Conserved Protein Domain Family
CCDC53

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pfam10152: CCDC53 
Subunit CCDC53 of WASH complex
CCDC53 is a component of the WASH complex, which plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
Statistics
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PSSM-Id: 401961
View PSSM: pfam10152
Aligned: 53 rows
Threshold Bit Score: 70.0085
Threshold Setting Gi: 134061208
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAM38230      25 VNRFVISTVQFLNRFSDECESRLVQTEVSLQQLELQTQLLEHMlLSsgAADpDAVEEEEEGGErfdgnddgascledgdd 104 Leishmania braz...
Q387Z1        22 VNKFVISTAQFLNRFAAYCESKLLETNRSLQRLETLTLLLEAK-IA--SVDdELKETQPQTVEgqttvkalgdnvarlmi 98  Trypanosoma brucei
CAM67251      36 VNRFVISTVQFLNRFSDECESRLVQTEESLQQLELQTQLLEHLlITssAADpEADEAEEEGGDhsndddggasyladgdd 115 Leishmania infa...
Q4DSA5        17 VNKFIISTTQFLNRFAAQCDSQLIEICRSLQRLEILTVLLENK-LK--SIDdDFSEVNAATPStsaaafpqsasvgvggs 93  Trypanosoma cruzi
ERN06426      32 VNIFIVDTARFLNRFSALCEQKLADVHRRILRLDATLTLLEAK-LR--SID-GIEEIKDGSRVkercfey---------- 97  Amborella trich...
EAX98312      35 INQFTERTVDFLNRFSNICDMKLLEVSQRINNIEILTKILESK-LE--SVK-GLGFVPGQPLPpssapspq--------- 101 Trichomonas vag...
EFA84223      42 VNNFVINTTQFLNRFNYLCEQKLTDVSNQLNRLEVTMSLLEIK-LG--SID-GLESLPTANAPimtntasgasssaappp 117 Heterostelium a...
XP_004356907  22 VNNFVINTTQFLNRFSLLCEQKLVDVSNHLNRLEVTMSLLEIK-LG--SID-GLESLPTANAPtyhtttntsgatapppp 97  Cavenderia fasc...
7_pfamImport   1 INNFVANTTRFLNHFAHECEERITRVSDNVTRVEILLAILEAK-LN--SIP-DLSVTDAEVAAaatsddvrklnsnqmdl 76 
EDV29265      30 INYYITYTVNFVNRFSSVNEERLEEVTTRLQKLEVAMAVLEAK-LS--SVP-GLENVTAD-------------------- 85  Trichoplax adha...
CAM38230     105 qdmmrdngsvasvaydyrqrhsrgggprafskksdvesvlglpaspsnnrrsggpppppgDYRKGPPRPPPGMSRAAAAA 184 Leishmania braz...
Q387Z1        99 pdrqvp--------------------------------ppmpglspeggqrrlpppppshQNRKGPPPPPGSAAPAVKA- 145 Trypanosoma brucei
CAM67251     116 qdmvrddgseasaaydyrqrr--grgrrgasengdaesvlglpapppkdrrsggpppppgNYRKGPPRPPPGVARAAAAA 193 Leishmania infa...
Q4DSA5        94 tplaivdre-------------------------vpppmpgllsasgghhhppppppphlQRRNGPPPPPGVAIQTRVNG 148 Trypanosoma cruzi
ERN06426      98 -----------------------------------------------------tngscssAERSHEPTYGSIMTLSESHA 124 Amborella trich...
EAX98312     102 ----------------------------------------------------agvppppaADGAPAPPPPPPPPGAGADG 129 Trichomonas vag...
EFA84223     118 ppgstt-------------------------------ttttannisnasappppppppgsISTNAAPPPPPPPPGSSAAA 166 Heterostelium a...
XP_004356907  98 -------------------------------------------ptasspaapptsstasgGAPPPPPPPPPPGKGAAAAS 134 Cavenderia fasc...
7_pfamImport  77 gisdqdlpsvdtaaane---------mplppppppaehvevvvdgmppppppssmdgfemALTVPRPPSPGALSLTDSMP 147
EDV29265      86 ------------------------------------------------------------SQDQPTVQQQQSTVQQQQST 105 Trichoplax adha...
CAM38230     185 QEAEAARAATLSIVGAPVLMPPlsaeapapppplelrpGRLLMRNHPRLRGYFQLLSLRVPKAFVKMKMQADGFQGEWLD 264 Leishmania braz...
Q387Z1       146 -------PPPPPVPLPPLMPGPpppgalpvqpppmplmGGVPMRSHPRLAGYYQMLALRVPAEVIKEKMRSDGYQPEWLD 218 Trypanosoma brucei
CAM67251     194 QEAEAARVATLAMVGAPVLMPQlsgdapapppplelrpGRLLMRNHPRLHGYFELLSLRVPAAFVKAKMQADGFQGEWLD 273 Leishmania infa...
Q4DSA5       149 SAVVPIQPPPPVPPMPPSSLGQlpvgslppppppmpllGGFTMCTHPRLQGYFQMLALRVPVEAVKAKMQMDGHQPEWLD 228 Trypanosoma cruzi
ERN06426     125 PQQTPSTSVQPSTPSQ----------------------NQPPFDDDPRLARFCRMLHFGVPEQAVKMQMSIEGMDPSLLN 182 Amborella trich...
EAX98312     130 QAPPPPPPPDGAAPPAEGEAAAegegqaaegenaepeaDPNDVRNDPRYAPYLKYLKIRVPLIAFRQKMIDEGLDPTLLE 209 Trichomonas vag...
EFA84223     167 PPPPPPPSSSSGSSSDSNS-------------------AAITYRDDPRYKPYFNLFAKGVPLVAFQGKMIADGLNPNAil 227 Heterostelium a...
XP_004356907 135 GPPPPPPPPSSSHQSDNEEEIIivpt--------aasnGGISYKEDPRYAPFFDLNRKGVPVVAFQSKMLALGLDPNAIs 206 Cavenderia fasc...
7_pfamImport 148 PPPPPSQGDFHAPPPDEVRVQSdg-------------pSMLKLKDDPVYAKYFTMRRLGIPDSVIEHKLMMDGMSTNIL- 213
EDV29265     106 IQQQQSTATEGLQQDNIQQSEG----------------DFIALKDDARYKKFFSMLRVGIPNQAIKLKMTVEGLDPAMLD 169 Trichoplax adha...
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