8EL7,6VU8


Conserved Protein Domain Family
Ric8

?
pfam10165: Ric8 (This model is not part of the current CDD release)
Guanine nucleotide exchange factor synembryn
Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.
Statistics
?
PSSM-Id: 519211
Aligned: 88 rows
Threshold Bit Score: 261.001
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
8EL7_B        69 CLEVLRILSRDKKILVPVTTKENMQIL---------------------LRl--AklhesddslekvsefpVI-------- 117 house mouse
EDO46011       1 -LNALRILSRDKNGLGLLTSEKSSKALtcigptevdtvylrmmnydgcVKtsgTi------------------------- 54 
XP_032511673  66 CLATIRLLSRDKNELESLICEKWVLTL---------------------IEragLfnfvdpedtm---------------- 108
XP_011137861  70 CLAALRILSRDKTNLDELITDNAVKII---------------------LLntgLtkiydeeq------------------ 110
Q29IC2        66 CLNTVRILTRDEFSLQTNYIEHEVSQL---------------------LRlarVeassl-------klpaTPdelkqqee 117 Drosophila pseu...
XP_002055343  66 CLNTVRILTRDEFSLQTHFVEQELGTL---------------------LSlarInassnedgaqp--------------- 109
XP_003137192  67 ILRFLRILARDKQNLDQLLSSGLVQDV---------------------LGvglLterlfe-------------------- 105
Q9GSX9        65 LLETIKILSREKDGLEGLLNDPLCDKI---------------------LAfaeLssnenns------------------- 104 Caenorhabditis ...
EGT48653      66 LLETIRLLSRDRNGLEGLLNVDLCNKV---------------------LAfagLqtgegvp------------------- 105
EFO99368      66 LLETVRLLSRERDGLESLLNNDLCDKI---------------------LRhaaLkwedgyp------------------- 105
8EL7_B       118 -----------------VESLKCLCNIVFNSQMAQQ-----------LSleL-NLAAKLCNLLrkC-------------- 154 house mouse
EDO46011      55 -----------------IESLKCLCNIMYHSAPAREhcikfdvtlslLHrlKn--------------------------- 90 
XP_032511673 109 -------dinmpakevvMEALKCLCNIAFNSEVARAlcahssiaqglVArlRs--------------------------- 154
XP_011137861 111 ----------isytvvmIESLKLLCNLLFNSVKMQQskvlisslpylMDrvRn--------------------------- 153
Q29IC2       118 gqlqlqeqpslaqsdiiAEALKCLCNLVYQSADCRRqclrqhcldaiLKrvA---------------------------- 169 Drosophila pseu...
XP_002055343 110 -------qlddaqaeviAEALKCLCNLVYQSADCRRqclrqhsldvlVKrlGt--------------------------- 155
XP_003137192 106 -----------fdwesfIQAEMCLINILFNSKLARDefnei-asdllLSriRlLSETSRSSSK--Qrnnddiratekdig 171
Q9GSX9       105 -----------ktvhtlMEAQKCLINTLFHSQRMRDrfyanpktgenLQffLgefeenrrk------------------- 154 Caenorhabditis ...
EGT48653     106 -----------knphalMEAQKCLINTMYHSQRMRDvfyateensenLLfyLlefspqnrk------------------- 155
EFO99368     106 -----------ksvhalMEAQKCLVNTMFHSAKMRDrfyldsqnsenILqfLsefdesqrk------------------- 155
8EL7_B       155 --------------KDrkfINDIKCFDLRLLFVLSLLhTDIRsqLRYELQGLPlLTQILESAFSIKWTD-------Eyes 213 house mouse
EDO46011      91 -------------wADksvPQDVFYFDLRLMFLLTAFeGAIRktAFEN-KGLCiLTHALDSQVPGKDD------------ 144
XP_032511673 155 -------------yKEipfKDDIMLFDMKLLFILTALrPDIKtkIKDELHGMDyLVSCMNELVLASHEPqqdvagcT--- 218
XP_011137861 154 --------------YTndtPYDVKLFDMRILFLITALnTSTRniIKHDLCGDVcLIKIIEDFVTRNQD------------ 207
Q29IC2       170 --------------SSmrhPCALEYYDMKLLFLLTALePAARtrLQIDLNGLTyMTKWLDDKLAEPSC------------ 223 Drosophila pseu...
XP_002055343 156 -------------aSStryPCTLEYYDMKLLFLLTALePTARtrLQIDLNGLTyMTKWLDDKLADSAT------------ 210
XP_003137192 172 isakpkifeslvefLNneqIDLVAFYDLRIAFVASAQsKDLQlyWLKDGCEV--FLKILEQSLHFPER------------ 237
Q9GSX9       155 -----tssidwirlLNpvqAAEIWYFYHRIAFIATALgREFQknWANDPKTIDsLLLAVEICTNRSEN------------ 217 Caenorhabditis ...
EGT48653     156 -----tsehqwireMHevqAAEVWFFYHRIGFISTAMsRDFQkkWANEPKMIDnLLPAVEYIIEKKDF------------ 218
EFO99368     156 -----eskiewireMNqvqSSEVWYFYHRIAFIATAMnRDFQksWANNPQMIDhLLTAVRCVLGKTSV------------ 218
8EL7_B       214 A-IDHNGPPLSPQETDCAIEALKALFNVTVDSWkvhke--sdshQFRVMAAVLRHCLL-IVGPTEDkteelhSNAVNLLS 289 house mouse
EDO46011     145 ------RDRTHSSNGKDGSEILKVIFNVTMAMPkelth--etqeHYERIALITSTLFT-HVKALPDgaenvhNHAMNAIN 215
XP_032511673 219 DiEMSHNCLLLDHQQAIACEILKTQFNLTLHTGssdpvseeeevIYLKLMPSLTALLY-ARTTSQEklmelhSNIANLLT 297
XP_011137861 208 ---NNETTIIKTEEITVICEVLKVLFNLYIQSDdtgi---edqeKHKNLMLILYKLLI---LKYSMqqddleSNVINLLT 278
Q29IC2       224 ----------SEEQLNIICELLKVMFNVTS-APdkspn--eyeiQSLHLTGVLRELLLrFGKMATDkersvvTHAINLLT 290 Drosophila pseu...
XP_002055343 211 --------AASEEQLNIICELLKVMFTVTS-APdkspn--eyeiQSLHLTGVLRELLLrFGRLSTEreraivTHAINLLT 279
XP_003137192 238 ----LKQNSRWRSFAEHTNWALKILFNIFCYSRdds-----vesNAKQCMLLCSKIVT-LENIDPSle----qsAVDVIA 303
Q9GSX9       218 ----------STQDINRATEALKTFFNVFCHFHgdvka--idhkNAAKTCQILRDAIC-SDVLTDDvv----qsAIHCLS 280 Caenorhabditis ...
EGT48653     219 ----------ISQDRERANEALKTFFNIFCHFHgevqa--idqkHAIKATRILRDIIC-SDRSDDEli----msAVHAVS 281
EFO99368     219 ----------PQIDLLRANEALKSFFNVFCHFHgevea--inkkKAMEACEVLRDTICsVDIVGDDvi----qsAIHALS 282
8EL7_B       290 NVPVs------------CLDVLIC---------------------PLtheetaqeaatldelP-SDkttekdtalknstm 335 house mouse
EDO46011     216 SMPKeamhflywgfpksVGKAFt--------------------------------------------------------- 238
XP_032511673 298 SVPPvfyqfltpelnegESAQYvy-------------------------------------------------------- 321
XP_011137861 279 VILYscytpiiqpvkynDRKSVyq-------------------------------------------------------- 302
Q29IC2       291 NISSsclieltlkcsnaEEQPKKAvegvakak------pakccalCfe-------------------------------- 332 Drosophila pseu...
XP_002055343 280 NISDsclteltlkcnsaDTETESVkectvasgttepqpaskccalCfe-------------------------------- 327
XP_003137192 304 VFPLsfellt--pkiqhTEKKD------------------------------------------TNvih----------- 328
Q9GSX9       281 VPPLpmvlsvlcgknskNNGGE-----------------------NE---------------EeKFfve----------- 311 Caenorhabditis ...
EGT48653     282 VPPLpivlsvwcqdpekDAKAT-Ae--------------------DD---------------EvVDlfr----------- 314
EFO99368     283 VPPLpmilsvicgdptvPLDTT-Ss-------------------iDN---------------QsIEeer----------- 316
8EL7_B       336 vyngMNMEAIHVLLNFMEKRIDK----------------GSSy------rEGLTPVLSLLTECSRAHRNIRKFLKDQVLP 393 house mouse
EDO46011     239 ----NNMAAIMSLLKHIESRIdss------------------------naDSLVPEISALCCLAKGDSIIRKYLRLEILP 290
XP_032511673 322 --dgHNMDALQSLLQLLLYRL-------------------SItettknqyENLSPILTVLNKSARSCRVQRKFLRQEVLP 380
XP_011137861 303 ---gMDMSAICVLLRFLDQRLdckt----------------------hliENISPVVTALIRLVKSERIIRKYVRLQILP 357
Q29IC2       333 ---kRNVRCLTVLLNYLRQAL-------------------AQqeaeasshELLSPVLTVLVKCSRSDRVMRHYLRQEILP 390 Drosophila pseu...
XP_002055343 328 ---kRNVRSLAVLLDYLRGGL-------------------AQqeteasshELLSPVLTVLVKCARSDRTMRHYLRKEILP 385
XP_003137192 329 --ggRDMTFANAVLHALERRLEAenn---------------------eknELLGTFLTVLIRLSSQVKEARRYLRLLVIP 385
Q9GSX9       312 --elSNMQLTEAILMHLDKQLTKvvalllndapnqqqnpMLSaeas-tltDLVGPYFQVLARLCTDSKYVRRYCRIRVIP 388 Caenorhabditis ...
EGT48653     315 --eyDDMKMTEALLSSLDKQLTVavkmln-----ntphdKVStean-tlcDLIGPYFQALARLCVESKHARRYCRIRVIP 386
EFO99368     317 --efKNMTMIEALLMALDKQLARavalln-----stpndQVSqean-tltDLTGPYFQALARLCVESKHVRRYCRIRVLP 388
8EL7_B       394 PLR--DVTN---RPEVGSTVRNKLVRLMTHVDLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAggrgdn 468 house mouse
EDO46011     291 PLQ----AVshtRPEEGSAIKNKLIKMMTAPGD-IRDMVADFLFILCKENTDRLIKYTGYGNAAGLLARKGLMAggqgng 365
XP_032511673 381 PLR--DVSR---PPEQGDTLRNQLCRLLTTPITSVRDLVAEFLFILCKEKVGRMVKYTGFGNAAGHLAQKGLMGggrgpa 455
XP_011137861 358 PLK--DVMN---RPEEGTTLRAKLCKLLTSPLIELRDLVAELLFILCKENVNRMVKYTGYGNAAGMFAKKGLLGrnqaet 432
Q29IC2       391 PLR--DVSQ---RPEIGQELRNHLCRFLTLPAMILRDLAAELLFVLCKEDVGRMIKYTGYGNAAGLFAKRGILDcrrveg 465 Drosophila pseu...
XP_002055343 386 PLK--DVSK---RPEIGNELRNHLCRFLTLPAMILRDLAAELLFILCKEDVGRMIKYTGYGNAAGLFAKRGVLDcrrieg 460
XP_003137192 386 PLHatDVER---RPDDGIELRNRMIRLMMSISN-IQDLAAEFIFILCKKSVNRFVKYCGFGHAAGLLANRGILNalntpk 461
Q9GSX9       389 PLVseEVQK---RPEENNTLRGRIARIMMLPSS-TKDVAAEFLFIICKRSVNRMIKYLGFGHSAGHLANLGLLGqinqpk 464 Caenorhabditis ...
EGT48653     387 PLVadEVKK---RPEEHDSLRGRIVRIMMLPSA-TKDVAAEFLFIICKRSVNRMIKYFGFGHSAGHLANMGLLGqinqqk 462
EFO99368     389 PLVadEVKK---RPEEHNSLRGRIVRIMMLPSA-TKDVAAEFLFIICKRSVNRMIKYVGFGHSAGHLANLGLLGqinqpk 464
8EL7_B       469 wy--xededxdTEEYKNAKPNINLITGHLEEPMP-NpidEMTEEQKEYEAMKLVNMLDKLSREELLKPMGLKPDG 540 house mouse
EDO46011     366 geyssdeensdTDEYVQVKNQIDPIIGAIPPDRP-NpldGMTDEEKEEEAMKLGEMIEHLNKMGVIQTAEIGPDG 439
XP_032511673 456 y---ssssdsdTEEYREAEPHIDPVVGCTRPPRN-NpweGMTDEQKEYEAMKLVNLFDKMLSQGVVKPARVGPDG 526
XP_011137861 433 ay-ssesedseTEEYLKYKEQINPVTGCFEHPKP-NpleGMTEEQKEFEALQLVDLVDKLTREGVVRPCRIGEDG 505
Q29IC2       466 adyssdsedsdTEEYKKHQQGINPVLGCVEPKSKhNpldDMTEEQKESEALQLVNLIEQLRQGGIVKPALIDKDG 540 Drosophila pseudoobs...
XP_002055343 461 adyssdsedsdTEEYKQQQQSFNPVLGCVEQPKR-NpleGMTEEQKEYEALQLVNLLEKLRKDGIVQPALIDKDG 534
XP_003137192 462 hh--sdseaseTEDYKAVETQVNPVTGCIDPAVE-NpftGMTEEQKEYEVHRLMNDINKLMNQGLITPGQIGKDG 533
Q9GSX9       465 ha--sdsedseTEDYNQIKDSVNPVTGAIYPSDHgSalaGMSEEQKEYEAMKLVDAMNQMMETGIVKPGTIGDDG 537 Caenorhabditis elegans
EGT48653     463 ha--sdsedseTEEYNQVRDNVNPVTGAIYPEDHgSalaGMSDEQKEYEAMKLVDAMNKMMDAGIVKPGTIGEDG 535
EFO99368     465 ha--sdsedseTEDYNKVKDCVNPVTGAMYPPDHgSalaGMSDEQKEYEAMKLVDAMNKMMETGIVKPGTIGDDG 537
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap