8C6I


Conserved Protein Domain Family
G8

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pfam10162: G8 (This model is not part of the current CDD release)
G8 domain
This domain is found in disease proteins PKHD1 and CEMIP2 (also known as KIAA1199) and is named G8 after its 8 conserved glycines. It contains 10-beta strands and an alpha-helix. CEMIP2 is an inactive cell surface hyaluronidase that, unlike its mouse orthologue, has no catalytic hyaluronic acid-degrading activity, but acts as a regulator of hyaluronan (HA) metabolism through regulation of expression of CEMIP and HAS2.
Statistics
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PSSM-Id: 519208
Aligned: 112 rows
Threshold Bit Score: 77.2785
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8C6I_A          40 NWDPGqd-----------saKQVVIKEGDMLRL---TSDATVHSIVIQdgGLLVFgDn---KdgsrNITLRTHYILIQdg 102  human
39_pfamImport    1 GWGGSsgsi-------pgpgEDVIILPNRTILVd--VALPPLRGLYIL--GTLEFpSs---S----SNALSAACVLVLg- 61  
38_pfamImport    1 CSipg-------------pgEDVIILPTHWCLL---VGRQQGKGWSTQ--SDLCFtVd--------RNVLSLWGIRGPk- 53  
XP_001019841  2659 SWQGIkvdgingdivnavgaTTLVIPCPWEILVd--QDLTQFSQIIVQ--GNLRIdYt---Q----NINISADAIWLKg- 2726
Q22PA4        2629 TWQGVsidgnpgptinssgnSTLWIPCPWEVVVd--QDLTKYTQIIVE--GNLRIdPt---K----NVNIQANGIWLKg- 2696 Tetrahymena ...
Q22PG1        2649 TWQGItfdgnqgivlntqgnSTLYIPCPWEVVVd--QDITQYTQIIVE--GNLRVdPt---K----NINVQANGIWLRg- 2716 Tetrahymena ...
22_pfamImport    1 TRGFLvppa--------sgnYTIYLHCDDRCELylsNSSRPEDQVQIA--AQPRY-Vs---N----YYTLDSQKSKVL-- 60  
XP_002507739  4952 VWTDGvyps-------pattDVVYVPPGTTLAVd--VARADVRFWIVD--GTLTV-PpdapD----EVVIAAESIMVNg- 5014
XP_064411311  2913 GWGGYnhtv-------psagDDVIILPNRTIVVd--VALPLLRRLYIL--GTLKFpVt---S----SNILSAACIVVLg- 2973 coelacanth
XP_028906523  2760 GWGGYndtl-------pspgDDILILPNRTILVd--VDLPCFKGFYVL--GTLQFpVd---R----SNVLCAACIVILg- 2820 platypus
8C6I_A         103 gALHIG--------AE--KCRYK--SKATITLYGks---dE--GES---MPTFGKKFIGVEaGGTLELHG-A-RKa-SWT 159  human
39_pfamImport   62 gVLRVG--------SS--EHPLErdLKLLFLLRAse--giYcdRLE---DINVHPGSIGV--YGQVQIYS-AyPKm-PWT 122 
38_pfamImport   54 -------------sSF--QHPLKqdLKLLILLRAse--giYcdRLE---EINVHPGSIGV--YGKVQIYS-GyPGk-SWT 109 
XP_001019841  2727 -GLFIAeg-----aTA--GSPYT--KKLTIKLTGnrdqqtQfiVDN---TIEVGNK--VILnTGNFTLLG-NpPAs-TVA 2789
Q22PA4        2697 -GLFIAeg-----sTP--GSPYT--YNLNIQLNGnqdqptQfvIDP---LVDVGNK--VILnTGNFTLIG-NpPSt-TYT 2759 Tetrahymena ...
Q22PG1        2717 -GMFIAeg-----aTP--GTPYT--NNLTIILTGdrdqqtQflVDS---QLDVGNK--VIFnTGNFTLLG-NpPAt-TST 2779 Tetrahymena ...
22_pfamImport   61 -SLEKGkpyymellHQ--EYAVV--ASINIGLFRgdssftKdqTDD---AVNEVQKIIATYe--VITFNS-WpADvkAVQ 129 
XP_002507739  5015 gKLRVG--------GEfaTHPKK--KTVTFELRGe-----Rg-sVS---IAGAGPRSIVAId-GEVLLRGhAaAT--EWS 5072
XP_064411311  2974 gSLIVG--------SS--QAPLGkeQKLQIILRAs-----EgvHCDhlkGVHVDPGSIGV--YGKLQIYS-AyPEi-SWT 3034 coelacanth
XP_028906523  2821 gELKVG--------TF--LSPLEtgQGISILLRAse--gvScdRLA---GVSTNPGTIGV--YGKVELHS-GyPRk-SWT 2881 platypus
8C6I_A         160 LLA 162  human
39_pfamImport  123 HLG 125 
38_pfamImport  110 HLG 112 
XP_001019841  2790 RLT 2792
Q22PA4        2760 QLA 2762 Tetrahymena thermophila SB210
Q22PG1        2780 RLA 2782 Tetrahymena thermophila SB210
22_pfamImport  130 EVQ 132 
XP_002507739  5073 TLA 5075
XP_064411311  3035 HLG 3037 coelacanth
XP_028906523  2882 HLG 2884 platypus
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