Conserved Protein Domain Family
BRI3
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pfam10164: BRI3 (This model is not part of the current CDD release)
Brain protein I3
This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein I3 (Bri3). Their function is unknown but they appear to play a role in TNF-induced cell death.
Links
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Statistics
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PSSM-Id: 519210
Aligned: 11 rows
Threshold Bit Score: 111.924
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006000844  28 SYGTIPAAQ-------VGFQPPPPYPYPAapgfsggpp-pasvqppysSTYTIIQQPa-TTSVVVVG------GCPACRV 92 
XP_003229961  35 NYGAIPHAPppyapgyVVPPIPPPHSFPN-------------------TTYTIIQQPlpTTSVVVVG------GCPACRV 89 
P28662        29 GYGAIPTAPppppypyLVTGIPTshpr-----------------vyniHSRTVTRYP--ANSIVVVG------GCPVCRV 83  house mouse
XP_009026329  67 NYSSTTTTTnqqttvyTSQPVPPfhqqq----------------qrvlVTAPIV--Pa-DQSIIIVG------GCPVCRI 121
XP_001983825  18 mqATMPSAPdtrlitgVHHGAPTapnnmas------------ygafetTPVSIVVHPsqPAQIFLIN------ACPSCRI 79 
XP_002431287  17 PYSAYPTEVqqygfqtPVTQQPNytpq-----------------qyipTPTFIQPSPv-NQTVVIMG------GCPSCRT 72 
XP_002127472  10 AYGHQP----------VYNQQPMPMQQPMpmqqpvinvv-------qqqqqqqqqQP----SVVVVGgqggglGCRRCGA 68 
XP_001851394  58 NYGSIQSS---------GVKVPLQPGVVVplgqatg------agggpsTTATTVVIP---QEIIVVG------GCPVCRI 113
XP_014327891  33 GYGAIPAA------------APPPYHYPDgpgyppaqmgpavsqqpytSTYAII-QP----SVVVVG------GCPACRV 89 
XP_003964604  30 GYGSIPPP------------APPPYAYPDpqgypsaqtvpavsqqpyhGTYAII-QP----SVVVVG------GCPACRV 86 
1_pfamImport   2 GYGAIPAA------------GPPPYQFPDgrafpsaqmgpavsqqpcvGTYAII-QP----SVVVVG------GCPACRV 58 

XP_006000844  93 GVLEDDFTCLGILCAIVFFPIGILFCLALRQRRCPNCGATF 133
XP_003229961  90 GVLEDTFTCLGVLCAIAFFPVGILFCLALRQRRCPNCGATF 130
P28662        84 GVLEYCFTCLGIFLAIVLFPFGFLCCFALRKRRCPNCGAVF 124 house mouse
XP_009026329 122 GVLQDDFTCLGVCCAIVFFPMGLLFCLLFRERRCNNCGAVF 162
XP_001983825  80 GYLEDTFSPLGLCCAIFFFPLGILCCLAMREKRCSNCGATF 120
XP_002431287  73 GTLESDFTCCGILCAIFCFPIGILCCLCMKQKKCNQCGATF 113
XP_002127472  69 TGLSDSFTCCGICLAIFFFPIGLICCFCMREKKCSGCGApy 109
XP_001851394 114 GMLEDDFTCCGIFCAIFFFPVGILCCLAMKNRRCSNCGAQF 154
XP_014327891  90 GVLEDDFTCLGILCAIFFFPLGILFCFALRQRRCPNCGATF 130
XP_003964604  87 GVLEDDFTCLGILCAIFFFPLGLLFCFALRQRRCPNCGATF 127
1_pfamImport  59 GVLEDDFTCLGILCAIFFFPLGILFCFALRQRRCPNCGATF 99
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