7FIK


Conserved Protein Domain Family
Nup88

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pfam10168: Nup88 (This model is not part of the current CDD release)
Nuclear pore component
Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.
Statistics
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PSSM-Id: 519213
Aligned: 16 rows
Threshold Bit Score: 859.748
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7FIK_Y         6 HWQSALSEHALFSSLKER------LRDVEELREegerra-------skdkqlRNLLCVLDGDLLVWDAEECAFHTVTLRS 72  African clawed ...
NP_001016790   6 HWQSSLSEHALFSRLKERtreveeLREEGERRTrkd-------------kqlRNLLCVLDGDLLVWDSEECAFLTVRLRS 72 
2_pfamImport   1 TDMLNLNKLEMFQTMRKV------LETDGANTV-------------------RNLIAYKDQILYIWNPDECCLYSLLLNT 55 
1_pfamImport   1 TDPLCLNKHNLFLELKNG------LSGNIKDT--------------------RNILEIRDNVLYVWNANDSCVMTLNVAA 54 
XP_001993730   5 TDVLDLNKTELFAKIRNG------LP-IVPQT--------------------QNLLDCKDDLLYAWDSNESCLLVTNWRA 57 
XP_002000916   4 TDVLELNKTELFTKIRTV------LP-IGTQT--------------------QNLLDCKDDLLYAWNSVDSCLLVTNWRV 56 
XP_002053740   4 TDVLELNKTELFAKIRNG------LP-IVPQT--------------------QNLLDCKDDLLYAWNSSDSCLLVTNWRV 56 
XP_002072670   4 TDVLGLNKTEIFAKIRDG------LP-IVQES--------------------QNLLDCKDDLLFAWNSNDCSLLVKNWRA 56 
Q9GYU8         4 TDVLELNKTELFAKIRNG------LP-VVQRT--------------------QNLLDCKDDLLFAWHAKDSCLLVRNWRS 56  fruit fly
Q3SZ56        13 LWQTWLPNHAVFLRLREG------LKNQSSTETekpasslpsspplppqlltRNLVLGLGGELFLWDPEESSFLVVRLRG 86  cattle
7FIK_Y        73 Ls---V------ESTGNSSSgEQKLLCTNPPLFDVNEVLLSPTQHHVALVGSKGVMVLEIPKRWGKKSEFEGGEK---TV 140 African clawed ...
NP_001016790  73 L----S------VESTGSSG-EQKLLCTNPPLFEVNEVLLSPTQHHVALVGSKGVMVLEIPKRWGKKSEFEGGEK---TV 138
2_pfamImport  56 V-------------HEEQPS-YQKLFPGSPPLFDVDEILINEPGTLCALVGSKGVSVMRFPKRMGSKSLYDTSGSlgeGI 121
1_pfamImport  55 S-----------REKDGDVL-YQKLRPTDPPIFEIKHLLINETGTQLVLWGNLGLVIMELPKRWGKDCAFQGGKK---EI 119
XP_001993730  58 SllqqE------ATKRAKVS-YQTLIPSHTVGLHVERVNASQEGSLVALSGPRGVFILEVPRRCGPDGNFMDGKP---SI 127
XP_002000916  57 AllqaE-------PKRAKIS-YQTLIPSNAVGLQVDRVVVSNEGSLIALSGPQNVTILEVPRRSGPDGYLMDGKP---QI 125
XP_002053740  57 AllqpE-------PKRAKVS-YQTLIPSNSIGLNVDRVVVSHEGSLVALSGPRGVTILDVPRRSGPDGCFMDGKP---QT 125
XP_002072670  57 SlmeaDtvpestATKQKKIT-YQTLIPSSTLSLDVDRVVASNECSLVALSAPRGVCILDLPRRWGPEGYFDGGKA---II 132
Q9GYU8        57 Sl-----------AAKVNIQ-FQTLIPSSLVSLEVDRVLASNEGSLVALSGPRGVVIMELPRRWGPDGYYKDGKP---VI 121 fruit fly
Q3SZ56        87 Ps--gA------GEEPSLSQ-YQRLLCINPPLFEIYQVLLSPTQHHVALIGIKGLMILELPKRWGKNSEFEGGKS---TV 154 cattle
7FIK_Y       141 NCRTIPIAERIFTSSTSLLLKQAIWYPSETQEPHLILLTSD-NILRLYnLQDLFTPVKVISLSSAEE--DTTLPHNGRS- 216 African clawed ...
NP_001016790 139 NCRAIPIAERIFTSSTSLVLKQALWYPSETQEPHLILLTSD-NILRLYnLHDPLTPEKVISLSSAEE--ETTLPHNGRS- 214
2_pfamImport 122 TCSTSLLQDKFFITKHLTDVKRVRWYPGSPEDNHLVVLTNNkNCLRLF--KVDKGTGKLVSIWRLGPqtSRILAS----- 194
1_pfamImport 120 RCMVY---------NETIDIRKARWHPGSTNDSHLLILTSE-NTFRLY-ECELGNKPRLIRSWKVGR----VPFGSPSKi 184
XP_001993730 128 TCRTYNLDAQLFKSNPQLEVRQLRWHPDSVSDSTLLVLLSN-NTIRVY------NHSKLRHVWKVGP--HSVKTSANSSl 198
XP_002000916 126 TCRSYNLDVLLFQNNPQLEVCQVRWHPDSVSDSTLLVLLSN-NTMRVY------NHAKLRHVWKVGP--YTVKKGANTSl 196
XP_002053740 126 TCRTYNLDALLFQNNPQLEVRQLRWHPDSVSDSTLLVLLSN-NTMRVY------NHAKLRHVWKVGP--HTVKTGANTSl 196
XP_002072670 133 TCRTYNLDGQLFQSNPHLEVRQIRWHPNSVSDSMLLILFNN-NTIRLY------NHYKLMHVWQVGP--TIVRSGLRTSa 203
Q9GYU8       122 TCRTFGLDTQLFLKNPHLEVRQVRWHPHSVSDSTLLVLLNN-NTIRVY------NHSKLRHVWQVGP--PVLRSGANNSl 192 fruit fly
Q3SZ56       155 NCSTTPVAERFFTSSTSLTLKHAAWYPSEMLEPHIVLLTSD-NVIRIYsLREPQTPTKVIVLSEAEE--ESLILNKGRA- 230 cattle
7FIK_Y       217 YKAS-LGETAVACDFGPL-AvLPKG------FGQHS--------------KEDTVAYPLYILYETGETYLMYIDLQKSNI 274 African clawed ...
NP_001016790 215 YKAS-LGETAVACDFGPLtP-LPKG------FGQYN--------------KEDTVAYPLYILYETGETYLMYIDLQKSNI 272
2_pfamImport 195 -----LGDTAVDFDFAPPvLl----------GSRIQ--------------SDPSIMWPILVLQGNGDVLCMNTTVDESM- 244
1_pfamImport 185 PDFTsLGDTAVDFDFATPtLcKPEMfigkdiNKDNVv-------------DWNQIEWPILVLRGNGEVRIVRGNILHDTH 251
XP_001993730 199 TDF---GETSVDFDIAPAvKsRTTAet--ktDDSLAnssta-----takaKKEKVEWPIVVLRENGNIYILLAGIDSAIT 268
XP_002000916 197 SDF---GETSIDFDIAPAvKtSAAAsdettdns----------tlnstktPKEKVEWPIVILRENGNVYVLLTGIDSDIT 263
XP_002053740 197 SDF---GETSVDFDIAPAvKsSAnd----eaNTSLStthnkt--qsaaktSKEKVEWPIVILRENGNIYMMLAGIDSEIT 267
XP_002072670 204 LDF---GEAAVDFDIAPPvKsKRDLte--elEESVNltd--------nslKQDKIEWPLVLLRENGNIYILMTEMSSDRT 270
Q9GYU8       193 CDF---GELAVDFDIAPAaKpRVTEpetagnNETTLdksnktlvaakslpKQERIEWPMVVLRENGNIYILMTGVDSENT 269 fruit fly
Q3SZ56       231 YTAS-LGETAVAFDFGPLsA-VPKHi-----FGQKG--------------KEEVAAYPLYILYENGETFLTYISLLHSPG 289 cattle
7FIK_Y       275 TVGK--LLGPLPMYPAAEDNYGYDACALLCLPCVPNIIVIATESGLLYHCVVL---EGEEDDEQTSNKSWNASCDLI--- 346 African clawed ...
NP_001016790 273 KVGK--LLGPLPMYPAAEDNYGYDACAVLCLACVPNIIVIATESGLLYHCVVL---EGEDDDEQTSNKSWNSSCDLI--- 344
2_pfamImport 245 NIKSakITGPLTMYPPADDNYSEDACSILVMDTIPPSVVIASNFGELYNCLLLpdtQAKNEDEYESSEy----------- 313
1_pfamImport 252 ENPV--VSESLSIYPPVDDNYGIDSCSIMCLQTTPPIVIIATCTGKIYHAILL---KDELIDDDNDRKSWSQYDSTYnly 326
XP_001993730 269 R-----LQGPITITPQASANYGLESCALQIIPSLPPTVIIAESTGKLHHALLL---EAESAE-----LSFSEVDDFLlie 335
XP_002000916 264 R-----LQGPITITPQTSSNYGVESCALLIIPSLPPTVIIAESTGRLHHALML---EAETTE-----RSFNDADDGLlie 330
XP_002053740 268 R-----LQGPITITPQTSANYGLESCALLIIPSLPPTVIIAESTGRLHHALLL---ESETKE-----HSFSDVDECLiie 334
XP_002072670 271 R-----LQGPITITPQKRDNYGLESSSIMVIPSLPPTLVIGESSGKLHHALLL---EAATPE-----HSLNEVDDFIvie 337
Q9GYU8       270 R-----LQGPVTITPQAHDNYGLESCALMIIPSLPPTIVIAESNGKLHHALLM---EAEATE-----HSFNEVDDSVlie 336 fruit fly
Q3SZ56       290 SVGK--LLGPLPMHPAAEDNYGYDACAVLCLPCVPNILVIATESGMLYHCVVL---EGEEEDDQTSEKSWDSRADLI--- 361 cattle
7FIK_Y       347 P---SLYVFECVELELALKFATEe-EESlelDF----ACPIKLHRDPICPSRYHCTHVAGVHSVGLTWFNKLEKFLSS-G 417 African clawed ...
NP_001016790 345 P---SLYVFECVELELALKLATEe-EES---MEld-fSCPIKLHRDPICPSRYHCTHVAGVHSVGLAWFNKLEKFLGS-G 415
2_pfamImport 314 QheySLHIIETIELELGLNVEDNgeYDT---------SNTIQLKRDAAVTSRYWCLHNTGVHSVTVPLSELLDEFSKT-- 382
1_pfamImport 327 TpeeALYVYECVEIELGLFFAD---EDE---KY----NCPIHIRADKGNRSRYFCSHNAGIHMISLPMVSQLLEYINSpK 396
XP_001993730 336 PsewTLHVTETVELELGLSAA----TGD---AY----SCPIHLKRDLINEMRYFAYHNAGLHIVTVNFIAELQRFLDS-- 402
XP_002000916 331 PsqwTLHVTETVELELGLSASAPnsTSN---AY----SCPIHLKRDVVNEMRYFAYHNAGLHIITVNFISELQRFLDS-- 401
XP_002053740 335 PsewTLHVTETVELELGLSSGTAndTNG---AY----SCPIHLKRDLINEMRYFAYHNAGLHSITVNFISELQRFLDS-- 405
XP_002072670 338 PseyVIHVRETVELELGIKSGT---SKS---NY----KSPVYLKRDVINELRYFAYHNAGLHVVTVNFISELQRYLES-- 405
Q9GYU8       337 PaeyVVHVLETVELELGISAPATg--KE---GG----NCPIYLKRDLINELRYFAYHNAGLHAVTVSFIAELQRYLES-- 405 fruit fly
Q3SZ56       362 P---SLYVFECVELELALKLASG--EDE---PFdsdfSCPIKLHRDPKCPSRYHCTHEAGVHSVGLTWIHKLHKFLGS-D 432 cattle
7FIK_Y       418 EEDKDSLQELAAEQKCLVEHILC--TKPLRCRLPSPIQGFWIISdlfLGTS-MICITCDFECIVRPL---------LTTI 485 African clawed ...
NP_001016790 416 EEDKDSLQELAAEQKCLVEHILC--TKPLRCRLPSPIQGFWIISdlsLGTS-MICITCDFECIARPL---------LTTI 483
2_pfamImport 383 -NPDDFRGSPDIQGQSFVEYYIC--TG-LMNGETKPIKGFAILS---FPTDlLVTLLSNGEVVTQAIpdfhynklsIANM 455
1_pfamImport 397 ENEDARLPSLSNQSS--SQYLICrrTKHTQANESTPILGFGLLQ---EPCV-LIALLHTGDIV-VRC---------VIDL 460
XP_001993730 403 EAEDNQL-ILTTPSS--AEYILC--TKFDSTEHTNPVLGIALLQ---MPAG-LVLLLSSGQVISLKL---------VIDA 464
XP_002000916 402 EAEDNQL-VISTPSC--AEYILC--TKFDSSDRINPVIGIALMQ---MPSG-LVLLLGSGQVISLKL---------VIDA 463
XP_002053740 406 EAEDDQL-VLSTPSS--AEYILC--TKFDSSDRVNAVFGIALMQ---MPAG-LVLLLSSGQVISLKL---------VIDS 467
XP_002072670 406 EAEEDQL-NFTTPSR--AEYILC--TKFDSSDHINAVFGIALLQ---TPAG-VVVLLGSGQVISLKL---------VVDA 467
Q9GYU8       406 ESDEDRL-ELAVSAS--AEYILC--TKFDSSETVNAVFGLALLQ---IPAG-IVLLLGSGQVISLKL---------VIDA 467 fruit fly
Q3SZ56       433 EEDKDSLQELATEQKCFVEHILC--TKPLPCRQPAPIRGFWIVPd-iLGPT-MICITSTYECLIRPL---------LSTV 499 cattle
7FIK_Y       486 -----RPPSPPLLCSQSDKSSTE------IL--PhvladvkgPFEEHIRGILRRN--SANPLLlnsSSKDSSPPPEECLQ 550 African clawed ...
NP_001016790 484 -----RPPSPPLLCFKIDKSSTEiiphvlEDvkG--------PFEEHIRGILRRN--SANPLLlnsSSKDSSPPPEECLQ 548
2_pfamImport 456 ytnedNPASEDQVDSSENVDKDD--------------------FSSFISALLQKEngTRNTIL-----KLGPDVPKEIVV 510
1_pfamImport 461 yyfpkIEPPEPVIDKKEKVNKEE--------------------FDVYIKKLLKHE--TSQPLI-----KVGSKSPRESLQ 513
XP_001993730 465 ql--lVTVREKVQHTSNDTAVDQ------QGg-T--------SFADDIKALLQRS--VSQPIL---ADKLATQSAHERYE 522
XP_002000916 464 ql--lMTSKKELQLTATDAALDE------QGsgP--------SFAEKIKTMLQRT--VNQPIL---ADKMASSSAHERYE 522
XP_002053740 468 ql--lVTTKQQLQRTATDDVLGQ------QGegP--------SFTDTIKALLMRS--VSQPIL---ADKMASSSAHERYE 526
XP_002072670 468 ql--lVSPSEQ---TLTTSSVEQ------GEagQ--------TFQDKIKSILQRS--VNQPIL---ADK-PSSNANEGYE 522
Q9GYU8       468 ql--lVTPNEN---KPVDSEVSQ------QEsgP--------PFVDTIKSLLQRS--VNQPIL---ADKLSSPSAQESFE 523 fruit fly
Q3SZ56       500 -----HPASPPLLCTREDVEVAEsplrilAEtpD--------SFEKHIRSILQRS--VANPAFlksSEKDMAPPPEECLQ 564 cattle
7FIK_Y       551 LLSRATQVFREEYLLKQDLANEEIQRRVKLLIAQKEKQLEDLRYCREERKSLTETAERLAEKFEEAKEKQEDLINRLKRI 630 African clawed ...
NP_001016790 549 LLSRATQVFREEYLLKQDLAKEEIQRRVKLLIVQKEKQLEDLQYCKEERKSLTEMAERLAEKFEEAKEKQEDLINRLKRI 628
2_pfamImport 511 QMVLQTINMRRGTLNNHKIVSEEIERRVRMLAKAKERQLQEMQRLEEARKKLQDDVENKAEKLDEISNKQEKLTQRASSM 590
1_pfamImport 514 LLYHATDIFRKEHFVKHDTVREEIGKKVRALKVMKIQLLKDLETLIETKKELHQTAERLAERYEDIKDEQEKLAQKAKEV 593
XP_001993730 523 LLNQAIEVLRTQYFKRHELVRSEFAKRINCIKLQRKQQLEEIKSLENEREIISERAHKLAERFEEISDNQEVLVRRCQKL 602
XP_002000916 523 LLNQAVEVLRTQYLKRHELVRAEFAKHIKCIKLQKQQQLQEIKSLENEREIISERAHKLAERFEEISDNQELLVRRCQKL 602
XP_002053740 527 LLNQAIEVLRSQYLKRHELVRVEFAKRINCIKLQKQQQLQEIKSLEKEREIISERAHKLAERFEEISDNQEILMRRCQKL 606
XP_002072670 523 LLSQAIVVLRSQYLKRHELVLVEFAKHINQIRIKRDQQLQEIQDLEDEREVISERAHKLAERFEEISDNQDWLVRKCHRL 602
Q9GYU8       524 LLNQAIEVLREQYLKRHDLVRAAFTRHINQIQLKKEQQLQEIQDLEQERELISERAHKLAERFEEISYNQELLVRKCNAL 603 fruit fly
Q3SZ56       565 LISRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLNYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKV 644 cattle
7FIK_Y       631 LRSFHTQLPVLSESERDMKKELQATNQQLQQLGNSINQVNRKMSYQEKQMEKG--KSP-RKSSLTLSDYQKKNIKAVLKE 707 African clawed ...
NP_001016790 629 LRCFNTQLPVLSESERDMKKELHATQEQLQQLGNAINQVNRKMSYQEKQMEKG--KSP-RKSSLTLSDYQKKNIKVVLKE 705
2_pfamImport 591 LLRLVSAAPDSISIKKK-RELLEGYKTKMDLMNKRIEEAREKWNIVQSESAAAvyKQIyGSRSLKLTLEQELVIKGNLSE 669
1_pfamImport 594 LRLVNYKEPSMTPIERAEAEELRKMEMKIEVMKIRLLDLKKK-SEQIGHTENN--ESIeDKKEIVFKDDQEKIIKNTLGQ 670
XP_001993730 603 MQDANAKLPNSIRAEREFALEVSRINTDTKTMAAALDKAKKGLSKQRYHIAKS--QESaKTDAYKLPEKQHRTITEILTQ 680
XP_002000916 603 MQLANSVLPNSIVAEREFAQEVGRIDKATKAIAAALDTAKKTYNKQRYHIAKS--EGTnASDAYQLPERQQRTITEILTQ 680
XP_002053740 607 MQDANAVLPNSVLAEREFALEVARINKATKSMAAALDTAKKTFNKQRYHIAKS--QEMaKNNVYELPEKQRRTITEILTQ 684
XP_002072670 603 LQNANTALPNSVVAEREFAQQVANINKANKKIAAALEDAKKTMNKQRYFIAKN--QDEvRQNAFELPEKQNRTITEILMQ 680
Q9GYU8       604 MQRANASLPNSVIAEREFSQEVIRLNKVTQSLAAGLETAKKTFNKQRYHIAQS--QEDlKKNAYELPEKQHRTITEILTQ 681 fruit fly
Q3SZ56       645 LHSFHSQLPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQRKMEKV--LSP-QKPTITLSAYQRKCIQSILKE 721 cattle
7FIK_Y       708 HGEHIQEMVKQINNIRNHVN 727 African clawed frog
NP_001016790 706 HGENIQEMVKQINNVRNHVN 725
2_pfamImport 670 MGSTILDLEKKVRDLRTVIN 689
1_pfamImport 671 MAKDIKELIMEVKKFEEEVS 690
XP_001993730 681 LSSEIERQITDAKRINKIMG 700
XP_002000916 681 LSSEIDRQISDVKRINKIVG 700
XP_002053740 685 LSSEIDRQITDVKRINKIIG 704
XP_002072670 681 LASEIDRQVTDVKRINKIIG 700
Q9GYU8       682 LTGEIDRQITDVKRINKIVG 701 fruit fly
Q3SZ56       722 EGEHIREMVKQINDIRNHVN 741 cattle
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