Conserved Protein Domain Family
McrBC

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pfam10117: McrBC 
McrBC 5-methylcytosine restriction system component
Members of this family of bacterial proteins modify the specificity of mcrB restriction by expanding the range of modified sequences restricted.
Statistics
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PSSM-Id: 431067
Aligned: 18 rows
Threshold Bit Score: 255.298
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7VG80        71 L--------KAQNYVGLIQAKSGF---CVEILPK--TFRTAK---KNegfkiqnctckktqdttkqpqnmesnppkckvc 134 Helicobacter he...
Q0KFR0        65 V--------QVTSFVGVIRAPDGF---QIEVLPK--VGKAIG---GGav------------------------------- 97  Cupriavidus nec...
1_pfamImport   1 L--------QVKNYAGVISLPGNA---FIEVLPK--TGRRDE----Nid------------------------------- 32 
WP_011721515  45 niiwtrntiifiNYVGYIKLS-TV---DIEILPK--ISINEEnpeIE--------------------------------- 85  Clostridium novyi
Q188G2        54 L--------RFINYVGIICFE-NV---ILEILPK--LSLSDNlv------------------------------------ 83  Clostridioides ...
WP_011751479  45 V--------TAEHAVGAVRRGDL----VVRVTPK--VGAAKV-------------------------------------- 72  unclassified No...
WP_011690728  58 I--------EPVGMVGSVRTPTV----QLEVRPKdrLGLSRL-------------------------------------- 87  Arthrobacter sp...
Q5JH86        62 L--------KTHGSVGFAYYLGDDgivLVQVLPK--PFRYDRe------------------------------------- 94  Thermococcus ko...
Q8CYQ4        68 IfetvnqkiKTGNVIGFLGYGQE----RLTISSR--FSDESN-------------------------------------- 103 Streptococcus p...
Q8DT82        58 VletvsgqiKTQNIIGFLGYENE----RLTIHSR--FANGDD-------------------------------------- 93  Streptococcus m...
Q7VG80       135 eaKALLLKMLQ-----SLKDSPFKQSHFAHLKLTKM-PLLEIFILM--FLQELEKLVKKGLKSDYIVCEENRNFLKGKLL 206 Helicobacter he...
Q0KFR0        98 eaRKLLIEMLC-----CLQGFRHVKTDSANISAARM-PLLEVFVAE--FLRAVDHIVKRGLRSDYSSRQDNLYALRGKLL 169 Cupriavidus nec...
1_pfamImport  33 iaRQQLLMMLR-----TLKSFRHIATSASRVRTSKM-PLMDVFIQQ--FIDSVQQIVRQGLKRDYLRQQDNLPWMKGKLR 104
WP_011721515  86 --RKALLNMLS-----ICGILNISYSDISLSNIYKM-NLNEILSFL--FAKNLQKELIKGIYQEYIYVEKNNNLLKGRIL 155 Clostridium novyi
Q188G2        84 kdREILLQMLS-----ICNKIPITMNEKIRLSLKNY-NLLNFFVMY--FIESMQTQMKKGIYFEYINKIENLNVMRGKIL 155 Clostridioides ...
WP_011751479  73 ------LTLLA-----RAQGVRGLKVDPELVGVAPHaDISAVLAVL--FAQEAATAMAAGPLRGYRSEDQTLPVLRGRVR 139 unclassified No...
WP_011690728  88 ------LFLLS-----YAGNQGFREDPVAAVEDPDL-----WSALAvsLVQLADRALSRGVLQGYLTVDESLRTVKGRIR 151 Arthrobacter sp...
Q5JH86        95 -dGRSLLFFLQlfnmyYQMGLEPGEIRALVFEYGRQkALDEIFKYL--YVLMLSRALSRGLYYEYGEIEESSQTVRGRIL 171 Thermococcus ko...
Q8CYQ4       104 --DHFLHYLLN-------KVLYINLTSLDVALSREE-RLYQLLMYL--FPKYLQAAIRKGLYKEYHRFSHNDSNVKGVIV 171 Streptococcus p...
Q8DT82        94 --NYFLHYMLQ-------KVLQLNLTSLDVGLSQED-SWYQLLIYL--FPKYLQAALRKGLYKEYQRFFYNDSHVKGTIE 161 Streptococcus m...
Q7VG80       207 FHQNLKLNFAHRERFFTSSDEFSVNIAPNRIIKSTLELLNTQN---------LSTNTSA--KLMQMRFIFLDIPPSQSID 275 Helicobacter he...
Q0KFR0       170 IAPHLQQNLYRADRFFTDHDEFTIDRPENRLLHAALRRVLELS---------ASQLNQ---LARELAFVFAEVPVSAQPQ 237 Cupriavidus nec...
1_pfamImport 105 VSAQISKNCVHRDRFQVEFDDYSSERPENRILKTAIDKIRRQI---------SNPQLLL--QVNSLQVHFDDITPVGDVR 173
WP_011721515 156 IQQHIKNIASHTPKVFCGYEEFSVDNKLNQILNYCINILIKNV---------KNQETIK--SLRYAQACFVDITQRKINN 224 Clostridium novyi
Q188G2       156 LSTYAKEKGISPMKIRCEYDEYSENNFLNQVLKKACISILCRI---------NDNSIQG--KIKKILSYFQNVDLIHIDR 224 Clostridioides ...
WP_011751479 140 LREQHLRRFGLPVPLEVTVDEWTLDTDDNRRTRAAATALLALP---------GVPEHSTq-ALRRLDRLL-GEAKLLAPG 208 unclassified No...
WP_011690728 152 ISDQISRRPGMLVPLEVSYDEFTEDIAENRILRAALERMARVP---------RVRPDVQs-RLRLLLGKLDAVTRLR-PG 220 Arthrobacter sp...
Q5JH86       172 V-NELARRPAWKADLPVRYSLLLEDNPLNRVLKGALEVAVKSA---------RLSETRK--VGGILLDLFRDVGDPK--P 237 Thermococcus ko...
Q8CYQ4       172 VRNHLKKNLPFTGNIAYTTREFTYDNPLMQLVRHTIEYIKNQKsigqgvldnLSTSRENvsEIVRVTPSYKLADRAKITR 251 Streptococcus p...
Q8DT82       162 VARHIKKNVPFTGKITYSTREFSFDNALMQLIRHTIAFIQHTVpngrallssSASVRENtaEIVRVTPSYKFSDRAKIIH 241 Streptococcus m...
Q7VG80       276 KDLSKCQNLGYFRNYKMILQWCEIFLKRKSFAPYQKDS-KAYALLFDMNKLFESFVAsemkKWLCdmklsyenkvfieqi 354 Helicobacter he...
Q0KFR0       238 IDFQRVRLDRGMGYYADALAWARLILDEESPLTGAGAH-CAPSMLFPMEAVFEAFVA----KHLAk-------------- 298 Cupriavidus nec...
1_pfamImport 174 IAFDQVRLDRHMRHYELALAWARLILMGQSPHCMQGDA-NAISLLFPMEAVFESFVT----AWMRh-------------- 234
WP_011721515 225 DEILSYKFNRLNNRYKQVFELAKMIIMGYSSLGSGVDK-KTYGILFKMNDVFEKYIE----KVLY--------------- 284 Clostridium novyi
Q188G2       225 KKLLDYKFYKNNDRFKDCYLLARLLLLNLSMDNSQNNQ-EAFSILFEINTLYEEYIG----ILIKs-------------- 285 Clostridioides ...
WP_011751479 209 APLEPWTPTRLNVKMHRLLHLADVVLAHTSVEHEAGAT-QTHGFVVNMAWLFETLIA----RLLE--------------- 268 unclassified No...
WP_011690728 221 APLPPWQATRMNTRYHAVLRLSEVILRNASAEAGDGKQ-QTASFVVDMGQVFEDFVG----TALRe-------------- 281 Arthrobacter sp...
Q5JH86       238 GDFGKVSFNHLNERFRTVFRLARVMYFG---LAAGGSRkFLPGVFIRMDELFETLVY----RTLKt-------------- 296 Thermococcus ko...
Q8CYQ4       252 RNQSKPIRHAYFHEYRNLQELCLMILNQEKHGLGYQDQ-KIYGILFDVAWLWEEYVY----TLLPk-------------- 312 Streptococcus p...
Q8DT82       242 LNQTCPIRHAYYYEYGKLQQLCLMILHQTKHGLNQSQQ-KIHGLLFDVAWLWEEYLA----TLLGe-------------- 302 Streptococcus m...
Q7VG80       355 frESKKDSYLKTQEKSKY-LIVE-GDKNR------FLLNPDIvgYQkQTKETF---FIADTKWKILSKE----QQNYG-- 417 Helicobacter he...
Q0KFR0       299 --QLARPLILKSQARSHH-LVRH-REQNW------FRLKPDL--LIrNADRDL---LVLDTKWKLLDGMkangTDKYG-- 361 Cupriavidus nec...
1_pfamImport 235 --RYNDNWHVKAQVDSHT-LVRL-NGKGV------FKLRPDI--HLrPRGENGdqaMICDVKWKMVESGka----tLE-- 296
WP_011721515 285 --TNLEDSIVHYQHSKYK-LLVN-EDTEKk----vFKLIPDI--VIeKDGIER---IIIDTKWKSVSNE----YNRHG-- 345 Clostridium novyi
Q188G2       286 -iWDNSFRETYIQDKSKF-LLKN-EQTGKk----nFNLRPDIv-LYdLKNEYE---IIIDTKWKAIEV-----DSNVF-- 347 Clostridioides ...
WP_011751479 269 ----EQTLGLVPQQTMPLdTLGR------------LSIKPDL--LFdGPGGVV---AVADTKYKLLDDNg---------k 318 unclassified No...
WP_011690728 282 -aMTAYPGEMRLQYNALLnEAVRdSDR--------LTVNPDAvhLLgGRPV-----VVYDTKYRA--------ATDQG-- 337 Arthrobacter sp...
Q5JH86       297 --VLDNEAEVRFQVQLPH-VIKN-AGEIEarfgalFMMGNPLpdIVvSTDEGT---CVVEVKYRNLYVYhrgeNRAHRkl 369 Thermococcus ko...
Q8CYQ4       313 -gFVHPRNKDKTDGISVFsVGKR-------------KVYPDF--YDrERK------IVLDAKYKKLE------LTEKG-- 362 Streptococcus p...
Q8DT82       303 -dFEHPQNKVSKGGISVFqSGNG------------RKVYPDF--YSrPLG------VVLDAKYKKLE---------KG-- 350 Streptococcus m...
Q7VG80       418 VSQS-DMYQIFAYLAKYQCNQGF------LIYP 443 Helicobacter hepaticus
Q0KFR0       362 LSQS-DFYQLQAYGQSYLSGRGDv----vLIYP 389 Cupriavidus necator H16
1_pfamImport 297 QSQA-DLYQMLAYGVNYQEGIGDm----lLIYP 324
WP_011721515 346 VKRE-DIYQMYAYLTRYQNVNTAi-----LLYP 372 Clostridium novyi
Q188G2       348 YRSS-DIYQMYAYITAYENAKRCi-----LLYP 374 Clostridioides difficile 630
WP_011751479 319 VPNA-DVYQLVTYCARLGLSTGH------LIYS 344 unclassified Nocardioides
WP_011690728 338 ASLSaDHFQMLAYCTALRVPTAW------LVYA 364 Arthrobacter sp. FB24
Q5JH86       370 VRKSdELYQAYTYSRLVSEYLGAkrvpvlLVYP 402 Thermococcus kodakarensis KOD1
Q8CYQ4       363 INRE-DLFQLISYSYILKAEKAG------LVFP 388 Streptococcus pneumoniae R6
Q8DT82       351 IARE-DLFQLITYSYISKAQLAG------LIFP 376 Streptococcus mutans
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