Conserved Protein Domain Family
SCHIP-1_C

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pfam10148: SCHIP-1_C 
Schwannomin-interacting protein 1, C-terminal
SCHIP-1 is a coiled-coil protein that specifically associates with schwannomin, a protein involved in NF2-associated and sporadic schwannomas and meningiomas. This entry represents the C-terminal domain, which contains a leucine zipper coiled-coil structure implicated in their dimerization. This domain is also found in its isoforms such as IQCJ-SCHIP-1.
Statistics
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PSSM-Id: 490942
Aligned: 5 rows
Threshold Bit Score: 281.838
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_046648038   41 KRNDREEIRRRLAMGVEaEDGQ------ESDKGKRPSLQSRLQSGMNLQICFMNETADGGDIDNQKELLDNLKLGSPQS- 113 
2_pfamImport    1 RRNDREEIRRRLAMGAE-DDYFskivnpENRPIRKPSFQSRIKTGRNLQICFVNEAQSDTESVSSDSESCPTLSRLPRGn 79  
EFN70358      947 RRNDREEIRRRLAMGPDaEDLR-------AERGRKPSLQSRLQSGMNLQICFMNETSSDTESPGSEND------TSPGSt 1013
EFA04405      114 RRTDREEIRRRLAMGSE-DDYY------TDRPGRKPSLQARLQSGMNLQICFMNETVSDTESPNSDNECPLTNPKQPKTc 186 
XP_008759305   12 QKNERESIRQKLALGSFfDDGPgi--ytSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSK-TETSLDTPLS- 87   Norway rat
XP_046648038  114 ---------DIKNPYVSLPVVSSLKQPKl-----qQELAELDFFSQQAKLQMEARTALAQAKELARVQMQV------ERQ 173 
2_pfamImport   80 sinq-ikklQAANPYSSNPLSVSCTDGKns----qLENTDNDFFTKQARLQIEARMALAQARIWRTCKWRVdsisfiEKQ 154 
EFN70358     1014 ptslgskqlGGKQHAPMRPQVLSLPSLRlesanstPPVDEADFFARQARLQTEARMALAQAKEMAHMQMEV------ERQ 1087
EFA04405      187 pktspektlP-----PARPATLSLGQPLlqp--vtQPMTETDFFARQARLQTEARMALAQAKEMARMQMEI------ERQ 253 
XP_008759305   88 ---------------PMSKQSSSYSDRDtteeeseSLDD-MDFLTRQKKLQAEAKMALAMAKPMAKMQVEV------EKQ 145  Norway rat
XP_046648038  174 QRKHTRISDL------VRQSLEKLGIPFPWDCRRLSRQILTELNIAQLQVIVNDLHTQIEGLNEELVQLLLKRDDCHMEQ 247 
2_pfamImport  155 KQSLSPVTEI------IQTSMKKVGVPLPQQKRRVSRQTLTDLNVAQLQVIVNDLHSQIETFNANLVQLLMDRDDLHMGQ 228 
EFN70358     1088 RLKQSPITEM------VRCSLEKVGVQLGEDRRRLSRVLLTELNVAQLQVVANDLHARIAALNEALVEGLLRRDDLHMEQ 1161
EFA04405      254 RQKKSPITEM------VRNSLEKVGIPFPEEKRRLSRQILTEMNVAQLQVIVNDLHTQIETLNESLVKFLMDRDDLHMEQ 327 
XP_008759305  146 NRKKSPVADLlphmphISECLMK---------RSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQ 216  Norway rat
XP_046648038  248 DSMLVDIEDLTRFLTAKQA 266 
2_pfamImport  229 DAMLVDIEDLTRYLSAKEQ 247 
EFN70358     1162 DSMLVDVEDLTRYLGAKQE 1180
EFA04405      328 DSMLVDIEDLTRYLGAKEQ 346 
XP_008759305  217 DAMLVDIEDLTRHAESQQK 235  Norway rat
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