Conserved Protein Domain Family
MPP6

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pfam10175: MPP6 (This model is not part of the current CDD release)
M-phase phosphoprotein 6
This family represents the M-phase phosphoprotein 6 (MPP6) which is involved in the generation of the 3' end of the 5.8S rRNA precursor. MPP6 is required for the integrity maintenance of the rRNA processing complex as it mediates the interaction between MTR4 (RNA helicase) and RRP6 (an 3'-5' exonuclease), and the recruitment of Nuclear VCP-like 2 (NVL2) to the nuclear exosome.
Statistics
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PSSM-Id: 519220
Aligned: 41 rows
Threshold Bit Score: 45.8935
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003685451   9 GKLTSRVMNMKFMKFANNGEELTDPRGNASgalnnananhkgrdsaiTKKFNEASEWKLERMKINPESSDKSVnttltrk 88 
XP_004182406   3 GKLSSSVKSMKFMRFANGESEQSVEMSSNEap--------------qPKYAHDNSNWSLAPRKTEKSGNNKAKkvriik- 67 
XP_003957809   6 GKLSNRVMNMKFMKFSNDDASTTSADSSRSasvn---------srtnNSKFHDNSEWYTTNSTVTNNDPKKKItkkflkk 76 
XP_022464045   5 GALSSRVMNMKFMKFGASASAGASASAGASaegtsstatedggstgsSSAENAGQQLAQQHRTQEQFTVTLPAgvsrrtk 84 
XP_002551736   7 GKLSSRVMNMKFMKQADQAEEIEQEKQKV-------------------QHHVDTSEWALSGGEEFKSRLRP--------- 58 
Q6CTZ1        11 GKLSNRVMNMKFMKHAEQADKVKQTEETI-------------------KKLVDSSEWRIGDNVKLLTKLANKSk------ 65  Kluyveromyces l...
XP_002546217   4 GGLSNRVMNMKFMKKAEDNQISKQRKEEQ-------------------KKIHDLSEWIMPNSDKLLKLASMKP------- 57 
XP_011271229   6 GGFSKNVLNMKFMKQAEKRAEEQDEEQQE-------------------SKLKDLSEWKTSNAEKLKQKAQAKP------- 59 
XP_003673400   6 GSLSSRVMNMKFMKFSRNNNNNDEENTSDSressin-----nndetsNKNFRDNSEWKLEPNTTPIKGKKVIRikkknq- 79 
Q6FIY3         5 GELSSRVMNMKFMKFMRPEGQDNKDEGTSK------------------HTHLDASKWDLKSSVNSDSTNKRRVvvkra-- 64  [Candida] glabrata
XP_003685451  89 i-ikikktptVVSNVGVASLqrlrtpe-----------tnmlpvMRGRRVIG--------EPEvtlg---------krkA 139
XP_004182406  68 ----tktrysKPMNVGITTIsrvaq---------------essfVRGRRVIEttnp-telEN------------------ 109
XP_003957809  77 ---kpmmnkvVTSNVSFTTLkqgktvade-------dtihmktlNKGRMVFGd--------------------------- 119
XP_022464045  85 slqvrrrrpvVLSNASYTDLnrg------------------mlnMEGRTTFGap-------------------------- 120
XP_002551736  59 ----------QLRTAGTTEImeqt----------------qsapVVGRRKFGsqaktepeGTTepgldelwenqkgkkrK 112
Q6CTZ1        66 ----------VVQNVGFSAIkslndedskidtndlststlrtsvNAGRRIFG--------NKLgra----------tpgS 117 Kluyveromyces l...
XP_002546217  58 ----------KIETVGYGNImsssny-------------nysstTSVRKTWGdv-------------------------- 88 
XP_011271229  60 ----------KVIAVGFTALnsln----------------ngppVIGRRTFG---------------------------- 85 
XP_003673400  80 ----lrshpnVIQDVGITYIqsnl-----------------nnaIMGRQTIRddke-tenEKDn---------------K 122
Q6FIY3        65 -----skalkIMENVGITSVkaedds-------------nkssaLHGRRIFG--------EN------------------ 100 [Candida] glabrata
XP_003685451 140 DEGNEEPSDSLQK-----EVDEDSYEPSLDKIFKsskKVD--------------SKKNKNKKK 183
XP_004182406 110 KKRKAESEASDQNklvteDEDDYVPDDNLDTLF----------------------KKGNKKQK 150
XP_003957809 120 --KKRTAEEEKLQ-----ENENDDDDYELDKMFKa-------------------SLKKNKKSK 156
XP_022464045 121 pkRAREEDEAGQG-----WKDADADGYDLDKILKetaTSKd------------tTKKSKKTKR 166
XP_002551736 113 AGEAAGEKDEKET-----DQSEDEEEEAPAKRFKsqqEKT--------------DKRERKSSK 156
Q6CTZ1       118 DGSSNDKKRSFEE-----KDEDDVSTTDLEKLWEa------------------eTQTKKQKKS 157 Kluyveromyces lactis
XP_002546217  89 nkAKLAVEEITDDkkpvdADDDDEPPLDLNTMWKkrkLE---------------SSSKSNKKK 136
XP_011271229  86 ----ETKKEEKKP-----EQEQEGKVNDLDKLWQkqkEERsepksgkrskdeipKKTQNKKRK 139
XP_003673400 123 ENENENQEHTKRP-----RDDEPEDDYDLDKIFKesmSKNk-------------HNNKKQKKN 167
Q6FIY3       101 KNKRVAEEEEENK-----TEQEPKQEKDMDELFKesrRNTk-------------PKKKSHKKH 145 [Candida] glabrata
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