Conserved Protein Domain Family
BORCS8
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pfam10167: BORCS8 
BLOC-1-related complex sub-unit 8
This is the N-terminal 80 residues of a family of proteins conserved from plants to humans. It contains a characteristic NEP sequence motif. Family members include BORCS8 (BLOC-1-related complex sub-unit 8) also known as MEF2BNB. It constitutes sub-unit 8 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery.
Links
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Statistics
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PSSM-Id: 490960
Aligned: 24 rows
Threshold Bit Score: 118.483
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002977431   2 DAKLGEALQQAHDLAADMVKQMANEPSVGLYFVQQHVHKAVPAIVSLKDQVGDCAHDSGLSTEDAKDALATVRNFKGVGP 81 
XP_003105087  11 TREIESRARIISDRISESIRLLDNEPSLALYRLQEHTVRSLPGIVNRRIQLTQQSATLSGAQFDLENCLSTTTNMQNASS 90 
Q9D6Y4         3 EPEMQLKGKKVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKSLVDSSV 82  house mouse
XP_005999487   3 DQEMQIKVKRVTDKFTESMYVLANEPSLALYRLQEHVRRSLPELVQHKTDMQSWEEQSQGAIYTVEYACSAVKGMTNSSV 82 
Q4S3C1         3 DQEMHLKVRRVADKFTESMYFLANEPSVALYRLQEHVRRSLPELVQHKTDMQSWEEQSQGAIYTVEYACSAVKSMTNSSI 82  spotted green p...
A7SGF0        11 HPETEYRLKKVSEKFIESIHLMVNEPSVGLYRIQEHVRRSLPQLVDKKMELRSCQNQINGVCYDLDYSIKTVQSMQHIP- 89  starlet sea ane...
XP_004352336  26 DANTAESILKSNKKISDYIHHLANEPSVGMYHVQEHIRKAVPKNVTLKKEVKNLTSHIEDISYNVDDSIKAIQSINEIT- 104
XP_020435383  23 DANTADSIFKANKKISDYVHQIANEPSVGMYHVQEHIRKTIPKNVAIKKEIRELDTHIEELMYNVDDSSATIQSIAEIQ- 101
O80964         3 EFSTVDGFAEINESLAEMIKYIANEPSVGLYYIQQHIRNAAPNVINLNNNVLEKSRETGLHTEDLEDSIAMVKSMKDCGS 82  thale cress
1_pfamImport   1 LFSTVEGFVEIIESLMDMIKFIANKPSAGIFYVQQHTHTAVPNLINLTIKIEGKFRQVTLHTADSEDSIIMVRSMKECGF 80 

XP_002977431  82 PViERMMKRLNSSIQALQPSRSKESSySVSEMA 114
XP_003105087  91 SF-ENCIEMLRNCMFYKQQLDFDSTRkATSSDS 122
Q9D6Y4        83 YF-RSVEGLLKQAISIRDHMNTSAQGhSQEKLS 114 house mouse
XP_005999487  83 HF-KSIEGLLRQAICIKDRMSSSQSRsTIDTQA 114
Q4S3C1        83 YF-KNIDSLLRQTISMKEQISNSQGRsPHVSAP 114 spotted green pufferfish
A7SGF0        90 HF-TIIQECLRSAIASKKNLDAAKLErRSKKVD 121 starlet sea anemone
XP_004352336 105 TF-NHIHELLVSSIDRASKLVNNKSLaYVNSQQ 136
XP_020435383 102 TF-NHIHDLLLSSIDKVSKLVNNKSLqFINSSH 133
O80964        83 PIaDEMIGDIKNSLAIMSSKQPRRGViLNSTSP 115 thale cress
1_pfamImport  81 SItNEIMKTLRHSLAVVFKKHLRNGSiRRPSSS 113
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