Conserved Protein Domain Family
CR6_interact

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pfam10147: CR6_interact 
Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.
Statistics
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PSSM-Id: 490941
Aligned: 6 rows
Threshold Bit Score: 174.682
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9VP13        29 LPASLVgdv-dvePTYPQTV----DRSGLQPQHKNVLLNKLPYQEPHSWI-----------HLTEKYQRQAFGRYGAQ-S 91  fruit fly
2_pfamImport   1 LPLTFVdddaestEAREARIaalrNKSRLLPQHRNMLHGVLPYEQSQSWI-----------HDTVKYKRMMLGRYGIDgS 69 
1_pfamImport   1 LPAAIInenvedsSVHARRL----NKSGLQEQHKNIVMGVPPYRDAQSWI-----------HLTEKYQRKVYGLYGAK-S 64 
P90915        24 LVRSFA-------TNSSEEIapkvDVSFLRPRHRIIAAGGMPPVQFDS-------------ERERASRRERFGKYGLK-S 82  Caenorhabditis ...
Q5XJW2         1 MAAP---------ATRSRYLlr--ltVTLGPRSRSYHAPPPPRRRPAPHWpdrenlmtprwQLTPRYAAKQFGRHGAI-S 68  Norway rat
A1A4P4         1 MAAP---------VRQTRSLlg--wvTTLGPGSRGYRAPPPPRRSREPWWpdpddpltprwQLGPRYAAKQFARHGAA-S 68  domestic cattle
Q9VP13        92 NVNPKICFDShGEK----DSRQVMQLETLLKMLEKNRAQKAEELARINAREEDIA------KKMEKLTQWKADLHAKIAK 161 fruit fly
2_pfamImport  70 KVDPRVCFPTkKEAyeraEYERVAFPFSLKQMMDANESERKARKAQIEAREAEVA------RKLEKLDQWTADLNARIAK 143
1_pfamImport  65 NVNPKICFDSkAEQ-------EVMQLDTFFKVLEKSRLEKAEKIQKTNDRDEDIA------KKLDKLEQWKSDLNAKVAK 131
P90915        83 GVPVEELFPT---------AEEIEEEEAIGLFREFNNAKKEYKELQKKKRESELAriaeleKNLKKYPATLAKYEASLVK 153 Caenorhabditis ...
Q5XJW2        69 GVPPASLWPS-SEQlcelEAEEREWYPSLATMQESLRVQQQAAEARRQAREQHIA------ECMAKMPQMIENWRKQKRE 141 Norway rat
A1A4P4        69 GVDPGSLWPS-REQllelEAEEREWYPSLAVMQESLRVQQLAEEQKRQAREQLIE------ECMAKMPQMIENWRRQQQA 141 domestic cattle
Q9VP13       162 READAAAAIQRKERLVEEVRRHFGFKVDTRDERFKEMLEQKEKEDKKKQKEAKRKAKEEKMMAKLVEKAS 231 fruit fly
2_pfamImport 144 KEAEARAAKERKDRLVEEVRRHFGFKVDPRDERFQEMLALKEREDRKKVKEAKRKEKEEKMMEKLQKKTA 213
1_pfamImport 132 REAEAAAAIARKERLVEEVRRHFGFKVDTRDERFKEMLEQKEKEDKKKQKEAKRKAKEEKMMAKLVEKTS 201
P90915       154 QEQEKDEKEVALEKRIRDIQEYFGYWMDPKDPRFEVMLQQKEAEEKKAVKMAKRDEIQKKRFAENVqg-- 221 Caenorhabditis elegans
Q5XJW2       142 RWEKIQADKERRARLQAEAQEQLGYHVDPRSARFQELLQDLDKQQRKRLKEERQRQKKEARIAAMASAEG 211 Norway rat
A1A4P4       142 RREKAQADKERRARLQAEAQERLGYHVDPRSARFQELLQDLEKQHRKRLKEEKQRKKKEARAAAMAAAAA 211 domestic cattle
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