Conserved Protein Domain Family
NDNF

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pfam10179: NDNF (This model is not part of the current CDD release)
Neuron-derived neurotrophic factor, first Fn(III) domain
This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.
Statistics
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PSSM-Id: 519224
Aligned: 20 rows
Threshold Bit Score: 87.4842
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003772822 192 VTLVWKPSPTAsLLKQPIQY--CVVINKEH---------NFKSLCAVEAKMtaDDAFMmapkpgLDFSPFDFAHFGFPSE 260
XP_030835790 198 VSLAWKPSPSDvVYHQPVRY--CLAINTRR---------NYHTWCGVQSSVpgGGSNPfpssqtR---------FGFDSE 257
XP_008197087 158 LTVKWNPSL---VDPQGTDY--CLVVGTKP---------PVGSLCAAQQD------------------------------ 193
XP_002633683 180 AQITWKISPQV-RNAEPGRYriCTIVSRQDp--------EFAGMCDDVEE------------------------------ 220
Q9N397       180 TLITWKISPQV-RNAEPGRYriCTIVSRRDp--------EFAGMCDHVEE------------------------------ 220 Caenorhabditis ...
XP_002049441 194 LIVKWERSK---LDYHAMHY--CLVIQRVTdfstsssggGFDSFCEAVYEY--GRQQQaharaaAGPCSGAGNILDLVWS 266
XP_002063681 213 MIVKWEHSK---FDYHAMHY--CLVIQRIVgat---gppNYNNFCEAVNAY--VEQSPrsfamaATSCSTENNLLSLIWS 282
Q9W192       208 MIVKWERSK---FDFHVMHY--CLVIQRLSmdt---prmIFTNFCQAVSAY--TDQQP------MTPSCAAGGPLEGIWG 271 fruit fly
7_pfamImport   1 ALIKWEKSK---LDIHAMHY--CLAVSTSR---------RQRSLCQAVGNTi-----------hPASTCDSIAINEYLKR 55 
XP_014350356  71 VTLSWKPSPPVlQDKHNIQY--CLLVNQEH---------NYKSLCAAETSM-------------KFSNRFEPSSFVMSIR 126 coelacanth
XP_003772822 261 NSPGRERSFSGKpvpklgr------hiyskakVDIQKICIGNKNIYTV-SDLKPDTQYYFDVFVVKMPSNTSTAYIGTFA 333
XP_030835790 258 REMRKARKQIQDeqavls---------rseeaPDMVIECVGSKTLHTI-TNLDPGTRYFFDLFAVDQVTNRSVAYLGTSI 327
XP_008197087 194 --------------------------------PALAVACVGRKTHHTI-TGLKHSQKYYFSVFAINNQSNFTYPY-GTIS 239
XP_002633683 221 --------------------------------GVEAVKCVPQMNNSVVmGQLWRDRTYYVTVFVRDQKRGSSSAYEVQTI 268
Q9N397       221 --------------------------------GVETVKCVPQTNNTVViGSLRRDRTYFVTVFVRDHKRGTSSAYEVQTI 268 Caenorhabditis ...
XP_002049441 267 RPPMRARHLNPR--------------------HNLHIVCTGARTKQLL-RGLQPNSNYRLQLFGVHQRRQNLTLPLASSQ 325
XP_002063681 283 TPAKHERRLNPR--------------------HNLHIVCTGKRRQQTL-RRLLPKSNYRLDLYGVHQNRQNLTMLLGSTQ 341
Q9W192       272 APPQRERRLNPR--------------------QNVHIVCTGKRRQQLL-RRLLPRSSYHLDLFGIHQGRQNLTLRLASSQ 330 fruit fly
7_pfamImport  56 QLPRDERKMDPN--------------------AETTLVCTGSRTKQLI-RGMKPNVTYFVDVFAIHSRHNNLSFLLGATQ 114
XP_014350356 127 SDLQKTQapkfkyskdllqlfndlnliyrgssSDVRHICIGTNTVYTV-PNLSPNTQYYFDVFVINLFTNASAAYTGTFA 205 coelacanth
XP_003772822 334 RTK 336
XP_030835790 328 YTR 330
XP_008197087 240 SVF 242
XP_002633683 269 QTP 271
Q9N397       269 QTS 271 Caenorhabditis elegans
XP_002049441 326 VHF 328
XP_002063681 342 VSF 344
Q9W192       331 VNF 333 fruit fly
7_pfamImport 115 VQL 117
XP_014350356 206 KTL 208 coelacanth
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