involved in small nuclear RNA (snRNA) U1 and U2 transcription, and in their 3'-box-dependent processing. This complex associates with the C-terminal domain of RNA polymerase II largest subunit and is recruited to the U1 and U2 snRNAs genes. This entry represents the N-terminal domain of the Integrator complex subunit 3 (Ints3), also known as SOSS complex subunit A (SOSSA). It is a component of the sensor of single-stranded DNA complex (SOSS), which associates with single-stranded DNA, important for DNA repair and efficient homologous recombination. This subunit serves as a central adaptor for SOSS complex assembly and stability, and facilitates the accumulation of the complex to the sites of DNA damage. This region acts as a scaffold for SOSSB1 and SOSSC interaction and it is not essential for ssDNA binding.
Links
?
Statistics
?
PSSM-Id: 490982
Aligned: 24 rows
Threshold Bit Score: 499.837
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_004365555  133 HAHNNVVSALCYGMLTgltlgkplpqivvgvhpplnpsESAALSELsllyLRQLRDVVRDNFIFLVSLLDR-LCGTFAHR 211 
1_pfamImport    1 EEHEAKSVGVMFHILTcg-------------------eNQELFSRM----IRYINGGGVDYWHTILCNMNM-ALFELWTF 56  
EGT39095       56 EEHDIKSIGVMYHILTsi-------------------eNQELFQKM----LKYINGGGVDYWHTVLCNMNM-ILFECWPF 111 
NP_001293423   56 EEHDVKSIGLMYHILTsg-------------------eNPDLFGKM----IRYVTGGGAEYWHHVLCNMNM-ILFEVWPF 111 
XP_006676969   49 TDYEQVAGGLLHGILT----------------------NEIQFERY----FQLLAFVVRDGFATVIHKLKYvSETDKFKM 102 
EPB87097       59 KEYNEVILALLYGALT----------------------ETENARMF----FQSIASVNRDNYFALIQKLQSiLISAKFQY 112 
XP_020521189   44 SEYVQLNQALAYAILT----------------------QPQLSKVH----ITHLHTIVTDGYRSFVSLLVK-LVSESYRK 96  
KRG92099       44 DQYALLNGAILHGALT----------------------EPHFSKTH----IKHLHAIVTDGYATFVNLLLD-AVLQLYPK 96  
XP_009132998   45 QESLELSRAIVYALLC----------------------DSGSSKTH----IKHLHAVVTDGYAFFTSLLVG-IVVELYGK 97  
O23315         49 QEYLELNKAIVYGVLC----------------------EPNSSKTH----IKHLHALVTDGYAFFTSLLIG-IVVELYVK 101  thale cress

XP_004365555  212 LLDSVRPQVVALVDHLIVS--RVQGAENLVPLLLRQIRSGDVSASNTHFASLVLDTLIQpHLQW-VYLY--PALVSQIFY 286 
1_pfamImport   57 IHWTCKEQLMRLIREGVRQ--NVKQIENVVMSAFRTTISSSDFVTKTRILNYLSSIIRE-HDMWfKSQKscSALVSTILT 133 
EGT39095      112 IHLACKEQLLRLIREAVRL--NVKQIENVLMNVYRVATVSADPPGKQRIFKKLTGMIRE-NEAWfKGQKqcTALVANILT 188 
NP_001293423  112 LHLLCKEQLLRLIREAVRQ--NVKQVENVLMNAFRMSIGSSDFATKQRIFMKLNSMIRE-NEAWfKSQKacAALVANILT 188 
XP_006676969  103 LNRFAQKQSIWLLDKLLTTlpMTEQLSYIILRFMRQIKHGNCSKDNIAYTKFIVDFLTS-KRAI-IAKD--KVLARHVVF 178 
EPB87097      113 LRSPVRDQVFWLISELTNL--GAQHVDSLYLILMRQIKCGDASQFNTTLCDHILRLFEL-HKSW-LETN--PRVIPFAVY 186 
XP_020521189   97 LFESARAQLIWVFGKLIEV--EALGVENLLVSLLRQIISGDFSHESLWLSMELLKVLNQ-NWGWvLRKQ---NSMTSALF 170 
KRG92099       97 LLHSAKTQLLWLTEEMVHV--LAIGYDAVLVSLLRQIGAADCTEGNLNLCSELVTLFLK-QFDRlLEDA--PHVLSSALY 171 
XP_009132998   98 LVDSAKVQLLWLTKEMVDA--SSVGLEDLLVSLLRRIGSGDYGEQNVWLCSELVSLFLD-KWDClLEDA--PLVLTSALY 172 
O23315        102 LVDSAKIQLIWVTKEMIDV--SSVGIEDLVVSLLRRIG---------------ISLFLE-KWEClLDDS--PLVLTSALY 161  thale cress

XP_004365555  287 TYLRLIADHAr------------vAPQLDRLRQRETEFCLTLWRERFVDCSAIGRDVLRALQLVGNLPEFASLWTDLIHR 354 
1_pfamImport  134 SVSHAIVSSPa------------pLTKDDVFRENMTNFVHFVIKTRKPDCATLGRDFLLILIKLGKLPQIEDIWKDLAQN 201 
EGT39095      189 CTASVIASSPa------------pMTAQDTFRETLIDFVHFVIKNKKTDCQTLGRDFILVLMRLGKLPQIEDIWKDIATN 256 
NP_001293423  189 CTTSVIISSPa------------pISSQDTFRESQLDLVQWVIKSRKIDCLTLGRDFILILIRLGKMPQIEEIWKDIVAN 256 
XP_006676969  179 MLVRAIADHL----------------HHLDLRTKEMALFFSLISSNIQDCVYIGRDFIRSLMEISKIPSIAKLLLSIMQS 242 
EPB87097      187 TFLRAIADHR--------------TSQLQPLQQKEIRFVHMLMREKWMHCVPIGRDLIRVLKELSTIPEFSQIWDDVVNH 252 
XP_020521189  171 TYLRLLADHYkf-----------pNPNLVVLKMMEIGFCIRVLRESFHSCMGIGRDLIRLLQDLVLIPEFRDLWKDLISN 239 
KRG92099      172 AFLRILSDQFrvcvekletlkrldIEKLETLKRREIHLCVKIVREEFHLCLKIGRDFIRLLQDLAHVPEFKALLQDIVFN 251 
XP_009132998  173 SFLRLLADHCrv----------tgIPKLENVKRLEIKFCVKMFREQLHLSLKIGRDLVRLLQDLVHISEFKEIWNDLVCS 242 
O23315        162 SFLRLLADHYrv----------lgVVKLENVKRLEIKFCVKMFREQLHLSLKIGRDLILLLQDLSHVSEFREIWNDLVSN 231  thale cress

XP_004365555  355 PTTL-NAHFPGVKQILRTDTRARFLV-GRTTLDLESKLRFLLTTVKHGELRRYYQWFAKKYLEAPESEAMLPDLIRYVCC 432 
1_pfamImport  202 PSSY------GVSGIADYMSKPNMLQqLRLSVELMRRIEFMVHH-GGKNLQIYFSWLTNKFLRSNDGVGVRAECVRFLMS 274 
EGT39095      257 PASY------GVAGIEDFLSKPHVLQhLRLSIELDRKLQFMVNN-GGKNMLIYFSWFSNKYLRGADGPALRAECVRQLLY 329 
NP_001293423  257 PASF------GVSNLEEYMTKQNVLQhVRISIELERKVQFMVVN-GGKNLLTYFTWLNNKFFRANDGPALRAECVRYVLS 329 
XP_006676969  243 PSPE-YPNIPSLSDFLDRPTPREFLI-SRLTPDMEIRIVFILNSVPKRLSFTFIEQFRKRFL-TLESETLLPDIIRYICG 319 
EPB87097      253 PQKL-SPKFGGIQTMLNSPTPRDFLK-CRLTPDIEHKLLFILQNLRITHFQKNLNWFTQRFLSAPESEPFYVDVVRYLVA 330 
XP_020521189  240 PSAFnVPEFSDISQIYCLKTPNRYFL-LRITPEMETQLRFMLSHVKWGNQIRYQEWFASKFLSKPNRESLICDIIRFICC 318 
KRG92099      252 PSVFnVVGFKDVSQIYCTRTSSRYSL-LRISPEMETQLRFWLTDIKLGHHRRHQLWFANKFLNERDKEFLIVDIVRFICC 330 
XP_009132998  243 ----------DVSKIYQLKTSSRYFL-LRITPEMETQLRFLLGNVKLGSHKRHQIWFLKKFLLGPEKETVLIDIVRFICC 311 
O23315        232 ----------HCSEIYQLKTSSRYFL-LRITPEMETQLRFLLGNVKLGSHKRHQIWFLKKFLLGPEKETLLIDIVRFVCC 300  thale cress

XP_004365555  433 AYHPTNEVLASDVAPRWMTISWLMWRAKSP-TAMADVRLALFYDWMFFDPAR-SNIMNIEPGILLIQHML---------- 500 
1_pfamImport  275 MQLDPAKLPAIVFENRVQLLHLLIATCQPG-PDQQWLKLCLFLDWFGCDERTpMNFNNIDVPLNVIRHSLflqappphqs 353 
EGT39095      330 MAPDQKQ--PGSYDNRIQIIHLLVTTAQPV-AEQQWLKLCLFADWFGCDEKNiTNFGYVETPFLVLRYALflptmpshpn 406 
NP_001293423  330 MNLDPAKALPNAQENRVQLLHLLISTVPSG-PELQWLKLCLFADWFGCDDKNsANLMCVENSFSVVRYALfltptgpqqn 408 
XP_006676969  320 AIHPNNAILASDIVQRWHLISILLRGIKAP-ACAQSCKLSLYFDWLFFNHAS-DSVMSLEPGILVMVKNL---------- 387 
EPB87097      331 GWYPSNQILQSDIVPRYVVIGSMIRSIKSN-IVAANVRTALIFDWLFFKPT--DNIMFIEPAMLLMERSA---------- 397 
XP_020521189  319 AHHPPNEVIQSNVISRWAISGWLLKCCKKF-HVEANAKLALFYDWFFFDEQF-DNIMNIEPAMLLMLNSI---------- 386 
KRG92099      331 AHHPPNEIIQSDIFPRWALIGWLLTCCRKK-HVEESVKLALFYDWLFFDERM-DSIMNIEPAILLMVHSV---------- 398 
XP_009132998  312 VVHPTNEIIRSEIMPRWAVIGWFLDLCKQNhHVEGRVKLALFYDWLFFDERI-DSIMNVEPAVLLMLWSI---------- 380 
O23315        301 VIHPTNEIIRSEIMPRWAIIGWLLELCRQNhHIERSVMLALFYDWLFFDERI-DNIMNVEPAALLMVWSI---------- 369  thale cress

XP_004365555  501 -----NMNGTFAASLLEFVCLIATEFVPSL-SSSITTSLRAAFYTCVSKRVIPSLSAIVNHTSIDEPLRDKFNT 568 
1_pfamImport  354 sliqgSHCSHFANSLLEFVCKSVDVILPII-APQIRKNVNNAMRGC-RDRMQHNFSQILDNHKIDRRVTDLLRS 425 
EGT39095      407 tivqnSHGAQFANSLFEYICKSVDVFIPHL-SGYVRKNVNNAMRCC-RDRLPHIFPQVMENTKIDRKIVDLLKT 478 
NP_001293423  409 sivqgSHCSQFANSLLEFLCKSVDVLLPPAyAEPIRRNVNSAMRFI-KDRLQHNLPQILENSKIDRKVSELLRN 481 
XP_006676969  388 -----QTSPAISATMLEFLALIADRFLPTL-SAHIYHNLKLSMSIVVEKRVITSLSLILLSPQLDEFTKETVTK 455 
EPB87097      398 -----ERYAHITASLMQFLKRSVDEYFPPM-KDYMSQCVACGMRVMLSKGVIRSLLPIYRCPATDQVTRDYMQA 465 
XP_020521189  387 -----HMHIDVTQTLLDFLFLVMDNYDVNR-KEIIAQGIYTSLHALVRRGVVHSLEPLLSSSRISPMLREKLKN 454 
KRG92099      399 -----PKFINMTHALLEFLLHLVDRYDVGR-RSVIVKGVSSAFQLLVRKGVVRSLNVLTSCSALNPGLREGLKR 466 
XP_009132998  381 -----PQYPHITHSLLEFLLHLVDTYDIAC-RDMIMRGVASAFREIERKGVVQSLDMFLSNPEIATDLKKKLAN 448 
O23315        370 -----PQYPHITHSLLEFLLHLVETYDITR-RDTIVRGLTSAFREIERKGVIRSLDIFLANPALAPDLKKKLAN 437  thale cress
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap