Conserved Protein Domain Family
Brr6_like_C_C

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pfam10104: Brr6_like_C_C 
Di-sulfide bridge nucleocytoplasmic transport domain
Brr6_like_C_C is the highly conserved C-terminal region of a group of proteins found in fungi. It carries four highly conserved cysteine residues. It is suggested that members of the family interact with each other via di-sulfide bridges to form a complex which is involved in nucleocytoplasmic transport. Brr6 in yeast is an essential integral membrane protein of the NE-ER, wit two predicted transmembrane domains, and is a dosage suppressor of Apq12, pfam12716.
Statistics
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PSSM-Id: 401919
View PSSM: pfam10104
Aligned: 131 rows
Threshold Bit Score: 80.3251
Threshold Setting Gi: 121898901
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6FRL2        34 KPVYLIACMVVAIGSICLIIAFMKEIRKDVDVKLEIEMLQHLRKIDQCKYNYRINECd---pGVR-VRA-LDKLCEEWYE 108 [Candida] glabrata
A0CXU9        59 DYIGAWAIAMLKSLILIFFLFIAYQIYQDIQANIEISKTKTMIEMKNCGVEYEQNQC-----SEHfFIDsMAQRCKELEI 133 Paramecium tetr...
A0C5B7        59 DYIGIWAIAILKSFFLICFLLMVYEIYKDIQAHIDISKTQVLIEMKNCGAEYEQNLC-----SENyLIEsMAQKCKELEI 133 Paramecium tetr...
EAY03978      38 IIVNIIIKIIFTIIGLFLFFITFRSISLDIKKREKDFYEMKKIEIEKCKKDYEDNLCdqninEPR-----YQEACMNFKK 112 Trichomonas vag...
EAX86212      44 NFISITSRVFMVIIFLSCTISLLTSIPYEIANRVTALDEFHENIREQCIRDYMENQC-----NTTqVPD-LIAYCQQKWN 117 Trichomonas vag...
Q7RJ14       199 RWLRVIFNIIITSLIVTLIYFIFISIREDINKKVAIQVQNVKEESNTCKKQYYAHKC-----GTVnLPL-LNEKCEEWLK 272 Plasmodium yoel...
EDO08709     295 GWVRAFFNVAVTSVILYIGFVFIMAIGKDIANGLEKRRQMVKAEAMMCQELYKKNRC-----RTVnIPA-LEQQCREWET 368 Babesia bovis
Q4UFW0       279 NWLKTILNIIVTFILIYILIVIFIILRKDIINHINNNKTVVHNKSQVCFNEYTKNKC-----NVIkIPA-MESKCKEWEL 352 Theileria annulata
ESX01967     200 TYLQILLNTLTACYCLKLGYDGIQGIKVDIERAVKQKIHTSYFEIEACRRKYVENHCd---pYTR-LPA-LQETCLQWEA 274 Ogataea parapol...
XP_001834758   7 rkLTTTFHVLIIISTAYTAVQTALILAQDIRHLFEQRRREQAFEIAACRSKYDANHC-----GTFpAPL-LEEQCAELSL 80  Coprinopsis cin...
Q6FRL2       109 CMTvGDAlsknsKFTKKRAALWA-ETLGEILNAFMNSIKIKTWGLLMISITMSILAINVS 167 [Candida] glabrata
A0CXU9       134 CIN-QDI-----EMKVRTKQLWL-KVLGNSFENIFEDLSYKTCVMLTLIAITLSVFFNIC 186 Paramecium tetraurelia
A0C5B7       134 CIN-QNI-----EMKVRTQQLWL-QVLGNSFENMFKTLSLKTCVMISFISITTSIVfikn 186 Paramecium tetraurelia
EAY03978     113 C---KDS-----KIEIEKSEITF-NYLGQAINDFFEALSFATIAKILFCFLAGYFLINFI 163 Trichomonas vaginalis G3
EAX86212     118 CIH---------EPFVSSTHCGIfQYILDIRNAFFSQLTVRSSALLGMTLAFFIFFSlkr 168 Trichomonas vaginalis G3
Q7RJ14       273 CMN-TDH-----KLYQDISFLSA-QMLGQIMNAFIVQFEWKSICVIAFIFLLIFIGSNYA 325 Plasmodium yoelii yoelii
EDO08709     369 CMY-KDA-----ILYDDASFLSA-EVLGGVINKFVSQLDARTVGIVVITFLAFFVGSNCA 421 Babesia bovis
Q4UFW0       353 CMK-KDS-----LVYEDVSSISV-EIIGSLINKLISQLDLKAILFLIIIILLVIIIkikn 405 Theileria annulata
ESX01967     275 CMN-RNP-----FLSVSYTTLLA-EILGTILSSFAEPLNVKSFS-LLFMILGFCYLSNFG 326 Ogataea parapolymorpha DL-1
XP_001834758  81 CMI-RDP------AVIHRFSLVG-EYLGKTVNGFLGSISWGSAAFIGITFTTWFPVCYrw 132 Coprinopsis cinerea okayama7#130
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