pfam10187: FAM192A_Fyv6_N (This model is not part of the current CDD release)
FAM192A/Fyv6, N-terminal domain
This is a the N-terminal domain of the mammalian PIP30/FAM192A protein and the fungal Fyv6 protein. PIP30/FAM192A acts as a regulator PA28-gamma, a nuclear activator of the 20S proteasome. PIP30 favors PA28-gamma interaction with the 20S proteasome while inhibiting its association with coilin, a central component of nuclear Cajal bodies. Fyv6 is involved in telomere length regulation and required for survival upon exposure to K1 killer toxin. It promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase.
Jiyao W et al.(2023). "The conserved domain database in 2023.",