7CGP


Conserved Protein Domain Family
Tim29
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pfam10171: Tim29 (This model is not part of the current CDD release)
Translocase of the Inner Mitochondrial membrane 29
This is a family of proteins conserved from nematodes to humans. The function is not known. However, family members such as the import inner membrane translocase sub-unit Tim29 (C19orf52) found in human, is shown to be required for the stability of the TIM22 complex. TIM22 complex imports and inserts multi-pass trans-membrane proteins into the mitochondrial inner membrane by formation of a twin-pore translocase with components in the outer and inner membranes. TIM29 is integrated into the inner member with the C terminus exposed to the inter-membrane space and able to contact the translocase of the outer membrane. It is required for complex stability and for the addition of the TIMM22 protein to the complex.
Links
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Statistics
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PSSM-Id: 519216
Aligned: 27 rows
Threshold Bit Score: 180.136
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7CGP_C        24 KPGVWArlgsWARALLRDYAEACRDASAEARARPGRAAVYVGLLGGAAACFTLAPSEGAFEEALLEASGTLLLLAPATRN 103 human
XP_002636731  14 GTSIKE----YFQRMGNDYATVARETAAGAKERPLKAGIVLSGLGFLTYAYRTNPTELEMLDYLCERRQQMVLVPNTEHN 89 
Q1HQH1        41 KGTIWEkwamYWRNLIRDYKEMIMDTGKTMRERPVRSGVYLTLLGTTYYCCANNPDEADFVNRFRQCANELQLVHPSCQN 120 yellow fever mo...
1_pfamImport   7 KGTIIEkwadYWKNLFIDYRQMLQDLRSDIQDDPMKAMKWTTGIITFYLLSRNNPTECDFKDNLKIINNEVGLVSEECLN 86 
XP_002431373  30 KGTVVEkwikYWEGLINDYADVFRDSIKESKSKPYKTGLLALSGCFLTYAVYNNPTEQDFRDSVIYYQNLFGLVGKPVRN 109
Q9W4R8        28 KGTFVEkwvqYWNGLVRDYTEVAVGVVRESYTKPKKALLYGTGMLFMYQANLKNPGEEAFMTLLRGATNRMITVPVELQN 107 fruit fly
XP_002071750  28 KGTVVEkwvnYWHGLVRDYSEVTIGVVKESYAKPKKALAYATGITLLYKAVENNPDHEAFMTILRRNSNRMITVPTERQN 107
XP_002055472  28 KGTVVEkwanYWKGLLRDYSEVAVGVIKESYAKPKKTLAYGTCLIALYQTAKNNPDHLAFMTLLRKQTNRMITLPPAQQN 107
XP_001990904  28 KGTTVEkwanYWKGLMSDYAEVATSVVKESYARPKRTLIYGTAIVALYQMAKNNPDQYAFSSLLRTQTNRMITLPPEQQN 107
XP_001626519  24 ENLKQRkigrSAFAVYVDYKAVFVDFFKGARSKPLRTSLGLGLLGFGYVVYLNNPDDDSYNDTLLDNANELLQVGERIRN 103

7CGP_C       104 RESEAFVQRLLWLRGRGRLRYVNLGLCSLVYEAPFDAQASLYQARCRYLQP-RWTDFPGRVLDVGFVGRWWVLGAWMRDC 182 human
XP_002636731  90 PTTTKELVSRDFLLSQKRLHHYNLWFFSLLVAGDYNKNLRIYSSQDSNLKDwPWTELWRNIVDVGALGKWYWMDNAFVDY 169
Q1HQH1       121 PTASAHIQFLQKCYNEGIVRRISLGVVSFIWLDNFDRGVAIYKAICPYLQP-RYMTFHERIVDVGFNNEWWLLRKKMIDY 199 yellow fever mo...
1_pfamImport  87 PKAVEHLRFLDTCYNQEVIHYRSLGILSVMYTSELSNSCDLYRAHCTYTKP-TYFSFPSRIVDIGFMGKWWNLFIKSTNY 165
XP_002431373 110 PGVDVYLKSLENSFNFKVIRRLSLGIFCFIWIDNYDEALGLYKAQCKYLKP-RYLTFYERVIDVGFLNKFWILEKNMRDY 188
Q9W4R8       108 PVSADYLLTLERAINQKKLRLLSLGICTILWVDLYDEDDCTYPAICEYTNV-GVFNFHERIIDVGFWNQYWRLKWKMRNY 186 fruit fly
XP_002071750 108 PEASQYLVTLERAINQKKLRLLSLGAFTLLWVDLYDEDDCTYPAICEYTTV-SWLNFHERVIDVGFWNEFWRLRWKMRNY 186
XP_002055472 108 PESAEYLIMLERAINQKKLRLLSLGFFTLMWVDMYDEDDCTYPAICEYTTV-GLLNFHERIIDVGFWNQFWRLKWKMRNY 186
XP_001990904 108 SESSDYLVMLERAINQNKLRLLNLGICTLLWVDMFDEDDCTYPAICEYTTV-NYLSFHERIIDVGFWNQYWRLKWKMHNY 186
XP_001626519 104 PSSDVYTQEMLQLFYQGKLRRQSFGLFSLMMQTEFGKDCDLYEQHCYYTKT-RWVDLWKYVRDFGILGHWYKLETAMIDY 182

7CGP_C       183 DIND 186 human
XP_002636731 170 DINT 173
Q1HQH1       200 DINE 203 yellow fever mosquito
1_pfamImport 166 DVNY 169
XP_002431373 189 DINP 192
Q9W4R8       187 DVNY 190 fruit fly
XP_002071750 187 DINY 190
XP_002055472 187 DINY 190
XP_001990904 187 DVNY 190
XP_001626519 183 DVNQ 186
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