Conserved Protein Domain Family
RlaP
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pfam10127: RlaP 
RNA repair pathway DNA polymerase beta family
Family of the DNA polymerase beta superfamily, with closest affinities to the Minimal Nucleotide Transferase clade (MNT). Observed in diverse RNA repair genome contexts centered on both RtcB and Rnl-type (ATP-grasp fold) repair ligases. Members of this family of bacterial proteins catalyze the transfer of nucleotide residues from nucleoside diphosphates or triphosphates into dimer or polymer forms.
Links
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Statistics
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PSSM-Id: 490924
Aligned: 20 rows
Threshold Bit Score: 201.77
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q853S4  16 HEPVQGAFETSHSSS----HHqqi---aldGLIYLSEVGSTLHGVSTDatSDDIDE--MGIAIEPPRCVIGFerfdlyeY 86  Mycobacterium phage Bxz1
Q2SQI3   2 EKRIQETLERIEWEH----DV---------RVLYACESGSRAWGFASR--DSDYDV--RFIYQRPLSHYLSL-------G 57  Hahella chejuensis KC...
Q8SCS5  12 RVTINVELDRIEKKY----GV---------KIIYACESGSRGWGFAST--NSDYDV--RFIYVNHPSHYVRV-------D 67  Pseudomonas virus phiKZ
Q65NN4   2 KQRIEEELKNIEATY----GV---------KILYAVESGSRAWGLPSQ--DSDYDV--RFIYVHQKDWYLSI-------D 57  Bacillus licheniformi...
Q0ATC2  15 HDTILNQLRQIETRE----NV---------RILFAIESGSRAWGFPSP--DSDYDA--RFVYARPRDWYLSL-------E 70  Maricaulis maris MCS10
Q0BVF7  15 RSVIQERLDRIVAEN----HV---------RILLAVESGSRAWGFPSP--DSDYDV--RFVYVRNRDEYLRL-------H 70  Granulibacter bethesd...
Q2RSZ8  23 GPAAARAVAAFAEAE----GV---------SLPHAALTGPLAWGLPDD--GVSAPVvcACVFIRPAQAYLGL-------V 80  Rhodospirillum rubrum...
Q9S235   2 IDALDIDLAPVVAEQ----PF---------PVLFATVSGAHLYGFPSR--DSDVDL--RGAHLLPAADLVGLrepeetrS 64  Streptomyces coelicolor
Q7ULC4  64 HHDQLVRLSEFKNQFirntTAplmdsglyeRVIYRCVIGSRAYGLDDE--DSDTDR--RGIYLPPAELHWSL-------- 131 Pirellula sp.
Q5YSM9   8 SVHGSAEFQRIANQ----------------NTVLRGQVGSGLHGVTTG--ADDRDE--MGVCIEPPEYVIGLdrfeqyiF 67  Nocardia farcinica

Q853S4  87 RT--KPVSVRSQAGDID-RTIYSLRKYAHLLASGNPTVLMPMFAPAD--KLRYVHPLGQVLRENVGHFLSRQTGQRFLGY 161 Mycobacterium phage Bxz1
Q2SQI3  58 KR--RDVIELPIVDELD-VNGWDISKALTLLRSGSATLQEWLNSPIV--YSRDVVFLAQMKYVASLSARPVTLFHHYFSM 132 Hahella chejuensis KC...
Q8SCS5  68 NEa-RDTIEEMVSKELD-LAGWSITKTLQLAYKSNPTLLEWLNSPIV--YRKVDRDYKLIRDAALKHFIPESSYMHYISM 143 Pseudomonas virus phiKZ
Q65NN4  58 AK--RDVIELPIDDSLD-ISGWELTKALRLFRKSNPPLLEWLSSGTV--YYEAYSLAEKMRRLKSRAFSPVSCMYHYLNM 132 Bacillus licheniformi...
Q0ATC2  71 PG--RDVIELPIDGDLD-INGWDIKKALNLLLKPNPVLLEWLSSPIR--YMWDETTCARLKGFAERVAHGPACVHHYFNL 145 Maricaulis maris MCS10
Q0BVF7  71 AP--RDVIETPLLDEID-LNGWDIRKALGLLLKSNAVIGEWMVSPIQ--YCTAHPVIERLNDLAGKVLNRHHLAWHYHSM 145 Granulibacter bethesd...
Q2RSZ8  81 EP--PDILHLDATDDMPaVVGWDARRVLRMALRSNAVVWEWLASPVIdgPGARADFREAFLALATRGYARSTLLGHYLGV 158 Rhodospirillum rubrum...
Q9S235  65 RMwdRDGVE------MD-LVTHDLRKFVRLMLRRNGYVLEQLLSPLV---VHTTEAHRELAGHAPGVL-TAHHAHHYRGF 133 Streptomyces coelicolor
Q7ULC4 132 ----YGVPEQLENDQTQ-EVYWELQKFIVLALKANPNVLECLYSPIV----EKVTPLGKDLLAMRDAFLSKLVFQTFSGY 202 Pirellula sp.
Q5YSM9  68 RT--QPEGVRSGAGDLD-LTVYSLRKWARLAAQGNPTVLLLMFIPEQ--EIVVTSHVGRDLQAHPDRFLSRQVAHRFAGY 142 Nocardia farcinica

Q853S4 162 LNRQRSRY----LDPEr--TDsthasrpelveaygwdTKAGYHALRLAIQGAELMKHRTiTLPME--------------P 221 Mycobacterium phage Bxz1
Q2SQI3 133 ARKERERL----AAGE---VN----------------AKRYAYMLRTLLAAMWVAEHRT-PPPVRfyelkarmlgggslV 188 Hahella chejuensis KC...
Q8SCS5 144 AKQTKMRW----LSDEk--VR----------------MKKYFYSLRPLLAAMWVRESLE-HPPMVfhdllpl-ltdpilY 199 Pseudomonas virus phiKZ
Q65NN4 133 ASGNFRDY----LTREe--VK----------------IKKYFYVLRPILACQWIESRRT-VPPIEfqvlldeltedgplK 189 Bacillus licheniformi...
Q0ATC2 146 GESLLNRH----IAPKd-qVN----------------LKKYFYIVRPAMALRWVRMHADiIPPMNfqellagidvsaelT 204 Maricaulis maris MCS10
Q0BVF7 146 GRKSAERW----LTGDe-pVP----------------VKRYFYALRPALALRYLRLHAGkRLPMHvsalmeasdlsrslL 204 Granulibacter bethesd...
Q2RSZ8 159 AKAAMNAY----FPDEpreAA----------------RIKYMHTLRALMAVDWILGKNA-PPPPDwarlr----agaslP 213 Rhodospirillum rubrum...
Q9S235 134 AQTQWRLF----ERTG----E----------------LKPLLYTFRVLLTGVHLMRTGEvqphlptl-----veevdaaP 184 Streptomyces coelicolor
Q7ULC4 203 VASQFKKMqtdiRNQGr--VK----------------WKHVMHLIRLLLSGTHVLQNGEiiv---------------dvG 249 Pirellula sp.
Q5YSM9 143 LMSQRDQMlgvkSKKHt--NRpelvd------vygfdTKFAYHMVRLGVQGVELLTTGRiTLPMP--------------E 200 Nocardia farcinica

Q853S4 222 DRREFLLNVRNGQFTKDQV--VTWLESTFVPL---LEHEIehSTLPEQ--------PEWRYINHLLVQ 276 Mycobacterium phage Bxz1
Q2SQI3 189 AEVDALLERKAKGNEKEVIkpVTAIDCFADGQ---FEALE--AVRFDAvd-----kLDLETIDRVFMQ 246 Hahella chejuensis KCTC 2396
Q8SCS5 200 KRIQELVNDKVGATEQDLIdrCPILDQFIDFQ---LSREKpdFGKYERpdiyaltdLAWHFVDQYKID 264 Pseudomonas virus phiKZ
Q65NN4 190 TEIHQLLERKKKGEEFNLEpqNPILHEFIERE---LERLQtvAKAYKTdh-----eDLTQELDRLFRE 249 Bacillus licheniformis DSM 13 = A...
Q0ATC2 205 DALNELLIAKSQSKEVGLAprVGVIDAFIEAE---FDWARevSKGLKSer-----rNLRDEADGLFRD 264 Maricaulis maris MCS10
Q0BVF7 205 EQINTLIAAKRLTNEQTNGarYPELDALIRQE---LAILPesEQTRPPml-----dRHRREADQLFLD 264 Granulibacter bethesdensis CGDNIH1
Q2RSZ8 214 AEAAPLLDALEVGPPAERR--HPVLDGWIDSV---FEASRakGGDLSDd------hPPLAELDGLYRS 270 Rhodospirillum rubrum ATCC 11170
Q9S235 185 VYLPELVAAKAEREHGDAGvdHARVRADVERLhtvLDEAQaaSVLPDAp-------TAYDALHDFVVR 245 Streptomyces coelicolor
Q7ULC4 250 QHRDRLLTIKHGDMPFHA---ADEWRQELQRE---FESAFqtTPLPDR--------PDYERANAFLID 303 Pirellula sp.
Q5YSM9 201 PERAWLTELRHGLHTKEE---ALERAADLLAQ---LNHLSlhADLPPE--------PDWARINRWLID 254 Nocardia farcinica
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