Q5RD58        41 SHLHGRLMLLHSLPC--FIEKD--LKEA-LTQFIEEESLSDYDRDA----EASLEAVKSGEVDL-HQLASTWAKAYAETT 110 Sumatran orangutan
2_pfamImport   1 KELVARVMNYHDIPC--FVETG--LNNK-LKNFVDNERQNLHDDQA----ALLLQKIRDDPTLI-DHVADVVAEKYKNTW 70 
NP_001071257  41 SDLHGRIMLLHRIPC--FVETD--LKNR-LGSFIESETLADYDRDA----EAALQKLTSGEVDI-NKLTNLWAKAYSETT 110
EEC12362      42 keivFRLMQEEQLPC--YVEDD--LTTS-LSDFIAHETEQFFDQTS----STAIEKFQRDG-DV-EALTARWTRDFREAS 110
EFA10962      30 GELVHVLILKNNLPI--YVEKD--LAEN-LSQFVNDWSIKHNNEHT----ASLIDDARNDKTNI-DEITKEWEKLMREEM 99 
Q7QB80        38 AELSHQIVAVRMDPImkFLKADreLLPT-LQAFVERENQSFYDERD----ELLLDKFRHGSPDV-DGLALDTEKLYREEI 111 Anopheles gambi...
1_pfamImport   1 DELSHRIINGFNLPL--NVIEE--LSSE-LQKFVEKCTIDFYDCQT----VDAIESIRNESIEV-EDIVKYWEKAFQEET 70 
XP_002430569  41 REFTYRILYNNKIPH--YLFDD--VYSQ-LEKFVETETLRYYDEVA----EEKLKEFKNDDFDV-DSVVKYWEKLFKNET 110
XP_002118317  15 NELAHRLITAHNLPC--YLLGK--LQAS-LKEFVSSTLCQLQVDKA----EQSIHHLKQFGPDViKDISDHWCKCLQDEV 85 
Q54R54       250 lektkddldeiesfnsqqqQQQ--QQQQ-QQQTPQKQQPPPPQQTP----QQSQQSQPQSSGGIiDSIGQNLDKGVA--- 319 Dictyostelium d...
NP_001256329  49 EDWVGKLRAQ---PSgkFLDYE--GAKEaLRKFIYSETINHQNRRTisniECAVKKKREMGMPL-------FQPSRNRRL 116 Caenorhabditis ...

Q5RD58       111 LEHARPEEp---------SWDEDFADVYHDLIHS-PASETLLNLEHNYFVSISELIGERDVELKKLRE----------RQ 170 Sumatran orangutan
2_pfamImport  71 QEYAPPIS----------TQPNNFPLSYHYLIHS-PAMQILMQLEKKYHSAVAKLLSDKEQSLTKMCE----------RH 129
NP_001071257 111 LEHARPEEa---------SWDEDFASVYHELIHS-PASETLLNLEHNYFVSVSELISERDMELKKLQE----------RQ 170
EEC12362     111 LAEEE-------------TPDSRFPHMYHTLIHS-PALDTVLNLEHTYAVAVGDMVRERDETLGRLQK----------RQ 166
EFA10962     100 AEYGERRCa---------SDEELFATAYHKMVHS-PALETMLQLEHMYSKTVRAKTEEKNRCIQNLSM----------KQ 159
Q7QB80       112 LEFADRVGp---------TDEEIFAQSYHQLVHS-SLLPEILAKEREYARTIASLTTQMTQQITTMNT----------LH 171 Anopheles gambi...
1_pfamImport  71 FSFTDNKGp---------SNDQLFGTAFHKLAHSgPSLDAILHIEYGYAQAVQDIMSRKCRQVTSLTK----------TQ 131
XP_002430569 111 VEYCEPTGt---------TDEELFSMVYHKLVHS-GALESILKKEQMYGATATSLAHKRKKEIKELSEkqvfiyvkinKQ 180
XP_002118317  86 AHWSDHSNkrnavqsiqlDNGQSVAQVYHALIHS-PAMEAILQLEYTYASVVKEIVKQRNTELEQFEI----------QH 154
Q54R54       320 ------------------RASSFFSFGFNKKNNQtPPINSPPSTPQLSSDDPNNVNNNSNNNNNNNNNn---------NN 372 Dictyostelium d...
NP_001256329 117 LEPRRKPVv---------PFEEKFTYVVEQ--SSsENLLTLMRMEVFMKKQMTDMIRARNWEVDQLS-----------KQ 174 Caenorhabditis ...

Q5RD58       171 GIEMEKVMQEL-------GKSLTDQDVNSLAAQHFESQQD------------LENKWSNELKQSTAIQKQEYQEWVIKLH 231 Sumatran orangutan
2_pfamImport 130 RGEMSRACDHV-------GFEYTTEDVSILATKQLADTDR------------MQKHWEDNYRRLTEEQKQEYCDLVIRLA 190
NP_001071257 171 AVEMNKVMQEL-------GKTLCDQDVNTVAAQHFEAQQV------------LESKWASELKQVTGIQKQEYQEWVMKLH 231
EEC12362     167 TSEMERCVQQV-------GLTLTDRDINDIAARHFEETQAs----------rLMDQWDKRIGSLKQTQRKEFWEWVRTVH 229
EFA10962     160 TEEMNHAVDRL-------EQDMTESKINELVARHYEAHSL------------LKVKLTSELDTIKEAQRREYREWLMQML 220
Q7QB80       172 QEEIESKIKLL-------DISITPENINHMLAKQYGMQNM------------IRKQCESELESTRGHQKHEYRNWVTQHV 232 Anopheles gambi...
1_pfamImport 132 TEEMNYAMDGL-------NKYTTEDDINALALKHFDDQTL------------LQGKWNSRLDTLKQEQRTGYREWVMKTV 192
XP_002430569 181 NDEMTVAMQDLhsmtiesEIRVSEKDINDLAAKHFEEQCL------------TSGRLNSEVEALHQSQRKEYRAWLMAMY 248
XP_002118317 155 QQQLEIAIQ---------SGIASDRKVSRLAAQHMEELQF------------KNAKWNSTLSDLMENQKREFYAWMVRVY 213
Q54R54       373 TQSKPIGINNNnnnnssnNRQRTDSQVSPPNSLNSSSPNKppqpttplnnnnSNNNNNNNNNNNNSIQRKS--------- 443 Dictyostelium d...
NP_001256329 175 CEKLVAETG---------DPDMHPHKISMLNEKLRQ----------------VHTTYSFQVADLSDTQKSKYRKAVDSLY 229 Caenorhabditis ...

Q5RD58       232 QDLK-----------NPNNS-SLSEEIKVQPSQFRESVEAIGRIYEEQRK----------------LEESFTIHLGAQLK 283 Sumatran orangutan
2_pfamImport 191 EEMK-----------QSDNKlNENGPVHNEVQRLLDHNRGRSLVSTRDPSedvesessvtvscgilMEESFTINLGAQLK 259
NP_001071257 232 RDLQ-----------NPNNS-TINEEIKVQPGQLGEAGEAADRLFEEQRQ----------------LEESFTIHLGAQLK 283
EEC12362     230 EDYT-----------TSKGDrGFGARMRAASRSLAGHEVDNWTPPPPRPS------------------ESFTIHLGSQLK 280
EFA10962     221 EQNQ----------------------------ATSSLPTPNSPLTPHTPQpaiyssecarsidtpiLEESFTIHLGSQLK 272
Q7QB80       233 DESFlgq------seSPTQIgNRWSMISTQAPS---------------------------------MEESFTIHLGSQLK 273 Anopheles gambi...
1_pfamImport 193 EEMQgvdglyspignSPINIvTNGFTISNM--SLYD------------------------------MEESFTIHLGSQMK 240
XP_002430569 249 ENEAl----------SPTLHlTSTSPKVLDNSSLDSGISSQPEPWPH-------------------FEESFTIHLGSQLK 299
XP_002118317 214 NSMVenngvptertlS-----MPHSIVATLSRAAPDSHLNHESNNHVDNR----------------MEESFTIYLGTQKK 272
Q54R54       444 ---------------------STGSSSTNLQPTLQRKQSGGAGNIPIINSgss-----------ssKFEDFTIGVGVQKK 491 Dictyostelium d...
NP_001256329 230 SRGS-------------------------IPAELLDDVILDEHAIPRPVAtttgg-------yadgVNESFTIYIGSQLK 277 Caenorhabditis ...

Q5RD58       284 TMHNLRLLRADML-DFCKH--KRNHRsg----vKLHRLQTALSLYSTSLCGLVLLVD-NRINSYSGIKRDFATVCQECTD 355 Sumatran orangutan
2_pfamImport 260 TMHNIRLVVADML-YFCRY--SDDGEm------EAQRFQTAMSLYSNSLSAIVLITD-KNLNECSGIEKEFRTVCESSTE 329
NP_001071257 284 TMHNLRLVRSDVL-DFCKH--RRHSSsg----vKLRRLQTALSLYSTSLCGLVLLVD-NRVNSYSGIKRDFATVSQECTD 355
EEC12362     281 VMHNLRLLSANVL-DLCRHttyg------mgvpAPQRLQMAMSLHSNSLSGLVLLVD-NRINSYVGIKREFAAICHESTE 352
EFA10962     273 QMHNIRILSANVM-ELCAV--EDNDQss---epKPQLLQTALALYSSDLSGLVLMTD-NKIG--SRLTQDFQEICQRTTE 343
Q7QB80       274 HMHNIRILSTRVA-DLCSP--LYGDA-------SFGGPNVALGLYSSSLCGIVVLTPsGTITPDREIRRN----ANMSTE 339 Anopheles gambi...
1_pfamImport 241 STHNIRIMSADTL-NLLSLtlEENGTvv----hHPQRLQTVLELYSQDLKGLVLFIDtNNLDFYSGLAKEFFDICDGSTE 315
XP_002430569 300 QMHNVRILSANAL-DFCKIklPPEGVsh----vEPRRSETALSLYSSSLSGIVLLVDvGSFDGFAGLAKDFVDVCQQTTE 374
XP_002118317 273 TMHNIRLMIGHPL-DLCRS--AYTGSigsgigpPPQRIQTALSLYSSTLNGLILLVD-DKPNCYTGIKNEFAMICEESSE 348
Q54R54       492 KIFNFKLIEESPL-QLCRPitslt-----gdykKSKRVDYIKTLYSDSLSAVILIID-PSLQFNTENEKKFIKYCNMSTE 564 Dictyostelium d...
NP_001256329 278 SMHNVCLVTVDRLtDLCQTleg--------dwtTSSRLEMATKLYSRNLSGTTLLVP-RDPMMHINSSSDFFKICEQSTD 348 Caenorhabditis ...

Q5RD58       356 FHFPRIEEQLEVVQQVVLYARTQRRSKlkesldsgnQNGGNDDKTKNAERNYLN---VLPGEFYITRHSNLSEIHVAFHL 432 Sumatran orangutan
2_pfamImport 330 FHFETLQDQTTKVKEHALEASERRNRS---------LSSEETIEYKQNIDEMDGtgtLNEGDFYITKHSNLSQVHLVFHL 400
NP_001071257 356 FHFPRVDEQLEIVQQVVLYARAQRNSKqreq-pempRNGGNEDKNKILDRNSSN---ILQGEFYITRHSNLSEVHIVFHL 431
EEC12362     353 LHFADIDDQLETVRAKAREVAEIRTAAs--------LSGSDGSSSQSSRRSSFSgqdHSPGDFYVTRHSNLSEAHVVFHV 424
EFA10962     344 FHFPHIDDQLDKISNTAQLYLKSQKEN---------------------SNRNINselLQAGDFYITRHSNLAQVHVIFHM 402
Q7QB80       340 FHFEQIDRQIEKIQEDLRNLQHGHAVE---------AGGAQSLAAAAGRRPDRTvvtVKPGDAFITRHSNLSHSHVIFHL 410 Anopheles gambi...
1_pfamImport 316 FHFNSLQDQLEIIKSDLKVAVENRKCK---------GPVSNFLSPELQARRNKSk-lLQCGDVYITKHSNLASVHLVFHM 385
XP_002430569 375 FHFNNIESQLEAIKIQVKDAVQWRSEK------------AKNSSGYQNSKMSSGgksLQAGDLYITKHSNLSQVHVVFHL 442
XP_002118317 349 FHFLSHPEQLHHIRRSIQKSQSTRAKRq-------dSEDNDIDSLEIFWDEDDDsvvLALGDFYSTHHSNLSDIHVVYHL 421
Q54R54       565 LHFDSIDSQIHTFKQSLLKEEEREKEE---------------------NNNNNNnikLSNGDFFITKHSNLSDVQVVFHL 623 Dictyostelium d...
NP_001256329 349 LHFDSLAEQLKKTLAANRERNSWKADKideetskliAEGKTPPEQLVPSSALRQdptCTVGDVYITRHSNLHKVQIVYHL 428 Caenorhabditis ...

Q5RD58       433 CVDD----HVKS-GNITARDPAIMGLRNILKVCCTHDITTISIPLLLVH-DMSEEMTIPWCLRRAELVFKCVKGFMMEMA 506 Sumatran orangutan
2_pfamImport 401 VAEEnqlrTKASlTTVTSRHSVILGLRHILKVASSHDIRHITIPLLLSH-ELTEEITFQWCVKRAELVMKCIKGFMMEMA 479
NP_001071257 432 CVDD----NVRS-GNITARDPAIMGLRNILKVCCTHDITTITIPLLLVH-DMSEEMTIPWCLKRAELVFKCVKGFMMEMA 505
EEC12362     425 VGDE----SLRG-ADVGSRHPVILGLRNVLRVAHERDVCGVTLPLLLSH-ELYEEMTIPWCLRRAELVFKCIKGFMIEMA 498
EFA10962     403 VSDD----SLRG-SDINSRHPVVLGLRNILKTACSNDITSLTIPLLLQY-EMTEEMTISWCEKRAELVFKCVKGFMIEMA 476
Q7QB80       411 ISDE----TFQSpSEINSRHPVILGLRNILKIASRHDITTLTIPALLRH-EMSEDMTVSWCIRRAELVFKCAKGFMIESA 485 Anopheles gambi...
1_pfamImport 386 VIDD----SLKS-GDINSRHPVILGLRNILKTACSYDITMITIPLFLTH-EMTEDMTVPWCQKRAELVLKCVKGFMIESV 459
XP_002430569 443 LVDD----SVKN-SDVNSRHPVILGLRNILKTAASYDITTITLPLLLTN-EMSEGMTVAWCSKRAELVFKCVKGFMIEAA 516
XP_002118317 422 VVND----DVKS-DRLPNRHPILTGLRNALNTAASNDVTTITIPLLLVN-EMTEEMTISWCVKRAELIFKCVKGFMMENE 495
Q54R54       624 VIDSknrtPLGGdNQLSTTSDIAKGLRNILLTASKYGIGNITIPICLTEsELDLNVTNSNLLSRCVSVLSVTRASLTSLQ 703 Dictyostelium d...
NP_001256329 429 VVDE----TLQS-LEINSRHPCLAGVRNIIRTAARYNTSTIHIPLLLID-RPDESTTIAWCLKRAEMLFKCVKGYLMEVC 502 Caenorhabditis ...

Q5RD58       507 SWDGGISRT-----VQFLVPQSISEE--MFYQLSNMLPQIFRVSSTL 546 Sumatran orangutan
2_pfamImport 480 TWDGGISRT-----IQFVIPPGVSEE--AFDRLRYTLPEVFRTTSTR 519
NP_001071257 506 SWDGGISRT-----VQFLVPQSISEE--MFYQLSNMLPQIFRVSSTL 545
EEC12362     499 SLVGEETRT-----VQFLVPQGISED--LFASLSAMLSSIFRVSNPL 538
EFA10962     477 SWGGSELKN-----LQFMLPQGISSR--VFQSLTEMLPRIFKVSNPK 516
Q7QB80       486 SWGGAELNT-----LQLLLPHDISEE--LFRTLADMVPHVFRVANPK 525 Anopheles gambiae str. PEST
1_pfamImport 460 SLGGSELKT-----IQFLVPKGISEE--VFGILATMVPTIFRVSTPL 499
XP_002430569 517 GVGGADIIN-----LQFLVPSGISAE--VFSTLATMLPTIFRVCNPL 556
XP_002118317 496 MWSNNQACI-----VQFLIPKGISEE--MFNTFTGMLPGIFRMAAAL 535
Q54R54       704 EM--TSIKT-----VQFSLPSQLDSGntIFK---GPIAQKWKSAINP 740 Dictyostelium discoideum AX4
NP_001256329 503 --SGMDVESlphynVHFVLPSGLSPT--IYTAITNMFPSIFHLVPGV 545 Caenorhabditis elegans