Conserved Protein Domain Family
BORCS6
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pfam10157: BORCS6 
BLOC-1-related complex sub-unit 6 C-terminal helix
This is a family of conserved proteins found from nematodes to humans. Family members include BORCS6 (BLOC-1-related complex sub-unit 6) also known as Lyspersin (lysosome-dispersing protein) or C17orf59. It constitutes sub-unit 6 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery. this entry represents a C-terminal alpha helix according to structure predictions.
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Statistics
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PSSM-Id: 490951
Aligned: 40 rows
Threshold Bit Score: 83.3875
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_021958000  110 ICVSDLNLMvNEMEMEAKKLAQSVDTLTENLTGILHSLSSM-------TVDCVFTASDGVSQLCDTADASIKVMYQVMAK 182 
XP_016608687   22 TVPIDPTLI-DEIEKTAEQVSADVVRFLGNLKTRMDEITSY-------THESVGVNRQAVNSLSHSIEESIDQMTGLINA 93  
TPX77108       43 SVPIDPSMI-EAIEVNARALAGELDRVIGNFESKMAEIATH-------AHDSVAIHTDAVKACCDALDASRSNMLALITT 114 
RIB18200       33 TPPINPNLL-NELEEQARGIAENLEAMFQNLKSQMFEASVL-------TSASFDVYKQTVENYSTEIKEASNKTRELIEL 104 
XP_031025706   30 SVPLDPQLL-DDIEREAHNIAADYADMIQRLQNRIINACIFislliqwTRESVSVNKLAVNNLCDTVDTGVKRATELINR 108 
ORX83259        9 GPKLDNFQV-NELEKEAVQLSHNLDEVLFTLERQMKECAEF-------TLKSIEAYKLGIDSVGNTVEEGIQSTVELIRK 80  
XP_024389649   76 DIATAVKLV-KAVEDDAKAVAGSLVGLFSSLQSALSEVTGS-------SVDHMKCHSEAAGLLQDASIDAAAKGQRFINA 147 
KYQ89352      233 LTNVGFKTL-KSIEMDAMKCSESVIALTRSLNYSLQMMTKM-------SVELFHAYKMSTDSLCQNAVNSMRETEIMITR 304 
Q54Q24        349 LTNVGFATL-KNIECNAIKCSEEVVLLTKTLHQSLSTITKI-------SIELFETFNGSTEVTCNAIGYSVNETKTMIDK 420  Dictyostelium...
XP_020437990  368 LSNVGFNTL-KSVEMDSLRCAESVVTLTRNLNYSLMVMSRM-------SVELFNNLKMSNDMVCFTIGGGVGQTEKLINK 439 

XP_021958000  183 CEELNKAVQPLYQVNQQIKETKRLLDKVE 211 
XP_016608687   94 VDELSHDMTAVQTLAGEIKTIKDALDRVE 122 
TPX77108      115 VDELSEDMAGVESLALQIKALKEALDVIE 143 
RIB18200      105 CDQLDKEFVDVQTLASNIKNIKQQVDTLH 133 
XP_031025706  109 TEEL--DFATIKGFNEQVKSMKLMLDAME 135 
ORX83259       81 CDELDKDFAAIHNLSAQIKNLNQTLDVLE 109 
XP_024389649  148 CLRLNEEMKSVGNLAAQLKALRQVVDQFE 176 
KYQ89352      305 CIELNEQTKSIQNLHQKIKLIKENINRFE 333 
Q54Q24        421 CFELNNHTKSVISLHQKIKTVRDQLDKFD 449  Dictyostelium discoideum
XP_020437990  440 CIELNEQAKSMTLLHQKIKQIREYVDKLE 468
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